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Liver transplantation with simultaneous splenectomy increases risk of cancer development and mortality in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 930-939页

作者： hsiu-lung fan Chung-Bao Hsieh Shih-Ming Kuo Teng-Wei Chen Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11409Taiwan Division of Pediatric Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11409Taiwan

BACKGROUND Splenectomy has previously been found to increase the risk of cancer development,including lung,non-melanoma skin cancer,leukemia,lymphoma,Hodgkin’s lymphoma,and ovarian *** risk of cancer development in liver transplantation(LT)with simultaneous splenectomy remains *** To compare hepatocellular carcinoma(HCC)recurrence and de novo malignancy between patients undergoing LT with and without simultaneous *** We retrospectively analyzed the outcomes of 120 patients with HCC within the University of California San Francisco criteria who received LT with(n=35)and without(n=85)simultaneous splenectomy in the Tri-Service General *** and multivariate Cox regression analyses for cancer-free survival and mortality were *** comparison of the group survival status and group cancer-free status was done by generating Kaplan–Meier survival curves and log-rank *** The splenectomy group had more hepatitis C virus infection,lower platelet count,higher-fetoprotein level,and longer operating *** and age were both positive independent factors for prediction of cancer development[hazard ratio(HR):2.560 and 1.057,respectively,P<0.05].Splenectomy and hypertension were positive independent factors for prediction of mortality.(HR:2.791 and 2.813 respectively,P<0.05).The splenectomy group had a significantly worse cancer-free survival(CFS)and overall survival(OS)curve compared to the non-splenectomy group(5-year CFS rates:53.4%vs 76.5%,P=0.003;5-year OS rate:68.1 vs 89.3,P=0.002).CONCLUSION Our study suggests that simultaneous splenectomy should be avoided as much as possible in HCC patients who have undergone LT.

关键词： Hepatocellular carcinoma Liver transplantation Splenectomy De novo malignancy Age Hypertension

Predictors of the outcomes of acute-on-chronic hepatitis B liver failure

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World Journal of Gastroenterology 2012年第36期18卷 5078-5083页

作者： hsiu-lung fan Po-Sheng Yang Hui-Wei Chen Teng-Wei Chen De-Chuan Chan Chi-Hong Chu Jyh-Cherng Yu Shih-Ming Kuo Chung-Bao Hsieh Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical Center Division of General Surgery Department of SurgeryMackay Memorial Hospital School of Medicine University of PittsburghPittsburghPA 15261United States Division of Pediatric Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical Center

AIM： To identify the risk factors in predicting the out- come of acute-on-chronic hepatitis B liver failure pa- tients. METHODS： We retrospectively divided 113 patients with acute-on-chronic liver failure-hepatitis B virus （ACLF-HBV） and without concurrent hepatitis C or D virus infection and hepatocellular carcinoma into two groups according to their outcomes after anti-HBV therapy. Their demographic, clinical, and biochemical data on the day of diagnosis and after the first week of treatment were analyzed using the Mann-Whitney U test, Fisher＇s exact test, and a multiple logistic regres- sion analysis. RESULTS： The study included 113 patients （87 men and 26 women） with a mean age of 49.84 years. Fifty- two patients survived, and 61 patients died. Liver failure （85.2%）, sepsis （34.4%）, and multiple organ failure （39.3%） were the main causes of death. Mul- tivariate analyses showed that Acute Physiology and Chronic Health Evaluation （APACHE） Ⅱ scores ≥ 12 [odds ratio （OR） = 7.160, 95% CI： 2.834-18.092, P 〈 0.001] and positive blood culture （OR = 13.520, 95% CI： 2.740-66.721, P = 0.001） on the day of diagnosis and model for end-stage liver disease （MELD） scores 28 （OR = 8.182, 95% CI： 1.884-35.527, P = 0.005） after the first week of treatment were independent predictors of mortality. CONCLUSION： APACHE II scores on the day of diag- nosis and MELD scores after the first week of anti-HBV therapy are feasible predictors of outcome in ACLF- HBV patients.

关键词： Lamivudine Liver failure Hepatitis B virus Acute Physiology and Chronic Health Evaluation ]]score Model for end-stage liver disease scores

Comprehensive risk assessment for early neurologic complications after liver transplantation

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World Journal of Gastroenterology 2016年第24期22卷 5548-5557页

作者： Si-Yuan Wu Teng-Wei Chen An-Chieh Feng hsiu-lung fan Chung-Bao Hsieh Kuo-Piao Chung Division of Organ Transplantation Surgery Department of Surgery Tri-Service General Hospital National Defense Medical Center Institute of Health Policy and Management College of Public Health National Taiwan University

AIM: To determine risk factors for early neurologic complications(NCs) after liver transplantation from perspective of recipient, donor, and surgeon. METHODS: In all, 295 adult recipients were enrolled consecutively between August 2001 and February 2014 from a single medical center in Taiwan. Any NC in the first 30 d post-liver transplantation, and perioperative variables from multiple perspectives were collected and analyzed. The main outcome was a 30-d NC. Generalized additive models were used to detect the non-linear effect of continuous variables on outcome, and to determine cut-off values for categorizing risk. Risk factors were identified using multiple logistic regression analysis. RESULTS: In all, 288 recipients were included, of whom 142(49.3%) experienced at least one NC, with encephalopathy being the most common 106(73%). NCs prolonged hospital stay(35.15 ± 43.80 d vs 20.88 ± 13.58 d, P 27.6 kg/m^2, Child-Pugh class C, history of preoperative hepatoencephalopathy or mental disorders, day 7 tacrolimus level > 8.9 ng/m L, and postoperative intraabdominal infection were more likely associated with NCs. Novel risk factors for NCs were donor age < 22 or ≥ 40 years, male-to-male gender matching, graftrecipient weight ratio 0.9%-1.9%, and sequence of transplantation between 31 and 174. CONCLUSION: NCs post- liver transplantation occurs because of factors related to recipient, donor, and surgeon. Our results provide a basis of risk stratification for surgeon to minimize neurotoxic factors during transplantation.

关键词： Risk Liver transplantation Neurotoxicity syndromes Donor Learning curve

Complete Universal Scaling in First-Order Phase Transitions

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Chinese Physics Letters 2024年第10期41卷 8-13页

作者： fan Zhong School of Physics and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China

Phase transitions and critical phenomena are among the most intriguing phenomena in nature and *** are classified into first-order phase transitions(FOPTs)and continuous *** the latter shows marvelous phenomena of scaling and universality,whether the former behaves similarly is a long-standing controversial *** we definitely demonstrate complete universal scaling in field driven FOPTs for Langevin equations in both zero and two spatial dimensions by rescaling all parameters and subtracting nonuniversal contributions with singular dimensions from an effective temperature and a special field according to an effective *** offers a perspective different from the usual nucleation and growth but conforming to continuous phase transitions to study FOPTs.

关键词： theory. transitions scaling

Semi-analytical Solutions for Wellbores with Graded Skin Zones in Poroelastic Media

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Acta Mechanica Solida Sinica 2024年第3期37卷 385-395页

作者： Zhiqiang fan Zhihe Jin School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China Department of Mechanical Engineering University of MaineOronoME04469USA

In analyzing the complex interaction between the wellbore and the reservoir formation,the hydromechanical properties of the region proximal to the wellbore,referred to as the“wellbore skin zone”,play a pivotal role in determining flow dynamics and the resulting formation *** models of the wellbore skin zone generally assume a constant permeability throughout,resulting in a sharp permeability discontinuity at the skin-reservoir *** paper introduces a model for a wellbore with a continuously graded skin zone of finite thickness within a poroelastic *** solutions are derived using the Laplace transform method,addressing both positive and negative skin *** results are presented to illustrate the effects of graded permeability/skin zone thickness on pore pressures and stresses around a *** results highlight a distinct divergence in stress and pore pressure fields when comparing wellbores with negative skin zones to those with positive skin zones or no skin at all.

关键词： Poroelastic Graded permeability Analytical solution Wellbore Skin zone

A progressive framework for rotary motion deblurring

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Defence Technology（防务技术） 2024年第2期32卷 159-172页

作者： Jinhui Qin Yong Ma Jun Huang fan fan You Du School of Electronic Information Wuhan UniversityWuhan430072China

The rotary motion deblurring is an inevitable procedure when the imaging seeker is mounted in the rotating *** rotary motion deblurring methods suffer from ringing artifacts and noise,especially for large blur *** solve the above problems,we propose a progressive rotary motion deblurring framework consisting of a coarse deblurring stage and a refinement *** the first stage,we design an adaptive blur extents factor(BE factor)to balance noise suppression and details *** a novel deconvolution model is proposed based on BE *** the second stage,a triplescale deformable module CNN(TDM-CNN)is designed to reduce the ringing artifacts,which can exploit the 2D information of an image and adaptively adjust spatial sampling *** establish a standard evaluation benchmark,a real-world rotary motion blur dataset is proposed and released,which includes rotary blurred images and corresponding ground truth images with different blur *** results demonstrate that the proposed method outperforms the state-of-the-art models on synthetic and real-world rotary motion blur *** code and dataset are available at https://***/JinhuiQin/RotaryDeblurring.

关键词： Rotary motion deblurring Progressive framework Blur extents factor TDM-CNN

Seismic response of pile-supported structures considering the coupling of inertial and kinematic interactions in different soil sites

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1350-1361页

作者： Huiling ZHAO fan ZHANG Department of Civil Engineering Shanghai UniversityShanghai 200444China

Dynamic soil−pile−superstructure interaction is crucial for understanding pile behavior in earthquake-prone *** the safety of piles requires determining the seismic bending moment caused by combined inertial and kinematic interactions,which is *** paper addresses this problem through numerical simulations of piles in different soil sites,considering soil *** reveal that the period of the soil site significantly affects the interaction among soil,piles,and *** moments in soft and hard soil sites exceed those in medium soil sites by more than *** modes of piles exhibit distinct characteristics between hard and soft soil *** soil sites exhibit a singular inflection point,while hard soil sites show two inflection *** soft soil sites,pile-soil kinematic interaction gradually increases bending moment from tip to head,with minor influence from superstructure’s inertial *** hard soil sites,significant inertial effects from soil,even surpassing pile-soil kinematic effects near the tip,lead to reversed superposition bending ***’s inertial interaction notably impacts pile head in hard soil sites.A simplified coupling method is proposed using correlation coefficient to represent inertial and kinematic *** findings provide insights into complex seismic interactions among soil,piles,and structures.

关键词： pile seismic response soft soil inertial interaction kinematic interaction

Impact of non-ideal UE hardware on cell-free massive MIMO network with centralized operation

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Science China(Information Sciences) 2024年第4期67卷 255-271页

作者： Ning LI Pingzhi fan Institute of Mobile Communications Southwest Jiaotong University

This paper investigates the impact of non-ideal user equipment(UE) hardware on a cell-free(CF) massive MIMO(mMIMO) network with centralized operation under spatially correlated channels. The minimum mean-squared error(MMSE) estimator can be derived with the help of the generic non-ideal UE hardware model. It is demonstrated that even if the effective signal-to-noise ratio approaches infinity, pilot contamination and imperfect hardware can cause a non-zero estimation error floor. After that, a lower bound is determined for the ergodic uplink capacity of the centralized CF mMIMO network under non-ideal UE hardware. Moreover, the optimal receive combining vector is obtained to maximize the uplink spectral efficiency(SE). The maximum ratio(MR) and regularized zero-forcing(RZF) combining schemes are offered as alternatives in light of the computational complexity of the MMSE receiver. Comparing the RZF to the MMSE scheme under different levels of hardware impairments, our findings indicate that the RZF receiver suffers a negligible loss in total SE. For MR combining, a novel closed-form uplink achievable SE expression is obtained based on the MMSE estimator and the use-and-then-forget bounding technique. This expression gives vital insights into the achievable uplink performance with UE hardware impairments. Besides, for various hardware impairment factors, the impact of pilot sequence length on average sum SE is disclosed for different receive combining schemes. To increase the overall SE of the max-min fairness scheme, a heuristic fractional power control scheme with UE hardware impairments is developed, which can essentially avoid sacrificing the SE of other UEs while maximizing the SE of the unluckiest UE in the whole network. Finally,our theoretical performance analysis and power control algorithm are validated by simulation results, and fundamental design guidelines are provided for selecting hardware satisfying the practical UE requirements.

关键词： cell-free massive MIMO centralized operation spatially correlated channels hardware impairments channel estimation uplink spectral efficiency optimal receive combining pilot length design fractional power control

Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction:Efficient photodegradation of organic pollutant and toxicity evaluation

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Journal of Materials Science & Technology 2024年第3期170卷 200-211页

作者： Yanyan Zhao Xu fan Hongxing Zheng Enzhou Liu Jun fan Xuejun Wang College of Biology Pharmacy and Food Engineering Shangluo UniversityShangluo 726000China QinLing-Bashan Mountains Bioresources Comprehensive Development C.I.C. Shaanxi University of TechnologyHanzhong 723001China School of Chemical Engineering Northwest UniversityXi’an 710069China

Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of *** this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants *** Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and *** study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,*** improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation ***,a S-scheme charge transfer mechanism including multiple charge transfer channels was *** work could provide an effective strategy for organic pollutants degradation in wastewater.

关键词： Photocatalysis S-scheme heterojunction AgInS_(2) Bi_(2)WO_(6) Toxicity experiments