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Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

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确定FMS托盘数目的有效方法

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控制与决策 1989年第3期4卷 52-54页

作者：周陆英胡保生西安交通大学

选择合适的托盘数目是FMS设计中必须解决的问题,托盘数目也即为系统的缓冲容量,它关系到机床的利用率、系统的维护以及系统的柔性.本文应用闭排队网络方法在FMS设计过程中确定最优托盘数目.

关键词： FMS 托盘数目闭排队网络优化

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Quantitative analysis of the difference of lesion degree between male and female COVID-19 based on digital modeling

Quantitative analysis of the difference of lesion degree bet...

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中国解剖学会2021年年会

作者： Yu huan Liu Guangxing Zhan Meizhi Zhang Zhenwu Sheng Ting Liu Yating Mi Sirong Xie Liang Zhang Feng hu luying He Wenyan Rao Libing hunan Medical College

The purpose of this study is to research the difference of lesion volume and its constituent ratio of lung volume of Novel Coronavirus Pneumonia (NCP) between male and female by digital *** this study,the CT imaging data and clinical data of 40 NCP patients in huaihua were collected and divided into two groups:male (n=22) and female (n=18) according to *** lesions and lung contours were reconstructed by using the CT image data of the two groups in the same period,and the lesion volume and its constituent ratio to lung volume were calculated and analyzed.

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Study on bone morphology and development of children based on digital three-dimensional reconstruction

Study on bone morphology and development of children based o...

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中国解剖学会2021年年会

作者： Mi Sirong Xie Liang hu luying Zhang Feng He Wenyan Liu Guangxing Zhang Zhenwu Yu huan Zhan Meizhi Liu Yating Sheng Ting Peng Wen Liu Qiangsheng Rao Libing hunan Medical College

This study aims to construct the skeletal system of children at different ages through digital modeling techniques,explore the law of morphological development of childen’s skeletal system,so as to provide a reference for the study of children’s bone development and digital *** this study,12 normal boys were selected from 6 age stages (0-6 months,6-12 months,1-3 years old,3-5 years old, 5-7 years old, 7-10 years old).All patients underwent CT plain scan with a slice thickness of 0.625 mm.

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信息技术在注射剂型慈善赠药管理中的应用与实践

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中国药师 2018年第10期21卷 1804-1807页

作者：周晓芳黄萍胡璐莹黄晓龙浙江省肿瘤医院药剂科杭州310000

目的:介绍信息技术在我院注射剂型慈善赠药应用与实践中的作用,探讨新时期注射用剂型慈善赠药信息化管理模式。方法:以赫赛汀注射剂赠药为例全面介绍注射剂型赠药管理系统,比较2016年10月～2017年4月(信息系统实施前),和2017年5～10月(... 详细信息

目的:介绍信息技术在我院注射剂型慈善赠药应用与实践中的作用,探讨新时期注射用剂型慈善赠药信息化管理模式。方法:以赫赛汀注射剂赠药为例全面介绍注射剂型赠药管理系统,比较2016年10月～2017年4月(信息系统实施前),和2017年5～10月(信息系统实施后)本院赫赛汀赠药成品输液合格率、每瓶赫赛汀赠药管理及调配人力资源耗用时间、赠药管理流程相关医生、护士、患者的满意度情况。结果:信息系统实施前后赫赛汀赠药成品输液合格率分别为94. 29%和99. 05%,每瓶赫赛汀赠药管理及配制人力资源耗用时间在系统实施前后为2. 11和0. 36工时,赠药工作流程相关的医生、护士、患者的总满意度分别为78%,42%,62%和98%,96%,98%,信息系统实施前后比较差异均有统计学意义(P <0. 01)。结论:将日渐增多的注射剂型慈善赠药采用信息化管理能够保证临床用药的安全、有效、方便,该系统十分值得推广和应用。

关键词：信息技术慈善赠药注射剂型

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Sulfur metabolism by marine heterotrophic bacteria involved in sulfur cycling in the ocean

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Science China Earth Sciences 2018年第10期61卷 1369-1378页

作者： Xin hu Jihua LIU huaiwei LIU Guangchao ZhuANG luying XUN Institute of Marine Science and Technology Shandong University State Key Laboratory of Microbial Technology Shandong University Department of Marine Sciences University of Georgia

Sulfur cycling in the biosphere is tightly interwoven with the cycling of carbon and nitrogen,through various biological and geochemical *** microorganisms,due to their high abundance,diverse metabolic activities,and tremendous adaptation potential,play an essential role in the functioning of global biogeochemical cycles and linking sulfur transformation to the cycling of carbon and *** many coastal regions are severely stressed by hypoxic or anoxic conditions,leading to the accumulation of toxic sulfide.A number of recent studies have demonstrated that dissimilatory sulfur oxidation by heterotrophic bacteria can protect marine ecosystems from sulfide ***-oxidizing bacteria have evolved diverse phylogenetic and metabolic characteristics to fill an array of ecological niches in various marine ***,we review the recent findings on the microbial communities that are involved in the oxidation of inorganic sulfur compounds and address how the two elements of sulfur and carbon are interlinked and influence the ecology and biogeochemistry in the *** the metabolic enzymes and pathways of sulfur-oxidizing bacteria not only provides an insight into the microbial sulfur metabolism,but also helps us understand the effects of changing environmental conditions on marine sulfur cycling and reinforces the close connection between sulfur and carbon cycling in the ocean.

关键词： Sulfur cycling Sulfur oxidation Heterotrophic bacteria Metabolic pathway

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Neutronic analysis of ITER radial x-ray camera

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Plasma Science and Technology 2019年第2期21卷 105-112页

作者： luying NIU Hongrui CAO Kun XU Liqun hu Institute of Plasma Physics Chinese Academy of Sciences

The radial x-ray camera(RXC) is designed to measure the poloidal profile of plasma x-ray emission with high spatial and temporal resolution. The RXC diagnostic system consists of internal camera module and external camera module that view the core region and outer region through the vertical slots of the diagnostic first wall and diagnostics shield module of the equatorial port plug. To ensure the normal performance of the silicon photodiode array detectors of the cameras in the hard neutron irradiation environment in ITER tokamak, it is necessary to calculate neutron flux, radiation damage and the nuclear heating of the silicon photodiode array detectors and simulate the radiation maps of the range of RXC. This work estimated the nuclear environment of RXC based on Monte Carlo N-particle transport code, plasma scenarios of ITER tokamak and the RXC-integrated ITER CLITE model. The neutron flux of silicon photodiode array detectors and the lifetime of the silicon photodiode detector in the camera were calculated. The neutronic analysis results show that the shielding design has achieved the effect as expected and is able to guarantee the normal work of the detector during the ITER deuterium–deuterium phase without replacement, three detectors of the external camera can be operated during the whole deuterium–tritium phase without replacement.

关键词： tokamak radial x-ray camera neutronic

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Quantitative analysis of the difference of lesion degree between male and female COVID-19 based on digital modeling

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解剖学杂志 2021年第S1期44卷 241-241页

作者： Yu huan Liu Guangxing Zhan Meizhi Zhang Zhenwu Sheng Ting Liu Yating Mi Sirong Xie Liang Zhang Feng hu luying He Wenyan Rao Libing hunan Medical College Huaihua 418000

关键词： female technology. lung

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Study on bone morphology and development of children based on digital three dimensional reconstruction

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解剖学杂志 2021年第S1期44卷 241-241页

作者： Mi Sirong Xie Liang hu luying Zhang Feng He Wenyan Liu Guangxing Zhang Zhenwu Yu huan Zhan Meizhi Liu Yating Sheng Ting Peng Wen Liu Qiangsheng Rao Libing hunan Medical College Huaihua 418000

This study aims to construct the skeletal system of children at different ages through digital modeling techniques,explore the law of morphological development of childen's skeletal system,so as to provide a reference for the study of children's bone development and digital *** this study,12 normal boys were selected from 6 age stages(0-6 months,6-12 months,1-3 years old,3-5 years old,5-7 years old,7-10 years old).All patients underwent CT plain scan with a slice thickness of 0.625 *** collected CT data was imported into Mimics 19.0 software for three dimensional reconstruction of children's whole body bones.3D printing of children's bone model was used to construct children's bone system.T wo dissected bone specimens were randomly selected and compared with 3D printed models for specific bony landmarks to verify the accuracy of modeling.

关键词： anatomy children printing

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The silencing transcription factor REST targets UCHL1 to regulate inflammatory response and fibrosis during cardiac hypertrophy

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Genes & Diseases 2024年第6期11卷 91-94页

作者： Wenze Cao huan Liu Ye Xu Sangyu hu Yujie Yang Li Li luying Peng State Key Laboratory of Cardiology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Institute of Medical Genetics Tongji UniversityShanghai 200092China Heart Health Center Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Medical Genetics Tongji University School of MedicineShanghai 200092China Research Units of Origin and Regulation of Heart Rhythm Chinese Academy of Medical SciencesBeijing 100730China

RE1 silencing transcription factor(REST)plays a key role in embryonic development and fetal cardiac gene reactivation.1 However,understanding of the role of REST in cardiac remodeling is very limited.A recent study has shown that cardiac-specific REST knockout increases Gao expression,and impairs Ca^(2+)processing in ventricular 1 myocytes,leading to cardiac dysfunction.

关键词： cardiac fetal REST

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