检索结果-南通市图书馆

Analysis of The Correlation Between inhA Gene Mutation and Resistance to Protionamide in Drug-Resistant Mycobacterium Tuberculosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Nursing Research 2024年第4期8卷 132-136页

作者： xulin huang Tian Zheng Shutao Li Xinjiang Uygur Autonomous Region Infectious Disease Hospital(Sixth People’s Hospital of the Autonomous Region) Urumqi 830063China The Eighth Affiliated Hospital of Xinjiang Medical University Urumqi 830000China

Objective: To investigate the characteristics of katG and inhA gene mutations in multidrug-resistant tuberculosis (MDR-TB), pre-extensively drug-resistant tuberculosis (preXDR-TB), and their correlation with resistance to protionamide (Pto). Methods: A total of 229 patients with MDR-TB and pre-XDR-TB diagnosed in the Eighth Affiliated Hospital of Xinjiang Medical University from January 2020 to February 2024 were selected to analyze the characteristics of katG and inhA mutations in MTB clinical isolates and their correlation with Pto resistance. Results: The mutation rate of katG (with or without inhA mutation) was 85.2%. The mutation rates in MDR-TB and pre-XDR-TB were 87.4% (125/143) and 81.4% (70/86), respectively. The mutation rate of inhA (including katG mutation) was 14.8% (34/229), which was 12.6% (18/143) and 18.6% (16/86) in MDR-TB and pre-XDR-MTB, respectively. There was no difference in mutation (P > 0.05). Conclusion: The total resistance rate to Pto in 229 strains was 8.7% (20/229), which was 8.4% (12/143) and 9.3% (8/86) in MDR-TB and pre-XDR-TB, respectively. Among the inhA mutant strains, 13 were resistant to the Pto phenotype, and the resistance rate was 65% (13/20). In MDR-TB and pre-XDR-TB strains resistant to Pto, inhA gene mutations occurred in 66.7% (6/9) and 63.6% (7/11), respectively. The resistance rates of MDR-MTB and pre-XDR-TB strains without inhA gene mutation to Pto were 2.4% (3/125) and 5.7% (4/70), respectively.

关键词： Tuberculosis Anti-multiple drug resistance Prothionamide Gene Mutations

Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第6期67卷 1318-1320页

作者： Yan hu Peishan hu Xiaozhong Peng Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu 610041China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Respiratory Health and Multimorbidity Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Neuronal activity plays a pivotal role in various physiological processes,including tissue development,homeostasis,and *** in recent years have improved our understanding of neuronal activity in brain cancers,such as glioblastoma(GBM)and diffuse midline gliomas(DMG),which are among the most prevalent and lethal cancers affecting children and ***,the neurons regulate brain cancers via two routes.

关键词： glioma homeostasis function

Antibodies elicited by Newcastle disease virus-vectored H7N9 avian influenza vaccine are functional in activating the complement system

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第6期23卷 2052-2064页

作者： Zenglei hu Ya huang Jiao hu Xiaoquan Wang Shunlin hu Xiufan Liu Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education of China Yangzhou UniversityYangzhou 225009China Animal Infectious Disease Laboratory School of Veterinary MedicineYangzhou UniversityYangzhou 225009China Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou UniversityYangzhou 225009China

H7N9 subtype avian influenza virus poses a great challenge for poultry *** disease virus(NDV)-vectored H7N9 avian influenza vaccines(NDV_(vec)H7N9)are effective in disease control because they are protective and allow mass *** note,these vaccines elicit undetectable H7N9-specific hemagglutination-inhibition(HI)but high IgG antibodies in ***,the molecular basis and protective mechanism underlying this particular antibody immunity remain ***,immunization with an NDV_(vec)H7N9 induced low anti-H7N9 HI and virus neutralization titers but high levels of hemagglutinin(HA)-binding IgG antibodies in *** residues(S150,G151 and S152)in HA of H7N9 virus were identified as the dominant epitopes recognized by the NDV_(vec)H7N9 immune *** transferred NDV_(vec)H7N9 immune serum conferred complete protection against H7N9 virus infection in *** NDV_(vec)H7N9 immune serum can mediate a potent lysis of HA-expressing and H7N9 virus-infected cells and significantly suppress H7N9 virus *** activities of the serum were significantly impaired after heat-inactivation or treatment with complement inhibitor,suggesting the engagement of the complement ***,mutations in the 150-SGS-152 sites in HA resulted in significant reductions in cell lysis and virus neutralization mediated by the NDV_(vec)H7N9 immune serum,indicating the requirement of antibody-antigen binding for complement ***,antibodies induced by the NDV_(vec)H7N9 can activate antibody-dependent complement-mediated lysis of H7N9 virus-infected cells and complement-mediated neutralization of H7N9 *** findings unveiled a novel role of the complement in protection conferred by the NDV_(vec)H7N9,highlighting a potential benefit of engaging the complement system in H7N9 vaccine design.

关键词： H7N9 subtype avian influenza virus NDV vector vaccine antibody immunity complement protection

Epidemiology and current management of cerebrovascular disease in China

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第5期21卷 465-474页

作者： Sheng-Shou hu The Writing Committee of the Report on Cardiovascular Health and Diseases in China

The Annual Report on Cardiovascular Health and Diseases in China(2022)intricate landscape of cardiovascular health in *** connection with the previous section,this fifth section of the report continues the dissection on the manage-ment of cardiovascular diseases(CVD).Cerebrovascular disease is the leading cause of death and loss of healthy life among Chinese *** on the results of GBD 2019,from 1990 to 2019,the years of life lost due to premature death caused by stroke showed a decreasing trend,while the years lived with disability still increased *** present,national mortal-ity surveillance system can provide national and provincial representative annual death data on cerebrovascular disease,but the national representative data on some other important epidemiological indicators(such as incidence,prevalence,disability rate,and case fatality rate)are scarce in *** the construction of large cohort population and extension of follow-up time,re-search on stroke-related risk factors is increasing,providing a basis for the prevention and control of risk *** to limited large-scale population-based intervention studies,there is a lack of epidemiological evidence to transform into feasible interven-tion strategies and *** recent years,great progress in endovascular treatment for basilar-artery occlusion has been achieved in China,but there is still much room for improvement of guideline-based anticoagulant treatment and lipid-lowering treatment,as well as standardized diagnosis and treatment among patients with ischemic stroke.

关键词： prevention diagnosis Epidemiology

The New Methods for Characterization of Molecular Weight of Supramolecular Polymers

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第10期42卷 1403-1413页

作者： hui Liu Rui hu Zi-Qing hu Xiao-Fan Ji Key Laboratory of Materials Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Materials Chemistry and Service FailureHubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Supramolecular polymers, as a type of dynamic polymers, are subordinate to the interdisciplinary field of polymer chemistry and supramolecular chemistry, whose development has greatly promoted the prosperity of new materials. Notably, molecular weight is one of the most important parameters of supramolecular polymers, which affects the physical/chemical properties and processing applications of *** new methods for characterizing the molecular weight of supramolecular polymers is crucial for advancing the development of supramolecular polymers. In this review, we elaborate and summarize three strategies for characterizing the molecular weight of supramolecular polymers that recently reported by our research group according to the characteristics of supramolecular polymers, including (1) the molecular weight distinction corresponding to variable fluorescence colors,(2) matching different molecular weights with different fluorescence lifetime,(3) transforming supramolecular polymers into mechanically interlocked polymers or covalent polymers. Besides, we also discuss the limitations of current methods for characterizing supramolecular polymers. We hope that this review can promote the development of supramolecular polymers and significantly inspire to exploit new methods to characterizing molecular weight of supramolecular polymers.

关键词： Dynamic polymers Mechanically interlocked polymers Molecular weight Self-assembly Supramolecular polymers

Cloud-Type-Dependent 1DVAR Algorithm for Retrieving Hydrometeors and Precipitation in Tropical Cyclone Nanmadol from GMI Data

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第3期41卷 407-419页

作者： Linjun HAN Fuzhong WENG Hao hu Xiuqing hu School of the Environment China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre Beijing 100081China Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological Center(National Center for Space Weather)of CMABeijing 100081China

Understanding the structure of tropical cyclone(TC)hydrometeors is crucial for detecting the changes in the distribution and intensity of *** this study,the GMI brightness temperature and cloud-dependent 1DVAR algorithm were used to retrieve the hydrometeor profiles and surface rain rate of TC Nanmadol(2022).The Advanced Radiative Transfer Modeling System(ARMS)was used to calculate the Jacobian and degrees of freedom(△DOF)of cloud water,rainwater,and graupel for different channels of GMI in convective *** retrieval results were compared with the Dual-frequency Precipitation Radar(DPR),GMI 2A,and IMERG *** is shown that from all channels of GMI,rain water has the highest△DOF,at *** to the radiance Jacobian to atmospheric state variables,cloud water emission dominates its *** rain water,the emission of channels 1–4 dominates *** with the GMI 2A precipitation product,the 1DVAR precipitation rate has a higher correlation coefficient(0.713)with the IMERG product and can better reflect the location of TC *** the TC eyewall,the highest radar echo top indicates strong *** the melting layer where Ka-band attenuation is strong,the double frequency difference of DPR data reflects the location of the *** DPR drop size distribution(DSD)product shows that there is a significant increase in particle size below the melting layer in the spiral rain ***,the particle size may be one of the main reasons for the smaller rain water below the melting layer retrieved from 1DVAR.

关键词： cloud-dependent 1DVAR hydrometeor precipitation GMI DPR

Quantitative estimation of global mean precipitation throughout the Phanerozoic era

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1616-1624页

作者： Xiujuan BAO Yongyun hu Laboratory for Climate and Ocean-Atmospheric Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China

Quantitatively estimating the global mean precipitation(GMP)throughout Earth's history is crucial for enhancing our understanding of long-term climate evolution and the hydrological ***,currently there is no established methodology for estimating global mean ***,we present the first study that estimates GMP in the Phanerozoic *** relationship between GMP and global mean surface temperature(GMST)is investigated by analyzing data from 23 models in the Coupled Model Intercomparison Project phase 6(CMIP6).The result reveals consistent and significant impact of temperature on precipitation,with a sensitivity range of 2–3%K^(-1).Additionally,we propose a method for accessing latitudinal variations in precipitation caused by land area distributions and paleo-Koppen climatic *** climatic belts are determined based on geological indicators such as coals,evaporites,and glacial *** GMP is thus quantitatively estimated by combining variations in GMST,land area distributions,and paleo-koppen climatic belts,spanning from 540 Ma to the present *** quantitative GMP curve demonstrates fluctuations in GMP about 500 mm yr^(-1),with values ranging from 948 to1442 mm yr-1over the Phanerozoic *** curve aligns closely with findings derived from numerical *** presented paleoprecipitation variations facilitate a more comprehensive understanding of the interconnected geological and paleoclimatic developments.

关键词： Paleoprecipitation Paleoclimate K?ppen climatic belts Global mean precipitation Hydrological cycle

BSIN: A Behavior Schema of Information Networks Based on Approximate Bisimulation

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2024年第4期29卷 1092-1104页

作者： Wujie hu Jinzhao Wu School of Electrical Engineering Guangxi UniversityNanning 530004China

Information networks are becoming increasingly important in practice. However, their escalating complexity is gradually impeding the efficiency of data mining. A novel network schema called the Behavior Schema of Information Networks (BSIN) is proposed to address this issue. This work defines the behavior of nodes as connected paths in BSIN, proposes a novel function distinguish behavior differences, and introduces approximate bisimulation into the acquisition of quotient sets for node types. The major highlight of BSIN is its ability to directly obtain a high-efficiency network on the basis of approximate bisimulation, rather than reducing the existing information network. It provides an effective representation of information networks, and the resulting novel network has a simple structure that more efficiently expresses semantic information than current network representations. The theoretical analysis of the connected paths between the original and the obtained networks demonstrates that errors are controllable;and semantic information is approximately retained. Case studies show that BSIN yields a simple network and is highly cost-effective.

关键词： data mining information network approximate bisimulation controllable error

Enhancement in the Hg^(0) oxidation efficiency and sulfur resistance of CuCl_(2)-modified MnO_(x)-CeO_(x) nanorod catalysts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第8期25卷 680-686页

作者： Shujie GAO Yongjin hu Zhichang JIANG Xiaoxiang WANG Dong YE Changxing hu College of Quality&Safety Engineering China Jiliang UniversityHangzhou 310018China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Institute of Industrial Ecology and EnvironmentCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China School of Mechatronics and Energy Engineering Ningbo Tech UniversityNingbo 315100China

In this study,a series of CuCl_(2)-modified MnO_(x)-CeO_(x)nanorods were synthesized for the oxidation of Hg^(0).The addition of CuCl_(2)resulted in an enhancement in the catalyst’s Hg^(0)oxidation ability,and Hg^(0)oxidation efficiency reached>97%from 150 to 250°*** the MnO_(x)-CeO_(x)catalysts,Mn^(4+)played the role of the active species for Hg^(0)oxidization,but in the CuCl_(2)-doped catalysts Cl−also contributed to Hg^(0)oxidation,conferring the superior performance of these *** introduction of SO_(2) led to a decrease in the availability of Mn^(4+),and the Hg^(0)oxidation efficiency of MnO_(x)-CeO_(x)decreased from about 100%to about 78%.By contrast,CuCl_(2)-promoted samples maintained a Hg^(0)oxidation efficiency of about 100%during the SO_(2) deactivation cycle due to the high reactivity of Cl−.

关键词： Hg^(0)oxidation CuCl_(2)modification MnO_(x)-CeO_(x)nanorods Sulfur resistance O_(x)idation activity