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Acute lung injury and acute respiratory distress syndrome： experimental and clinical investigations

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Journal of Geriatric Cardiology 2011年第1期8卷 44-54页

作者： hsing i Chen institute of Physiological and Anatomical Medicine Tzu Chi University Hualien 97004 Taiwan China

Acute lung injury （ALl） or acute respiratory distress syndrome （ARDS） can be associated with various disorders. Recent investigation has involved clinical studies in collaboration with clinical investigators and pathologists on the pathogenetic mechanisms of ALl or ARDS caused by various disorders. This literature review includes a brief historical retrospective of ALi/ARDS, the neurogenic pulmonary edema due to head injury, the long-term experimental studies and clinical investigations from our laboratory, the detrimental role of NO, the risk factors, and the possible pathogenetic mechanisms as well as therapeutic regimen for ALi/ARDS.

关键词： acute lung injury acute respiratory distress syndrome neurogenic pulmonary edema nitric oxide free radicals cytokines

iL-29 promoted obesity-induced inflammation and insulin resistance

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Cellular & Molecular immunology 2020年第4期17卷 369-379页

作者： Tian-Yu Lin Chiao-Juno Chiu Chen-hsiang Kuan Fang-Hsu Chen Yin-Chen Shen Chih-hsing Wu Yu-hsiang Hsu institute of Clinical Medicine College of MedicineNational Cheng Kung UniversityTainanTaiwanChina Graduate institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Division of Plastic Surgery Department of SurgeryNational Taiwan University HospitalTaipeiTaiwanChina Department of Family Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina Clinical Medicine Research Center National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainanTaiwanChina

Adipocyte-macrophage crosstalk plays a critical role to regulate adipose tissue microenvironment and cause chronic inflammation in the pathogenesis of ***-29(iL-29),a member of type 3 interferon family,plays a role in host defenses against microbes,however,little is known about its role in metabolic *** explored the function of iL-29 in the pathogenesis of obesity-induced inflammation and insulin *** found that serum iL-29 level was significantly higher in obese ***-29 upregulated iL-1β,iL-8,and monocyte chemoattractant protein-1(MCP-1)expression and decreased glucose uptake and insulin sensitivity in human Simpson-Golabi-Behmel syndrome(SGBS)adipocytes through reducing glucose transporter 4(GLUT4)and AKT *** addition,iL-29 promoted monocyte/macrophage *** of iL-29 could reduce inflammatory cytokine production in macrophage-adipocyte coculture system,which mimic an obese *** vivo,iL-29 reduced insulin sensitivity and increased the number of peritoneal macrophages in high-fat diet(HFD)-induced obese ***-29 increased M1/M2 macrophage ratio and enhanced MCP-1 expression in adipose tissues of HFD ***,we have identified a critical role of iL-29 in obesity-induced inflammation and insulin resistance,and we conclude that iL-29 may be a novel candidate target for treating obesity and insulin resistance in patients with metabolic disorders.

关键词： cytokine insulin resistance inflammation obesity

ionogels and eutectogels for stable and long-term EEG and EMG signal acquisition

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Materials Futures 2024年第3期3卷 95-110页

作者： Asmita Veronica Hnin Yin Yin Nyein i-Ming hsing Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Neurological injuries and disorders have a significant impact on individuals’quality of life,often resulting in motor and sensory *** assess motor performance and monitor neurological disorders,non-invasive techniques such as electroencephalography(EEG)and electromyography(EMG)are commonly *** employed wet electrodes with conductive gels are limited by lengthy skin preparation time and allergic *** dry electrodes and hydrogel-based electrodes can mitigate these issues,their applicability for long-term monitoring is *** electrodes are susceptible to motion artifacts,whereas hydrogel-based electrodes face challenges related to water-induced ***,ionogels and eutectogels derived from ionic liquids and deep eutectic solvents have gained immense popularity due to their non-volatility,ionic conductivity,thermal stability,and ***,in particular,exhibit superior *** characteristics make them suitable alternatives for the development of safer,robust,and reliable EEG and EMG ***,research specifically focused on their application for EEG and EMG signal acquisition remains *** article explores the electrode requirements and material advancements in EEG and EMG sensing,with a focus on highlighting the benefits that ionogels and eutectogels offer over conventional *** sheds light on the current limitations of these materials and proposes areas for further improvement in this *** potential of these gel-based materials to achieve a seamless interface for high-quality and long-term electrophysiological signal acquisition is *** the unique properties of ionogels and eutectogels holds promise for future advancements in EEG and EMG electrode materials,leading to improved monitoring systems and enhanced patient outcomes.

关键词： ionogel eutectogel electrode electroencephalography electromyography

Hysteresis and Multi-state Behavior of Counterflow Flame in a Blowing Cylindrical Burner

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Journal of Thermal Science 2009年第3期18卷 276-283页

作者： hsing-Sheng Chai General Education Division Aletheia University

This study focuses on flame hysteresis over a porous cylindrical burner. The hysteresis results from different operation procedure of the experiment. Gradually increasing inflow velocity can transform the envelope flame into a wake flame. The blow-off curve can be plotted by determining every critical inflow velocity that makes an envelope flame become a wake flame at different fuel-ejection velocities. in contrast, decreasing the inflow veiocity can transform the wake or lift-off flame into an envelope one. The reattachment curve can be obtained by the same method to explore the blow-off curve, but the intake process is reverse. However, these two curves are not coincident, except the origin. The discrepancy between them is termed as hysteresis, and it results from the difference between the burning velocities associated with both curves. At the lowest fuel-ejection velocity, no hysteresis exists between both curves owing to nearly no burning velocity difference there. Then, raising the fuel-ejection velocity enhances hysteresis and the discrepancy between the two curves. However, as fuel-ejection velocity exceeds a critical value, the intensity of hysteresis almost keeps constant and causes the two curves to be parallel to each other.

关键词： Hysteresis Blow-off curve Reattachment curve Cylindrical burner Counterflow flame

Degree of nutrient consumption as an aging index of upwelling or vertically mixed water in the northern Taiwan Strait

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Acta Oceanologica Sinica 2005年第1期24卷 115-124页

作者： CHEN Chentung Arthur hsing Liyu institute of Marine Geology and Chemistry National Sun Yat-sen University Kaohsiung ChinaInstitute of Marine Geology and Chemistry National Sun Yat-sen University Kaohsiung China

in order to determine the relative aging status of upwelled or vertically mixed water in the northern Taiwan Strait, a recently developed method of calculating the degree of nutrient consumption (DNC) was employed. Upwelling was detected at a water depth of about 75 m in summer. Bottom waters in the aphotic zone and newly-upwelled waters in the euphoric zone were found to be low in terms of their DNC. in general, a low DNC was noted alongside the other traditional upwelling indicators, such as lower temperature and degree of oxygen saturation, but higher salinity, apparent oxygen utilization, nutrient contents and chlorophyll-a. Enhanced vertical mixing, but without an apparent upwelling signal, was detected near the same location in winter.

关键词： upwelling degree of nutrient consumption Taiwan Strait dissolved organic nitrogen dissolved organic phosphorus

Crushed rocks stabilized with organosilane and lignosulfonate in pavement unbound layers:Repeated load triaxial tests

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Frontiers of Structural and Civil Engineering 2021年第2期15卷 412-424页

作者： Diego Maria BARBiERi inge HOFF Chun-hsing HO Department of Civil and Environmental Engineering Norwegian University of Science and TechnologyTrondheimTrøndelag7491Norway Department of Civil and Environmental Engineering Northern Arizona UniversityFlagstaffAZ86011USA

The creation of the new“Ferry-Free Coastal Highway Route E39”in southwest Norway entails the production of a remarkable quantity of crushed *** resources could be beneficially employed as aggregates in the unbound courses of the highway itself or other road pavements present *** innovative stabilizing agents,organosilane and lignosulfonate,can significantly enhance the key properties,namely,resilient modulus and resistance against permanent deformation,of the aggregates that are excessively weak in their natural *** beneficial effect offered by the additives was thoroughly evaluated by performing repeated load triaxial *** study adopted the most common numerical models to describe these two key mechanical *** increase in the resilient modulus and reduction in the accumulated vertical permanent deformation show the beneficial impact of the ***,a finite element model was created to simulate the repeated load triaxial test by implementing nonlinear elastic and plastic constitutive relationships.

关键词： organosilane lignosulfonate crushed rocks pavement unbound layers repeated load triaxial test finite element analysis

Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TiMP modulation

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Acta Pharmacologica Sinica 2006年第4期27卷 469-476页

作者： Tsung-hsing LEE Allan M CONCEJERO Departments of Anesthesiology Departments of Surgery Kaohsiung Chang Gung Memorial HospitalTaipeiChina

Aim:Liver fibrosis represents a process of healing and scarring in response tochronic liver *** therapies for liver fibrosis are ***-10（iL-10）is a cytokine that downregulates pro-inflarnmatory responses and has amodulatory effect on hepatic *** aim of this study was to investi-gate whether electroporative iL-10 gene therapy has an hepatic fibrolytic effect ***:Hepatic fibrosis was induced by administering carbon tetrachlo-ride（CCl4）for 10 weeks in *** human iL-10 expression plasmid was deliv-ered via electroporation after hepatic fibrosis was ***,reverse transcription polymerase chain reaction（RT-PCR）,immunoblotting,andgelatin zymography were used to investigate the possible mechanisms of actionof ***:Human iL-10 gene therapy reversed CCl4-induced liver fibrosisin ***-PCR revealed that iL-10 gene therapy attenuated liver TGF-β1,col-lagen α1,fibronectin,and cell adhesion molecule mRNA *** transfer,both the activation of(x-smooth muscle actin and cyclooxygenase-2were significantly ***,iL-10 significantly inhibited matrixmetalloproteinase-2（MMP-2）and tissue inhibitors of matrix metalloproteinase（TiMP）activation after ***:We demonstrated that iL-10gene therapy attenuated CCl4-induced liver fibrosis in ***-10 preventedupregulated fibrogenic and pro-inflammatory gene *** collagenolyticeffect may be attributed to MMP and TiMP ***-10 gene therapy maybe an effective therapeutic modality against liver fibrosis with potential clinicaluse.

关键词： interleukin-10 gene therapy liver cirrhosis gelatinase A tissue inhibitor of metalloproteinases cyclooxygenase 2

Oxidation mechanism of aluminum nitride revisited

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Journal of Advanced Ceramics 2017年第1期6卷 27-32页

作者： Chun-Ting YEH Wei-hsing TUAN Department of Materials Science and Engineering 'National Taiwan University' Taipei Taiwan 106 China

Different from the oxidation kinetics of other nitrides,the oxide layer on AlN can easily reach tens of micrometers at a temperature above 1200 ℃.in the present study,the oxidation mechanism of AlN is investigated through microstructure *** analysis indicates that the oxide layer is full of small *** formation of pores generates additional surface area to induce further *** reaction thus controls the oxidation in the temperature range from 1050 to 1350 ℃.The oxidation rate becomes slow as the oxide layer reaches a critical thickness.

关键词： oxidation mechanism aluminum nitride diffusion reaction

investigation of newly developed added damping and stiffness device with low yield strength steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2004年第3期5卷 77-85页

作者： SHiH Ming-hsiang GO Cheer-germ Department of Construction Engineering National Kaoshiang First University of Science and TechnologyDepartment of Civil Engineering National Chung Hsing University Taiwan 824 ChinaTaiwan 40227 China

Energy dissipators, isolated-resistant and specific structural forms for earthquake resistance are popular topics in the research to improve shock-resistance. in this work, experimental methods were used to investigate the property of low yield strength steel. Carbon content in LYS material is lower than that in other steels; the ultimate stress is three times the yield stress. The ultimate elongation rate is about 62% and the ductility is 23 times that of A36 steel. in order to overcome some defects of ordinary use metallic dampers, the mechanical characteristic of low yield strength steel is used to develop added damping and stiffness for rhombic steel plate absorber. Test of the energy dissipation behavior for this newly de-veloped device indicated that LYS could stably dissipate or absorb the input energy of earthquake. Then, the analytical model for the hysteretic behavior of this new device is proposed. Comparison of experimental data and numerical simulation results showed that this analytical model is suitable for simulating the hysteretic energy behavior of this new device.

关键词： Seismic shock absorbance elements Capability of seismic resistance Hysteretic behavior of rhombic steel plate Nonlinear analytical model