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Effectivity and safety of trifocal intraocular lenses and capsular tension rings implantation for cataract patients with axial high myopia

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 499-508页

作者： Shan hua Qiu-xia Xie hu Wang Jing-xiang Zhong Dongguan Aier Eye Hospital Jinan UniversityDongguan 523106Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Ophthalmology the Sixth Affiliated Hospital of Jinan UniversityDongguan 523576Guangdong ProvinceChina

●AIM:To assess effectivity and safety of trifocal intraocular lenses(IOLs)and capsular tension rings in treating cataract patients with axial high myopia.●METHODS:A prospective nonrandomized controlled clinical trial was conducted.Totally 98 eyes(74 patients)who underwent femtosecond laser-assisted cataract surgery(FLACS)with trifocal IOLs were enrolled in the study and followed up for 2y after surgery:46 eyes(33 patients)with capsular tension ring implantation in the long axial lengths(AL)group(260.05).The dysfunctional lens index and total modulation transfer function(MTF)average height were similar between the two groups.The postoperative internal coma aberrations in the axial high myopia eyes were significantly higher than that in the normal AL group(P<0.05).The total satisfaction score in the long AL group(91.32±2.76)was slightly higher than that in the normal AL group(90.36±3.47),but there was no difference(P=0.136).A statistically negative correlation was found between corrected distance visual acuity(CDVA)and dysfunctional lens index(r=-0.382,P=0.009),and between CDVA and the total MTF average height(r=-0.374,P=0.01).But there was no significant correlation between CDVA and total satisfaction score(r=0.059,P=0.696).Postoperative complications mainly presented as posterior capsular opacity(PCO),retinal detachment and cystoid macular edema.There was no difference in the incidence of fundus disease(6.5%vs 3.8%,P=0.663)or PCO(1

关键词： trifocal intraocular lenses capsular tension ring axial high myopia cataract visual quality

The ubiquitin codes in cellular stress responses

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Protein & Cell 2024年第3期15卷 157-190页

作者： xiangpeng Sheng Zhixiong xia Hanting Yang Ronggui hu Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Molecular Biology Shanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China State Key Laboratory of Animal Disease Control Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069China Department of Neurology State Key Laboratory of Medical NeurobiologyInstitute for Translational Brain ResearchMOE Frontiers Center for Brain ScienceZhongshan HospitalFudan UniversityShanghai 200032China

Ubiquitination/ubiquitylation,one of the most fundamental post-translational modifications,regulates almost every critical cellular process in eukaryotes.Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses,from exogenous factors to cellular reactions,causing a dazzling variety of functional consequences.Various forms of ubiquitin sig-nals generated by ubiquitylation events in specific milieus,known as ubiquitin codes,constitute an intrinsic part of myriad cellular stress responses.These ubiquitination events,leading to proteolytic turnover of the substrates or just switch in functionality,initiate,regulate,or supervise multiple cellular stress-associated responses,supporting adaptation,homeostasis recovery,and survival of the stressed cells.In this review,we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses,while discussing how stresses modulate the ubiquitin system.This review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

关键词： ubiquitin E3 ligase environmental stresses intercellular stresses stress response homeostasis

A Probing Model of Secret Key Generation Based on Channel Autocorrelation Function

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China Communications 2024年第6期21卷 163-175页

作者： xia Enjun hu Binjie Shen Qiaoqiao School of Electronic and Information Engineering South China University of TechnologyGuangzhou 510641China

Secret key generation(SKG)is a promising solution to the problem of wireless communications security.As the first step of SKG,channel probing affects it significantly.Although there have been some probing schemes,there is a lack of research on the optimization of the probing process.This study investigates how to optimize correlated parameters to maximize the SKG rate(SKGR)in the time-division duplex(TDD)mode.First,we build a probing model which includes the effects of transmitting power,the probing period,and the dimension of sample vectors.Based on the model,the analytical expression of the SKGR is given.Next,we formulate an optimization problem for maximizing the SKGR and give an algorithm to solve it.We conclude the SKGR monotonically increases as the transmitting power increases.Relevant mathematical proofs are given in this study.From the simulation results,increasing appropriately the probing period and the dimension of the sample vector could increase the SKGR dramatically compared to a yardstick,which indicates the importance of optimizing the parameters related to the channel probing phase.

关键词： channel autocorrelation function channel probing optimization problem physical layer security secret key generation

Attribution of Biases of Interhemispheric Temperature Contrast in CMIP6 Models

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Advances in Atmospheric Sciences 2024年第2期41卷 325-340页

作者： Shiyan ZHANG Yongyun hu Jiankai ZHANG Yan xia Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Systems Science Beijing Normal UniversityBeijing 100875China

One of the basic characteristics of Earth's modern climate is that the Northern Hemisphere(NH) is climatologically warmer than the Southern Hemisphere(SH). Here, model performances of this basic state are examined using simulation results from 26 CMIP6 models. Results show that the CMIP6 models underestimate the contrast in interhemispheric surface temperatures on average(0.8 K for CMIP6 mean versus 1.4 K for reanalysis data mean), and that there is a large intermodel spread, ranging from -0.7 K to 2.3 K. A box model energy budget analysis shows that the contrast in interhemispheric shortwave absorption at the top of the atmosphere, the contrast in interhemispheric greenhouse trapping, and the crossequatorial northward ocean heat transport, are all underestimated in the multimodel mean. By examining the intermodel spread, we find intermodel biases can be tracked back to biases in midlatitude shortwave cloud forcing in AGCMs. Models with a weaker interhemispheric temperature contrast underestimate the shortwave cloud reflection in the SH but overestimate the shortwave cloud reflection in the NH, which are respectively due to underestimation of the cloud fraction over the SH extratropical ocean and overestimation of the cloud liquid water content over the NH extratropical continents.Models that underestimate the interhemispheric temperature contrast exhibit larger double ITCZ biases, characterized by excessive precipitation in the SH tropics. Although this intermodel spread does not account for the multimodel ensemble mean biases, it highlights that improving cloud simulation in AGCMs is essential for simulating the climate realistically in coupled models.

关键词： interhemispheric temperature contrast energy balance shortwave cloud forcing ITCZ CMIP6 AGCM

Resveratrol combats chronic diseases through enhancing mitochondrial quality

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Food Science and human Wellness 2024年第2期13卷 597-610页

作者： Weichu Tao hu Zhang xia Jiang Ning Chen Tianjiu Research and Development Center for Exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Sports MedicineWuhan Sports UniversityWuhan 430079China The University Hospital of Wuhan Sports University Wuhan 430079China

Resveratrol(RSV),as a functional food component extracted from natural plants,has been widely studied and recognized in preventing and treating various diseases,with major mechanisms including executing anti-inflammation and anti-oxidation functions,and improving mitochondrial quality.Chronic diseases as non-communicable diseases are mainly caused by multiple factors,such as physiological decline and dysfunction in the body,and have become a significant challenge on public health worldwide.It is worth noting that chronic diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),muscle atrophy,cardiovascular disease,obesity,and cancer are accompanied by abnormal mitochondrial function.Therefore,targeted regulation of mitochondria may be a meaningful way to prevent and treat chronic diseases.Increasing evidence has confirmed that RSV is actively involved in regulating mitochondria,and it has become an essential consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding functions.In this article,current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are systematically summarized,which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.

关键词： Resveratrol Functional food Mitochondrial quality Chronic disease Anti-inflammation Anti-oxidation

Aerodynamic optimization of an adaptive flap for next-generation green aircraft

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Chinese Journal of Aeronautics 2024年第2期37卷 100-122页

作者： Tianlong LIN Rosario PECORA Danilo CILIBERTI Wei xia Shuling hu State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Deparment of Industrial Engineering Aerospace DivisionUniversity of Naples"FEDERICO II"Napoli 80125Italy

Adaptive,morphing flaps are taking ever-increasing attention in civil aviation thanks to the expected benefits this technology can bring at the aircraft level in terms of high-lift performance improvement and related fuel burnt reduction per flight.Relying upon morphing capabilities,it is possible to fix a unique setting for the flap and adapt the flap shape to match the aerodynamic requirements for take-off or landing.The proper morphed shapes can assure better high-lift performances than those achievable by referring to a conventional flap.Moreover,standing the unique flap setting for take-off and landing,a dramatic simplification of the flap deployment systems may be achieved.As a consequence of this simplification,the deployment system can be fully hosted in the wing,thus avoiding under-wing nacelles with significantly better aerodynamics and fuel consumption.The first step for a rational design of an adaptive flap consists in defining the target morphed shapes and the unique optimal flap setting in the take-off and landing phases.In this work,aerodynamic optimization analyses are carried out to determine the best flap setting and related morphed shapes in compliance with the take-off and landing requirements of a reference civil transport aircraft.Four different initial conditions are adopted to avoid the optimization falling into local optima,thus obtaining four groups of optimal candidate configurations.After comparing each candidate’s performance through 2D and 3D simulations,the optimal configuration has been selected.2D simulations show that the optimal configuration is characterized by a maximum lift increase of 31.92%in take-off and 9.04%in landing.According to 3D simulations,the rise in maximum lift equals 22.26%in take-off and 3.50%in landing.Numerical results are finally verified through wind tunnel tests,and the aerodynamic mechanism behind the obtained improvements is explained by carefully analyzing the flow field around the flap.

关键词： Morphing wings High-lift system Adaptive flap Computational Fluid Dynamics(CFD) Wind tunnel tests

An Adaptive Local Grid Nesting-based Genetic Algorithm for Multi-earth Observation Satellites' Area Target Observation

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Journal of Systems Science and Systems Engineering 2024年第2期33卷 232-258页

作者： Ligang Xing Wei xia xiaoxuan hu Waiming Zhu Yi Wu School of Management Hefei University of TechnologyHefei 230009China Key Laboratory of Process Optimization and Inteligent Decision-making Ministry of EducationHefei 230009China Intelligent Interconnected Systems Laboratory of Anhui Province Hefei 230009China

The Scheduling of the Multi-EOSs Area Target Observation(SMEATO)is an EOS resource schedul-ing problem highly coupled with computational geometry.The advances in EOS technology and the ex-pansion of wide-area remote sensing applications have increased the practical significance of SMEATO.In this paper,an adaptive local grid nesting-based genetic algorithm(ALGN-GA)is proposed for developing SMEATO solutions.First,a local grid nesting(LGN)strategy is designed to discretize the target area into parts,so as to avoid the explosive growth of calculations.A genetic algorithm(GA)framework is then used to share reserve information for the population during iterative evolution,which can generate high-quality solutions with low computational costs.On this basis,an adaptive technique is introduced to determine whether a local region requires nesting and whether the grid scale is sufficient.The effectiveness of the proposed model is assessed experimentally with nine randomly generated tests at different scales.The results show that the ALGN-GA offers advantages over several conventional algorithms in 88.9%of instances,especially in large-scale instances.These fully demonstrate the high efficiency and stability of the ALGN-GA.

关键词： Multi-EOSs scheduling area target observation adaptive genetic algorithm local grid nesting

Chemico-biological conversion of carbon dioxide

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Journal of Energy Chemistry 2024年第2期89卷 371-387,I0009页

作者： Liangwei hu Junzhu Yang Qi xia Jin Zhang Hongxin Zhao Yuan Lu Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China College of Biological and Chemical Engineering Jiaxing UniversityJiaxing 314000ZhejiangChina

The unabated carbon dioxide(CO_(2))emission into the atmosphere has exacerbated global climate change,resulting in extreme weather events,biodiversity loss,and an intensified greenhouse effect.To address these challenges and work toward carbon(C)neutrality and reduced CO_(2)emissions,the capture and utilization of CO_(2)have become imperative in both scientific research and industry.One cutting-edge approach to achieving efficient catalytic performance involves integrating green bioconversion and chemical conversion.This innovative strategy offers several advantages,including environmental friendliness,high efficiency,and multi-selectivity.This study provides a comprehensive review of existing technical routes for carbon sequestration(CS)and introduces two novel CS pathways:the electrochemicalbiological hybrid and artificial photosynthesis systems.It also thoroughly examines the synthesis of valuable Cnproducts from the two CS systems employing different catalysts and biocatalysts.As both systems heavily rely on electron transfer,direct and mediated electron transfer has been discussed and summarized in detail.Additionally,this study explores the conditions suitable for different catalysts and assesses the strengths and weaknesses of biocatalysts.We also explored the biocompatibility of the electrode materials and developed novel materials.These materials were specifically engineered to combine with enzymes or microbial cells to solve the biocompatibility problem,while improving the electron transfer efficiency of both.Furthermore,this review summarizes the relevant systems developed in recent years for manufacturing different products,along with their respective production efficiencies,providing a solid database for development in this direction.The novel chemical-biological combination proposed herein holds great promise for the future conversion of CO_(2)into advanced organic compounds.Additionally,it offers exciting prospects for utilizing CO_(2)in synthesizing a wide range of industrial products.Ultimately,t

关键词： Carbon dioxide Bioelectric synthesis Artificial photosynthesis Synthetic product

Transient flameout process of boron-magnesium agglomerates during combustion in oxygen-rich atmospheres

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Particuology 2024年第5期88卷 290-301页

作者： Lian Duan Zhixun xia Yunchao Feng Binbin Chen Likun Ma Jianxin hu College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China School of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan 411105China

In this study,boron–magnesium agglomerates with varying mass ratios were prepared by drying a micron-sized boron–magnesium mixed suspension,and the combustion process of these agglomerates under different oxygen-rich concentrations were investigated using a laser ignition system.The test results showed that when the mass fraction of magnesium powder in boron-magnesium agglomerates exceeded a certain threshold(between 2%and 5%),flame extinction and reignition occurred after a significant reduction in the agglomerate volume during combustion.This process is referred to as the transient flameout process,which is affected by the magnesium content of the agglomerate and the oxygen concentration in the ambient atmosphere.An increase in the magnesium content or oxygen concentration makes this phenomenon more pronounced.During weakening of the flame intensity,a dark film gradually covered the particle surfaces.X-ray diffraction and elemental analyses of the cross-section and outer surface of the condensed combustion product suggested that the dark film is primarily composed of Mg-B-O ternary oxides.This film prevents direct contact between boron and oxygen,thereby inhibiting surface and gas-phase reactions and leading to the occurrence of the transient flameout phenomenon.

关键词： Agglomerated particle Boron–magnesium fuel Boron combustion Transient flameout process Solid fuel ramjet