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基于“浊毒-线粒体自噬”探讨慢性肾脏病心脏损害

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云南中医中药杂志 2024年第1期45卷 18-22页

作者：郭敏杨芮胡良伟晏子友江西中医药大学江西南昌330006 江西中医药大学附属医院江西南昌330006

心脏损害是慢性肾脏病进展过程中常见并发症之一,大量研究表明线粒体自噬能干预慢性肾脏病心脏损害的病程。线粒体自噬是当今医学调控慢性肾脏病心脏损害重要靶点及研究课题。慢性肾脏病患者体内毒素代谢异常,同时心肾两脏富含线粒体,... 详细信息

心脏损害是慢性肾脏病进展过程中常见并发症之一,大量研究表明线粒体自噬能干预慢性肾脏病心脏损害的病程。线粒体自噬是当今医学调控慢性肾脏病心脏损害重要靶点及研究课题。慢性肾脏病患者体内毒素代谢异常,同时心肾两脏富含线粒体,慢性肾脏病后期尿毒症毒素内积,线粒体凋亡及受损线粒体释放出的大量有害物质的过程与中医浊毒内生相似。通过从慢性肾脏病、线粒体自噬与浊毒的关系,慢性肾脏病并发心脏损害的浊毒理论,浊毒、线粒体自噬与心脏损害的联系,浊毒-线粒体自噬-慢性肾脏病并发心脏损害的形成,中医药祛浊毒理论干预线粒体自噬治疗慢性肾脏病心脏损害来论述。

关键词：慢性肾脏病心脏损害浊毒线粒体自噬中医药治疗

急性缺血性脑卒中患者前蛋白转化酶枯草溶菌素9与血脂水平及临床意义

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吉林医学 2024年第6期45卷 1300-1303页

作者：胡群亮田竺吴焕成张盛蕊天津市北辰医院脑系科天津300400

目的:探讨前蛋白转化酶枯草溶菌素9(PCSK9)与急性缺血性脑卒中(AIS)患者的血脂水平及与AIS严重程度的相关性。方法:选取天津市北辰医院诊治的200例AIS患者作为AIS组,另选取体检的200例健康者为对照组。收集两组临床资料,检测两组血脂和P... 详细信息

目的:探讨前蛋白转化酶枯草溶菌素9(PCSK9)与急性缺血性脑卒中(AIS)患者的血脂水平及与AIS严重程度的相关性。方法:选取天津市北辰医院诊治的200例AIS患者作为AIS组,另选取体检的200例健康者为对照组。收集两组临床资料,检测两组血脂和PCSK9水平,AIS组根据美国国立卫生研究院脑卒中量表(NIHSS)进行评分,分为轻-中度组(NIHSS评分<15分)和重度组(NIHSS评分≥15分)。使用Pearson相关性分析探讨在AIS组中PCSK9与AIS患者血脂水平、AIS严重程度相关性。结果:AIS组的三酰甘油(TG)、血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、PCSK9水平均高于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平低于对照组,差异有统计学意义(P<0.05)。AIS组患者PCSK9水平与TG、TC、LDL-C、HDL-C均存在相关性(P<0.05)。重度组患者的PCSK9表达水平显著高于轻-中度组(P<0.05)。结论:脑卒中患者多伴随有血脂异常、PCSK9蛋白水平升高,且PCSK9蛋白水平与AIS患者的血脂水平、疾病严重程度存在一定相关性。

关键词：急性缺血性脑卒中前蛋白转化酶枯草溶菌素9(PCSK9) 血脂严重程度

美国牛蛙蝌蚪约氏不动杆菌的分离、鉴定及耐药性分析

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水产学报 2024年第5期48卷 131-140页

作者：丁戈野李纯徐杨陈晓颖张秋实胡亮邓新兰刘小燕冯兴浪李军华湖南农业大学水产学院

为探明2023年3月初引起中国重庆市渝北区某牛蛙养殖场暴发疾病的原因，本实验从患病美国牛蛙蝌蚪肝脏和肠道中分离优势菌，采用形态学观察、生理生化实验、16S rDNA和rpoB基因序列测定、系统发育学分析进行鉴定。为确定该菌株的致病机... 详细信息

为探明2023年3月初引起中国重庆市渝北区某牛蛙养殖场暴发疾病的原因，本实验从患病美国牛蛙蝌蚪肝脏和肠道中分离优势菌，采用形态学观察、生理生化实验、16S rDNA和rpoB基因序列测定、系统发育学分析进行鉴定。为确定该菌株的致病机理，对该菌株进行了人工感染实验、组织病理学观察、毒力基因检测、生长特性研究及药物敏感性实验。结果显示，在患病濒死美国牛蛙蝌蚪的肝脏和肠道中分离得到的其中一株优势菌命名为LT202303，经鉴定为约氏不动杆菌。该菌株携带OmpA、Omp34和OmpTsx等3种毒力基因，具有较强的耐盐性和在广泛的pH范围内生存的能力，对美国牛蛙蝌蚪的半数致死浓度为6.8×10～6CFU/mL，发病临床症状为肝脏红肿并伴有大量白色结节，肠道透明发黄。组织病理学观察发现该菌株可引起美国牛蛙蝌蚪肝脏和肠道的明显炎症反应和病灶性坏死。药敏实验结果显示，分离菌LT202303是一种产β-内酰胺酶的多重耐药细菌。本研究表明，约氏不动杆菌对牛蛙蝌蚪具有高致病力，可引起肝脏和肠道等多器官组织的病理损伤最终引发机体的损伤甚至死亡。本研究首次报道约氏不动杆菌感染引起的美国牛蛙蝌蚪传染病的暴发，为该疾病的诊断和防控提供理论参考。

关键词：约氏不动杆菌美国牛蛙蝌蚪分离鉴定耐药性

Robust microporous metal-organic framework with high moisture tolerance for efficient separation of propylene from propane

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Chinese Journal of Structural Chemistry 2023年第2期42卷 29-34页

作者： Shan-Qing Yang Lei Zhou Bo Xing Ying-hui Zhang Tong-liang hu School of Materials Science and Engineering National Institute for Advanced MaterialsNankai UniversityTianjin300350China

Adsorptive separation of propylene(C_(3)H_(6))from propylene/propane(C_(3)H_(8))is desired to replace energy-intensive cryogenic distillation for its energy efficiency,economical viability,and environment *** this work,we report a cupper-based robust microporous metal-organic framework,Cu-Hmpba,constructed by the hard soft acid-base principle using the bifunctional pyridylcarboxylate ligand featuring methyl group,for high-efficient separation of the propylene/propane *** the synergistic effect of the protective group and hard soft acid base principle,Cu-Hmpba possesses good solvents stability,especially water ***-Hmpba exhibits the adsorption capacity of C_(3)H_(6)with 2.10 mmol g^(-1)and good equimolar C_(3)H_(6)/C_(3)H_(8)selectivity with 2.24 at ambient *** gas adsorption experiments,IAST selectivity calculations and theoretical calculations comprehensively support the selective adsorption toward C_(3)H_(6)among C_(3)H_(6)/C_(3)H_(8)***,it could maintain stable under moisture environment,suggesting its potential for the industrial separation of C_(3)H_(6)/C_(3)H_(8)*** results of experiments and simulations demonstrate that the Cu-Hmpba would be a candidate adsorbent for the separation and purification of light hydrocarbons,and this work provides the insight of syn-thesizing stable MOF materials for separating high-value chemicals.

关键词： Metal-organic framework Adsorptive separation Propylene/propane separation Energy efficient

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香菇柄贡菜牛肉酱制作工艺研究

中国调味品 2024年第2期49卷 110-113页

作者：王露姚丽姗徐丹崔震昆李红波胡梁斌莫海珍陕西科技大学食品科学与工程学院西安710021 河南科技学院食品学院河南新乡453003

文章以香菇柄、贡菜和牛肉为主要原料制作香菇柄贡菜牛肉酱。选定了对产品品质影响最大的香菇柄添加量、牛肉添加量、豆瓣酱添加量和蒜蓉辣椒酱添加量作为实验对象,通过单因素实验和正交实验确定了主料和辅料的最优配比。结果表明,各原... 详细信息

文章以香菇柄、贡菜和牛肉为主要原料制作香菇柄贡菜牛肉酱。选定了对产品品质影响最大的香菇柄添加量、牛肉添加量、豆瓣酱添加量和蒜蓉辣椒酱添加量作为实验对象,通过单因素实验和正交实验确定了主料和辅料的最优配比。结果表明,各原料最佳配比为香菇柄添加量15%、牛肉添加量25%、豆瓣酱添加量10%和蒜蓉辣椒酱添加量15%,按照此配比制作的产品感官评价结果最好。在香菇柄牛肉酱中加入贡菜,既能赋予产品更高的营养价值,也能使产品的口感更加脆爽,制作的香菇柄贡菜牛肉酱鲜香麻辣,色泽诱人,符合大众的口味。

关键词：香菇柄贡菜牛肉酱感官评定

Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： TAN hui-qun hu Zhi-shui DONG liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

An Adaptive Program Recommendation System for Multi-User Sharing Environment

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China Communications 2024年第6期21卷 112-128页

作者： Sun Shiyun hu Zhengying Wei Xin Zhou liang School of Communications and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China

More and more accounts or devices are shared by multiple users in video applications,which makes it difficult to provide recommendation *** recommendation schemes overlook multiuser sharing scenarios,and they cannot make effective use of the mixed information generated by multi-user when exploring users’potential *** solve these problems,this paper proposes an adaptive program recommendation system for multi-user sharing ***,we first design an offline periodic identification module by building multi-user features and periodically predicting target user in future sessions,which can separate the profile of target user from mixed log ***,an online recommendation module with adaptive timevarying exploration strategy is constructed by jointly using personal information and multi-user social information provided by identification *** one hand,to learn the dynamic changes in user-interest,a time-varying linear upper confidence bound(LinUCB)based on personal information is *** the other hand,to reduce the risk of exploration,a timeinvariant LinUCB based on separated multi-user social information from one account/device is proposed to compute the quality scores of programs for each user,which is integrated into the time-varying LinUCB by cross-weighting ***,experimental results validate the efficiency of the proposed scheme.

关键词： adaptive exploitation LinUCB multiuser recommendation system

Analysis of the one-decoy-state SARG04 quantum cryptography protocol in the presence of afterpulse effects

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Communications in Theoretical Physics 2024年第6期76卷 66-71页

作者： hu Nian Ya-Feng Nie Chun-Mei Zhang liang-liang Lu Key Laboratory of Optoelectronic Technology of Jiangsu Province School of Physical Science and TechnologyNanjing Normal UniversityNanjing 210023China Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Hefei National Laboratory Hefei 230088China

The SARG04 quantum key distribution protocol can offer greater robustness against photon number splitting attacks than the BB84 protocol that is implemented with weak *** this paper,we propose a tight key analysis for the SARG04 protocol,by considering the one-decoy method and investigating its performance under the influence of a detector *** results demonstrate that an increase in block size leads to a slight increase in both the secure key rate and the maximum transmission ***,the detector afterpulse plays a crucial role in practical applications and has a more pronounced effect on the SARG04 protocol compared to the BB84 protocol.

关键词： Quantum key distribution SARG04 protocol one decoy afterpulse

Rational construction of densely packed Si/MXene composite microspheres enables favorable sodium storage

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Rare Metals 2022年第5期41卷 1626-1636页

作者： hui-Qi Wang Ya-Xin Zhao Li Gou Li-Yong Wang Mei Wang Ying Li Sheng-liang hu School of Energy and Power Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The fast and reversible sodiation/desodiation of anode materials remains an indelible yet fascinating ***, a class of the densely packed Si/MXene composite microspheres is constructed and prepared, taking advantages of the synergistic effects of the activated Si nanoparticles and conductive flower-like MXene microspheres with ample ion-diffusion pathways. Consequently,the intrinsic MXene nanosheets with intelligently regulated interlayer spacing can accommodate the volume change induced strain during cycling, and the strong interaction between the Si and MXene matrix greatly contributes to the robust structural stability. As expected, the Si/MXene composite architecture exhibits boosted sodium storage performance, in terms of an inspiring reversible capacity of 751 mAh·g^(-1)at 0.1 A·g^(-1), remarkable long-term cycling stability of 376 mAh·g^(-1)at 0.1 A·g^(-1) over 500 cycles, and outstanding rate capability(after one consecutive current density changing from 0.1 to 2.0 A·g^(-1), a large capacity of 275 mAh·g^(-1) is regained after suddenly returning the initial current density back to 0.1 A·g^(-1) and in the subsequent 200 cycles this composite architecture anode still delivers a capacity of 332 mAh·g^(-1)). The kinetics analysis indicates superior pseudocapacitive property, high electronic conductivity, and favorable sodium-ion adsorption and diffusion capability,confirming fast sodium storage performance. Impressively, ex-situ X-ray diffraction and selected area electron diffraction characterizations corroborate the formation of NaSi;as the main sodiation products during the reversible evolutions of cycled proceeding with sodium-ion insertion. This work sheds light on the elaborate design of silicon-based nanostructured anodes towards advanced high-performance sodium-ion batteries.

关键词： Silicon MXene Composite microspheres Sodium-ion batteries Flower-like anode Efficient sodiumion storage