检索结果-南通市图书馆

Impact of androgen-deprivation therapy on the outcome of dose-escalation prostate cancer radiotherapy without elective pelvic irradiation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第5期19卷 596-601页

作者： Wei-Hsien Hou Chao-Yuan Huang Chia-Chun Wang Keng-hsueh Lan Chung-Hsin Chen Hong-Jen Yu Shih-Ping Liu Ming-Kuen lai Yeong-Shau Pu Jason Chia-Hsien Cheng Division of Radiation Oncology Department of Oncology National Taiwan University Hospital Taipei Taiwan China Department of Urology National Taiwan University Hospital Taipei Taiwan China Department of Oncology National Taiwan University Hospital Taipei Taiwan China Graduate Institutes of Oncology National Taiwan University College of Medicine Taipei Taiwan China Graduate Institutes of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan China

The benefit of androgen-deprivation therapy （ADT） in combination with dose-escalated radiotherapy （DERT） for localized prostate cancer has not been determined in randomized studies. In this study, the benefit of ADT was assessed in patients uniformly treated with dose-escalated intensity-modulated radiation therapy （IMRT） to the prostate and seminal vesicles but not pelvis. In all, 419 patients with localized prostate adenocarcinoma underwent definitive IMRT （cumulative dose 78 Gy）, with 32.6%, 33.1%, 32.1%, and 2.1% having T1 through T4 disease, respectively, and 51.2% having high-risk disease. ADT was given to 76.1% of patients. With a median follow-up of 60 months, 5-year biochemical failure-free, disease-free, and overall survival rates were 87%, 86%, and 87%, respectively. T stage was an independent predictor of all three rates. Five-year pelvic nodal recurrence rate was 2.9%. ADT improved biochemical failure-free and disease-free survival but not overall survival. ADT showed benefit in high-risk disease but not intermediate-risk disease. Late gastrointestinal and genitourinary toxicities ≥ grade 2 occurred in 11.0% and 6.7%, respectively. In conclusion, DERT with 78 Gy yields good disease control and low rate of pelvic nodal recurrence. ADT improves disease-free survival in patients with high-risk but not intermediate-risk disease.

关键词： androgen-deprivation therapy dose-escalation prostate cancer radiotherapy

Separability criteria based on a class of symmetric measurements

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2023年第6期75卷 51-58页

作者： Lemin lai Shunlong Luo Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Highly symmetric quantum measurements,such as mutually unbiased measurements(MUMs)and general symmetric informationally complete positive-operator-valued measures(GSICPOVMs),play an important role in both foundational and practical aspects of quantum information ***,a broad class of symmetric measurements were introduced[K Siudzińska,(2022)***.A 105,042209],which can be viewed as a common generalization of MUMs and *** this work,the role of these symmetric measurements in entanglement detection is *** specifically,based on the correlation matrices defined via(informationally complete)symmetric measurements,a separability criterion for arbitrary dimensional bipartite systems is *** is shown that the criterion is stronger than the method provided by Siudzińska,meanwhile,it can unify several popular separability criteria based on MUMs or ***,using these(informationally complete)symmetric measurements,two efficient criteria are presented to detect the entanglement of tripartite quantum *** detection power and advantages of these criteria are illustrated through several examples.

关键词： entanglement detection separability criterion symmetric measurement correlation matrix

Relationship between Atmospheric Heat Source over the Tibetan Plateau and Precipitation in the Sichuan–Chongqing Region during Summer

在线全文

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2017年第3期31卷 555-566页

作者： Xin lai Yuanfa GONG College of Atmospheric Sciences Chengdu University of Information Technology (CUIT)/Plateau Atmosphere and Environment Key Laboratory of Sichuan Provinceand Joint Laboratory of Climate and Environment Change of CUIT

NCEP-NCAR reanalysis data and a 47-yr daily precipitation dataset from a network of 42 rain gauges are used to analyze the atmospheric heat source （〈Q1〉） anomaly over the Tibetan Plateau （TP） and its influence on the summer precipitation anomaly in the Sichuan-Chongqing region. Results show that the vertical advection of 〈Ql〉 over the central TP is a major factor affecting summer precipitation in the Sichuan-Chongqing region. When the vertical ad- vection of〈Q1〉 over the central TP is strengthened, the South Asian high shifts further than normal to the south and east, the western Pacific subtropical high shifts further than normal to the south and west, and the Indian low weak- ens. This benefits the transport of warm moist air from the low latitude oceans to the Sichuan-Chongqing region. Correspondingly, in the high latitudes, two ridges and one trough form, which lead to cool air moving southward. These two air masses converge over the Sicbuan -chongqing region, leading to significant precipitation. In contrast, when the vertical advection of 〈Q1〉 over the central TP is weakened, the South Asian high moves to the north and west, the subtropical high moves eastward and northward, and the Indian low strengthens. This circulation pattern is unfavorable for warm air advection from the south to the Sichuan-Chongqing region, and the cool air further north cannot move southward because of the presence of two troughs and one ridge at high latitude. Thus, ascent over the Sichuan-Chongqing region is weakened, resulting in less precipitation.

关键词： Tibetan Plateau atmospheric heating source/sink Sichuan-Chongqing region precipitation variability

Coupled effects of climate change and human activities on vegetation dynamics in the Southwestern Alpine Canyon Region of China

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2024年第10期21卷 3234-3248页

作者： lai Jinlin QI Shi School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China

The driving effects of climate change and human activities on vegetation change have always been a focal point of ***,the coupling mechanisms of these driving factors across different temporal and spatial scales remain *** Southwestern Alpine Canyon Region of China(SACR),as an ecologically fragile area,is highly sensitive to the impacts of climate change and human *** study constructed a vegetation cover dataset for the SACR based on the Enhanced Vegetation Index(EVI)from 2000 to *** autocorrelation,Theil-Sen trend,and Mann-Kendall tests were used to analyze the spatiotemporal characteristics of vegetation cover *** main drivers of spatial heterogeneity in vegetation cover were identified using the optimal parameter geographic detector,and an improved residual analysis model was employed to quantify the relative contributions of climate change and human activities to interannual vegetation cover *** main findings are as follows:Spatially,vegetation cover exceeds 60%in most areas,especially in the southern part of the study ***,the border area between Linzhi and Changdu exhibits lower vegetation *** factors are the primary drivers of spatial heterogeneity in vegetation cover,with temperature having the most significant influence,as indicated by its q-value,which far exceeds that of other ***,the interaction q-value between the two factors significantly increases,showing a relationship of bivariate enhancement and nonlinear *** terms of temporal changes,vegetation cover shows an overall improving trend from 2000 to 2020,with significant increases observed in 68.93%of the study *** these,human activities are the main factors driving vegetation cover change,with a relative contribution rate of 41.31%,while climate change and residual factors contribute 35.66%and 23.53%,*** thoroughly exploring the coupled mechanisms of vegetation change,this

关键词： Enhanced vegetation index Climate change Human activities Spatial heterogeneity Coupled mechanisms

Mathematical modeling of cancer treatment with radiation and PD-L1 inhibitor

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2020年第3期63卷 465-484页

作者： Xiulan lai Avner Friedman Institute for Mathematical Sciences Renmin University of ChinaBeijing 100872China Mathematical Bioscience Institute&Department of Mathematics Ohio State UniversityColumbusOH 43210USA

Radiation therapy is a longstanding cancer treatment. More recently, it has been demonstrated that radiation therapy(RT) elicits anti-cancer immune response. For this reason, there is a growing interest in combining RT with immunotherapy, specifically with checkpoint inhibitors such as anti-CTLA-4 and anti-PDL1. In the present paper, we develop a mathematical model of combination therapy with RT and *** model is used to compare different schedules in clinical trials. Simulations of the model show that applying both RT and anti-PD-L1 at the same week has more benefits than applying them in separate adjacent ***, applying anti-PD-L1 before RT has more benefits than applying RT before anti-PD-L1.

关键词： mathematical model anti-PD-L1 radiotherapy combination therapy scheduling

Synthesis of novel cyclohexanediol-derived chiral phosphite ligands and their application in the Cu-catalyzed conjugate addition of organozinc to cyclic enones

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2016年第2期27卷 271-276页

作者： Zeng-Bo Pang Hai-Feng Li lai-lai Wang State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100039 China

A series of novel chiral diphosphite ligands have been synthesized from（1R,2R）-trans-1,2-cyclohexanediol,（1S,2S）-trans-1,2-cyclohexanediol, racemic trans-1,2-cyclohexanediol and chlorophosphoric acid diary ester, and were successfully employed in the Cu-catalyzed asymmetric 1,4-conjugate addition of diethylzinc to cyclohexenone with up to 99% ee. It was found that ligand 1,2-bis[（R）-1,10-binaphthyl-2,2＇-diyl]phosphitecyclohexanediol 6a derived from racemic diol skeleton can show similar catalytic performance compared with ligand（1R,2R）-bis[（R）-1,1＇-binaphthyl-2,2＇-diyl]phosphitecyclohexanediol 6a＇ derived from enantiopure starting material. A significant dependence of stereoselectivity on the type of enone and the ring size of the cyclic enone was observed. Moreover, the configuration of the products was mainly determined by the configuration of the binaphthyl moieties of diphosphite ligands in the 1,4-addition of cyclic enones.

关键词： Racemic and chiral cyclohexanedio Phosphite ligands Organozinc Cyclic enones Cu-catalyzed conjugate addition

Rarefaction Wave Interaction and Shock-Rarefaction Composite Wave Interaction for a Two-Dimensional Nonlinear Wave System

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2021年第1期42卷 135-150页

作者： Geng lai Sisi XIE Department of Mathematics Shanghai UniversityShanghai 200444China

In order to construct global solutions to two-dimensional(2 D for short)Riemann problems for nonlinear hyperbolic systems of conservation laws,it is important to study various types of wave *** paper deals with two types of wave interactions for a 2 D nonlinear wave system with a nonconvex equation of state:Rarefaction wave interaction and shock-rarefaction composite wave *** order to construct solutions to these wave interactions,the authors consider two types of Goursat problems,including standard Goursat problem and discontinuous Goursat problem,for a 2 D selfsimilar nonlinear wave *** classical solutions to these Goursat problems are obtained by the method of *** solutions constructed in the paper may be used as building blocks of solutions of 2 D Riemann problems.

关键词： Nonlinear wave system Rarefaction wave Shock-rarefaction composite wave Wave interaction Characteristic decomposition

Evaluation on Stability of Stope Structure Based on Nonlinear Dynamics of Coupling Artificial Neural Network

在线全文

学校读者我要写书评

暂无评论

Journal of University of Science and Technology Beijing 2002年第1期9卷 1-4页

作者： Meifeng Cai Xingping lai Civil and Environmental Engineering School University of Science and Technology BeijingBeijjing 100083China Xi'an Science and Technology University Shanxi Strata Control Key LaboratoryXi'an 710054China

The nonlinear dynamical behaviors of artificial neural network (ANN) and their application to science and engineering were summarized. The mechanism of two kinds of dynamical processes, i.e. weight dynamics and activation dynamics in neural networks, and the stability of computing in structural analysis and design were stated briefly. It was successfully applied to nonlinear neural network to evaluate the stability of underground stope structure in a gold mine. With the application of BP network, it is proven that the neuro-com- puting is a practical and advanced tool for solving large-scale underground rock engineering problems.

关键词： coupling neural network nonlinear dynamics structural stability stope parameters

Epigenetics of cutaneous T-cell lymphoma:biomarkers and therapeutic potentials

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2021年第1期18卷 34-51页

作者： Pan lai Yang Wang Department of Dermatology and Venereology Peking University First HospitalBeijing Key Laboratory of Molecular Diagnosis on DermatosesNational Clinical Research Center for Skin and Immune DiseasesBeijing 100034China

Cutaneous T-cell lymphomas(CTCLs)are a heterogeneous group of skin-homing non-Hodgkin *** are limited options for effective treatment of patients with advanced-stage CTCL,leading to a poor survival *** plays a pivotal role in regulating gene expression without altering the DNA *** alterations are involved in virtually all key cancerassociated pathways and are fundamental to the genesis of *** recent years,the epigenetic hallmarks of CTCL have been gradually elucidated and their potential values in the diagnosis,prognosis,and therapeutic intervention have been *** this review,we summarize the current knowledge of the best-studied epigenetic modifications in CTCL,including DNA methylation,histone modifications,micro RNAs,and chromatin *** epigenetic regulators are essential in the development of CTCL and provide new insights into the clinical treatments of this refractory disease.

关键词： Epigenetics cutaneous T-cell lymphoma DNA methylation histone modification micro RNA chromatin-remodeling complex