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几种时频分析方法对比及在煤田地震勘探中的应用

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物探与化探 2009年第6期33卷 691-695,709页

作者：胡明顺潘冬明徐红利赵立瑰中国矿业大学资源与地球科学学院江苏徐州221008 中国矿业大学岩土工程新技术发展有限公司江苏徐州221008

由于不同时频分析方法有其特有时频特性,为提高煤田地震资料处理精细程度,对比研究选择最佳方法十分重要。针对短时傅氏变换、小波变换、S变换,Wigner-Ville分布及其改进分布和Choi-Williams分布等几种经典时频分析方法,进行数值模拟研... 详细信息

由于不同时频分析方法有其特有时频特性,为提高煤田地震资料处理精细程度,对比研究选择最佳方法十分重要。针对短时傅氏变换、小波变换、S变换,Wigner-Ville分布及其改进分布和Choi-Williams分布等几种经典时频分析方法,进行数值模拟研究,分别从时间分辨率、频率分辨率及干扰项影响程度等详细分析了各种方法的优缺点。最后选用SPWVD进行初至拾取和S变换分频显示解释陷落柱,取得了良好的效果。

关键词：短时傅氏变换 S变换 Wigner-Ville分布初至拾取单频剖面

Opinion consensus incorporating higher-order interactions in individual-collective networks

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Chinese Physics B 2024年第7期33卷 105-115页

作者：叶顺涂俐兰王先甲胡佳王薏潮 hubei Province Key Laboratory of Systems Science in Metallurgical Process Wuhan University of Science and TechnologyWuhan 430065China College of Science Wuhan University of Science and TechnologyWuhan 430065China Economics and Management School of Wuhan University Wuhan UniversityWuhan 430065China

In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.

关键词： two-layer social networks individual and collective opinions higher-order interactions consensus Lyapunov's first method

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基于模型正演的折射静校正方法研究与应用

地球物理学进展 2011年第2期26卷 687-693页

作者：尹奇峰潘冬明夏暖李娟娟胡明顺中国矿业大学资源与地球科学学院徐州221116

随着地震勘探区域地质条件复杂化,静校正在资料处理中的作用日显重要.本文模拟研究了折射波在不同地质条件中的特性,完成了正演模型下的折射波静校正量计算,并将静校正后记录与理论模型记录对比,分析该方法的准确性,总结折射波静校正方... 详细信息

随着地震勘探区域地质条件复杂化,静校正在资料处理中的作用日显重要.本文模拟研究了折射波在不同地质条件中的特性,完成了正演模型下的折射波静校正量计算,并将静校正后记录与理论模型记录对比,分析该方法的准确性,总结折射波静校正方法的技术难点,提出一种更准确优越的解决方法.最后,运用该方法选取最合理的参数,并配合先进的处理软件对实际资料进行处理,有效地消除了长波长剩余静校正量,得到了较高质量的叠加剖面.

关键词：折射静校正正演模拟地表模型初至拾取浮动基准面

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VSP初至逐层递推层速度反演研究及应用

物探与化探 2019年第3期43卷 608-617页

作者：罗天柱胡明顺韩迪任义强中国矿业大学资源与地球科学学院江苏徐州221116 深部岩土力学与地下工程国家重点实验室江苏徐州221116

利用VSP资料准确获取地层速度,对地震数据时深转换和偏移成像具有重要的作用。受激发接收条件变化、近源动态干扰和初至拾取误差等因素,VSP资料初至时间往往含有一定程度的随机干扰。笔者研究了当VSP资料初至时间存在随机噪声干扰和仅... 详细信息

利用VSP资料准确获取地层速度,对地震数据时深转换和偏移成像具有重要的作用。受激发接收条件变化、近源动态干扰和初至拾取误差等因素,VSP资料初至时间往往含有一定程度的随机干扰。笔者研究了当VSP资料初至时间存在随机噪声干扰和仅有深部接收数据的情况下,不同井源距VSP资料逐层递推反演层速度的误差特性。研究表明:①井源距越大,其对应资料初至反演速度误差越小;②当仅有深部资料时,井源距越小,其资料反演结果与实际地层速度更接近。为此,提出初至时间平滑后再反演,多井源距反演结果求平均的方法,从而提高层速度反演精度。利用该研究结论,在某海上Walkaway-VSP资料处理中,取得了较好的效果。

关键词：逐层递推反演 VSP 层速度井源距误差分析

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井地地震CT成像数值模拟研究与应用

地球物理学进展 2009年第4期24卷 1399-1404页

作者：胡明顺潘冬明李兵李娟娟李红立中国矿业大学资源与地球科学学院徐州221008 中国科学院兰州地质研究所兰州730000 广州地铁设计研究院广州510010

由井地地震CT成像原理决定,其在提高生产效率、降低生产成本和扩大勘察范围上具有突出优势.本文针对井地观测系统,重点通过对ART和SIRT重建方法进行数值模拟对比研究,分析得出二者在井地地震CT应用中的优缺点及适用条件,提出了如何提高... 详细信息

由井地地震CT成像原理决定,其在提高生产效率、降低生产成本和扩大勘察范围上具有突出优势.本文针对井地观测系统,重点通过对ART和SIRT重建方法进行数值模拟对比研究,分析得出二者在井地地震CT应用中的优缺点及适用条件,提出了如何提高影响成像质量的射线分布密度、均匀性和正交性.最后选择收敛快速稳定的SIRT算法应用于实际,取得良好的生产效果,很好的验证了井地CT成像技术的正确性,可行性和实用性.

关键词：井地地震图像重建反投影重建代数重建联合迭代重建

概率神经网络技术在煤田地震反演中的应用研究

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地球物理学进展 2012年第2期27卷 715-721页

作者：李娟娟崔若飞潘冬明胡明顺张应华中国矿业大学资源与地球科学学院徐州221116 煤层气资源与成藏过程教育部重点实验室徐州221116 深部岩土力学与地下工程国家重点实验室徐州221116 云南大瑞煤业集团有限公司小海子煤矿曲靖655813

实现从构造勘探向岩性勘探阶段的转变,是煤田地震勘探亟待解决的重要问题。其中,地震反演技术是岩性勘探的一种重要手段。为了规避常规反演方法的固有限制,利用概率神经网络技术预测井数据和地震数据之间的非线性关系,得到密度数据体和... 详细信息

实现从构造勘探向岩性勘探阶段的转变,是煤田地震勘探亟待解决的重要问题。其中,地震反演技术是岩性勘探的一种重要手段。为了规避常规反演方法的固有限制,利用概率神经网络技术预测井数据和地震数据之间的非线性关系,得到密度数据体和速度数据体,并获得相应的波阻抗数据体。对某矿区的实际地震资料采用该技术进行岩性反演,得到了较为准确的波阻抗数据体,为岩性解释提供了不可或缺的资料。

关键词：波阻抗反演概率神经网络交叉验证

基于催化发夹组装和荧光共振能量转移的生物传感器检测EV71病毒

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分析化学 2023年第1期51卷 93-101页

作者：田梓佚徐牧岑胡顺铭张楚妍陈琛李永新四川大学华西公共卫生学院/四川大学华西第四医院

以肠道病毒71型(EV71)为检测对象，建立了基于催化发夹组装(CHA)和荧光共振能量转移(FRET)的生物传感器。设计了检测EV71 VP1基因的CHA信号放大策略，该体系由一对发夹探针(H1、 H2)构成，H1和H2分别标记了荧光基团Cy3和Cy5。当体系中有... 详细信息

以肠道病毒71型(EV71)为检测对象，建立了基于催化发夹组装(CHA)和荧光共振能量转移(FRET)的生物传感器。设计了检测EV71 VP1基因的CHA信号放大策略，该体系由一对发夹探针(H1、 H2)构成，H1和H2分别标记了荧光基团Cy3和Cy5。当体系中有VP1基因时，可引发H1和H2催化自组装反应，从而使得Cy3和Cy5相互靠近并发生FRET,导致Cy3荧光信号降低，Cy5信号增强；当体系中没有VP1基因时，H1和H2则稳定存在于反应体系中，不发生FRET,只检测到Cy3的荧光信号。优化了缓冲液浓度、 H1与H2的比例、反应温度和反应时间。在最优条件下，所构建的传感器的Cy5与Cy3的荧光强度比值与EV71 VP1基因浓度在0.5～20 nmol/L范围内呈良好的线性关系，检出限为73 pmol/L(3σ)。咽拭子样品的加标回收率为99.6%～103.1%,相对标准偏差在0.3%～1.7%之间。本方法具有较好的特异性及抗干扰能力，在EV71监测和手足口病早期诊断方面具有良好的应用前景。

关键词：肠道病毒71型催化发夹组装荧光共振能量转移生物传感器手足口病

SHR-A1811(antibody-drug conjugate)in advanced HER2-mutant non-small cell lung cancer:a multicenter,open-label,phase 1/2 study

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3483-3492页

作者： Ziming Li Zhengbo Song Wei Hong Nong Yang Yongsheng Wang Hong Jian Zibin Liang Sheng hu Min Peng Yan Yu Yan Wang Zicong Jiao Kaijing Zhao Ke Song You Li Wei Shi shun Lu Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiaotong University School of MedicineShanghai 200030China Phase I Clinical Trial Ward Zhejiang Cancer HospitalHangzhou 310000China Department of Thoracic Oncology Zhejiang Cancer HospitalHangzhou 310000China Department of Lung&Gastrointestinal Oncology Hunan Cancer HospitalChangsha 410031China Thoracic Oncology Ward/Cancer Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Thoracic Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 51900China Department of Medical Oncology Hubei Cancer HospitalWuhan 43000China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430200China Department of Thoracic Medicine Harbin Medical University Cancer HospitalHarbin 150081China Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Geneplus-Beijing CoLtd.Beijing 102206China Jiangsu Hengrui Pharmaceuticals Co.Ltd.Shanghai 200120China

A dose-escalation and expansion,phase 1/2 study(***,NCT04818333)was conducted to assess the novel antibodydrug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer(NSCLC).Here,we report results from the phase 1 *** who had previously failed or were intolerant to platinum-based chemotherapy were enrolled and received SHR-A1811 intravenously at doses of 3.2 to 8.0 mg/kg every 3 *** escalation followed a Bayesian logistic regression model that included overdose control,with subsequent selection of tolerable levels for dose ***,63 patients were enrolled,including 43 receiving a recommended dose for expansion of 4.8 mg/*** patients had HER2-mutant ***-limiting toxicity occurred in one patient in the 8.0 mg/kg dose ***≥3 treatment-related adverse events occurred in 29(46.0%)*** patient in the 6.4 mg/kg cohort died due to interstitial lung *** of April 11,2023,the 4.8 mg/kg cohort showed an objective response rate of 41.9%(95%Cl 27.0-57.9),and a disease control rate of 95.3%(95%Cl 84.2-99.4).The median duration of response was 13.7 months,with 13 of 18 responses *** median progression-free survival was 8.4 months(95%CI 7.1-15.0).SHR-A1811 demonstrated favourable safety and clinically meaningful efficacy in pretreated advanced HER2-mutantNSCLC.

关键词： SHR HER2 doses

Risk assessment,fitness cost,cross-resistance,and mechanism of tetraniliprole resistance in the rice stem borer,Chilo suppressalis

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Insect Science 2024年第3期31卷 835-846页

作者： Hao Sun Shuai Wang Chong Liu Wen-Kai hu Jin-Wei Liu Ling-Jun Zheng Meng-Yue Gao Fang-Rui Guo Song-Tao Qiao Jun-Li Liu Bo Sun Cong-Fen Gao shun-Fan Wu College of Plant Protection Nanjing Agricultural UniversityState&Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjingChina Bayer Cropscience(China)Co. Ltd.HangzhouChina

The rice stem borer(RSB),Chilo suppressalis,a notorious rice pest in China,has evolved a high resistance level to commonly used ***,a new anthranilic diamide insecticide,effectively controls multiple pests,including ***,the potential resistance risk of RSB to tetraniliprole is still *** this study,the tetraniliprole-selection(Tet-R)strain was obtained through 10 continuous generations of selection with tetraniliprole 30%lethal concentration(LC_(30)).The realized heritability(h^(2))of the Tet-R strain was 0.387,indicating that resistance of RSB to tetraniliprole developed rapidly under the continuous selection of *** Tet-R strain had a high fitness cost(relative fitness=0.53).We established the susceptibility baseline of RSB to tetraniliprole(lethal concentration at LC_(50)=0.727 mg/L)and investigated the resistance level of 6 field populations to *** tested strains that had resistance to chlorantraniliprole exhibited moderate-to high-level resistance to tetraniliprole(resistance ratio=27.7-806.8).Detection of ryanodine receptor(RyR)mutations showed that the Y4667C,Y4667D,I4758M,and Y4891F mutations were present in tested RSB field *** mutations were responsible for the cross-resistance between tetraniliprole and ***,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-mediated genome-modified flies were used to study the contribution of RyR mutations to tetraniliprole *** order of contribution of a single RyR mutation to tetraniliprole resistance was Y4667D>G4915E>Y4667C~~I4758M>*** addition,the I4758M and Y4667C double mutations conferred higher tetraniliprole resistance than single Y4667C *** results can guide resistance management practices for diamides in RSB and other arthropods.

关键词： Chilo suppressalis diamide resistance fitness cost cross-resistance RyR target-site mutations