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Predicting portal venous anomalies by left-sided gallbladder or rightsided ligamentum teres hepatis: A large scale, propensity scorematched study

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World Journal of Gastroenterology 2023年第27期29卷 4344-4355页

作者： hsuan-yin lin Rheun-Chuan Lee Jyh-Wen Chai Chiann-Yi Hsu Yen Chou Hsuen-En Hwang Chien An Liu Nai-Chi Chiu Ho-Hsian Yen Department of Radiology Taichung Veterans General HospitalTaichung 407219Taiwan Department of Radiology Taipei Veterans General HospitalTaipei 11267Taiwan School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112Taiwan Department of Medical Research Taichung Veterans General HospitalTaichung 40705Taiwan Department of Radiology Fu Jen Catholic University HospitalTaipei 24352Taiwan Department of Radiology Far Eastern Memorial HospitalNew Taipei City 220Taiwan

BACKGROUND Right-sided ligamentum teres(RSLT)is often associated with portal venous anomalies(PVA)and is regarded as a concerning feature for hepatobiliary *** studies consider RSLT to be one of the causes of left-sided gallbladder(LGB),leading to the hypothesis that LGB must always be present with ***,some cases have shown that right-sided gallbladder(RGB)can also be present in livers with *** To highlight the rare variation that RSLT may not come with LGB and to determine whether ligamentum teres(LT)or gallbladder location is reliable to predict *** This study retrospectively assessed 8552 contrast-enhanced abdominal computed tomography examinations from 2018 to 2021[4483 men,4069 women;mean age,59.5±16.2(SD)years].We defined the surrogate outcome as major *** cases were divided into 4 subgroups according to gallbladder and LT *** one hand,we analyzed PVA prevalence by LT locations using gallbladder location as a controlled variable(n=36).On the other hand,we controlled LT location and computed PVA prevalence by gallbladder locations(n=34).Finally,we investigated LT location as an independent factor of PVA by using propensity score matching(PSM)and inverse probability of treatment weighting(IPTW).RESULTS We found 9 cases of RSLT present with *** the LGB cases,RSLT is associated with significantly higher PVA prevalence than typical LT[80.0%vs 18.2%,P=0.001;OR=18,95%confidence interval(CI):2.92-110.96].When RSLT is present,we found no statistically significant difference in PVA prevalence for RGB and LGB cases(88.9%vs 80.0%,P>0.99).Both PSM and IPTW yielded balanced cohorts in demographics and gallbladder *** RSLT group had a significantly higher PVA prevalence after adjusted by PSM(77.3%vs 4.5%,P<0.001;OR=16.27,95%CI:2.25-117.53)and IPTW(82.5%vs 4.7%,P<0.001).CONCLUSION RSLT doesn't consistently coexist with *** can predict PVA independently while the gallbladder location does not serve as a suf

关键词： Right-sided ligamentum teres Left-sided gallbladder Portal venous anomalies Inverse probability of treatment weighting Average treatment effect in the treated

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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High glucose reduces Nrf2-dependent cRAGE release and enhances inflammasome-dependent IL-1βproduction in monocytes:the modulatory effects of EGCG

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Food Science and Human Wellness 2024年第3期13卷 1531-1542页

作者： Chi-Hao Wu yin-hsuan Chang Chin-lin Hsu Sheng-Yi Chen Gow-Chin Yen Graduate Programs of Nutrition Science School of Life ScienceTaiwan Normal UniversityTaipei 106209TaiwanChina Department of Food Science and Biotechnology Chung Hsing UniversityTaichung 40227TaiwanChina School of Nutrition Chung Shan Medical UniversityTaichung 40201TaiwanChina

Soluble receptor for advanced glycation end products(sRAGE)acts as a decoy sequestering of RAGE ligands,thus preventing the activation of the ligand-RAGE axis linking human ***,the molecular mechanisms underlying sRAGE remain *** this study,THP-1 monocytes were cultured in normal glucose(NG,5.5 mmol/L)and high glucose(HG,15 mmol/L)to investigate the effects of diabetesrelevant glucose concentrations on sRAGE and interleukin-1β(IL-1β)*** modulatory effects of epigallocatechin gallate(EGCG)in response to HG challenge were also *** enhanced intracellular reactive oxygen species(ROS)generation and RAGE *** secretion of sRAGE,including esRAGE and cRAGE,was reduced under HG conditions,together with the downregulation of a disintegrin and metallopeptidase 10(ADAM10)and nuclear factor erythroid 2-related factor 2(Nrf2)nuclear ***,the HG effects were counteracted by siRAGE and exacerbated by *** immunoprecipitation results showed that Nrf2 binding to the ADAM10 promoter and HG interfered with this *** data reinforce the notion that RAGE and Nrf2 might be sRAGE-regulating *** HG conditions,the treatment of EGCG reduced ROS generation and RAGE ***-stimulated cRAGE release was likely caused by the upregulation of the Nrf2-ADAM10 *** inhibited HG-mediated NLRP3 inflammasome activation at least partly by stimulating sRAGE,thereby reducing IL-1βrelease.

关键词： Epigallocatechin gallate(EGCG) Inflammasome Nuclear factor erythroid 2-related factor 2(Nrf2) Receptor for advanced glycation end products(RAGE) Soluble RAGE(sRAGE)

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[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 96-103页

作者： Rui-Jia Zhang ying-Shi lin Lan-yin Tu Zi-Tong Chen Wei-Wei Zhang Tian-Gang Luan Bao-Wei Chen School of Life and Health Sciences Hainan University Haikou 570228 China. School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. School of Artificial Intelligence Sun Yat-sen University Zhuhai 519082 China. Guangzhou Center for Disease Control and Prevention Guangzhou 510440 China. School of Marine Sciences Sun Yat-sen University Zhuhai 519082 China.

While human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, the molecular mechanisms responsible for PFOA-induced intestinal toxicity are unclear. Herein, we examined the toxicity of PFOA toward human colorectal cancer cells (HCT116) from three dimensions: the cytotoxic phenotype, cell respiration, and transcription levels of metabolism-related genes. Formazan was used to assess how PFOA exposure affects HCT116-cell relative viability, after which the mitochondrial respiratory activities of these cells were determined by analyzing extracellular flux. The quantitative real-time polymerase chain reaction (qPCR) method was used to detect metabolism-related gene expression levels. The cytotoxicity assay revealed that the HCT116 showed significantly inhibited relative activities compared to those of the control when exposed to 300 μmol/L PFOA for 48 h (<0.01), with most cells retained at the G0/G1 stage. In contrast, the mitochondrial respiratory activities of the HCT116 were promoted by concentrations of PFOA as low as 50 μmol/L. Two genes related to cellular metabolism (dipeptidase 1 () and sphingosine kinase 1 ()) were found to be related to the PFOA-promoted formation of ulcerative colitis using our self-developed Metabolic Gene and Pathway Query software and Comparative Toxicogenomics Database (CTD). The qPCR studies revealed that and expression levels were enhanced by 8-10 times in HCT116 exposed to 300 μmol/L PFOA relative to the control, whereas this trend was not observed for HCT116 exposed to 50 μmol/L PFOA. Collectively, these results suggest that the respiratory activity of cellular mitochondria may serve as an index for determining the interference effects associated with PFOA and that metabolic pathways mediated by and may be involved in the development of PFOA-induced ulcerative colitis. Future studies should investigate the relationships between changes in metabolism-related genes ( and ) and the mitochondrial respiratory act

关键词： Metabolic Gene and Pathway Query software human colorectal enterotoxicity metabolic disorder perfluorooctanoic acid (PFOA)

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Engineering of Fe d-band center in Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles via orbital coupling for high-efficiency oxygen reduction electrocatalysis

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Nano Research 2025年第1期18卷 129-139页

作者： Jiayi Liu Jingwen yin yingzi lin Mingxin Pang Huan Pang Songtao Zhang lin Xu Jun Yang Yawen Tang Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Center of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023Chin a 2 State Key Laboratory of Multiphase Complex Systems Center of MesoscienceInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China Testing Center Yangzhou UniversityYangzhou 225009China

The deliberate engineering of the d-band center of metal site represents an effective strategy to boost the intrinsic electrocatalytic performance toward the oxygen reduction reaction(ORR).Herein,following a heterointerfaceinduced orbital coupling rationale,we report a judicious design of an efficient ORR electrocatalyst consisting of Fe_(3)O_(4)/CeO_(2)hetero-nanoparticles in-situ encased into N-doped carbon nanofibers(abbreviated as Fe_(3)O_(4)/CeO_(2)@N-CNFs hereafter).The theoretic calculations uncover that the Fe_(3)O_(4)/CeO_(2)heterointerface-triggered orbital coupling can cause the down shift of the d-band center positions of Fe sites,which leads to the weakened chemisorption of oxygenated groups and lowered energy barrier for the potential-determining step,ultimately dramatically boosting the ORR intrinsic *** a consequence,the well-designed Fe_(3)O_(4)/CeO_(2)@N-CNFs display admirable ORR activity with a half-wave potential of 0.84 V and outstanding structural/electrochemical stability in an alkaline electrolyte,surpassing the commercial Pt/C benchmark and a majority of recently reported Fe_(3)O_(4)-based *** encouragingly,the Fe_(3)O_(4)/CeO_(2)@N-CNFsincorporated Zn-air battery outperforms the Pt/C-assembled counterpart with higher power density,larger energy density,and excellent cycling stability,serving as a competent candidate for ORR-involved renewable energy *** study offers an innovative approach for the rational manipulation of the d-band center and interfacial electron behavior of active sites toward the optimization of electrocatalytic performance.

关键词： hetero-nanoparticles electrospinning interfacial engineering orbital coupling oxygen reduction reaction

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A Novel Product Remaining Useful Life Prediction Approach Considering Fault Effects

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1762-1773页

作者： Jingdong lin Zheng lin Guobo Liao Hongpeng yin School of Automation Chongqing UniversityChongqing 400044China

In this paper,a novel remaining useful life prediction approach considering fault effects is *** Wiener process is used to construct the degradation process of single performance characteristic with the fault *** first passage time based remaining useful life distribution is calculated by assuming fault occurrence moment is a random variable and follows a certain *** maximization algorithm is employed to estimate model parameters,where the fault occurrence moment is considered as a missing ***,a Copula function is used to describe the dependence between the multiple performance characteristics and derive joint remaining useful life(RUL)distribution of product with the fault *** effectiveness of the proposed approach is verified by the experiments of turbofan engines.

关键词： Degradation process fault effects fault occurrence moment(FOM) performance characteristic(PC) remaining useful life(RUL)

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Using hydrochemical signatures to characterize the long-period evolution of groundwater information in the Dagu River Basin,China

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Frontiers of Environmental Science & Engineering 2021年第5期15卷 311-323页

作者： Ziyue yin Qing lin Shaohui Xu School of Environmental Science and Engineering Qingdao UniversityQingdao266071China

The evolution of hydrochemical compositions influenced by long-period interactions between groundwater and the geo-environment is a fundamental issue for exploring groundwater quality and *** study systematically investigated the hydrochemical processes and anthropogenic interference occurring in the river basin by bivariate plots,Gibbs diagrams,saturation index,and the major ions *** changes in groundwater hydrochemistry have been observed in the study area,illustrating the origins of major ions are affected by various internal and external *** highlighted that TDS varied from freshwater to brackish water,ranging between 187.90 and 2294.81 mg/***^(2+)and HCO_(3)^(−)are the dominant ions in the studied *** results gained by Gibbs diagrams,bivariate plots,saturation index,and the major ions ratios demonstrated that minerals dissolution/precipitation,cation exchange,and human inputs play crucial roles in the unconfined ***,the overuse of nitrogen fertilizer,livestock manure,and industrial/domestic sewage led to nitrate and nitrite contamination and brought significant challenges to the surrounding *** present study could make an unambiguous identification of natural processes and anthropogenic interventions influencing groundwater hydrochemistry’s long-period evolution and create a preliminary strategy for groundwater resources management.

关键词： Groundwater quality Hydrochemical signatures Spatial-temporal variations Water-rock interactions Anthropogenic interventions

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Size effect on the static behavior of electrostatically actuated microbeams

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Acta Mechanica Sinica 2011年第3期27卷 445-451页

作者： Li yin Qin Qian lin Wang Department of Mechanics Huazhong University of Science and Technology 430074 Wuhan China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment 430074 Wuhan China

We present a new analytical model for electrostatically actuated microbeams to explore the size effect by using the modified couple stress theory and the minimum total potential energy principle. A material length scale parameter is introduced to represent the size-dependent characteristics of microbeams. This model also accounts for the nonlinearities associated with the mid-plane stretching force and the electrostatical force. Numerical analysis for microbeams with clamped-clamped and cantilevered conditions has been performed. It is found that the intensity of size effect is closely associated with the thickness of the microbeam,and smaller beam thickness displays stronger size effect and hence yields smaller deffection and larger pull-in voltage. When the beam thickness is comparable to the material length scale parameter,the size effect is significant and the present theoretical model including the material length scale parameter is adequate for predicting the static behavior of microbeam-based MEMS.

关键词： Electrostatically actuated microbeam - Size ef-fect.Deflection. Pull-in voltage . MEMS

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Joint study on VMs deployment, assignment and migration in geographically distributed data centers

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Frontiers of Computer Science 2016年第3期10卷 559-573页

作者： Chuang lin Min YAO yin LI Department of Computer Science and Technology Tsinghua University Beijing 100084 China

Enterprises build private clouds to provide IT re- sources for geographically distributed subsidiaries or prod- uct divisions. Public cloud providers like Amazon lease their platforms to enterprise users, thus, enterprises can also rent a number of virtual machines （VMs） from their data centers in the service provider networks. Unfortunately, the network cannot always guarantee stable connectivity for their clients to access the VMs or low-latency transfer among data centers. Usually, both latency and bandwidth are in unstable network environment. Being affected by background traffics, the net- work status can be volatile. To reduce the latency uncertainty of client accesses, enterprises should consider the network status when they deploy data centers or rent virtual data cen- ters from cloud providers. In this paper, we first develop a data center deployment and assignment scheme for an enter- prise to meet its users＇ requirements under uncertain network status. To accommodate to the changes of the network status and users＇ demands, a VMs migration-based redeployment scheme is adopted. These two schemes work in a joint way, and lay out a framework to help enterprises make better use of private or public clouds.

关键词： data center deployment VMs migration Min-Max stochastic optimization

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Network Robustness Depth and Topology Management of Networked Dynamic Systems

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Journal of Systems Science & Complexity 2016年第1期29卷 1-21页

作者： WANG Leyi lin Feng yin George Department of Electrical and Computer Engineering Wayne State University Department of Mathematics Wayne State University

Networked control systems are subject to adversary conditions that affect their network *** ensure reliable system operations,network topologies need to be characterized and managed for their impact on the overall system *** paper introduces the concept of network robustness depth for this *** event systems are used as a foundation to model dynamic behavior of network topologies,support their analysis,and carry out their *** analysis relates the link reliability probabilities to a probabilistic characterization of network robustness *** topology management strategies are discussed,including passive methods,random strategies,and optimization *** respective benefits and limitations are *** using platoon control as a platform of hybrid(continuous and discrete event) systems and packet erasure channels as a communication protocol,the results are demonstrated with case studies.

关键词： Network depth network topology robustness

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