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Numerical Investigation on the Self-Induced Unsteadiness in Tip Leakage Flow of a Micro-Axial Fan Rotor

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Journal of Thermal Science 2015年第4期24卷 334-343页

作者： CHEN Jinxin lai Huanxin School of Mechanical and Power Engineering East China University of Science and Technology

The self-induced unsteadiness in tip leakage flow(TLF)of a micro-axial fan rotor is numerically studied by solving Reynolds-averaged Navier-Stokes *** micro-axial fan,which is widely used in cooling systems of electronic devices,has a tip clearance of 6%of the axial chord length of the *** the design rotation speed,four cases near the peak efficiency point(PEP)with self-induced unsteadiness and four steady cases which have much weaker pressure fluctuations are *** the"interface"separating the incoming main flow and the TLF defined by Duet al.[1],an explanation based on the propagation of the low energy spot and its multi-passing through the high gradient zone of the relative total pressure,is proposed to clarify the originating mechanism of the *** the operating points near the PEP,the main flow is weaker than the TLF and the interface moves *** low energy spot which propagates along in the close behind of the interface has opportunity to circulate in the circumferential direction and passes through the sensitive interfaces several times,a slight perturbation therefore may be magnified significantly and develops into the self-induced *** explanation is demonstrated by numerical results.

关键词： micro-axial fan tip leakage flow (TLF) self-induced unsteadiness secondary flow mechanism.

Analytical solutions for elastic binary nanotubes of arbitrary chirality

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Acta Mechanica Sinica 2016年第6期32卷 1046-1057页

作者： lai Jiang Wanlin Guo State Key Laboratory of Mechanics and Control for Mechanical Structures and Key Laboratory for Intelligent Nano Materials and Devices (MOE) Nanjing University of Aeronautics and Astronautics

Analytical solutions for the elastic properties of a variety of binary nanotubes with arbitrary chirality are obtained through the study of systematic molecular mechanics. This molecular mechanics model is first extended to chiral binary nanotubes by introducing an additional out-of-plane inversion term into the so-called stick-spiral model, which results from the polar bonds and the buckling of binary graphitic crystals. The closed-form expressions for the longitudinal and circumferential Young's modulus and Poisson's ratio of chiral binary nanotubes are derived as functions of the tube diameter. The obtained inversion force constants are negative for all types of binary nanotubes, and the predicted tube stiffness is lower than that by the former stick-spiral model without consideration of the inversion term, reflecting the softening effect of the buckling on the elastic properties of binary nanotubes. The obtained properties are shown to be comparable to available density functional theory calculated results and to be chirality and size sensitive. The developed model and explicit solutions provide a systematic understanding of the mechanical performance of binary nanotubes consisting of III-V and II-VI group elements.

关键词： Binary nanotubes Elastic properties Molecular mechanics Chirality Analytical solutions

On-line linear time construction of sequential binary suffix trees

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Journal of Systems Engineering and Electronics 2009年第5期20卷 1104-1110页

作者： lai Huoyao Liu Gongshen School of Information Security Engineering Shanghai Jiaotong Univ. Shanghai 200240 P. R. China

Suffix trees are the key data structure for text string matching, and are used in wide application areas such as bioinformatics and data compression. Ukkonen algorithm is deeply investigated and a new algorithm, which decreases the number of memory operations in construction and keeps the result tree sequential, is proposed. The experiment result shows that both the construction and the matching procedure are more efficient than Ukkonen algorithm.

关键词： suffix tree sequential linear time construction.

Power Flow Analytical Solutions and Multi-dimensional Voltage Stability Boundaries Based on Multivariate Quotient-difference Method

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1168-1178页

作者： Chengxi Liu Qiupin lai School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Hubei Engineering and Technology Research Center for AC/DC Intelligent Distribution Network Wuhan 430072China IEEE

This paper proposes a novel Multivariate Quotient-Difference(MQD)method to obtain the approximate analytical solution for AC power flow ***,in the online environment,the power flow solutions covering different operating conditions can be directly obtained by plugging values into multiple symbolic variables,such that the power injections and consumptions of selected buses or areas can be independently *** method first derives a power flow solution through a Multivariate Power Series(MPS).Next,the MQD method is applied to transform the obtained MPS to a Multivariate Pad´e Approximants(MPA)to expand the Radius of Convergence(ROC),so that the accuracy of the derived analytical solution can be significantly *** addition,the hypersurface of the voltage stability boundary can be identified by an analytical formula obtained from the coefficients of *** direct method for power flow solutions and voltage stability boundaries is fast for many online applications,since such analytical solutions can be derived offline and evaluated online by only plugging values into the symbolic variables according to the actual operating *** proposed method is validated in detail on New England 39-bus and IEEE 118-bus systems with independent load variations in multi-regions.

关键词： Analytical power flow solution multivariate power series multivariate Padéapproximants multivariate quotient-difference multi-dimensional voltage stability boundary

Speckle-type POZ protein mutations interrupt tumor suppressor function of speckle-type POZ protein in prostate cancer by affecting androgen receptor degradation

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Asian Journal of Andrology 2014年第5期16卷 659-660页

作者： John lai Cancer Program Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane Queensland Australia Australian Prostate Cancer Research Centre-Queensland Translational Research Institute Queensland University of Technology Brisbane Queensland Australia

Large scale exome sequencing studies have ＇revealed regions of the genome, which contribute to the castrate resistant prostate cancer （CRPC） phenotype.1-3 Such studies have identified mutations in genes, which may have diagnostic/prognostic potential, or which may be targeted therapeutically. Two of these genes include the androgen receptor （AR） and speckle-type POZ protein （SPOP） genes. However, the findings from these exome sequencing studies can only be translated therapeutically once the functional consequences of these mutations have been determined. Here, we highlight the recent study by An et al.4 which investigated the functional effects of mutations in the SPOP gene that were identified in the aforementioned exome sequencing studies, particnlarly in the context of SPOP-mediated degradation of the AR.

关键词： Speckle-type POZ protein

Molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor

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Acta Pharmacologica Sinica 2006年第7期27卷 888-894页

作者： Anthony F lai Cardiff CF14 4XN Cardiff University UK Wales Heart Research Institute Wales College of Medicine

Aim:To elucidate the molecular nature of sulfhydryl modification by hydrogenperoxide on type 1 ryanodine receptor(RyR1).Methods:Rabbit skeletal musclesarcoplasmic reticulum was treated with hydrogen peroxide,then RyR1 complexwas *** proteins in the complex were analysed by electrophoresis,Western blot and electron ***:(1)Hydrogen peroxide inducesinter-subunit cross-linking within the tetrameric RyR1 molecule;(2)in parallel tointer-subunit cross-linking,the RyR1 molecule changes morphology;(3)the chemi-cal and morphological changes are reversible:upon reduction by reducing agents,the RyR1 molecule regains its original ***:These findings suggestthat the molecular mechanism of RyR1 channel activity in sarcoplasmic reticulumregulated by hydrogen peroxide is through inter-subunit cross-linking within thetetrameric RyR1 molecule,which in turn induces structural changes of RyR1.

关键词： Ca2+ release channel/ryanodine receptor hydrogen peroxide reactive oxygen redoxsensitive ion channel

Advances in halide perovskite semiconductors for energy-integrated and energy-resolved X-ray detection

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第10期25卷 824-840页

作者： Yibin lai Yang(Michael)YANG State Key Laboratory of Modern Optical Instrumentation Institute for Advanced PhotonicsCollege of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

X-ray andγ-ray detectors are widely used in medical,military,security,material analysis,and industrial *** recent years,perovskite materials have become promising materials for radiation detection owing to their strong stopping power,considerable carrier transportation ability,and simple synthesis *** studies have demonstrated both direct and indirect radiation detectors using perovskite *** this review,we aim to elucidate the mechanism by which X-rays andγ-rays interact with matter,explain the principles of the energy integrating mode and photon counting mode for direct detection,and discuss the key factors determining device ***,we summarize recent advances in perovskite-based radiation detectors for both ***,we identify challenges that need to be overcome to enable perovskite materials to be successfully commercialized.

关键词： Halide perovskite X-ray Direct detection Photo counting

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

A Criterion for Elliptic Curves with Second Lowest 2-Power in L(1)(Ⅱ)

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Acta Mathematica Sinica,English Series 2005年第5期21卷 961-976页

作者： Chun lai ZHAO LMAM School of Mathematical Sciences Peking University Beijing 100871 P. R. China

Let D = p1p2 …pm, where p1,p2, ……,pm are distinct rational primes with p1 ≡p2 ≡3（mod 8）, pi =1（mod 8）（3 ≤ i ≤ m）, and m is any positive integer. In this paper, we give a simple combinatorial criterion for the value of the complex L-function of the congruent elliptic curve ED2 ： y^2 = x^3- D^2x at s = 1, divided by the period ω defined below, to be exactly divisible by 2^2m-2, the second lowest 2-power with respect to the number of the Gaussian prime factors of D. As a corollary, we obtain a new series of non-congruent numbers whose prime factors can be arbitrarily many. Our result is in accord with the predictions of the conjecture of Birch and Swinnerton-Dyer.

关键词： Elliptic curve L-function Congruent number BSD conjecture