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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing he Jue Shi Zihe hu Yanyan Zhou Zhijian Xie Yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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A New Adaptive Formant Vocoder

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Journal of Systems Engineering and Electronics 1991年第1期2卷 89-96页

作者： hu Yi and he DehuanBeijing Institute of Remote Sensing Equipment, P. O. Box 3925, Beijing 100854, China Beijing Institute of Remote Sensing Equipment P. O. Box 3925 Beijing 100854 China

A new type of vocoder system based upon formant analysis is presented in this paper. The LMS adaptive algorithm is used for tracking formants of speech signals. The results of computer simulation show that the new voc... 详细信息

关键词： Adaptive formant vocoder Formant analysis LMS adaptive algorithm.

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Research of Transformer Optimal Design Modeling and Intelligent Algorithm

Research of Transformer Optimal Design Modeling and Intellig...

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第五届（2010）中国管理学年会——平行管理分会场

作者： ZHANG Shuang,hu Qing-he,Wang Xing-wei

The paper studies transformer optimal design,establishes optimal transformer model based on total owning *** adopts penalty function to process objective function with weighted *** prematurity and low speed of convergence of Simple Genetic Algorithm,improved adaptive genetic algorithm is *** increases crossover and mutation rates,and improves fitness *** is adopted to search for minimum total owning cost of *** result shows that the algorithm performs well,increases converging speed and betters solution.

关键词： Transformer Optimal design Genetic algorithm Total owning cost

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Design,synthesis and biological evaluation of indole derivatives as novel inhibitors targeting B-Raf kinase

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Chinese Chemical Letters 2014年第2期25卷 351-354页

作者： Zeng Wu Ming Yan Shi-he hu Zhi-Cheng Yu Yong Zhu Ya-Dong Cheng Hai-Chun Liu Yan-Min Zhang Si-hui Yao Wei-Fang Tang Tao Lu Department of Organic Chemistry China Pharmaceutical University National Nanjing Center for Drug Screening China Pharmaceutical University Laboratory of Molecular Design and Drug Discovery School of SciencesChina Pharmaceutical University State Key laboratory of Natural Medicines China Pharmaceutical University The headmaster's Office China Pharmaceutical University

A series of novel indole derivatives were designed and synthesized and their inhibitory activity against B-Raf and hepG2 cell were also described. Among them, compounds 7a and 7b exhibited excellent potency, which sho... 详细信息

关键词： B-Raf kinase inhibitors Receptor-based drug discovery Indole derivatives Biological evaluation

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微型氙气供给模块性能研究及在轨应用

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推进技术 2023年第6期44卷 42-47页

作者：官长斌王冕高鹤胡贺然北京控制工程研究所北京100098

传统氙气供给系统由于系统复杂、重量体积大、价格昂贵、生产周期长等劣势,已无法适应低轨互联网卫星星座对低功率霍尔电推进系统的轻质化、低成本及快速研制的发展要求。本文提出一种基于复杂流体通道先进成型和微型化流体控制部件相... 详细信息

传统氙气供给系统由于系统复杂、重量体积大、价格昂贵、生产周期长等劣势,已无法适应低轨互联网卫星星座对低功率霍尔电推进系统的轻质化、低成本及快速研制的发展要求。本文提出一种基于复杂流体通道先进成型和微型化流体控制部件相结合的Bang-Bang控制型微型氙气供给模块,对其结构组成和工作原理进行了介绍。基于Matlab与AMESim联合仿真方式搭建了其系统动态仿真模型,并采用Peng-Robinson方程考虑了氙气的超临界特性,对其Bang-Bang压力控制特性进行仿真研究。对微型氙气供给模块与600W霍尔推力器的在轨数据进行了分析,产品在轨工作稳定,在轨数据与仿真结果相吻合。

关键词：霍尔电推进系统微型氙气供给模块 Bang-Bang控制仿真分析在轨应用

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A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China

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Chinese Medical Journal 2019年第13期132卷 1516-1523页

作者： Kun Wang Li Zhang Zhong-hu he Zuo-Jing Liu Lu Zhang Nan hu Zhu Jin Yang Ke Li-Ping Duan Department of Gastroenterology Peking University Third HospitalBeijing 100191China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China

Background: The exact relationship between gastroesophageal reflux disease (GERD) and esophageal squamous cell cancer (ESCC) is far from clarification. The aim of this study was to investigate the epidemiology of GERD in a region with high prevalence of ESCC in China. Methods: A population-based, cross-sectional study was conducted in a high ESCC prevalent area, Anyang, henan, China. All subjects fulfilled questionnaires and underwent gastroendoscopy with routine esophageal biopsy. The subjects were divided into GERD subtypes (reflux esophagitis [RE] and non-erosive reflux disease [NERD]) and controls. Odds ratios (ORs) and 95% confidence intervals (Cis) were calculated to examine risk factors for RE and NERD. Results: A total of 2844 subjects were finally enrolled. The prevalence of GERD (RE + NERD) was 17.3%. Among them, 271 (9.53%) adults were diagnosed with RE. The prevalence of RE increased with age (7.09% in 45-50 years, 8.00% in 51-60 years, and 9.53% in 61-69 years,x^2 = 62.216, P he silent RE. A total of 221 (7.77%) subjects were diagnosed with NERD. Frequent liquid food consumption (OR [95% CI]: 1.502 [1.076-2.095]) was independent risk factor for RE as well as age, male gender, high body mass index (BMI), ever smoking. Age was independent risk factor for NERD. For silent RE, age, male gender, and frequent liquid food consumption were risk factors. Conclusions: In the population with high prevalence of ESCC, a high prevalence of GERD and inverted proportion of RE/NERD were presented. Age was an independent risk factor for GERD. The male gender, high BMI, smoking, and frequent liquid food consumption may be risk factors for RE but not for NERD.

关键词： Gastroesophageal reflux disease Esophageal squamous cell cancer Prevalence Risk factors

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Some Asymptotic Properties for Multivariate Partially Linear Models

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Chinese Quarterly Journal of Mathematics 2011年第2期26卷 270-274页

作者： ZHOU Xing-cai hu Shu-he Department of Mathematics and Computer Science Tongling University Tongling 244000 China Department of Mathematics Anhui University Hefei 230039 China

The paper considers a multivariate partially linear model under independent errors,and investigates the asymptotic bias and variance-covariance for parametric component βand nonparametric component F（·）by the GJS ... 详细信息

关键词： multivariate partially linear models GJS estimator asymptotic properties

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比较法视野下侵权行为的获利返还——以英国法中“放弃侵权之诉”的发展为线索

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河南大学学报（社会科学版） 2016年第6期56卷 49-54页

作者：胡和平湖南警察学院学报编辑部湖南长沙410138

在英国法严格诉讼形式背景之下,为了在侵权诉讼中变通适用准契约性质的诉讼,要求侵权人返还因侵权行为而获得的不正当利益,拟制出支付的承诺,而认可侵权行为的合法性,被称为"放弃侵权之诉";伴随诉讼格式的废除,诉因与救济方式的对应模... 详细信息

在英国法严格诉讼形式背景之下,为了在侵权诉讼中变通适用准契约性质的诉讼,要求侵权人返还因侵权行为而获得的不正当利益,拟制出支付的承诺,而认可侵权行为的合法性,被称为"放弃侵权之诉";伴随诉讼格式的废除,诉因与救济方式的对应模式被打破,返还侵权行为获利也逐渐发展成为针对获利型侵权行为普遍适用的一种救济方式。侵权行为的获利返还救济将不当得利应予返还的基本观点引入到侵权损害赔偿的体系之中,是对侵权损害赔偿的补偿功能的一种有效扩展。从比较法的角度分析,我国《侵权责任法》第20条在涉及人身权益的损害时首次认可了侵权行为获利返还的救济方式,但对其功能属性及法律适用方面还缺乏必要的立法说明。为此,对英国法侵权行为获利返还这一传统做法进行比较法上的梳理,以期能为我国《侵权责任法》第20条相关问题的探讨提供些许启示和参考。

关键词：利益返还放弃侵权之诉侵权损害赔偿不当得利返还请求权

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Yield and Quality Performance of Japonica Rice Varieties Grown in the Late Season in a Double Rice Cropping System of China

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Agricultural Science & Technology 2015年第1期16卷 70-76,98页

作者： Shan huANG hu he Xiufu ZHANG Weixing ZHANG Xiaohua PAN Collaborative Innovation Center for the Modernization Production of Double Cropping Rice/Jiangxi Key Laboratory of Crop Physiology Ecology and Genetic Breeding Ministry of Education Jiangxi Agricultural University China National Rice Research Institute

Meeting the demand for high-quality japonica rice is a major challenge facing China's grain security. In the present study, a two-year field experiment was conducted to investigate the yield, quality, and profitability of japonica rice varieties(including hybrids and inbreds) grown in the late season as compared with local elite indica hybrids in a double rice cropping system of China where indicas are traditionally planted. Indica hybrids had significantly longer vegetative(from sowing to heading) and total(from sowing to maturity) growth durations than japonicas in both2011 and 2012, while reproductive growth duration(from heading to maturity) was longer for indica hybrids than for japonicas in 2011 but not in 2012. Indica hybrids produced higher grain yield than japonicas in 2011, but with no significant differences in 2012. Japonicas had higher brown rice, milled rice, and head rice percentages than indicas, but had lower gelatinization temperature and amylose content,while with no significant differences in gel consistency and protein content. Indica hybrids tended to have lower chalky grain percentage and chalkiness degree than japonicas, though the differences were not statistically significant due to large genotypic variations. The net returns were 16.1% and 9.9% greater for indica hybrids than for japonica hybrids and japonica inbreds in 2011, with only 3.8% and 1.3% in2012, respectively. Thus, our results suggest that replacing indicas with japonica varieties as late rice may not be feasible at the present site unless locally adapted japonica varieties are developed.

关键词： Grain quality Indica Japonica Late rice Yield

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深基坑综合支护技术研究

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中北大学学报（自然科学版） 2011年第6期32卷 796-800页

作者：胡俊合山西建筑工程(集团)总公司山西太原030002

根据饱和黄土高灵敏度的特点,考虑周边特殊环境,本着安全、经济的原则,认真分析了实际工程项目开挖过程中出现的周围土层存在大量水平管路、管线的情况,采用了土钉墙+高灵敏度锚杆、超前锚杆等技术,根据"换撑原理"应用了钢管内撑技术,... 详细信息

根据饱和黄土高灵敏度的特点,考虑周边特殊环境,本着安全、经济的原则,认真分析了实际工程项目开挖过程中出现的周围土层存在大量水平管路、管线的情况,采用了土钉墙+高灵敏度锚杆、超前锚杆等技术,根据"换撑原理"应用了钢管内撑技术,对深基坑开挖支护进行了研究.结果表明:运用这些技术手段,确保了周边建(构)筑物的安全,取得了很好的经济效益和社会效益.

关键词：深基坑超前锚杆综合支护技术高灵敏土

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