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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei zha.guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

PdNi/N-doped graphene aerogel with over wide potential activity for formic acid electrooxidation

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Journal of Energy Chemistry 2021年第8期30卷 748-754,I0016页

作者： Yufei Bao Meng zha Pengliang Sun guangzhi hu Ligang Feng School of Chemical Science and Technology and Institute for Ecological Research and Pollution Control of Plateau Lakes Yunnan UniversityKunming 650504China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Anti-CO poisoning ability is significant in formic acid oxidation in the fuel cell ***,Pd Ni alloy supported on N-doped graphene aerogel(Pd Ni/gA-N)was found to have catalytic ability toward formic acid electrooxidation over a wide potential range because of the improved anti-CO poisoning *** catalyst was fabricated by simple freeze-drying of mixture solution of graphene aerogel,polyvinylpyrrolidone,Pd^(2+)and Ni^(2+)and the subsequent thermal annealing reduction approach in the N2/H2 ***-Ni alloy particles anchored over the folding N-doped graphene surface with a porous hierarchical architecture structure in the 3 D *** showed the catalytic performance of its maximum mass activity of 836 m A mg^(-1)in a broad potential range(0.2-0.6 V)for formic acid *** CO stripping experiment demonstrated its largely improved anti-CO poisoning ability with the peak potential of 0.67 V,approximately 60 and 40 m V less compared to those of Pd/gA-N and Pd/C *** high anti-CO poisoning ability and strong electronic effect resulting from the interaction between the3 D gA-N support and the Pd-Ni alloy makes it a promising catalyst for application in direct formic acid fuel cells.

关键词： Fuel cells Formic acid oxidation reaction PdNi graphene aerogel

Electrochemical oxygen evolution reaction efficiently boosted by selective fluoridation of FeNi3 alloy/oxide hybrid

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Journal of Energy Chemistry 2020年第8期29卷 166-171,I0006页

作者： Meng zha Chengang Pei Quan Wang guangzhi hu Ligang Feng Key Laboratory of Medicinal Chemistry for Natural Resource(Yunnan University) Ministry of EducationSchool of Chemical Science and EngineeringYunnan UniversityKunming 650091YunnanChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina

Performance boosting of hybrid metal oxide and metal alloy catalyst is crucial to the water electrolysis for hydrogen generation. Herein, a novel concept of selective fluoridation of metal alloy/oxide hybrid is proposed to boost their catalytic performance for the oxygen evolution reaction(OER). A well-recognized OER catalyst system of FeNi3 alloy/oxide embedded in nitrogen-doped porous nanofibers(FeNiO/NCF) is employed as a proof of concept, and it is selectively fluoridated by transforming the metal oxide to metal fluoride(FeNiF/NCF). The crystal structure and surface chemical state transformation are well supported by the spectroscopic analysis and the improved electrochemical performance for OER can be well correlated to the phase and structure change. Specifically, FeNiF/NCF can drive the benchmark current density of 10 mA cm-2 at 260 mV with a Tafel slope of 67 mV dec-1, about 70 mV less than that of FeNiO/*** catalytic kinetics, rapid charge transfer ability, high catalytic efficiency and stability are also probed by electrochemical analysis. The high surface area and roughness are found mainly generated via the high-temperature annealing for the metal alloy/metal oxide formation, and the low-temperature fluoridation process intrinsically contributes to the active structure formation. It is an efficient and universal approach to increase the catalytic performance of metal alloy/oxide for energy-relevant catalytic reactions.

关键词： Oxygen evolution reaction Water splitting FeNi Metal oxide Metal fluoride

Further results on differentially 4-uniform permutations over F2^2m

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Science China Mathematics 2015年第7期58卷 1577-1588页

作者： zha ZhengBang hu Lei SUN SiWei SHAN JinYong School of Mathematical Sciences Luoyang Normal University State Key Laboratory of Information Security Institute of Information EngineeringChinese Academy of Sciences Beijing Center for Mathematics and Information Interdisciplinary Sciences

We present several new constructions of differentially 4-uniform permutations over F22 mby modifying the values of the inverse function on some subsets of F22 m. The resulted differentially 4-uniform permutations have high nonlinearities and algebraic degrees, which provide more choices for the design of crytographic substitution boxes.

关键词： permutation differentially 4-uniform function nonlinearity algebraic degree

Two-stage Optimization for Active Distribution Systems Based on Operating Ranges of Soft Open Points and Energy Storage System

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 66-79页

作者： Can Wang Jianjun Sun Meng huang Xiaoming zha Wei hu School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China State grid hubei Electric Power Corporation Wuhan 430070China

Due to the lack of flexible interconnection devices,power imbalances between networks cannot be relieved ***,increasing the penetration of distributed generators exacerbates the temporal power imbalances caused by large peak-valley load *** improve the operational economy lowered by spatiotemporal power imbalances,this paper proposes a two-stage optimization strategy for active distribution networks(ADNs)interconnected by soft open points(SOPs).The SOPs and energy storage system(ESS)are adopted to transfer power spatially and temporally,*** the day-ahead scheduling stage,massive stochastic scenarios against the uncertainty of wind turbine output are generated *** improve computational efficiency in massive stochastic scenarios,an equivalent model between networks considering sensitivities of node power to node voltage and branch current is *** introduction of sensitivities prevents violations of voltage and ***,the operating ranges(ORs)of the active power of SOPs and the state of charge(SOC)of ESS are obtained from models between networks and within the networks,*** the intraday corrective control stage,based on day-ahead ORs,a receding-horizon model that minimizes the purchase cost of electricity and voltage deviations is established hour by *** studies on two modified ADNs show that the proposed strategy achieves spatiotemporal power balance with lower cost compared with traditional strategies.

关键词： Active distribution system operating range sensitivity soft open point(SOP) power imbalance

CirroData: Yet Another SQL-on-Hadoop Data Analytics Engine with High Performance

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Journal of Computer Science & Technology 2020年第1期35卷 194-208页

作者： Zheng-Hao Jin Haiyang Shi Ying-Xin hu Li zha Xiaoyi Lu Business-Intelligence of Oriental Nations Corporation Ltd. Beijing 100102China Department of Computer Science and Engineering The Ohio State UniversityOhio 43210U.S.A Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 101408China

This paper presents CirroData,a high-performance SQL-on-Hadoop system designed for Big Data analytics *** a home-grown enterprise-level online analytical processing(OLAP)system with more than seven-year research and development(R&D)experiences,we share our design details to the community about how to achieve high performance in *** optimization techniques have been discussed in the *** effectiveness and the efficiency of all these techniques have been proved by our customers'daily ***-level studies,as well as several real application case studies of CirroData,have been presented in this *** evaluations show that CirroData can outperform various types of counterpart database systems in the community,such as"Spark+Hive","Spark+HBase",Impala,DB-X/Y,greenplum,HAWQ,and *** can achieve up to 4.99x speedup compared with greenplum,HAWQ,and Spark in the standard TPC-H ***-level evaluations demonstrate that CirroData outperforms"Spark+Hive"and"Spark+HBase"by up to 8.4x and 38.8x,*** the meantime,CirroData achieves the performance speedups for some application workloads by up to 20x,100x,182.5x,92.6x,and 55.5x as compared with greenplum,DB-X,Impala,DB-Y,and HAWQ,respectively.

关键词： CirroData high performance SQL-on-Hadoop online analytical processing(OLAP) Big Data

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38,47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院北京100083 水利部水土保持监测中心北京100000

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象,通过调查采样和室内分析,探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复,先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展,土壤C∶P和N∶P显著增加,C∶N的变化无明显规律,在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0-40 cm土层的土壤N∶P较上一阶段增加40.2%,40-100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律,研究区土壤逐渐由C,N的限制转变为P的限制;(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关,与孔隙度呈显著正相关,土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加,改善土壤理化性质,在植被恢复过程应同时注重P元素的调控,以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Rayleigh wave phase velocities of South China block and its adjacent areas

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Science China Earth Sciences 2016年第11期59卷 2165-2178页

作者： L Jian XIE ZuJun ZHENg Yong zha Xiaohui hu Rui ZENg XinFu Earthquake Administration of Jiangxi Province Nanchang 330039 China State Key Laboratory of geodesy and Earth's Dynamics Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China

Using records of continuous seismic waveforms from 609 broadband seismic stations in the South China Block and its adjacent areas in 2010–2012, empirical green's functions of surface waves were obtained from cross-correlation functions of ambient noise data between these stations. High quality phase velocity dispersion curves of Rayleigh waves were obtained using time-frequency analysis. These interstation dispersion curves were then inverted to build Rayleigh wave phase velocity maps at periods of 6–50 s. The results of phase velocity maps indicate that phase velocities at 6–10 s periods are correlated with the geological features in the upper crust. Major basins and small-scale grabens and basins display slow velocity anomalies; while most of the orogenic belts and the fold belts display high velocity anomalies. With the gravity gradient zone along Taihang Mountain to Wuling Mountain as the boundary for the phase velocity maps at period of 20–30 s, the western area mainly displays low velocity anomalies, while the eastern side shows high velocity anomalies. Phase velocities in the eastern South China Block south to the Qinling-Dabie orogenic belt is higher than that in the eastern North China Block to the north, which is possibly due to the differences of tectonic mechanisms between the North China Craton and the South China Block. The phase velocities at periods of40–50 s are possibly related to the lateral variations of the velocity structure in the lower crust and upper mantle: The low-velocity anomalies in the eastern part of the Tibetan Plateau are caused by the thick crust; while the Sichuan Basin and the southern part of the Ordos Basin display distinct high-velocity anomalies, reflecting the stable features of the lithosphere in these blocks. The lateral variation pattern of phase velocities in the southern part of the South China Block is not consistent with the surface trace of the block boundary in the eastern Yunnan Province and its vicinities. The pha

关键词： South China block Ambient noise Phase velocity tomography Crust and upper mantle