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Improvement of the dissolution rate of silymarin by means of solid dispersions

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第二军医大学学报 2005年第2期26卷 229-229页

作者： Li FQ hu jh Department of Pharmaceutical Sciences Changhai Hospital Second Military Medical University Shanghai 200433 China

Solid dispersions of silymarin were prepared by the fusion method with the intention of improving the dissolution properties of silymarin. Polyethylene glycol 6000 (PEG 6000) was used as the inert hydrophilic matrix. The dissolution studies of the solid dispersions were performed in vitro. And the results obtained showed that the dissolution rate of silymarin was considerably improved when formulated in solid dispersions with PEG 6000 as compared to original drug, and the increased dissolution rate might be favorable for further oral absorption.

关键词： solid dispersions dissolution rate fusion method in vitro

Double DQN Method For Botnet Traffic Detection System

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Computers, Materials & Continua 2024年第4期79卷 509-530页

作者： Yutao hu Yuntao Zhao Yongxin Feng Xiangyu Ma School of Information Science and Engineering Shenyang Ligong UniversityShenyang110159China Graduate School Shenyang Ligong UniversityShenyang110159China

In the face of the increasingly severe Botnet problem on the Internet,how to effectively detect Botnet traffic in realtime has become a critical *** the existing deepQnetwork(DQN)algorithminDeep reinforcement learning can solve the problem of real-time updating,its prediction results are always higher than the actual *** Botnet traffic detection,although it performs well in the training set,the accuracy rate of predicting traffic is as high as%;however,in the test set,its accuracy has declined,and it is impossible to adjust its prediction strategy on time based on new data ***,in the new dataset,its accuracy has declined ***,this paper proposes a Botnet traffic detection system based on double-layer DQN(DDQN).Two Q-values are designed to adjust the model in policy and action,respectively,to achieve real-time model updates and improve the universality and robustness of the model under different data *** show that compared with the DQN model,when using DDQN,the Q-value is not too high,and the detectionmodel has improved the accuracy and precision of Botnet ***,when using Botnet data sets other than the test set,the accuracy and precision of theDDQNmodel are still higher than DQN.

关键词： DQN DDQN deep reinforcement learning botnet detection feature classification

Exposure of preimplantation embryos to insulin alters expression of imprinted genes

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Exposure of preimplantation embryos to insulin alters expres...

Supersaturation-driven self-assembly formation of ceftriaxone sodium spherulites:From amorphous form to spherulites

全国动物生理生化第十次学术交流会

作者： Shao WJ Tao LY Xie JY Gao C hu jh Zhao RQ Key Laboratory of Animal Physiology & Biochemistry,Nanjing Agricultural University,Nanjing,PR China.

Insulin promotes early embryonic development,but whether this action affects postimplantation fetal development and alters the expression of imprinted genes remain to be *** study analyzed the expression and methylati...

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Particuology 2024年第7期90卷 10-19页

作者： Shankun Liang Yuchao Niu Xueyan hu Wu Xiao Xuehua Ruan Gaohong He Xiaobin Jiang State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian116024China School of Chemical Engineering at Panjin Dalian University of TechnologyPanjin124221China

Drug particles with spherical morphology possess amazing advantages in terms of particle flowability,mechanical properties,drug solubility,and *** growth mechanism of drug spherulite is of great importance for the preparation and regulation of ***,ceftriaxone sodium spherulites were fabricated by the antisolvent crystallization method using dropwise addition of ceftriaxone sodium solution to *** observation of the whole crystallization process combined with electron microscopy technique revealed the spherical growth process from amorphous form to *** the supersaturation of the crystallization system was adjusted,the ceftriaxone sodium crystals transformed from amorphous form to *** the process of antisolvent crystallization with acetone as antisolvent,when the theoretical supersaturation degree S was higher than 2.62,the crystallization system tended to appear amorphous form;when S was between 2.57 and 2.62,the amorphous form transformed into clustered spherulites;when S was less than 2.57,the surface of spherulites will be covered with flaky crystal,which transformed into urchin-like *** the understanding of the spherical growth mechanism,the ceftriaxone sodium spherulites prepared in this research with modified supersaturation control had a low residue of antisolvent acetone,and the flowability was significantly improved.

关键词： Spherulite Ceftriaxone sodium Antisolvent crystallization Supersaturation Online observation

Mutation in a non-force-bearing region of protein L influences force-dependent unfolding behavior

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Chinese Physics B 2024年第7期33卷 624-629页

作者：蒋环杰王艳伟陈家媛胡丹潘海郭子龙陈虎 Department of Physics Wenzhou UniversityWenzhou 325035China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Laboratory for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China

Single-molecule magnetic tweezers(MTs) have revealed multiple transition barriers along the unfolding pathway of several two-state proteins, such as GB1 and Csp. In this study, we utilized MTs to measure the force-dependent folding and unfolding rates of both protein L(PLWT) and its Y47W mutant(PLY47W) where the mutation point is not at the force-bearing β-strands. The measurements were conducted within a force range of 3–120 pN. Notably, the unfolding rates of both PLWT and PWY47W exhibit distinct force sensitivities below 50 pN and above 60 pN, implying a two-barrier free energy landscape. Both PLWT and PLY47W share the same force-dependent folding rate and the same transition barriers,but the unfolding rate of PLY47W is faster than that of PLWT. Our finding demonstrates that the residue outside of the force-bearing region will also affect the force-induced unfolding dynamics.

关键词： protein folding magnetic tweezers protein L

Highly efficient chemicalproductionviaelectrified,transient high-temperature synthesis

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eScience 2024年第4期4卷 41-53页

作者： Yichen Dong Yi Rao Hanwen Liu Hao Zhang Rong hu Yingquan Chen Yonggang Yao Haiping Yang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In response to the current energy and environmental challenges,reducing or replacing reliance on fossil fuels and striving for carbon neutrality seems to be the only viable ***,a cutting-edge,eco-friendly method of chemical synthesis via transient Joule heating(jh)demonstrated significant promise across various domains,including methane reforming,ammonia synthesis,volatile organic compounds removal,plastic recycling,the synthesis of functional carbon materials from repurposed solid waste,*** this review,the advantages,and latest developments in thermochemical synthesis by flash and transient jh are comprehensively *** the ongoing heating process of conventional furnaces that consume fossil fuels,dynamic and transient jh can get significantly higher reaction rates,energy efficiency,flexibility,and ***,the transient reaction mechanism,data science optimization,and scale-up production models are discussed,and prospects for the integration of the electrified chemical industry with renewable energy for carbon neutrality and long-term energy storage are also envisioned.

关键词： Electrified chemicalsynthesis Transient heating Low-carbon production Gas-phasereaction Solid waste

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

A Novel Condensation Reaction of Alkyl Aryl Ketone with Ethyl Ortho-Formate under Microwave Irradiation

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Chinese Chemical Letters 1998年第1期9卷 1-4页

作者： Yu, jh hu, YL Yang, SY Yin, YQ Cai, LP Chinese Acad Sci Lanzhou Inst Chem Phys State Key Lab Oxo Synthesis & Select Oxidat Lanzhou 730000 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

Under microwave irradiation, boron trifluoride has been found to mediate a novel condensation reaction of alkyl aryl ketone with ethyl ortho-formate to give a series of new condensation products (5,6,7,8). Their structures were determined by IR, H-1/C-13-NMR, MS spectra, and the crystal structure of 8 was further defined by X-ray diffraction.

关键词： microwave irradiation condensation alkyl aryl ketone

Study of primary leiomyosarcoma induced by MNNG in BALB/C nude mice

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World Journal of Gastroenterology 2000年第1期6卷 128-130页

作者： Zhu JS Su Q Zhou JG hu PL Xu jh Institute of Oncology Hengyang Medical CollegeHengyang 421001China

INTRODUCTIONIt has been well known that MNNG is one of thestrong and multipotential carcinogens that havebeen frequently reported inducing malignant *** have successfully induced rat and doggastric adenocarcinomas,squ... 详细信息

关键词： Subject headings leiomyosarcoma stomach neoplasms MNNG BALB/C nude mice