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Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： Min Han Zishan Chen Shiying Zhou Zunde liao Xiangting yi Yao He yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling liao Xiao-Li Pu Zhi-yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao Sha liao Yu-Jiao Gao Xi Wang Li-Hong Guo Su Zheng Wu Yang yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

Two-stage Optimal Dispatching of AC/DC Hybrid Active Distribution Systems Considering Network Flexibility

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 52-65页

作者： yi Su Jiashen teh School of Electrical and Electronic Engineering Universiti Sains Malaysia(USM)14300 Nibong TebalPenangMalaysia IEEE

The increasing flexibility of active distribution systems(ADSs)coupled with the high penetration of renewable distributed generators(RDGs)leads to the increase of the *** is of practical significance to achieve the largest amount of RDG penetration in ADSs and maintain the optimal *** study establishes an alternating current(AC)/direct current(DC)hybrid ADS model that considers the dynamic thermal rating,soft open point,and distribution network reconfiguration(DNR).Moreover,it transforms the optimal dispatching into a second-order cone programming *** the different control time scales of dispatchable resources,the following two-stage dispatching framework is proposed.d dispatch uses hourly input data with the goal(1)The day-ahea of minimizing the grid loss and RDG *** obtains the optimal 24-hour schedule to determine the dispatching plans for DNR and the energy storage system.(2)The intraday dispatch uses 15-min input data for 1-hour rolling-plan dispatch but only executes the first 15 min of *** eliminate error between the actual operation and dispatching plan,the first 15 min is divided into three 5-min step-by-step *** goal of each step is to trace the tie-line power of the intraday rolling-plan dispatch to the greatest extent at the minimum *** measured data are used as feedback input for the rolling-plan dispatch after each step is executed.A case study shows that the comprehensive cooperative ADS model can release the line capacity,reduce losses,and improve the penetration rate of ***,the two-stage dispatching framework can handle source-load fluctuations and enhance system stability.

关键词： Two-stage dispatching network flexibility renewable distributed generator second-order cone programming(SOCP) alternating current(AC)/direct current(DC)hybrid active distribution system

豆浆中风味物质形成、与蛋白的互作机制及生物法改善豆浆风味的研究进展

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食品科学 2025年第2期46卷 280-289页

作者：高宇齐宝坤廖一闫世长李杨黄雨洋东北农业大学食品学院黑龙江哈尔滨150030 哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机... 详细信息

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机制以及通过生物方法改善豆浆风味的研究进展。通过无脂氧合酶大豆品种的开发、酶处理和微生物发酵等生物方法,可以有效地改善豆浆的风味,同时保持其营养价值。最后对未来改善豆浆风味的研究方向做出展望,以期为豆浆及其制品的品质提升和市场推广提供理论依据,为推动我国大豆制品市场的发展做出贡献。

关键词：豆浆风味物质-蛋白质互作生物方法风味改良

TPII:tracking personally identifiable information via user behaviors in HTTP traffic

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Frontiers of Computer Science 2020年第3期14卷 175-187页

作者： yi LIU Tian SONG Lejian liao School of Computer Science Beijing Institute of TechnologyBeijing 100081China Network Information Center Yan'an UniversityYan'an 716000China School of Computer ScienceBeijing Institute of TechnologyBeijing 100081China

It is widely common that mobile applications collect non-critical personally identifiable information(PII)from users'devices to the cloud by application service providers(ASPs)in a positive manner to provide precise and recommending ***,Internet service providers(ISPs)or local network providers also have strong requirements to collect PIIs for finer-grained traffic control and security ***,it is a challenge to locate PIIs accurately in the massive data of network traffic just like looking a needle in a *** this paper,we address this challenge by presenting an efficient and light-weight approach,namely TPII,which can locate and track PIIs from the HTTP layer rebuilt from raw network *** approach only collects three features from HTTP fields as users'behaviors and then establishes a tree-based decision model to dig PIIs efficiently and *** any priori knowledge,TPII can identify any types of PIIs from any mobile applications,which has a broad vision of *** evaluate the proposed approach on a real dataset collected from a campus network with more than 13k *** experimental results show that the precision and recall of TPII are 91.72%and 94.51%respectively and a parallel implementation of TPII can achieve 213 million records digging and labelling within one hour,reaching near to support 1Gbps wirespeed inspection in *** approach provides network service providers a practical way to collect PIIs for better services.

关键词： network traffic analysis personally identifiable information privacy leakage mobile applications HTTP

Static tainting extraction approach based on information flow graph for personally identifiable information

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Science China(Information Sciences) 2020年第3期63卷 156-172页

作者： yi LIU Lejian liao Tian SONG School of Computer Science and Technology Beijing Institute of Technology College of Mathematics and Computer Science Yan'an University

Personally identifiable information(PII) is widely used for many aspects such as network privacy leak detection, network forensics, and user portraits. Internet service providers(ISPs) and administrators are usually concerned with whether PII has been extracted during the network transmission process. However,most studies have focused on the extractions occurring on the client side and server side. This study proposes a static tainting extraction approach that automatically extracts PII from large-scale network traffic without requiring any manual work and feedback on the ISP-level network traffic. The proposed approach does not deploy any additional applications on the client side. The information flow graph is drawn via a tainting process that involves two steps: inter-domain routing and intra-domain infection that contains a constraint function(CF) to limit the "over-tainting". Compared with the existing semantic-based approach that uses network traffic from the ISP, the proposed approach performs better, with 92.37% precision and 94.04%recall. Furthermore, three methods that reduce the computing time and the memory overhead are presented herein. The number of rounds is reduced to 0.0883%, and the execution time overhead is reduced to 0.0153%of the original approach.

关键词： personally identifiable information network privacy leak detection static tainting network traffic analysis information flow graph inter-domain routing intra-domain infection constraint function

A NOTE ON STABILITY OF THE SPLIT-STEP BACKWARD EULER METHOD FOR LINEAR STOCHASTIC DELAY INTEGRO-DIFFERENTIAL EQUATIONS

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Journal of Systems Science & Complexity 2012年第5期25卷 873-879页

作者： Feng JIANG yi SHEN Xiaoxin liao Department of Control Science and Engineering Huazhong University of Science and Technology School of Statistics and Mathematics Zhongnan University of Economics and Law Department of Control Science and Engineering the Key Laboratory of Ministry of Eduction for Image Processing and Intelligent ControlHuazhong University of Science and Technology

In the literature （Tan and Wang, 2010）, Tan and Wang investigated the convergence of the split-step backward Euler （SSBE） method for linear stochastic delay integro-differential equations （SDIDEs） and proved the mean-square stability of SSBE method under some condition. Unfortu- nately, the main result of stability derived by the condition is somewhat restrictive to be applied for practical application. This paper improves the corresponding results. The authors not only prove the mean-square stability of the numerical method but also prove the general mean-square stability of the numerical method. Furthermore, an example is given to illustrate the theory.

关键词： General mean-square stability mean-square stability split-step backward Euler method stochastic delay integro-differential equations.

Invasive breast carcinoma with osteoclast-like stromal giant cells:A case report

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World Journal of Clinical Cases 2023年第7期11卷 1521-1527页

作者： yi-Jie Wang Chien-Peng Huang Zhi-Jie Hong Guo-Shiou liao jyh-Cherng Yu Department of Surgery Tri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Traumatology Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of General Surgery Department of SurgeryTri Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Invasive breast carcinoma with osteoclast-like stromal giant cells(OGCs) is an extremely rare morphology of breast *** the best of our knowledge,the most recent case report describing this rare pathology was published six years *** mechanism controlling the development of this unique histological formation is still ***,the prognosis of patients with OGC involvement is also *** SUMMARY We report the case of a 48-year-old woman,who presented to the outpatient department with a palpable,growing,painless mass in her left breast for about one *** and mammography revealed a 26.5 mm ×18.8 mm asymmetric,lobular mass with circumscribed margin and the Breast Imaging Reporting and Data System was category ***-guided aspiration biopsy revealed invasive ductal *** patient underwent breast conserving surgery and was diagnosed with invasive breast carcinoma with OGCs,grade Ⅱ,with intermediate grade of ductal carcinoma in situ(ER:80%,3+,PR:80%,3+,HER-2:negative,Ki 67:30%).Adjuvant chemotherapy and post-operation radiotherapy were initiated *** As a rare morphology of breast cancer,breast carcinoma with OGC occurs most often in relatively young women,has less lymph node involvement,and its occurrence is not racedependent.

关键词： Breast carcinoma Osteoclast stromal giant cell Pathology Histochemical stains Prognosis Case report