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天上的老虎

十月 2024年第1期 88-111页

作者：陈鹏不详

A.失业第121天,我想联系苏粒。我知道这时候联系她不太合适。什么时候才算合适?还要等多久?一辈子?不。不等了。不能再等了。如果还忌历史,当下的无足轻重只会离死亡更近一步。我果断发了短信(注意是短信不是微信):正路过金马碧鸡坊。... 详细信息

A.失业第121天,我想联系苏粒。我知道这时候联系她不太合适。什么时候才算合适?还要等多久?一辈子?不。不等了。不能再等了。如果还忌历史,当下的无足轻重只会离死亡更近一步。我果断发了短信(注意是短信不是微信):正路过金马碧鸡坊。之后我下楼吃了一碗米线,回到家,她的短信来了(整整二十年后,她的信息,来了):吃个饭吧,明晚7点。没说废话的意思是让我定地方,或者,是我们都知道的地方。我回过去:好的。她答:不见不散。

关键词：短信微信老虎

Radiotherapy enhances efficacy of PD-1 inhibitors in advanced hepatocellular carcinoma:A propensity-matched real-world study

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Chinese Medical Journal 2024年第11期137卷 1332-1342页

作者： Shujung hsu Yencheng Chao Yong Hu Yang Zhang Weifeng Hong Yixing Chen Rongxin Chen Zhaochong Zeng Shisuo Du Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pulmonary Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Liver Cancer Institute Zhongshan HospitalFudan UniversityShanghai 200032China

Background:To address the need for immunotherapy in patients with advanced primary hepatocellular carcinoma(HCC),combination with radiotherapy(RT)has emerged as a promising *** preclinical studies,irradiated tumors released tumor antigens to synergistically increase the antitumor effect of ***,we investigated whether RT enhances the efficacy of anti-programmed death receptor-1(PD-1)inhibitors in advanced HCC in real-world ***:Between August 2018 and June 2021,172 patients with advanced primary HCC were enrolled in the tertiary center(Zhongshan Hospital of Fudan University);95 were treated with a combination of RT and the inhibitor of PD-1(RT-PD1 cohort),and 77 were administered anti-PD-1 therapy(PD1 cohort).The first cycle of PD-1 inhibitors was administered within 60 days or concurrently with *** score matching for bias reduction was used to evaluate the clinical ***:Among 71 propensity-matched pairs,median progression-free survival was 5.7 months in the RT-PD1 cohort vs.2.9 months in the PD1 cohort(P<0.001).Median overall survival was 20.9 months in the RT-PD1 cohort vs.11.2 months in the PD1 cohort(P=0.018).Compared with patients in the PD1 cohort,patients in the RT-PD1 cohort had significantly higher objective response rates(40.8%,29/71 vs.19.7%,14/71,P=0.006)and disease control rates(62.0%,44/71 vs.31.0%,22/71,P<0.001).The incidences of toxic effects were not significantly different between the two ***:RT plus anti-PD-1 therapy is well *** enhances the efficacy of anti-PD-1 therapy in patients with advanced primary HCC by improving survival outcomes without increased toxic effects.

关键词： Radiotherapy Immune checkpoint inhibitor Programmed cell death receptor-1 Hepatocellular carcinoma Propensity score matching Treatment outcome Adverse effects

Jiaohong pills attenuate neuroinflammation and amyloid-βprotein-induced cognitive deficits by modulating the mitogen-activated protein kinase/nuclear factor kappa-B pathway

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Animal Models and Experimental Medicine 2024年第3期7卷 222-233页

作者： Hong Zhang Weiyan Cai Lijinchuan Dong Qing Yang Qi Li Qingsen Ran Li Liu Yajie Wang Yujie Li Xiaogang weng Xiaoxin Zhu Ying Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina

Background:Jiaohong pills(JHP)consist of Pericarpium Zanthoxyli(PZ)and Radix Rehmanniae,two herbs that have been extensively investigated over many years due to their potential protective effects against cognitive decline and memory ***,the precise mechanisms underlying the beneficial effects remain ***,research studies were conducted to investigate and validate the therapeutic effects of JHP on Alzheimer's ***:BV-2 cell inflammation was induced by *** mice were administered amyloid-β(Aβ).Behavioral experiments were used to evaluate learning and memory *** levels of nitric oxide(NO),tumor necrosis factor-alpha(TNF-α),interleukin-1β(IL-1β),and interleukin-10(IL-10)were detected using enzymelinked immunosorbent assay(ELISA).The protein expressions of inducible nitric oxide synthase(iNOS)and the phosphorylation level of mitogen-activated protein kinase(MAPK)and nuclear factor kappa-B(NF-κB)were detected using Western *** staining was used to detect neuronal ***:The results demonstrated that an alcoholic extract of PZ significantly decreased the levels of NO,IL-1β,TNF-α,and iNOS;increased the expression level of IL-10;and significantly decreased the phosphorylation levels of MAPK and NF-κ*** inhibitory effects were further confirmed in the AD mouse ***,JHP improved learning and memory function in AD mice,reduced neuronal damage,and enriched the Nissl bodies in the ***,IL-1βand TNF-αin the cortex were significantly downregulated after JHP administration,whereas IL-10showed increased ***:It was found that JHP reduced neuroinflammatory response in AD mice by targeting the MAPK/NF-κB signaling pathway.

关键词： amyloid-β(Aβ)protein BV2 neuroinflammation Pericarpium Zanthoxyli Radix Rehmanniae

Radiotherapy for hyoid bone metastasis from lung adenocarcinoma:A case report

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World Journal of Clinical Oncology 2024年第1期15卷 159-164页

作者： Jonathan hsu Kambridge Hribar Joseph Poen Medical School California University of Science and MedicineColtonCA 92324United States Department of Otolaryngology ENT Consultants of MarinGreenbraeCA 94904United States Radiation Oncology Marin Cancer CareGreenbraeCA 94904United States

BACKGROUND Metastasis to the hyoid bone is an exceptionally rare occurrence,with documented cases limited to breast,liver,colon,skin,lung,and prostate *** report highlights an unusual case involving the metastasis of lung adenocarcinoma to the hyoid bone,accompanied by a distinctive *** documentation involved surgical resection of the hyoid *** present a case displaying the benefits of palliative *** SUMMARY A 72-year-old non-smoking,non-alcoholic woman,initially under investigation for a year-long elevation in absolute lymphocyte count,presented with a monthlong history of intermittent throat *** negative findings in gastroenterological and otolaryngologic examinations,a contrast-enhanced chest computed tomography scan revealed a mediastinal mass and questionable soft tissue thickening in her left anterolateral *** imaging and biopsies confirmed the presence of lung adenocarcinoma metastasis to the hyoid *** patient was treated with platinum-based chemo-immunotherapy along with ***,the lung cancer was *** patient opted for palliative radiation therapy instead of surgical resection to address her throat *** a result,her throat pain was alleviated,and it also incidentally resolved her chronic *** is the second documented case of lung adenocarcinoma metastasizing to the hyoid *** Palliative radiotherapy may add to the quality of life in symptomatic patients with cancer metastatic to the hyoid bone.

关键词： Metastasis Radiotherapy Adenocarcinoma Hyoid Throat Headache Case report

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时空约束对运动出行的影响

华南理工大学学报（自然科学版） 2024年第2期52卷 113-123页

作者：杨亚璪翁唐政重庆交通大学交通运输学院重庆400074

运动出行(Active Travel或Active Mobility,AT或AM)是一种以出行者自我为驱动的出行方式,由于其占用道路面积小、机动性强、可持续性好,因此对缓解城市交通压力、改善城市交通的时空不合理性起着至关重要的作用。文中首先研究了运动出... 详细信息

运动出行(Active Travel或Active Mobility,AT或AM)是一种以出行者自我为驱动的出行方式,由于其占用道路面积小、机动性强、可持续性好,因此对缓解城市交通压力、改善城市交通的时空不合理性起着至关重要的作用。文中首先研究了运动出行的定义和内涵;其次从影响运动出行的时空条件出发,以点和线的视角将时间与空间拆分成出发时间、出行时间、出行距离与建成环境4类约束条件,依次阐述不同类型的时空条件特征,并对运动出行与时空约束间的潜在联系进行分析;接着以单一约束和多种时空组合作为切入点,分析其对运动出行的影响;通过归纳发现,时空约束对运动出行的影响比传统认知中更为复杂,主要呈非线性关系且存在相应的理论阈值;最后提出当前理论研究中的不足之处及未来的研究方向。文章旨在归纳时空对运动出行的制约作用,展示不同时空约束作用下运动出行的具体变化规律,以期改变城市出行者的固有思维,提高运动出行的分担率,促进城市交通出行结构的进一步优化。

关键词：城市交通时空约束运动出行时空组合

Regulatory role of electroacupuncture on satellite glial cell activity in the colon and dorsal root ganglion of rats with irritable bowel syndrome

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Journal of Traditional Chinese Medicine 2024年

作者： ZHANG Fang YAN Cuina weng Zhijun WU Luyi QI Li ZHAO Min XIN Yuhu WU Huangan LIU Huirong Key Laboratory of Acupuncture and Immunological Effects Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai Research Institute of Acupuncture and Meridian Shanghai University of Traditional Chinese Medicine Cancer Hospital Fudan University

Objective: To investigate the role of satellite glial cells in irritable bowel syndrome (IBS) and the effect of electroacupuncture (EA) at the Tianshu (ST25) and Shangjuxu (ST37) combination. Methods: A model for visceral hypersensitivity in IBS was induced through colorectal distension (CRD) stimulation. Clean-grade male Sprague-Dawley (SD) rats were randomly divided into four groups: a normal group (NG)， a model group (MG)， an electroacupuncture group (EA)， and a glial cell inhibitor group (FCA). Bilateral EA (2/100 Hz， 1 mA， 30 min) was administered at the Tianshu (ST25) and Shangjuxu (ST37) in week 6. Abdominal withdrawal reflex (AWR) scores were used to assess the behavioral response associated with visceral hyperalgesia， while hematoxylin-eosin staining was employed to evaluate pathological changes in the colon. The protein and mRNA levels of glial fibrillary acidic protein (GFAP) in the colon and colon-related dorsal root ganglion (DRG) were analyzed using immunofluorescence， immunohistochemistry， Western blotting， real-time polymerase chain reaction. The impact of EA on electrophysiological properties of colon-related DRG neurons was observed through whole-cell patch clamp analysis. Results: EA significantly reduced the visceral pain behavior scores in rats with IBS in response to graded (20， 40， 60， 80 mm Hg) CRD stimulation. Additionally， EA downregulated the protein and mRNA expression levels of GFAP in the colon and colon-related DRG of rats with IBS. EA also regulated the resting membrane potential， rheobase and action potential of colon-related DRG neurons in rats with IBS. Conclusions: EA can regulate the excitatory properties of colon-related DRG neurons by downregulating the protein and mRNA expression of GFAP in the colon and colon-related DRG， indicating a potential neurobiological mechanism by which EA relieves visceral hypersensitivity in rats with IBS.

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Aspartoacylase suppresses prostate cancer progression by blocking LYN activation

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Military Medical Research 2024年第2期11卷 180-205页

作者： Hong weng Kang-Ping Xiong Wang Wang Kai-Yu Qian Shuai Yuan Gang Wang Fang Yu Jun Luo Meng‑Xin Lu Zhong‑Hua Yang Tao Liu Xing Huang Hang Zheng Xing-Huan Wang Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Biological Repositories Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China Department of Pathology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for Pathology and Molecular Diagnostics Wuhan UniversityWuhan 430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan 430071China

Background:Globally,despite prostate cancer(PCa)representing second most prevalent malignancy in male,the precise molecular mechanisms implicated in its pathogenesis remain ***,elucidating the key molecular regulators that govern disease progression could substantially contribute to the establishment of novel therapeutic strategies,ultimately advancing the management of ***:A total of 49 PCa tissues and 43 adjacent normal tissues were collected from January 2017 to December 2021 at Zhongnan Hospital of Wuhan *** advanced transcriptomic methodologies were employed to identify differentially expressed mRNAs in *** expression of aspartoacylase(ASPA)in PCa was thoroughly evaluated using quantitative real-time PCR and Western blotting *** elucidate the inhibitory role of ASPA in PCa cell proliferation and metastasis,a comprehensive set of in vitro and in vivo assays were conducted,including orthotopic and tumor-bearing mouse models(n=8 for each group).A combination of experimental approaches,such as Western blotting,luciferase assays,immunoprecipitation assays,mass spectrometry,glutathione S-transferase pulldown experiments,and rescue studies,were employed to investigate the underlying molecular mechanisms of ASPA's action in *** Student‘s t-test was employed to assess the statistical significance between two distinct groups,while one-way analysis of variance was utilized for comparisons involving more than two groups.A two-sided P<0.05 was deemed to indicate statistical ***:ASPA was identified as a novel inhibitor of PCa *** expression of ASPA was found to be significantly down-regulated in PCa tissue samples,and its decreased expression was independently associated with patients’prognosis(HR=0.60,95%CI 0.40–0.92,P=0.018).Our experiments demonstrated that modulation of ASPA activity,either through gain-or loss-of-function,led to the suppression or enhancement of PCa cell proliferation,mig

关键词： Prostate cancer Aspartoacylase LYN JNK AP-1 C-Jun Phosphorylation

数字技术与治理共同体的互构模型:一个理论分析框架

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南昌大学学报（人文社会科学版） 2024年第4期55卷 115-128页

作者：翁俊芳华中科技大学马克思主义学院湖北武汉430074

利用数字技术构建新时代的社会治理共同体,具有重要的时代意蕴和实践价值。社会有机论、共同体理论、政治系统论为构建治理共同体提供了理论依据,在厘清大规模本土化的数字治理创新经验的基础上,把复杂的实践经验抽象成可研究的理论模... 详细信息

利用数字技术构建新时代的社会治理共同体,具有重要的时代意蕴和实践价值。社会有机论、共同体理论、政治系统论为构建治理共同体提供了理论依据,在厘清大规模本土化的数字治理创新经验的基础上,把复杂的实践经验抽象成可研究的理论模型。通过实践经验融合理论演绎,建构数字技术与治理共同体互构的复合系统模型,进一步解构数字技术与治理共同体互构的内在机理,展现数字技术作为输入变量在建构智慧城市与数字乡村过程中的作用机制与复杂过程。此模型是理论建构的一种探索和尝试,为中国数字治理的自主知识体系建构提供新思路。

关键词：数字治理数字技术治理共同体政治系统论互构模型

Effectiveness of cardioneuroablation in different subtypes of vasovagal syncope

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Journal of Geriatric Cardiology 2024年第6期21卷 651-657页

作者： Bin TU Zi-Hao LAI Ai-Yue CHEN Zhi-Yuan weng Si-Min CAI Zhu-Xin ZHANG Li-Kun ZHOU Li-Hui ZHENG Yan YAO Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesNational Key LaboratoryChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiac Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Cardiovascular Department The First Affiliated HospitalFujian Medical UniversityFujian Institute of HypertensionFujianChina Department of Cardiovascular The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiangChina

BACKGROUND Cardioneuroablation(CNA)has shown encouraging results in patients with vasovagal syncope(VVS).However,data on different subtypes was *** This observational study retrospectively enrolled 141 patients[mean age:40±18 years,51 males(36.2%)]with the diagnosis of *** characteristics among different types of VVS and the outcomes after CNA were *** After a mean follow-up of 4.3±1.5 years,41 patients(29.1%)experienced syncope/pre-syncope events after ***/pre-syncope recurrence significantly differed in each subtype(P=0.04).The cardioinhibitory type of VVS had the lowest recurrence rate after the procedure(n=6,16.7%),followed by mixed(n=26,30.6%)and vasodepressive(n=9,45.0%).Additionally,a significant difference was observed in the analyses of the Kaplan-Meier survival curve(P=0.02).Syncope/pre-syncope burden was significantly reduced after CNA in the vasodepressive type(P<0.01).Vasodepressive types with recurrent syncope/pre-syncope after CNA have a lower baseline deceleration capacity(DC)level than those without(7.4±1.0 ms vs.9.0±1.6 ms,P=0.01).Patients with DC<8.4 ms had an 8.1(HR=8.1,95%CI:2.2-30.0,P=0.02)times risk of syncope/pre-syncope recurrence after CNA compared to patients with DC≥8.4 ms,and this association still existed after adjusting for age and sex(HR=8.1,95%CI:2.2-30.1,P=0.02).CONCLUSIONS Different subtypes exhibit different event-free *** vasodepressive type exhibited the lowest event-free rate,but those patients with DC≥8.4 ms might benefit from CNA.

关键词： syncope subtypes diagnosis