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Chinese Chemical Letters 2015年第3期26卷 334-338页

作者： Yan Wu Wei-Qi Chen Yu-Qing Zhao hu-ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of EducationYanbian University College of Pharmacy Department of Chemistry Fudan University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow *** antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT *** 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.

关键词： antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate

Synthesis and positive inotropic evaluation of 1-(benzylamino)-3-(4,5-di-hydro[1,2,4]trizaolo[4,3-a]quinolin-7-yloxy)propan-2-ol derivatives

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Chinese Chemical Letters 2009年第2期20卷 175-177页

作者： Ting Ting Li Ling Zhang Zhe Shan Quan Hai Bo Zhu hu ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of Education Yanbian University College of Pharmacy Yanji 133000 China Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

In an attempt to search for more potent positive inotropic agents, a series of 1-（benzylamino）-3-（4,5-dihydro[ 1,2,4]trizaolo[4,3- a]quinolin-7-yloxy）propan-2-ol derivatives was synthesized in four steps using 6-hydroxy-3,4-dihydro-2（1H）-quinolinone as a starting material, and their positive inotropic activities were evaluated by measuring the coronary blood flow （CBF） and the left ventricular pressure （LVP） followed by calculating the rate of pressure development （dp/dtmax values） in the preparation of rat Langendorff＇s heart. Three compounds （5d, 5g, 5j） showed favorable activities, among which 5g was shown the most potent with dp/dtmax value of 9.7% and CBF value of 17.8% at a concentration of 1×10^-5 mol/L in our in vitro study.

关键词： 3,4-Dihydrotrizaolo[4,3-a]quinoline Positive inotropic activity Synthesis

Synthesis and biological evaluation of dihydrotriazine derivatives as potential antibacterial agents

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Chinese Chemical Letters 2017年第8期28卷 1737-1742页

作者： Tian-Yi Zhang Chao Li Yu-Shun Tian Jia-Jun Li Liang-Peng Sun Chang-Ji Zheng hu-ri piao Key Laboratory of Natural Resources of Changbai Mountain&Functional Molecules Ministry of EducationYanbian University College of PharmacyYanji133000China Department of Pharmacy Jilin Medical UniversityJilin 132013China

A series of 1,4-dihydro-1,3,5-triazine derivatives were designed and synthesized and their antibacterial and antifungal activities were evaluated. Most of the synthesized compounds showed potent inhibition of several Gram-positive bacterial strains（including multidrug-resistant clinical isolates） and Gramnegative bacterial strains, with minimum inhibitory concentrations（MICs） in the range of 2.1–181.2 mmol/L. Compounds 7a and 7c presented the most potent inhibitory activities against Grampositive bacteria（e.g., Staphylococcus aureus 4220）, Gram-negative bacteria（e.g., Escherichia coli 1924）,and the fungus Candida albicans 7535, with MICs of 2.1 or 4.1 mmol/L. Especially, compound 7a was the most potent, with an MIC of 2.1 mmol/L against four multidrug-resistant, Gram-positive bacterial *** cytotoxic activity of the compound 7a, 7c and 7f was assessed in HepG2 cells, and the results suggest that 1,4-dihydro-1,3,5-triazine derivatives bearing a 6-benzyloxynaphthalen moiety are interesting scaffolds for the development of novel antibacterial agents.

关键词： Antibacterial activitis Antifungal activities Cytotoxicity Minimal inhibitory concentration 1 4-Dihydro-1 3 5-triazine

Acyldesilylation of 5-Trimethylsilyl-2-furancarboxaldehyde

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Chinese Chemical Letters 1999年第1期10卷 11-12页

作者： hu ri piao Zhe Shan QUAN Kouji NAKAYAMA Akira TANAKA(School of Pharmacy，Yanbian University，Yanji，133000)(Faculty of Pharmaceutical Sciences，Josai University,Saitama，Japan 350-02) Yanbian Univ Sch Pharm Yanji 133000 Peoples R China Josai Univ Fac Pharmaceut Sci Sakado Saitama 35002 Japan

Acyldesilylation of 5-trimethylsilyl-2-furancarboxaldehyde with acyl chlorides was investigated and the unexpected 5-acyl-2-dichloromethylfuran were obtained as main products. The expected 5-acyl-2-furancarboxaldehyde... 详细信息

关键词： 2-acyl-5-dichloromethylfuran 5-acyl-2-furancarboxaldehyde 5-trimethyisilyl-2-furancarboxaldehyde acyldesilylation

The synthesis of pyrazole-based N-substitued rhodanine derivatives and their antibacterial activity study

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The synthesis of pyrazole-based N-substitued rhodanine deriv...

2011年全国药物化学学术会议——药物的源头创新

作者： Ming-Xia Song,Xin Jin,Chang-Ji Zheng,hu-ri piao~* Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education,Yanji,133002,P.R.China

＜正＞Emerging infectious diseases and the increasing number of multi-drug resistant microbial pathogens still make the treatment of infectious diseases an important and challenging problem [1].Therefore,there is an urgent need for development of new antibacterial agents with divergent and unique structure and with a mechanism of action possibly different from that of existing

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Synthesis and Positive Inotropic Evaluation Of[4,3-a]quinolin and dihydrobenzooxazol Derivatives

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Synthesis and Positive Inotropic Evaluation Of[4,3-a]quinoli...

2011年全国药物化学学术会议——药物的源头创新

作者： Yan Wu,Long-Xu Ma,Jian Che,Xun Cui,hu-ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain,Ministry of Education,Yanji,133002,P.R.China

＜正＞Cardiac glycosides,like digoxin,have consistently been one of the most frequently prescribed cardiotonics used for the treatment of congestive heart failure（CHF） for many years and are the only medications used without increasing the CHF patient’s mortality up to now,but their high toxicity and narrow therapeutic window still limit their clinical application as positive inotropic

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Synthesis and antibacterial activity of new rhodanine analogs

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Synthesis and antibacterial activity of new rhodanine analog...

2011年全国药物化学学术会议——药物的源头创新

作者： Li-Li Xu,Jing Miao,Chang-Ji Zheng,hu-ri piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain,Affiliated Ministry of Education,Yanji,133002,P.R.China

＜正＞Increasing resistance of microorganisms to currently available antimicrobial drugs is the major cause of morbidity and mortality throughout the world[1].Therefore,to explore and discover a new class of antibioti... 详细信息

关键词： rhodanine analog Antibacterial activity Minimal inhibitory concentration(MIC )

Synthesis and PTP1B Inhibitory Evaluation of 2-naphthol tyrosine derivatives

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Synthesis and PTP1B Inhibitory Evaluation of 2-naphthol tyro...

2011年全国药物化学学术会议——药物的源头创新

作者： Liang-Peng Sun a,Qiang Shen b,Jia Li b,hu-ri piao a,~* a Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules,Ministry of Education,Yanbian University College of Pharmacy,Yanji,133000,PR China b National Center for Drug Screening,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Science,Chinese Academy of Sciences,Shanghai 201203,China

＜正＞In recent years,a great attention are being payed to protein tyrosine phosphatase 1B（PTP1B） due to its pivotal role in type 2 diabetes and obesity as a negative regulator of the insulin and leptin-signaling pathway[1-2].Therefore,the search for potent small molecule protein tyrosine phosphatase 1B inhibitors is a major thrust area in the management of type 2 diabetes mellitus.

关键词： Protein tyrosine phosphatase 1B(PTP1B) Inhibitor Synthesis

Recent progress for hydrogen production by photocatalytic natural or simulated seawater splitting

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Nano Research 2020年第9期13卷 2313-2322页

作者： Jining Zhang Wenping hu Shuang Cao Lingyu piao CAS Center for Excellence in Nanoscience CAS Key Laboratory of Standardization and Measurement for NanotechnologyNational Center for Nanoscience and TechnologyBeijing 100190China School of Science Tianjin UniversityTianjin 300072China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesChina

Solar energy is an inexhaustible renewable energy *** the various methods for solar energy conversion,photocatalytic hydrogen(H2)production is considered as one of the most promising *** Fujishima pioneered this field in 1972,photocatalytic water splitting to produce H2 has received widespread *** to now,abundant semiconductor materials have been explored as photocatalysts for pure water splitting to produce ***,photocatalytic seawater splitting is more in line with the concept of sustainable development,which can greatly alleviate the problem of limited freshwater *** present,only few studies have focused on the process of H2 production by photocatalytic seawater splitting due to the complex composition of seawater and lack of suitable *** this review,we outline the most recent advances in photocatalytic seawater *** particular,we introduce the H2 production photocatalysts,underlying mechanism of ions in seawater on photocatalytic seawater splitting,current challenges and future potential advances for this exciting field.

关键词： photocatalytic seawater hydrogen production photocatalytic mechanism

Four decades of full-scale nitrous oxide emission inventory in China

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National Science Review 2024年第3期11卷 137-149页

作者： Minqi Liang Zheyan Zhou Peiyang Ren Han Xiao Xu-ri Zhongmin hu Shilong piao Hanqin Tian Qing Tong Feng Zhou Jing Wei Wenping Yuan School of Atmospheric Sciences Guangdong Province Data Center of Terrestrial and Marine Ecosystems Carbon Cycle Sun Yat-sen University State Key Laboratory of Tibetan Plateau Earth System Resources and Environment Institute of Tibetan Plateau Research Chinese Academy of Sciences Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province Hainan University Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking University Schiller Institute for Integrated Science and Society Department of Earth and Environmental Sciences Boston College Institute of Energy Environment and Economy Tsinghua University Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)

China is among the top nitrous oxide（N2O）-emitting countries, but existing national inventories do not provide full-scale emissions including both natural and anthropogenic sources. We conducted a four-decade（1980–2020） of comprehensive quantification of Chinese N2O inventory using empirical emission factor method for anthropogenic sources and two up-to-date process-based models for natural sources. Total N2O emissions peaked at 2287.4（1774.8–2799.9） Gg N2O yr-1in 2018, and agriculture-developed regions, like the East, Northeast, and Central, were the top N2O-emitting regions. Agricultural N2O emissions have started to decrease after 2016 due to the decline of nitrogen fertilization applications, while, industrial and energetic sources have been dramatically increasing after 2005. N2O emissions from agriculture, industry,energy, and waste represented 49.3%, 26.4%, 17.5%, and 6.7% of the anthropogenic emissions in 2020,respectively, which revealed that it is imperative to prioritize N2O emission mitigation in agriculture,industry, and energy. Natural N2O sources, dominated by forests, have been steadily growing from 317.3（290.3–344.1） Gg N2O yr-1in 1980 to 376.2（335.5–407.2） Gg N2O yr-1in 2020. Our study produces a Full-scale Annual N2O dataset in China（FAN2020）, providing emergent counting to refine the current national N2O inventories.

关键词： nitrous oxide four decades anthropogenic sources natural sources