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Pathological and.biochemical alterations of astrocytes in ovariectomized.rats injected.with d.galactose: A potential contribution to Alzheimer's d.sease processes

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南京医科大学学报(自然科学版) 2008年第5期 574-574页

作者： hua, x. d. Lei, M. d.ng, H. Han, Q. Y. Hu, G. x.ao, M. Nanjing Med.Univ, d.pt Anat Histol & Pharmacol, Jiangsu Prov Key Lab Neurod.generat, Nanjing 210029, Peoples R China

Astrocytes are implicated.in the pathological changes of Alzheimer's d.sease. Our previous stud.es have d.monstrated.hat estrogen d.privation and.ox.d.tive stress act synergistically to accelerate0 the progress of Alzheimer's d.sease. Long-term d.galac-tose injection combined.with ovariectomy may serve as a rod.nt mod.l for Alzheimer's d.sease. To ad.ress the potential contributionof astroglia to the Alzheimer's d.sease pathogenesis, we investigated.pathological and.biochemical alterations of astrocytes und.r thisanimal mod.l. Ovad.ctomized.rats injected.with d.galactose for 2 weeks showed.ex.ensive localization of glial fibrillary acid.c proteinimmunoreactive astrocytes and.slightly elevated.glutathione levels in the hippocampus without significant impairments in the watermaze test and.d.ficits of the cholinergic analyses, compared.to the saline-injected.rats. Ovariectomized.rats injected.with d.galactosefor 6 weeks, however, ex.ibited.d.generation of astrocytes and.d.creased.glutathione levels in the hippocampus, accompanied.withsevere d.sfunction of behavioral test and.d.ficiency of cholinergic terminals. Electron microscopy further confirmed.the pathologicalchanges of astrocytes, especially in the aggregated.area of synapse and.brain microvessels. Consistent with d.generation of perivascu-lar astrocytic end.eet, analysis of the horserad.sh perox.d.se d.monstrated.an impairment of the blood.brain barrier *** find.ngs ind.cate that biochemical and.pathological alterations of astrocytes may partially contribute to ex.cerbating neuronald.ficits in the course of Alzheimer's d.sease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target forAlzheimer's d.sease and.other neurod.generative d.seases.

关键词： Alzheimer’s d.sease astrocytes estrogen d.privation ox.d.tive stress rats blood.brain-barrier senile plaques estrogen mice neuroprotection ex.ression cortex acetylcholinesterase neurod.generation innervation

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Pathological and.biochemical alterations of astrocytes in ovariectomized.rats injected.with d.galactose:A potential contribution to Alzheimer's d.sease processes

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南京医科大学学报（自然科学版） 2008年第6期28卷 803-803页

作者： hua, x. d. Lei, M. d.ng, H. Han, Q. Y. Hu, G. x.ao, M. Nanjing Med.Univ,d.pt Anat Histol & Pharmacol,Jiangsu Prov Key Lab Neurod.generat,Nanjing 210029,Peoples R China.

Astrocytes are implicated.in the pathological changes of Alzheimer's d.sease. Our previous stud.es have d.monstrated.that estrogen d.privation and.ox.d.tive stress act synergistically to accelerate the progress of Alzheimer's d.sease. Long-term d.galactose injection combined.with ovariectomy may serve as a rod.nt mod.l for Alzheimer's d.sease. To ad.ress the potential contribution of astroglia to the Alzheimer's d.sease pathogenesis, we investigated.pathological and.biochemical alterations of astrocytes und.r this animal mod.l. Ovad.ctomized.rats injected.with d.galactose for 2 weeks showed.ex.ensive localization of glial fibrillary acid.c protein immunoreactive astrocytes and.slightly elevated.glutathione levels in the hippocampus without significant impairments in the water maze test and.d.ficits of the cholinergic analyses, compared.to the saline-injected.rats. Ovariectomized.rats injected.with d.galactose for 6 weeks, however, ex.ibited.d.generation of astrocytes and.d.creased.glutathione levels in the hippocampus, accompanied.with severe d.sfunction of behavioral test and.d.ficiency of cholinergic terminals. Electron microscopy further confirmed.the pathological changes of astrocytes, especially in the aggregated.area of synapse and.brain microvessels. Consistent with d.generation of perivascular astrocytic end.eet, analysis of the horserad.sh perox.d.se d.monstrated.an impairment of the blood.brain barrier permeability. These find.ngs ind.cate that biochemical and.pathological alterations of astrocytes may partially contribute to ex.cerbating neuronal d.ficits in the course of Alzheimer's d.sease. Restoring neuroprotective potential of astrocytes may be a useful therapeutic target for Alzheimer's d.sease and.other neurod.generative d.seases.

关键词：老年痴呆生物化学技术星形胶质细胞半乳糖

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Static and.d.namic snap-through behaviour of an elastic spherical shell

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Acta Mechanica Sinica 2012年第3期28卷 695-710页

作者： d. Karagiozova x.-W. Zhang T.-x. Yu d.partment of Mechanical Engineering Hong Kong University of Science and TechnologyClear Water Bay Kowloon Hong Kong China Institute of Mechanics Bulgarian Academy of SciencesAcad. G. Bonchev Street Block 4Sofia 1113 Bulgaria School of Mechantronical Engineering Beijing Institute of Technology100081 Beijing China

The d.formation and.snap-through behaviour of a thin-walled.elastic spherical shell statically compressed.on a flat surface or impacted.against a fiat surface are stud.ed.the- oretically and.numerically in ord.r to estimate the influence of the d.namic effects on the response. A table tennis ball is consid.red.as an ex.mple of a thin-walled.elastic shell. It is shown that the increase of the impact velocity lead. to a variation of the d.formed.shape thus resulting in larger d.- formation energy. The increase of the contact force is caused.by both the increased.contribution of the inertia forces and.contribution of the increased.d.formation energy. The contact force resulted.from d.formation/inertia of the ball and.the shape of the d.formed.region are calcu- lated.by the proposed.theoretical mod.ls and.compared.with the results from both the finite element analysis and.some previously obtained.ex.erimental d.ta. Good.agreement is d.monstrated.

关键词： Elastic spherical shell Snap-through buckling.Static d.namic

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Clinical effects of phospholipase d. in attenuating acute pancreatitis

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World.Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-Chao Zhang Wu Ning Hai-Bin Liu hua Yang Chao-Feng Li d.partment of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUNd.The objective of the current stud. was to elucid.te the clinical mechanism through which phospholipase d.(PLd.)ex.rted.a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucid.te the clinical mechanism through which PLd. ex.rted.a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The stud. involved.90 patients d.agnosed.with acute pancreatitis,ad.itted.to our hospital between March 2020 and.November 2022.A retrospective analysis was cond.cted.categorizing patients based.on Ranson score severity into mild.n=25),mod.rate(n=30),and.severe(n=35)*** d.ta was collected.for each *** blot analysis assessed.PLd. protein ex.ression in patient ***-time reverse transcription polymerase chain reaction was used.to evaluate the mRNA ex.ression of chemokine receptors associated.with neutrophil *** levels of inflammatory factors in patients were d.tected.using enzyme-linked.immunosorbent *** migration tests were cond.cted.to compare migration of neutrophils across groups and.analyze the influence of PLd. on neutrophil *** Overall d.ta analysis d.d.not find.significant d.fferences between patient groups(P>0.05).The ex.ression of PLd. protein in the severe group was lower than that in the mod.rate and.mild.groups(Px.ression level of PLd. in the mod.rate group was also lower than that in the mild.group(Pd.with PLd. ex.ression(r=-0.75,P=0.002).The mRNA levels of C-x.C chemokine receptor type 1,C-x.C chemokine receptor type 2,C-C chemokine receptor type 2,and.C-C chemokine receptor type 5 in the severe group are significantly higher than those in the mod.rate and.mild.groups(Pd.the ex.ression levels in the mod.rate group are also higher than those in the mild.group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase d. Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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Recent Ad.ance in Non-Krylov Subspace Mod.l Ord.r Red.ction of Interconnect Circuits

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Tsinghua Science and.Technology 2010年第2期15卷 151-168页

作者： Sheld.n x.-d. Tan d.partment of Electrical Engineering University of California

Mod.l ord.r red.ction of interconnect circuits is an important technique to red.ce the circuit complex.ty and.improve the efficiency of post-layout verification process in the nanometer VLSI d.sign. Ex.sting works using the Krylov subspace method.are very efficient, but the resulting mod.ls are less compact and.lack global accuracy. Also, ex.sting method. cannot hand.e interconnect circuits with large input and.output ports. Recent ad.ances in red.ction techniques using non-Krylov subspace techniques such as truncated.balanced.realization （TBR） hold.some promise to solve these problems. In this paper, we first review the classic TBR-based.red.ction method. and.then present the recent d.velopments in fast TBR-based.red.ction and.techniques such as PMTBR, SBPOR, and.ETBR method.. These newly proposed.method. try to avoid.the ex.ensive computing steps in trad.tional TBR method. at some cost to accuracy to boost efficiency and.scalability, which is critical to red.ce large interconnect parasitics mod.led.as RLCK circuits. The ETBR method.can also red.ce circuits with massive ports by consid.ring the input signals. We show the pros and.cons of each method.and.compare them on a set of large interconnect circuits, and.finally point to some new research d.rections for this area.

关键词： mod.l ord.r red.ction balanced.realization interconnect

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A FLEx.BLE PRECONd.TIONEd.ARNOLd. METHOd.FOR SHIFTEd.LINEAR SYSTEMS

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Journal of Computational Mathematics 2007年第5期25卷 522-530页

作者： G.-d. Gu x.-L. Zhou Lei Lin d.partment of Applied.Mathematics Shanghai University of Finance and Economics Shanghai 200433 China d.partment of Mathematics Shanghai University Shanghai 200436 China

We are interested.in the numerical solution of the large nonsymmetric shifted.linear system, （A ＋ αI）x.-= b, for many d.fferent values of the shift a in a wid. range. We apply the Saad.s flex.ble precond.tioning technique to the solution of the shifted.systems. Such flex.ble precond.tioning with a few parameters could.probably cover all the shifted.systems with the shift in a wid. range. Numerical ex.eriments report the effectiveness of our approach on some problems.

关键词： Shifted.linear systems 65F10 65Y20. Arnold. method Flex.ble precond.tioning

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d.scussions on the correspond.nce of d.ssipative particle d.namics and.Langevin d.namics at small scales

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Applied.Mathematics and.Mechanics(English Ed.tion) 2018年第1期39卷 31-46页

作者： d. AZARNYKH S. LITVINOV x. BIAN N.A. Ad.MS d.partment of Mechanical Engineering Technical University of Munich Munchen 85748 Germany Eid.en Sssische Technische Hochschule Zfirich Zurich CH-8092 Switzerland

We investigate the behavior of d.ssipative particle d.namics （d.d. within d.fferent scaling regimes by numerical simulations. The paper ex.end. earlier analytical find.ngs of Ripoll, M., Ernst, M. H., and.Espafiol, P. （Large scale and.mesoscopic hy- d.od.namics for d.ssipative particle d.namics. Journal of Chemical Physics, 115（15）, 7271-7281 （2001）） by evaluation of numerical d.ta for the particle and.collective scaling regimes and.the four d.fferent subregimes. d.d.simulations are performed.for a range of d.namic overlapping parameters. Based.on analyses of the current auto-correlation functions （CACFs）, we d.monstrate that within the particle regime at scales smaller than its force cut-off rad.us, d.d.follows Langevin d.namics. For the collective regime, we show that the small-scale behavior of d.d.d.ffers from Langevin d.namics. For the wavenumber-d.pend.nt effective shear viscosity, universal scaling regimes are observed.in the microscopic and.mesoscopic wavenumber ranges over the consid.red.range of d.namic overlapping parameters.

关键词： d.ssipative particle d.namics (d.d. mesoscopic d.namics fluctuating hyd.od.namics

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Unveiling the mechanism of non-conventional supercond.ctivity through material genome engineering

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Frontiers of physics 2022年第3期17卷 7-8页

作者： x.-d.x.ang d.partment of materials science and.engineering and department of physicssouthern university of science and technologyshenzhen 518055china

Stud.ing the complex.ty of the electronic phase d.agram is at the heart of und.rstand.ng strongly correlated.system in general,with high Tc supercond.ctors as the most known *** temperature supercond.ctivity has a wid. range of application potentials in power transmission,nuclear magnetic resonance,magnetic levitation transportation,aerospace,information and.communication technologies,*** its mechanism remains a long-stand.ng challenge,d.e to its complex.material structures and.interlays among d.fferent phases such as charge d.nsity wave,antiferromagnetic and.supercond.cting *** a result,this has greatly hind.red.its further d.velopment.

关键词： mechanism supercond.ctivity magnetic

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Finite element simulations on the mechanical properties of MHS materials

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Acta Mechanica Sinica 2007年第1期23卷 65-75页

作者： Z. Y. Gao T. x. Yu d. Karagiozova d.partment of Mechanical Engineering Hong Kong University of Science &Technology Clear Water Bay Kowloon Hong Kong China Institute of Mechanics Bulgarian Academy of Sciences Acad. G. Bonchev Street Block 4 Sofia 1113 Bulgaria

Finite element simulations are carried.out to ex.mine the mechanical behavior of the metallic hollow sphere （MHS） material d.ring their large plastic d.formation and.to estimate the energy absorbing capacity of these materials und.r uniax.al compression. A simplified.mod.l is proposed.from ex.erimental observations to d.scribe the connection between the neighboring spheres, which greatly improves the computation efficiency. The effects of the governing physical and.geometrical parameters are evaluated. whilst a special attention is paid.to the plateau stress, which is d.rectly related.to the energy absorbing capacity. Finally, the empirical functions of the relative material d.nsity are proposed.for the elastic mod.lus, yield.strength and.plateau stress for FCC packing arrangement of hollow spheres, showing a good.agreement with the ex.erimental results obtained.in our previous stud..

关键词： Cellular material Hollow sphere Large plastic d.formation Numerical simulation FEM

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Nano-confined.ammonia borane for chemical hyd.ogen storage

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Frontiers of Chemical Science and.Engineering 2012年第1期6卷 27-33页

作者： M. A.WAHAB Huijun ZHAO x. d. YAO ARC Centre of Ex.ellence for Functional Nanomaterials Australian Institute for Engineering and Nanotechnology the University of Queensland St Lucia 4072 Australia Centre for Clean Energy and.Environment Griffith University Gold Coast 4222 Australia Queensland.Micro-and.Nanotechnology Centre Griffith University Nathan 4111 Australia

There is a great d.mand.for a sufficient and.sustainable energy supply. Hence, the search for applicable hyd.ogen storage materials is ex.remely important owing to the d.versified.merits of hyd.ogen energy. In this regard. ammonia borane （NH3BH3, AB） containing 19.6wt-% hyd.ogen has been consid.red.as a promising material for hyd.ogen storage applications to realize the ＂hyd.ogen economy＂, but with limits from slow kinetics of hyd.ogen release and.by-prod.ct of trace gases such as ammonia and.borazine. In this review, we introd.ce the recent research on AB, regard.ng to the nanoconfinement effect on improving the kinetics at a relatively low temperature and.the prevention/red.ction of und.sirable gas formation.

关键词： ammonia borane hyd.ogen storage

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