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RepBoTNet-CESA:An Alzheimer’s Disease Computer Aided Diagnosis Method Using Structural Reparameterization BoTNet and Cubic Embedding Self Attention

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Computers, Materials & Continua 2024年第5期79卷 2879-2905页

作者： Xiabin Zhang Zhongyi hu Lei Xiao hui huang College of Computer Science and Artificial Intelligence Wenzhou UniversityWenzhou325035China Key Laboratory of Intelligence Image Processing and Analysis Wenzhou UniversityWenzhou325035China

Various deep learning models have been proposed for the accurate assisted diagnosis of early-stage Alzheimer’s disease(AD).Most studies predominantly employ Convolutional Neural Networks(CNNs),which focus solely on local features,thus encountering difficulties in handling global *** contrast to natural images,Structural Magnetic Resonance Imaging(sMRI)images exhibit a higher number of channel ***,during the Position Embedding stage ofMulti Head Self Attention(MHSA),the coded information related to the channel dimension is *** tackle these issues,we propose theRepBoTNet-CESA network,an advanced AD-aided diagnostic model that is capable of learning local and global features *** combines the advantages of CNN networks in capturing local information and Transformer networks in integrating global information,reducing computational costs while achieving excellent classification ***,it uses the Cubic Embedding Self Attention(CESA)proposed in this paper to incorporate the channel code information,enhancing the classification performance within the Transformer ***,the RepBoTNet-CESA performs well in various AD-aided diagnosis tasks,with an accuracy of 96.58%,precision of 97.26%,and recall of 96.23%in the AD/NC task;an accuracy of 92.75%,precision of 92.84%,and recall of 93.18%in the EMCI/NC task;and an accuracy of 80.97%,precision of 83.86%,and recall of 80.91%in the AD/EMCI/LMCI/NC *** demonstrates that RepBoTNet-CESA delivers outstanding outcomes in various AD-aided diagnostic ***,our study has shown that MHSA exhibits superior performance compared to conventional attention mechanisms in enhancing ResNet ***,the Deeper RepBoTNet-CESA network fails to make further progress in AD-aided diagnostic tasks.

关键词： Alzheimer CNN structural reparameterization multi head self attention computer aided diagnosis

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Recent progress and prospects of electrolytes for electrocatalytic nitrogen reduction toward ammonia

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Chinese Chemical Letters 2024年第4期35卷 3-16页

作者： Sajid Mahmood Haiyan Wang Fang Chen Yijun Zhong Yong hu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Department of ChemistryZhejiang Normal UniversityJinhua 321004China The Center for Applied Mathematics and Bioinformatics(CAMB) Gulf University for Science and TechnologyMishref 32093Kuwait Hangzhou Institute of Advanced Studies Zhejiang Normal UniversityHangzhou 311231China

Electrochemical nitrogen reduction reaction(ENRR) provides a promising strategy to achieve sustainable synthesis of ammonia. However, despite great efforts devoted to this research field, the problems such as low energy efficiency and weak selectivity still impede its practical implementation. Most of the research to date has been concentrated on creating sophisticated electrocatalysts, and adequate knowledge of electrolytes is still lacking. Herein, the recent progress in electrolytes for ENRR, including alkaline, neutral,acidic, water-in-salt, organic, ionic liquid, and mixed water-organic electrolytes, is thoroughly reviewed to obtain an in-depth understanding of their effects on electrocatalytic performance. Recently developed representative electrocatalysts in various types of electrolytes are also introduced, and future research priorities of different electrolytes are proposed to develop new and efficient ENRR systems.

关键词： Electrocatalytic nitrogen reduction Ammonia Electrolytes Production rate Faradaic efficiency

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Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer

Decrease in phosphorylated ERK indicates the therapeutic eff...

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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： Liu XL Xu YC Wang YX Chen Y Wang BB Wang Y Chen YH Tan C hu ld Ma QY Zhang YC Sun YM Gao YL Yang CH Ding J Meng LH University of Chinese Academy of Sciences Division of Anti-tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of Sciences Department of Medicinal Chemistry State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaUniversity of Chinese Academy of Sciences The Key Laboratory of Stem Cell Biology Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of Sciences

PI3 Ks are frequently hyper-activated in breast cancer and targeting PI3 Ka has exhibited promising but variable response in preclinical and clinical ***33 is a novel PI3 Kα-selective inhibitor in phase I clinical *** investigated the efficacy of CYH33 against breast cancer and explored potential predictive ***33 potently restrained tumor growth in mice bearing human breast cancer cell xenografts and in R26-Pik3 ca;MMTV-Cre transgenic ***33 significantly inhibited proliferation of a panel of human breast cancer cells,while diversity in sensitivity has been *** harboring activating PIK3 CA mutation,amplified HER2 were more responsive to CYH33 than their ***,cells in HER2-enriched or luminal subtype were more sensitive to CYH33 than basal-like breast *** to CYH33 has been further revealed to be associated with induction of G1 phase arrest and simultaneous inhibition of Akt and *** of patient-derived xenograft to CYH33 was also positively correlated with decrease in phosphorylated *** together,CYH33 is a promising PI3 Ka inhibitor for breast cancer treatment and decrease in ERK phosphorylation may indicate its efficacy,which provides useful clues for rational design of the ongoing clinical trials.

关键词： Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3K selective inhibitor CYH33 in breast cancer ERK

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Assessing target optical camouflage effects using brain functional networks:A feasibility study

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Defence Technology（防务技术） 2024年第4期34卷 69-77页

作者： Zhou Yu Li Xue Weidong Xu Jun Liu Qi Jia Jianghua hu Jidong Wu National Key Laboratory of Lightning Protection and Electromagnetic Camouflage Army Engineering University Nanjing 210007JiangsuChina Unit 31608 of PLA Xiamen 361000FujianChina School of Biological Sciences&Medical Engineering Southeast UniversityNanjing 210096JiangsuChina

Brain functional networks model the brain's ability to exchange information across different regions,aiding in the understanding of the cognitive process of human visual attention during target searching,thereby contributing to the advancement of camouflage *** this study,images with various camouflage effects were presented to observers to generate electroencephalography(EEG)signals,which were then used to construct a brain functional *** topological parameters of the network were subsequently extracted and input into a machine learning model for *** results indicate that most of the classifiers achieved accuracy rates exceeding 70%.Specifically,the Logistic algorithm achieved an accuracy of 81.67%.Therefore,it is possible to predict target camouflage effectiveness with high accuracy without the need to calculate discovery *** proposed method fully considers the aspects of human visual and cognitive processes,overcomes the subjectivity of human interpretation,and achieves stable and reliable accuracy.

关键词： Camouflage effect evaluation Electroencephalography(EEG) Brain functional networks Machine learning

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Shape estimation for a TPU-based multi-material 3D printed soft pneumatic actuator using deep learning models

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Science China(Technological Sciences) 2024年第5期67卷 1470-1481页

作者： hu Yu TANG Wei QU Yang XU huXiu KRAMARENKO Yu.Elena ZOU Jun State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou310058China School of Mechanical Engineering Zhejiang UniversityHangzhou310027China Institute of Process Equipment College of Energy EngineeringZhejiang UniversityHangzhou310027China Faculty of Physics Lomonosov Moscow State UniversityMoscow119991Russia Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences Moscow117393Russia

Real-time proprioception presents a significant challenge for soft robots due to their infinite degrees of freedom and intrinsic *** studies mostly focused on specific sensors and *** is still a lack of generalizable technologies for integrating soft sensing elements into soft actuators and mapping sensor signals to proprioception *** tackle this problem,we employed multi-material 3D printing technology to fabricate sensorized soft-bending actuators(SBAs)using plain and conductive thermoplastic polyurethane(TPU)*** designed various geometric shapes for the sensors and investigated their strain-resistive performance during *** address the nonlinear time-variant behavior of the sensors during dynamic modeling,we adopted a data-driven approach using different deep neural networks to learn the relationship between sensor signals and system states.A series of experiments in various actuation scenarios were conducted,and the results demonstrated the effectiveness of this *** sensing and shape prediction steps can run in real-time at a frequency of50 Hz on a consumer-level ***,a method is proposed to enhance the robustness of the learning models using data augmentation to handle unexpected sensor *** the methods are efficient,not only for in-plane 2D shape estimation but also for out-of-plane 3D shape *** aim of this study is to introduce a methodology for the proprioception of soft pneumatic actuators,including manufacturing and sensing modeling,that can be generalized to other soft robots.

关键词： shape estimation soft sensors and actuators 3D printing deep learning in robotics

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Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 120-135页

作者： Xiaomei Wu Renxiang Yuan Yichong Xu Kai Wang Hong Yuan Tingting Meng Fuqiang hu Department of Pharmacy Ruijin HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200000China College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China

The challenge in the clinical treatment of Parkinson's disease lies in the lack of disease-modifying therapies that can halt or slow down the progression. Peptide drugs, such as exenatide (Exe), with potential disease-modifying efficacy, have difficulty in crossing the blood-brain barrier (BBB) due to their large molecular weight. Herein, we fabricate multi-functionalized lipid nanoparticles (LNP) Lpc-BoSA/CSO with BBB targeting, permeability-increasing and responsive release functions. Borneol is chemically bonded with stearic acid and, as one of the components of Lpc-BoSA/CSO, is used to increase BBB permeability. Immunofluorescence results of brain tissue of 15-month-old C57BL/6 mice show that Lpc-BoSA/CSO disperses across the BBB into brain parenchyma, and the amount is 4.21 times greater than that of conventional LNP. Motor symptoms of mice in Lpc-BoSA/CSO-Exe group are significantly improved, and the content of dopamine is 1.85 times (substantia nigra compacta) and 1.49 times (striatum) that of PD mice. α-Synuclein expression and Lewy bodies deposition are reduced to 51.85% and 44.72% of PD mice, respectively. Immunohistochemical mechanism studies show AKT expression in Lpc-BoSA/CSO-Exe is 4.23 times that of PD mice and GSK-3β expression is reduced to 18.41%. Lpc-BoSA/CSO-Exe could reduce the production of α-synuclein and Lewy bodies through AKT/GSK-3β pathway, and effectively prevent the progressive deterioration of Parkinson's disease. In summary, Lpc-BoSA/CSO-Exe increases the entry of exenatide into brain and promotes its clinical application for Parkinson's disease therapy.

关键词： Blood-brain barrier Lipid nanoparticles Brain delivery facilitation α-Symuclein Parkinson's disease

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Heterogeneous population distribution enhances resistance to wheat lodging by optimizing the light environment

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Journal of Integrative Agriculture 2024年第7期23卷 2211-2226页

作者： Yibo hu Feng Qin Zhen Wu Xiaoqin Wang Xiaolong Ren Zhikuan Jia Zhenlin Wang Xiaoguang Chen Tie Cai College of Agronomy Northwest A&F UniversityYangling 712100China Key Laboratory of Crop Physi-Ecology and Tillage Science in Northwestern Loess Plateau Ministry of Agriculture and Rural AffairsNorthwest A&F UniversityYangling 712100China College of Agronomy Shandong Agricultural University/State Key Laboratory of Crop BiologyTai’an 271018China Xuzhou Institute of Agricultural Sciences in Jiangsu Xuhuai Area Xuzhou 221131China

Lodging is still the key factor that limits continuous increases in wheat yields today,because the mechanical strength of culms is reduced due to low-light stress in populations under high-yield *** mechanical properties of the culm are mainly determined by lignin,which is affected by the light ***,little is known about whether the light environment can be sufficiently improved by changing the population distribution to inhibit culm ***,in this study,we used the wheat cultivar“Xinong 979”to establish a low-density homogeneous distribution treatment(ld),high-density homogeneous distribution treatment(HD),and high-density heterogeneous distribution treatment(HD-h)to study the regulatory effects and mechanism responsible for differences in the lodging resistance of wheat culms under different population *** with ld,HD significantly reduced the light transmittance in the middle and basal layers of the canopy,the net photosynthetic rate in the middle and lower leaves of plants,the accumulation of lignin in the culm,and the breaking resistance of the culm,and thus the lodging index values increased significantly,with lodging rates of 67.5%in 2020–2021 and 59.3%in 2021–*** HD-h,the light transmittance and other indicators in the middle and basal canopy layers were significantly higher than those under HD,and the lodging index decreased to the point that no lodging *** with ld,the activities of phenylalanine ammonia-Lyase(PAL),4-coumarate:coenzyme A ligase(4CL),catechol-O-methyltransferase(COMT),and cinnamyl-alcohol dehydrogenase(CAD)in the lignin synthesis pathway were significantly reduced in the culms under HD during the critical period for culm formation,and the relative expression levels of TaPAL,Ta4CL,TaCOMT,and TaCAD were significantly ***,the activities of lignin synthesis-related enzymes and their gene expression levels were significantly increased under HD-h compare

关键词： canopy light environment lignin lodging population distribution wheat

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Optically driven intelligent computing with ZnO memristor

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Fundamental Research 2024年第1期4卷 158-166页

作者： Jing Yang Lingxiang hu Liufeng Shen Jingrui Wang Peihong Cheng huanming Lu Fei Zhuge Zhizhen Ye Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100029China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200072China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

Artificial vision is crucial for most artificial intelligence *** artificial visual systems have been facing challenges in terms of real-time information processing due to the physical separation of sensors,memories,and processors,which results in the production of a large amount of redundant data as well as the data conversion and transfer between these three components consuming most of the time and *** optoelectronic memristors with the ability to realize integrated sensing-computing-memory(ISCM)are key candidates for solving such challenges and therefore attract increasing *** present,the memristive ISCM devices can only perform primary-level computing with external light signals due to the fact that only monotonic increase of memconductance upon light irradiation is achieved in most of these ***,we propose an all-optically controlled memristive ISCM device based on a simple structure of Au/ZnO/Pt with the ZnO thin film sputtered at pure Ar *** device can perform advanced computing tasks such as nonvolatile neuromorphic computing and complete Boolean logic functions only by light irradiation,owing to its ability to reversibly tune the memconductance with ***,the device shows excellent operation stability ascribed to a purely electronic memconductance tuning ***,this study is an important step towards the next generation of artificial visual systems.

关键词： Memristor All-optically controlling ZnO thin filmArtificial vision Nonvolatile neuromorphic computing Logic-in-memory

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Ultracompact silicon on-chip polarization controller

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Photonics Research 2024年第2期12卷 183-193页

作者： WEIKE ZHAO YINGYING PENG MINGYU Zhu RUORAN LIU XIAOLONG hu YAOCHENG SHI DAOXIN DAI State Key Laboratory for Modern Optical Instrumentation Center for Optical&Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityZijingang CampusHangzhou 310058China School of Precision Instrument and Optoelectronic Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Optoelectronic Information Science and Technology Ministry of EducationTianjin 300072China Ningbo Research Institute Zhejiang UniversityNingbo 315100China

On-chip polarization controllers are extremely important for various optical *** this paper,a compact and robust silicon-based on-chip polarization controller is proposed and demonstrated by integrating a special polarization converter and phase *** special polarization converter consists of a 1×1 Mach–Zehnder interferometer with two polarization-dependent mode converters at the input/output *** light with an arbitrary state of polarization(SOP)is launched into the chip,the TE_(0)and TM_(0)modes are simultaneously *** polarization extinction ratio(PER)and the phase difference for the TE_(0)∕TM_(0)modes are tuned by controlling the first phase shifter,the polarization converter,and the second phase *** a result,one can reconstruct the light SOP at the output *** fabricated polarization controller,as compact as~150μm×700μm,exhibits an excess loss of less than 1 dB and a record PER range of>54 dB for arbitrary input light beams in the wavelength range of 1530–1620 nm.

关键词： polarization SOP interferometer

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“调气扶土”针法治疗贝尔麻痹急性期的临床观察

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中医药导报 2021年第4期27卷 77-79,83页

作者：胡梨雨于海波兰凯张金焕广州中医药大学第四临床医学院广东深圳518000 深圳市中医院广东深圳518000

目的:观察"调气扶土"针法治疗贝尔麻痹急性期的疗效。方法:将60例贝尔麻痹急性期患者随机分为对照组和治疗组,分别采用面瘫常规针刺治疗和"调气扶土"针法治疗。观察比较两组患者治疗前后面神经功能评分、面部血流灌注情况、并发症情况... 详细信息

目的:观察"调气扶土"针法治疗贝尔麻痹急性期的疗效。方法:将60例贝尔麻痹急性期患者随机分为对照组和治疗组,分别采用面瘫常规针刺治疗和"调气扶土"针法治疗。观察比较两组患者治疗前后面神经功能评分、面部血流灌注情况、并发症情况。结果:与治疗前比较,两组患者治疗后面神经功能评分、面部血流灌注量均显著改善(P<0.05);治疗后两组患者面神经功能评分、面部血流灌注量、并发症发生情况比较,差异均有统计学意义(P<0.05),且治疗组改善情况优于对照组,其并发症少于对照组。结论:"调气扶土"针法治疗贝尔麻痹急性期有效,能一定程度上降低并发症的发生,明显改善患侧血流灌注量。

关键词：贝尔麻痹血流灌注调气扶土针法临床观察

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