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Potential therapeutic role of spermine via Rac1 in osteoporosis:Insights from zebrafish and mice

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Zoological Research 2024年第2期45卷 367-380页

作者： Rui-Xue Jiang Nan hu Yu-wei Deng Long-wei hu Hao Gu Nan Luo Jin Wen Xin-Quan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Stomatology Shanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai 200125China Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China

Osteoporosis(OP)is a prevalent metabolic bone *** drug therapy is essential to prevent bone loss in osteoporotic patients,current treatments are limited by side effects and high costs,necessitating the development of more effective and safer targeted *** a zebrafish(Danio rerio)larval model of osteoporosis,we explored the influence of the metabolite spermine on bone *** showed that spermine exhibited dual activity in osteoporotic zebrafish larvae by increasing bone formation and decreasing bone *** not only demonstrated excellent biosafety but also mitigated prednisolone-induced embryonic neurotoxicity and ***,spermine showcased protective attributes in the nervous systems of both zebrafish embryos and *** the molecular level,Rac1 was identified as playing a pivotal role in mediating the antiosteoporotic effects of spermine,with P53 potentially acting downstream of *** findings were confirmed using mouse(Mus musculus)models,in which spermine not only ameliorated osteoporosis but also promoted bone formation and mineralization under healthy conditions,suggesting strong potential as a bonestrengthening *** study underscores the beneficial role of spermine in osteoporotic bone homeostasis and skeletal system development,highlighting pivotal molecular *** their efficacy and safety,human endogenous metabolites like spermine are promising candidates for new anti-osteoporotic drug development and daily bone-fortifying agents.

关键词： Osteoporosis Spermine Rac1 Zebrafish Mice

Seismic stability of expansive soil slopes reinforced by anchor cables using a modified horizontal slice method

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 377-387页

作者： Wang Long Chen Guoxing hu wei Zhou Enquan Feng Jianxue huang Anping School of Mechnical Engineering Jiangnan UniversityWuxi 214122China Institute of Geotechnical Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Geohazard Prevention and Geoenvironmental Protection Chengdu University of TechnologyChengdu 610059China Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013China Architectural Engineering College Guizhou Minzu UniversityGuiyang 550025China School of Civil Engineering Lanzhou University of TechnologyLanzhou 730050China

Earthquake-induced slope failures are common occurrences in engineering practice and pre-stressed anchor cables are an effective technique in maintaining slope stability,especially in areas that are prone to ***,the soil at typical engineering sites also exhibit unsaturated *** considerations of these factors in slope stability estimations are crucial in producing accurate *** this study,the seismic responses of expansive soil slopes stabilized by anchor cables is studied in the realm of kinematic limit analysis.A modified horizontal slice method is proposed to semi-analytically formulate the energy balance *** illustrative slope is studied to demonstrate the influences of suction,seismic excitations and anchor cables on the slope *** results indicate that the stabilizing effect of soil suction relates strongly to the seismic excitation and presents a sine shape as the seismic wave *** higher and steeper slopes,the stabilizing effect of suction is more *** critical slip surface tends to be much more shallow as the seismic wave approaches the peak and vice versa.

关键词： limit analysis expansive soil slope matric suction anchor cable pseudo-dynamic analysis

A novel seal-flow multi-vortex friction stir lap welding of metal to polymer matrix composites

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Chinese Journal of Aeronautics 2024年第1期37卷 451-462页

作者： Shuaiqiang NIAN Mingshen LI Shude JI wei hu Zhiqing ZHANG Zelin SUN College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

The friction stir lap welding(FSLW)of metal to polymer is a challenging work due to the unavoidable polymer *** this problem,a novel seal-flow multi-vortex friction stir lap welding(SM-FSLW)technology based on the subversively-designed multi-step pin was put *** 7075 aluminum alloy and short glass fiber-reinforced polyether ether ketone(PEEK)as research subjects,the welding temperature,material flow,formation and tensile shear strength of dissimilar materials lap joint under the SM-FSLW were studied and compared with those under traditional FSLW based on the conical *** multi-step pin rather than the conical pin effectively hindered the polymer overflowing due to the formation of vortexes by the step,thereby attaining a joint with a smooth *** with traditional FSLW,the SMFSLW obtained the higher welding temperature,the more violent material flow and the larger area with high flow velocity,thereby producing the macro-mechanical and micro-mechanical interlockings and then heightening the joint loading *** tensile shear strength of lap joint under SM-FSLW was 27.8% higher than that under traditional *** SM-FSLW technology using the multi-step pin provides an effective way on obtaining a heterogeneous lap joint of metal to polymer with the excellent formation and high strength.

关键词： Friction stir lap welding Metal to polymer Multi-step pin Material flow Tensile shear strength

Risk evaluation for diabetic retinopathy in Chinese renalbiopsied type 2 diabetes mellitus patients

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1283-1291页

作者： Shou-Yue huang Qi-wei hu Ze-wei Zhang Ping-Yan Shen Qiong Zhang Department of Ophthalmology Ruijin Hospital Affiliated Medical SchoolShanghai Jiao Tong UniversityShanghai 200025China Department of Nephrology Ruijin Hospital Affiliated Medical SchoolShanghai Jiao Tong UniversityShanghai 200025China

AIM:To investigate diabetic retinopathy(DR)prevalence in Chinese renal-biopsied type 2 diabetes mellitus(T2DM)patients with kidney dysfunction,and to further evaluate its relationship with diabetic nephropathy(DN)incidence and the risk factors for DR development in this ***:A total of 84 renal-biopsied T2DM patients were *** and imaging examinations were employed for DR *** information and clinical measures along with renal histopathology were analyzed for comparisons between the DR and non-DR *** factors on DR development were analyzed with multiple logistic ***:DR prevalence was 50%in *** incidences of DN,non-diabetic renal disease(NDRD)and mixed-type pathology were 47.6%,19.0%and 33.3%in the DR group respectively,while 11.9%,83.3%and 4.8%in the non-DR *** blood pressure,ratio of urinary albumin to creatine ratio,urinary albumin,24-hours urinary protein,the incidence and severity of DN histopathology were found statistically increased in the DR *** logistic regression analysis showed histopathological DN incidence significantly increased the risk of DR development[odds ratio(OR)=21.664,95%confidential interval(CI)5.588 to 83.991,P<0.001 for DN,and OR=45.475,95%CI 6.949 to 297.611,P<0.001 for mixed-type,respectively,in reference to (NDRD)],wherein DN severity positively ***:Renal histopathological evidence indicates DN incidence and severity increases the risk of DR development in Chinese T2DM patients inexperienced of regular fundus examinations.

关键词： diabetic retinopathy diabetic nephropathy vision threatens renal biopsy vision screening

Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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Food Science and human Wellness 2024年第4期13卷 1886-1905页

作者： wei Li Haihong Chen Hongliang Chen Ziyin Li wei hu Qinxuan Zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(huA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on huA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in huA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of huA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

Abnormal Traffic Detection for Internet of Things Based on an Improved Residual Network

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Computers, Materials & Continua 2024年第6期79卷 4433-4448页

作者： Tingting Su Jia Wang wei hu Gaoqiang Dong Jeon Gwanggil School of Computer Science and Technology Xinjiang UniversityUrumqi830046China School of Cyber Science and Engineering Jinling Institute of Technology CityNanjing210000China College of Information Technology Incheon National UniversityIncheon22012Korea

Along with the progression of Internet of Things(IoT)technology,network terminals are becoming continuously more *** has been widely applied in various scenarios,including urban infrastructure,transportation,industry,personal life,and other socio-economic *** introduction of deep learning has brought new security challenges,like an increment in abnormal traffic,which threatens network *** feature extraction leads to less accurate classification *** abnormal traffic detection,the data of network traffic is high-dimensional and *** data not only increases the computational burden of model training but also makes information extraction more *** address these issues,this paper proposes an MD-MRD-ResNeXt model for abnormal network traffic *** fully utilize the multi-scale information in network traffic,a Multi-scale Dilated feature extraction(MD)block is *** module can effectively understand and process information at various scales and uses dilated convolution technology to significantly broaden the model’s receptive *** proposed Max-feature-map Residual with Dual-channel pooling(MRD)block integrates the maximum feature map with the residual *** module ensures the model focuses on key information,thereby optimizing computational efficiency and reducing unnecessary information *** results show that compared to the latest methods,the proposed abnormal traffic detection model improves accuracy by about 2%.

关键词： Abnormal network traffic deep learning residual network multi-scale feature extraction max-feature-map

A new model simulating the development of gas condensate reservoirs

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Energy Geoscience 2024年第1期5卷 239-248页

作者： Yang Yang Zengmin Lun Rui Wang Maolei Cui wei hu Petroleum Exploration and Production Research Institute SINOPECBeijing100083China

A new simulation model for the development of gas condensate reservoirs is introduced based on the influence that phase change,non-Darcy flow,and capillary pressure have on the production of gas *** model predicts well performance,including bottom-hole pressure,oil/gas production rate,oil/gas recovery,gaseoil ratio,and the change in produced fluid *** also calculates dynamic characters,such as the change of pressure field and oil/gas saturation field during the development of gas condensate *** model is applicable to different boundary conditions(both constant-pressure and sealed boundary)and different production modes(both constant-pressure and constant-volume production modes).Model validation attempted using numerical simulation results for sealed boundary conditions with constant-pressure production mode has shown a relatively good match,proving its *** constant-pressure boundary conditions with constant-volume production mode,four stages are defined according to the dynamic behavior of production performance in the development of gas condensate reservoirs.

关键词： Gas condensate reservoir Phase behavior Numerical simulation Pseudo-pressure method

Geometric phase-encoded stimuli-responsive cholesteric liquid crystals for visualizing real-time remote monitoring:humidity sensing as a proof of concept

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Light(Science & Applications) 2024年第2期13卷 283-293页

作者： Shi-Long Li Zhao-Yi Chen Peng Chen wei hu Chaohong huang Sen-Sen Li Xuejia hu Yan-Qing Lu Lu-Jian Chen Department of Electronic Engineering School of Electronic Science and EngineeringXiamen University361005 XiamenChina College of Engineering and Applied Sciences Nanjing University210093 NanjingChina Fujian Key Laboratory of Ultrafast Laser Technology and Applications Xiamen University361005 XiamenChina

Liquid crystals are a vital component of modern photonics,and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid ***,existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools,which limits their practical ***,developing a platform that produces recognizable sensing signals is *** this study,we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns,rather than frequency *** demonstrate this platform’s effectiveness,we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q-plate pattern,which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal ***,we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular *** approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical *** ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid *** platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.

关键词： humidity visual liquid

Eu-MOF-Based Fluorescent Ratiometric Sensor by Detecting 3,4,5-Trihydroxybenzoic for Fingerprint Visualization on Porous Objects

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Photonic Sensors 2024年第1期14卷 85-98页

作者： Muwen LIANG Yabin ZHAO Yaping LUO Bin DU wei hu Bing LIU Xihui MU Zhaoyang TONG Department of Investigation People's Public Security University of ChinaBejing 100038China State Key Laboratory of NBC Protection for Civilian Beijing 102205China

Latent fingerprints(LFPs)at the crime scene are served as important clues to locate the trajectory of criminal behavior and portray the characteristics of the ***,visualizing LFPs is of considerable *** this work,the europium metal-organic framework(Eu-MOF)sensor was successfully constructed for sensitive detection of gallic acid(3,4,5-trihydroxybenzoic acid,GA)and visualization of the sweat *** boric-acid-modified Eu-MOF was prepared by using the simple one-pot solvothermal method using Eu as the metal i ion center and 3,5-dicarboxybenzeneboronic acid(BBDC)as the organic *** sensor showed desirable photoluminescent performance through the chelating of BBDC with Eu3+.The sensor exhibited the satisfactory linear relationship to GA in the range of 1 nM to 20 nM with a low detection limit of 0.34 nM under the optimized *** prepared sensor with ideal selectivity to GA was successfully applied for visualizing LFPs on porous substrates with the high contrast and superior *** the good performance of the sensor,all fingerprint images obtained from 1200 samples presented clear friction ridges and met the identification ***,the sensor had less impact on the subsequent deoxyribonucleic acid(DNA)detection,displaying a promising perspective for applications in extracting physical evidence of site investigation.

关键词： Europium metal-organic framework(Eu-MOF) photoluminescence 3,4,5-trihydroxybenzoic latent fingerprints(LFPs)development