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基于强化学习的多技能项目调度算法

控制理论与应用 2024年第3期41卷 502-511页

作者：胡振涛崔南方胡雪君雷晓琪华中科技大学管理学院湖北武汉430074 湖南大学工商管理学院湖南长沙410082

多技能项目调度存在组合爆炸的现象,其问题复杂度远超传统的单技能项目调度,启发式算法和元启发式算法在求解多技能项目调度问题时也各有缺陷.为此,根据项目调度的特点和强化学习的算法逻辑,本文设计了基于强化学习的多技能项目调度算法... 详细信息

多技能项目调度存在组合爆炸的现象,其问题复杂度远超传统的单技能项目调度,启发式算法和元启发式算法在求解多技能项目调度问题时也各有缺陷.为此,根据项目调度的特点和强化学习的算法逻辑,本文设计了基于强化学习的多技能项目调度算法.首先,将多技能项目调度过程建模为符合马尔科夫性质的序贯决策过程,并依据决策过程设计了双智能体机制.而后,通过状态整合和行动分解,降低了价值函数的学习难度.最后,为进一步提高算法性能,针对资源的多技能特性,设计了技能归并法,显著降低了资源分配算法的时间复杂度.与启发式算法的对比实验显示,本文所设计的强化学习算法求解性能更高,与元启发式算法的对比实验表明,该算法稳定性更强,且求解速度更快.

关键词：多技能资源项目调度智能算法强化学习并行调度

达格列净与西格列汀对肥胖2型糖尿病患者疗效及脂代谢指标的影响

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中国药物经济学 2024年第6期19卷 78-80页

作者：胡振涛内蒙古自治区第四医院药剂科呼和浩特010000

目的探讨达格列净与西格列汀对肥胖2型糖尿病患者疗效及脂代谢指标的影响。方法选取2021年1月至2023年1月内蒙古自治区第四医院收治的68例肥胖2型糖尿病患者作为研究对象,以双盲法将其分为试验组与对照组,每组34例。对照组予以西格列汀... 详细信息

目的探讨达格列净与西格列汀对肥胖2型糖尿病患者疗效及脂代谢指标的影响。方法选取2021年1月至2023年1月内蒙古自治区第四医院收治的68例肥胖2型糖尿病患者作为研究对象,以双盲法将其分为试验组与对照组,每组34例。对照组予以西格列汀,试验组采用达格列净治疗,比较两组疗效及脂代谢指标。结果试验组治疗有效率97.06%高于对照组的79.41%(P0.05);治疗后两组TC、TG以及LDL-C水平降低,且试验组低于对照组,差异有统计学意义(P<0.05)。结论达格列净相较于西格列汀对肥胖2型糖尿病具有更好的疗效,可以有效改善患者血糖以及脂代谢水平。

关键词：达格列净西格列汀肥胖 2型糖尿病疗效脂代谢

CRD-CGAN:category-consistent and relativistic constraints for diverse text-to-image generation

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Frontiers of Computer Science 2024年第1期18卷 61-75页

作者： tao hu Chengjiang LONG Chunxia XIAO College of Intelligent Systems Science and Engineering Hubei Minzu UniversityEnshi 445000China School of Computer Science Wuhan UniversityWuhan 430072China Key Laboratory of Performing Art Equipment&System Technology Ministry of Culture and TourismBeijing 100007China Meta Reality Labs BurlingameCA94010USA

Generating photo-realistic images from a text description is a challenging problem in computer *** works have shown promising performance to generate synthetic images conditional on text by Generative Adversarial Networks(GANs).In this paper,we focus on the category-consistent and relativistic diverse constraints to optimize the diversity of synthetic *** on those constraints,a category-consistent and relativistic diverse conditional GAN(CRD-CGAN)is proposed to synthesize K photo-realistic images *** use the attention loss and diversity loss to improve the sensitivity of the GAN to word attention and ***,we employ the relativistic conditional loss to estimate the probability of relatively real or fake for synthetic images,which can improve the performance of basic conditional ***,we introduce a category-consistent loss to alleviate the over-category issues between K synthetic *** evaluate our approach using the Caltech-UCSD Birds-200-2011,Oxford 102 flower and MS COCO 2014 datasets,and the extensive experiments demonstrate superiority of the proposed method in comparison with state-of-the-art methods in terms of photorealistic and diversity of the generated synthetic images.

关键词： text-to-image diverse conditional GAN relativi-stic category-consistent

The important role of Turbidity Maximum Zone in sedimentary dynamic of estuarine mangrove swamp

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Frontiers of Earth Science 2024年第1期18卷 219-226页

作者： tao LIU Ying LIU Baoqing hu Key laboratory of Environment Change and Resources Use in Beibu Gulf(Ministry of Education) Nanning Normal UniversityNanning 530001China School of Civil Engineering and Architecture Guangxi UniversityNanning 530004China

Sedimentation is a key process affecting wetland sustainability and carbon burial *** context of sea level rise,climate change and human activities,further understanding about the sedimentary dynamic in wetland is critical in predicting the landscape evolution or the change in carbon burial *** this study,based on the field hydrological observation in a mangrove system in the Nanliu River estuary,we found the net flux of suspended sediment to mangrove is 39−72 kg/m in tidal cycles with Turbidity Maximum Zone(TMZ)forming in surface layer and only is 9−18 kg/m in tidal cycles without *** higher net flux of suspended sediment to mangrove in tidal cycles with TMZ forming in surface layer is attributed to high SSC in rising tide and intense flocculation in *** significant discrepancy in sedimentation rate in the mangrove patches also can be explained by the probability of TMZ forming in the surface layer of *** future,rapid sea level rising may lead to the change of TMZ pattern in estuary,which will result in non-negligible variation in sedimentation rate in *** to the present data of sedimentation rate in wetlands,the fragility of wetlands in river estuary may be miscalculated.

关键词： mangrove wetland sedimentation Turbidity Maximum Zone Nanliu River

Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation

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Chinese Journal of Natural Medicines 2024年第4期22卷 307-317页

作者： tao Lei DOU Renjie CHEN Xueming CAO Yu DAI zhen hu Ziyan MA Zhi GE Xiaoming ZHANG Ling WANG Xiaoping Nanjing Institute for Food and Drug Control Nanjing 211198China State Key Laboratory of Natural Medicines School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), may result from immune system dysfunction, leading to the sustained overproduction of reactive oxygen species (ROS) and subsequent cellular oxidative stress damage. Recent studies have identified both peroxisome proliferator-activated receptor-γ (PPARγ) and endoplasmic reticulum (ER) stress as critical targets for the treatment of IBD. Oroxyloside (C22H20O11), derived from the root of Scutellaria baicalensis Georgi, has traditionally been used in treating inflammatory diseases. In this study, we investigated the molecular mechanisms by which oroxyloside mitigates dextran sulfate sodium (DSS)-induced colitis. We examined the effects of oroxyloside on ROS-mediated ER stress in colitis, including the protein expressions of GRP78, p-PERK, p-eIF2α, ATF4, and CHOP, which are associated with ER stress. The beneficial impact of oroxyloside was reversed by the PPARγ antagonist GW9662 (1 mg·kg^(−1), i.v.) in vivo. Furthermore, oroxyloside decreased pro-inflammatory cytokines and ROS production in both bone marrow-derived macrophages (BMDM) and the mouse macrophage cell line RAW 264.7. However, PPARγ siRNA transfection blocked the anti-inflammatory effect of oroxyloside and even abolished ROS generation and ER stress activation inhibited by oroxyloside in vitro. In conclusion, our study demonstrates that oroxyloside ameliorates DSS-induced colitis by inhibiting ER stress via PPARγ activation, suggesting that oroxyloside might be a promising effective agent for IBD.

关键词： Oroxyloside ER stress PPARγ Colitis

A Finite-Time Convergent Analysis of Continuous Action Iterated Dilemma

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 563-565页

作者： zhen Wang Xiaoyue Jin tao Zhang Dengxiu Yu Northwestern Polytechnical University

Dear Editor,In this letter, a finite-time convergent analysis of continuous action iterated dilemma(CAID) is proposed. In traditional evolutionary game theory, the strategy of the player is binary(cooperation or defec... 详细信息

关键词： lemma letter convergent

基于自然梯度的噪声自适应变分贝叶斯滤波算法

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自动化学报 2023年第10期49卷 2094-2108页

作者：胡玉梅潘泉胡振涛郭振西北工业大学自动化学院西安710072 信息融合技术教育部重点实验室西安710072 中国航空工业集团公司西安航空计算技术研究所西安710065 河南大学人工智能学院郑州450046 湖北航天技术研究院总体设计所武汉430040

考虑到运动目标跟踪系统机动、隐身等人为对抗特征以及非视距、干扰、遮挡等环境因素,其系统建模、估计与辨识过程中越来越无法回避非线性、非高斯以及参数未知等复杂系统特征的影响.针对过程噪声先验信息不准确以及量测噪声非高斯环境... 详细信息

考虑到运动目标跟踪系统机动、隐身等人为对抗特征以及非视距、干扰、遮挡等环境因素,其系统建模、估计与辨识过程中越来越无法回避非线性、非高斯以及参数未知等复杂系统特征的影响.针对过程噪声先验信息不准确以及量测噪声非高斯环境下运动目标的非线性状态估计问题,提出一种基于自然梯度的噪声自适应变分贝叶斯(Variational Bayes,VB)滤波算法.首先,利用指数族分布具有统一表达形式的优势,构建参数化逆威沙特(Inverse-Wishart,IW)分布作为状态一步预测误差协方差的共轭先验分布,同时选取学生t分布重构因量测随机缺失导致的具有非高斯特点的似然函数;其次,在变分贝叶斯优化框架下采用平均场理论将状态变量联合后验分布近似分解为独立的变分分布,在此基础上,结合坐标上升方法更新各变量的变分分布参数;进而,结合Fisher信息矩阵推导置信下界最大化关于状态估计及其估计误差协方差的自然梯度,使非线性状态后验分布的近似分布沿梯度下降,以实现对状态后验概率密度函数(Probability density function,PDF)的“紧密”逼近.理论分析和仿真实验表明:相对传统的非线性滤波方法,本文算法对噪声不确定问题具有较好的自适应能力,并且能够获得较高的状态估计精度.

关键词：非线性滤波自适应滤波变分贝叶斯推断自然梯度 Fisher信息矩阵

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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi hu zhen-Rui Cao Wei-Xiong zheng Min-Jie Zhao Jun-hua Gong Cong Chen Zhong-Jun Wu Rui tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

Removal of pathogenic indicator microorganisms during partial nitrification:the role of free nitrous acid

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 93-102页

作者： Jiaojiao Xu Xiaotian Chen Rui Tang Jingwei Feng Shoujun Yuan Wei Wang zhen-hu hu Anhui Engineering Laboratory of Rural Water Environment and Resource School of Civil EngineeringHefei University of TechnologyHefei 230009China Hefei 168 High School Hefei 230025China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China

Digested wastewater contains pathogenic microorganisms and high ammonia concentrations,which can pose a potential risk to public *** removal of pathogens and nitrogen is crucial for the post-treatment of digested *** nitrification-anammox is an energy-saving nitrogen removal *** nitrous acid(FNA),an intermediate product of partial nitrification,has the potential to inactivate ***,the efficiency and mechanisms of FNA-related inactivation in pathogens during partial nitrification remains *** this study,Enterococcus and Escherichia coli(***)were selected to investigate the efficiency and mechanisms of FNA-related inactivation in partial nitrification *** results revealed that 83%±13%and 59%±27%of *** and Enterococcus were removed,respectively,in partial nitrification process at FNA concentrations of 0.023−0.028 mg/*** the concentration of FNA increased from 0 to 0.5 mg/L,the inactivation efficiencies of *** and Enterococcus increased from 0 to 99.9%and 89.9%,*** exhibited a higher resistance to FNA attack compared to ***.3D-laser scanning microscopy(3D-LSM)and scanning electron microscopy(SEM)revealed that FNA exposure caused the surface collapse of *** and Enterococcus,as well as visible pore formation on the surface of *** cells.4',6-Diamidino-2-phenylindole dihydrochloride n-hydrate(DAPI)/propidium iodide(PI)and biomolecule leakage confirmed that inactivation of *** and Enterococcus occurred due to breakdown of cell walls and cell *** findings indicate that partial nitrification process can be used for the removal of residual pathogenic microorganisms.

关键词： Partial nitrification Free nitrous acid Pathogenic indicator microorganism Inactivation Cell structure