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易切削银亮棒钻孔开裂原因解析

冶金分析 2024年第4期44卷 9-16页

作者：张晓宇苏蒙蒙徐翔宇邹虎付建勋上海大学材料科学与工程学院先进凝固技术中心省部共建高品质特殊钢冶金与制备国家重点实验室芜湖新兴铸管有限责任公司

1215MS易切削钢具有良好的切削加工性能，其表面质量的好坏直接影响产品的生产加工。现某钢厂生产的1215MS易切削银亮棒钻孔加工后，零件芯部出现开裂现象。为了探究钻孔开裂原因，采用扫描电镜及能谱仪(SEM/EDS)等分析检测设备，对试... 详细信息

1215MS易切削钢具有良好的切削加工性能，其表面质量的好坏直接影响产品的生产加工。现某钢厂生产的1215MS易切削银亮棒钻孔加工后，零件芯部出现开裂现象。为了探究钻孔开裂原因，采用扫描电镜及能谱仪(SEM/EDS)等分析检测设备，对试样开裂区域进行研究。结果表明：1215MS易切削钢金相组织主要为铁素体+珠光体，占比分别为92.0%和4.4%,在试样开裂侧发现粗大的珠光体带状组织，其等效直径可以达到15.0μm,而普通珠光体等效直径为6.2μm。相较于铁素体组织，珠光体组织平均硬度较高，为243 HV0.01,高硬度的珠光体带在钻孔加工时导致钻头施力不均，引起材料开裂。

关键词： 1215MS 易切削钢银亮棒表面裂纹珠光体元素偏析扫描电镜(SEM) 能谱仪(EDS)

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铋系、铅系、硫系易切削钢的切削性对比研究

钢铁研究学报 2024年第8期36卷 1071-1079页

作者：赵欣宜徐翔宇张晓宇刘贝贝邹虎付建勋上海大学材料科学与工程学院先进凝固技术中心省部共建高品质特殊钢冶金与制备国家重点实验室上海200444 芜湖新兴铸管有限责任公司安徽芜湖214000

为探究铋系、铅系、硫系3种易切削钢切削性能的差异和铋对易切削钢切削性能影响及其作用机制,利用Kistler测力仪、表面粗糙度测量仪等对1215MS硫系易切削钢、1215Bi铋系易切削钢、12L14铅系易切削钢3种盘条开展了切削对比测试。结果表明... 详细信息

为探究铋系、铅系、硫系3种易切削钢切削性能的差异和铋对易切削钢切削性能影响及其作用机制,利用Kistler测力仪、表面粗糙度测量仪等对1215MS硫系易切削钢、1215Bi铋系易切削钢、12L14铅系易切削钢3种盘条开展了切削对比测试。结果表明:在转速w=1200r/min、切削深度ap=0.4mm、进给量f=0.2mm/r,且切削刀具和切削角度相同的的切削条件下,1215MS、1215Bi、12L14三种易切削钢盘条的切削合力分别为:130、123、116N;材料的表面粗糙度Ra分别为:5.3、4.9、4.6μm,C型屑的占比分别为:28%、37%、42%,1215Bi易切削钢的切削性接近于12L14易切削钢,显著优于1215MS易切削钢;在铋系易切削钢中,Bi元素以Bi颗粒的形式存在,或者附着在Mn S的表面,形成Bi-Mn S复合夹杂物,在切削过程中,切削热使得Bi颗粒发生熔融,起到了润滑作用,断屑性增加,改善了切削性能。

关键词：易切削钢 1215MS 1215Bi 12L14 Bi-MnS复合夹杂物切削性

李村煤矿顶板定向长钻孔瓦斯抽采参数优化研究

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煤炭工程 2024年第1期56卷 98-104页

作者：申海生邹虎刘垒赵春洲王彦敏曹良伟田锦绣田珑山西潞安矿业集团慈林山煤业有限公司李村煤矿山西长治046000

针对高抽巷工程量大、成本高、影响采掘接替等问题,分析了顶板定向长钻孔的合理布置范围、抽采机理及关键影响因素,并根据正交实验和方差分析确定了抽采效果敏感性指标。在李村煤矿1305工作面进行了顶板定向长钻孔代替高抽巷的试验,试... 详细信息

针对高抽巷工程量大、成本高、影响采掘接替等问题,分析了顶板定向长钻孔的合理布置范围、抽采机理及关键影响因素,并根据正交实验和方差分析确定了抽采效果敏感性指标。在李村煤矿1305工作面进行了顶板定向长钻孔代替高抽巷的试验,试验结果表明:顶板定向长钻孔达到了高抽巷瓦斯抽采的效果,将上隅角瓦斯浓度控制在安全范围内,且其施工进度快,成本低,有效解决了李村矿采掘接替紧张的局面。

关键词：顶板定向长钻孔高抽巷采空区抽采参数优化

Vesicular drug delivery systems for oral absorption enhancement

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Chinese Chemical Letters 2024年第7期35卷 73-88页

作者： Linghui zou Meng Cheng Kaili hu Jianfang Feng Liangxing Tu Jiangxi University of Chinese Medicine Nanchang 330006China Guangxi University of Chinese Medicine Nanning 530200China Shanghai University of Traditional Chinese Medicine Shanghai 201203China

Oral administration is the most acceptable route of drug delivery at this stage due to its convenience,safety,and ***,drugs given orally are exposed to a complex gastrointestinal environment,causing a tremendous challenge for their successful absorption into the *** the past decades,researchers have developed various novel pharmaceutical technologies to improve oral absorption,among which the vesicular drug delivery system(like liposomes,niosomes and transfersomes)has received extensive ***,there have been several investigations confirming the improved effect of vesicular drug delivery systems on oral drug ***,the clinical translation of oral vesicular drug delivery systems has been less impressive than implied by the positive results,and few vesicular formulations for oral use have been marketed *** this background,this article provides an overview of the current applications and challenges associated with the vesicular delivery systems available for oral drug delivery,specifically liposomes,niosomes,transfersomes,chitosomes and *** composition,formation mechanism,drug delivery advantages and application cases of these carriers in oral drug delivery are *** possible mechanisms by which vesicular carriers enhance oral drug absorption are analyzed in terms of the in vivo process of oral ***,the challenges that oral vesicular carriers now face,such as safety,undefined in vivo fate,and scale-up production,are summarized,while possible strategies to deal with them are *** reviewing the aforementioned,it can facilitate a more comprehensive knowledge of vesicular systems that can be used for oral drug delivery,providing a theoretical basis and reference for the design of oral formulations.

关键词： Vesicular Oral Mechanism Drug delivery Liposome Niosomes Transfersomes Chitosomes Bilosomes

Perpendicular-Cutdepth:Perpendicular Direction Depth Cutting Data Augmentation Method

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Computers, Materials & Continua 2024年第4期79卷 927-941页

作者： Le zou Linsong hu Yifan Wang Zhize Wu Xiaofeng Wang Anhui Provincial Engineering Laboratory of Big Data Technology Application forUrban Infrastructure School ofArtificial Intelligence and Big DataHefei UniversityHefei230601China Institute of Applied Optimization School of Artificial Intelligence and Big DataHefei UniversityHefei230601China

Depth estimation is an important task in computer *** data at scale for monocular depth estimation is challenging,as this task requires simultaneously capturing RGB images and depth ***,data augmentation is crucial for this *** data augmentationmethods often employ pixel-wise transformations,whichmay inadvertently disrupt edge *** this paper,we propose a data augmentationmethod formonocular depth estimation,which we refer to as the Perpendicular-Cutdepth *** method involves cutting realworld depth maps along perpendicular directions and pasting them onto input images,thereby diversifying the data without compromising edge *** validate the effectiveness of the algorithm,we compared it with existing convolutional neural network(CNN)against the current mainstream data augmentation ***,to verify the algorithm’s applicability to Transformer networks,we designed an encoder-decoder network structure based on Transformer to assess the generalization of our proposed *** results demonstrate that,in the field of monocular depth estimation,our proposed method,Perpendicular-Cutdepth,outperforms traditional data *** the indoor dataset NYU,our method increases accuracy from0.900 to 0.907 and reduces the error rate from0.357 to *** the outdoor dataset KITTI,our method improves accuracy from 0.9638 to 0.9642 and decreases the error rate from 0.060 to 0.0598.

关键词： Perpendicular depth estimation data augmentation

GOES-16 ABI Brightness Temperature Observations Capturing Vortex Rossby Wave Signals during Rapid Intensification of hurricane Irma(2017)

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Journal of Meteorological Research 2024年第4期38卷 768-783页

作者： Yanyang hu Xiaolei zou Joint Center of Data Assimilation for Research and Application Nanjing University of Information Science&TechnologyNanjing 210044

Geostationary Operational Environmental Satellite-16(GOES-16) Advanced Baseline Imager(ABI) observations of brightness temperature(TB) are used to examine the temporal evolutions of convection-affected structures of hurricane Irma(2017) during its rapid intensification(RI) period from 0600 to 1800 UTC 4 September *** ABI observations reveal that both an elliptical eye and a spiral rainband that originated from Irma's eyewall obviously exhibit wavenumber-2 TB *** elliptical eye underwent a counterclockwise rotation at a mean speed of a wavenumber-2 vortex Rossby edge wave from 0815 to 1005 UTC 4 *** the following about 2 hours(1025–1255 UTC 4 September),an inner spiral rainband originated from the eyewall and propagated at a phase speed that approximates the vortex Rossby wave(VRW) phase speed calculated from the aircraft reconnaissance *** the RI period of Irma,ABI TB observations show an on–off occurrence of low TB intrusions into the eye,accompanying a phase lock of eyewall TB asymmetries of wavenumbers 1 and 2 and an outward propagation of VRW-like inner spiral rainbands from the *** phase lock leads to an energy growth of Irma's eyewall *** the eye remained clear from 1415 to 1725 UTC 4 September,an inner spiral rainband that originated from a large convective area also had a VRW-like outward propagation,which is probably due to a vertical tilt of *** study suggests a potential link between convection sensitive GOES imager observations and hurricane dynamics.

关键词： Geostationary Operational Environmental Satellite(GOES)imager brightness temperature(TB) hurricane vortex Rossby wave(VRW)

Epilepsy: Quality of life and assessment scale evaluation

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Neural Regeneration Research 2008年第1期3卷 83-88页

作者： Fayun hu Xiaoyi zou Department of Neurology West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

BACKGROUND： Quality of life （QOL） is an important topic in current international research of epilepsy. In countries other than China, QOL in epilepsy has been well studied, and many assessment scales or QOL of epilepsy have been developed and used in the clinical practice. In China, concern for QOL of epilepsy patients is very recent, and QOL assessment scales, which correspond to China＇s basic conditions, are still needed. OBJECTIVE： This review aimed to analyze the primary influencing factors and assessment scales of QOL in epilepsy, to investigate the topics of current and future research for QOL of epilepsy patients, and to highlight the importance of QOL for epilepsy patients, according to China＇s basic conditions. RETRIEVAL STRATEGY： Using the terms ＂quality of life in epilepsy＂, we computer-retrieved from the PubMed （http：//***/PubMed） database human studies published between January 1998 and April 2007 in the English language. A total of 745 manuscripts were searched, of which 243 were review papers. At the same time, we computer-searched the China National Knowledge Infrastructure with the terms ＂epilepsy and quality and life＂ in the Chinese language for studies published between 2002 and 2007. Altogether, 181 Chinese literatures were retrieved, 32 of which were from high-impact journals. LITERATURE EVALUATION： The retrieved manuscripts were initially selected, but 50 were kept for further analysis. The selected manuscripts were as follows： 31 Chinese and/or English studies addressed the influencing factors of QOL for epilepsy patients, as well as assessment scales for QOL in different populations of epilepsy patients, of which 5 were review articles and the remaining 26 were clinical studies; and 19 Chinese and/or English literatures were rejected, because they were not in accordance with the inclusive criteria. DATA SYNTHESIS： QOL for epilepsy patients is an emerging field. At present, ＂the Liverpool group model for determining QOL in peo

关键词： epilepsy quality of life China.

A clinical trial termination prediction model based on denoising autoencoder and deep survival regression

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Quantitative Biology 2024年第2期12卷 205-214页

作者： huamei Qi Wenhui Yang Wenqin zou Yuxuan hu School of Electronic Information Central South UniversityChangshaHunanChina School of Computer Science and Engineering Central South UniversityChangshaHunanChina

Effective clinical trials are necessary for understanding medical advances but early termination of trials can result in unnecessary waste of *** models can be used to predict survival probabilities in such ***,survival data from clinical trials are sparse,and DeepSurv cannot accurately capture their effective features,making the models weak in generalization and decreasing their prediction *** this paper,we propose a survival prediction model for clinical trial completion based on the combination of denoising autoencoder(DAE)and DeepSurv *** DAE is used to obtain a robust representation of features by breaking the loop of raw features after autoencoder training,and then the robust features are provided to DeepSurv as input for *** clinical trial dataset for training the model was obtained from the *** dataset.A study of clinical trial completion in pregnant women was conducted in response to the fact that many current clinical trials exclude pregnant *** experimental results showed that the denoising autoencoder and deep survival regression(DAE-DSR)model was able to extract meaningful and robust features for survival analysis;the C-index of the training and test datasets were 0.74 and 0.75 *** with the Cox proportional hazards model and DeepSurv model,the survival analysis curves obtained by using DAE-DSR model had more prominent features,and the model was more robust and performed better in actual prediction.

关键词： clinical trials denoising autoencoder DeepSurv experimental termination survival analysis

Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo hu Wen Liu Yi zou Chenyang Jiao Jiazhen Zhu Qiang Xu Jianjun zou Yang Sun Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator