检索结果-南通市图书馆

Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles

Bone Research 2022年第2期10卷 310-325页

作者： hsu-wen tseng Dorothée Girard Kylie A.Alexander Susan M.Millard Frédéric Torossian Adrienne Anginot Whitney Fleming Jules Gueguen Marie-Emmanuelle Goriot Denis Clay Beulah Jose Bianca Nowlan Allison R.Pettit Marjorie Salga François Genêt Marie-Caroline Le Bousse-Kerdilès Sébastien Banzet Jean-Pierre Lévesque Mater Research Institute-The University of Queensland WoolloongabbaQLDAustralia Institut de Recherche Biomédicale des Armées(IRBA) INSERM UMRS-MD1197 ClamartFrance INSERM UMRS-MD 1197 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance INSERM UMS-44 Universitéde Paris-SaclayHôpital Paul BrousseVillejuifFrance UPOH(UnitéPéri Opératoire du Handicap Perioperative Disability Unit)Physical and Rehabilitation Medicine departmentRaymond-PoincaréHospitalAssistance Publique-Hôpitaux de Paris(AP-HP)GarchesFrance Universitéde Versailles Saint Quentin en Yvelines UFR Simone Veil-SantéEND:ICAP INSERM U1179Montigny le BretonneuxFrance

The cells of origin of neurogenic heterotopic ossifications(NHOs), which develop frequently in the periarticular muscles following spinal cord injuries(SCIs) and traumatic brain injuries, remain unclear because skeletal muscle harbors two progenitor cell populations: satellite cells(SCs), which are myogenic, and fibroadipogenic progenitors(FAPs), which are mesenchymal. Lineage-tracing experiments using the Cre recombinase/Lox P system were performed in two mouse strains with the fluorescent protein Zs Green specifically expressed in either SCs or FAPs in skeletal muscles under the control of the Pax7 or Prrx1 gene promoter, respectively. These experiments demonstrate that following muscle injury, SCI causes the upregulation of PDGFRα expression on FAPs but not SCs and the failure of SCs to regenerate myofibers in the injured muscle, with reduced apoptosis and continued proliferation of muscle resident FAPs enabling their osteogenic differentiation into NHOs. No cells expressing Zs Green under the Prrx1 promoter were detected in the blood after injury, suggesting that the cells of origin of NHOs are locally derived from the injured muscle. We validated these findings using human NHO biopsies. PDGFRα+mesenchymal cells isolated from the muscle surrounding NHO biopsies could develop ectopic human bones when transplanted into immunocompromised mice, whereas CD56+myogenic cells had a much lower potential. Therefore, NHO is a pathology of the injured muscle in which SCI reprograms FAPs to undergo uncontrolled proliferation and differentiation into osteoblasts.

关键词： progenitor injuries muscles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

引用

Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou Pang-Chi hsu Lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Numerical Simulation on a Tremendous Debris Flow Caused by Typhoon Morakot in the Jiaopu Stream,Taiwan

引用

Journal of Mountain Science 2014年第1期11卷 1-18页

作者： hsu Yu-chao YEN Haw tseng wen-hsiao JAN Chyan-deng Department of Hydraulic and Ocean Engineering National Cheng Kung University Blackland Research and Extension Center Texas A&M AgriLife Research Sun-Rise Engineering Consultant Company

In August 2009,Typhoon Morakot brought a large amount of rainfall with both high intensity and long duration to a vast area of ***,this resulted in a catastrophic landslide in Hsiaolin Village,***,large amounts of landslides were formed in the Jiaopu Stream watershed near the southeast part of the Hsiaolin *** Hsiaolin Village access road(Provincial Highway No.21 and Bridge No.8) was completely destroyed by the landslide and consequent debris *** major scope of this study is to apply a debris flow model to simulate the disaster caused by the debris flow that occurred in the Jiaopu Stream during Typhoon *** to the interviews with local residents,this study applied the destruction time of Bridge No.8 and Chen's house to verify the numerical debris flow *** the spatial rainfall distributions information,the numerical simulations of the debris flow are conducted in two *** the first stage(before the landslide-dam failure),the elevation of the debris flow and the corresponding potential damages toward residential properties were *** the second stage(after the landslidedam failure),comparisons of simulation results between the longitudinal and cross profiles of the Jiaopu Stream were performed using topographic maps and satellite *** summary,applications of the adopted numerical debris flow model have shown positive impact on supporting better understanding of the occurrence and movement of debris flow processes.

关键词： Typhoon Morakot Debris flow Numerical simulation Jiaopu Stream Hsiaolin Village

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamical complexity of Anosov systems driven by a quasi-periodic force

引用

Science China Mathematics 2025年第1期 89-136页

作者： wen Huang Zeng Lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Particle Trajectories in Nonlinear Water Wave on Uniform Current

引用

China Ocean Engineering 2008年第4期22卷 611-621页

作者： Hung-Chu hsu Yang-Yih CHEN Chia-Yan CHENG wen-Jer tseng Tainan Hydraulics Laboratory National Cheng Kung University Department of Marine Environment and Engineering National Sun Yat-Sen University Coastal and Offshore Resources Research Center Fisheries Research Institute Department of Civil Engineering Cheng Shiu University

The study in this paper is focusing on trajectories of particles in the irrotational progressive water waves coexisting with uniform current. The parametric equations of particle trajectories over a range of levels in a Lagrangian type of description are developed analytically via the Euler-Lagrange transformation. The Lagrangian wave period of particle motion differing from the Eulerian wave period and the mass transport can also be obtained directly. The third-order solution of particle trajectory exhibits that they do not move in closed orbital motion but represent a net movement that decreases exponentially with the water depth. Uniform current is found to have significant effect on the trajectories and drift velocity of gravity waves. Overall, the influence of increased uniform current is to increase the relative horizontal distance traveled by a particle, as well as the magnitude of the time-averaged drift velocity on the free surface. For adverse current cases, a reverse behavior is found. The obtained third-order solutions satisfy the irrotational condition contrasted to the Gerstner waves and are verified by reducing to those of two-dimensional gravity waves in Lagrangian coordinates.

关键词： wave current Lagrangian Euler- Lagrange transformation particle trajectory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

引用

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interactions of nonlinear gravity waves and uniform current in Lagrangian system

引用

Acta Oceanologica Sinica 2009年第1期28卷 89-98页

作者： hsu Hung-Chu CHEN Yang-Yih LI Meng-Syue tseng wen-Jer Tainan Hydraulics Laboratory National Cheng Kung University Department of Marine Environment and Engineering National Sun Yat-Sen University Department of Civil Engineering Cheng Shiu University

The particle trajectory on a weakly nonlinear progressive surface wave obliquely interacting with a uniform current is studied by using an Euler-Lagrange *** third-order asymptotic solution is a periodic bounded function of Lagrangian labels and time,which imply that the entire solution is *** explicit parametric solution highlights the trajectory of a water particle and mass transport associated with a particle displacement can now be obtained directly in Lagrangian *** angular frequency and Lagrangian mean level of the particle motion in Lagrangian form differ from those of the *** variations in the water particle orbits resulting from the oblique interaction with a steady uniform current of different magnitudes are also investigated.

关键词： Lagrangian particle trajectory nonlinear water wave current drift velocity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of compression garments on surface EMG and physiological responses during and after distance running

引用

Journal of Sport and Health Science 2020年第6期9卷 685-691页

作者： Wei-Chun hsu Li-wen tseng Fu-Chun Chen Li-Chu Wang wen-wen Yang Yi-Jia Lin Chiang Liu Graduate Institute of Biomedical Engineering National Taiwan University of Science and TechnologyTaipeiTaiwan 10607China National Defense Medical Center TaipeiTaiwan 11466China Graduate Institute of Sports Equipment Technology University of TaipeiTaipeiTaiwan 11153China Taiwan Textile Research Institute New Taipei CityTaiwan 23674China

Background:The few previous studies that focused on the effects of compression garments(CG)on distance running performance have simultaneously measured electromyogram,physiological,and perceptual ***,this study investigated the effects of CG on muscle activation and median frequency during and after distance running,as well as blood-lactate concentration and rating of perceived exertion(RPE)during distance ***:Eight healthy male recreational runners were recruited to randomly perform two 40 min treadmill running trials,one with CG,and the other with control garment made of normal *** RPE and the surface electromyography(EMG)of 5 lower extremity muscles including gluteus maximus(GM),rectus femoris(RF),semitendinosus(ST),tibialis anterior(TA),and gastrocnemius(GAS)were measured during the running *** blood-lactate levels before and after the running trial were ***:Wearing CG led to significant lower muscle activation(p0.05).Conclusion:Wearing CG was associated with significantly lower muscle activation and higher median frequency in the running-related key muscles during distance *** finding suggested that wearing CG may improve muscle function,which might enhance running performance and prevent muscle fatigue.

关键词： Blood lactate Compression garment Fatigue Muscle activation Rate of perceived exertion Running

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen Zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

引用

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han Yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：