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Investigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study

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Microsystems & Nanoengineering 2020年第1期6卷 927-938页

作者： Hae Gyun Lim hsiao-chuan liu Chi Woo Yoon Hayong Jung Min Gon Kim Changhan Yoon Hyung Ham Kim KKirk Shung Department of Creative IT Engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea NIH Resource Center for Medical Ultrasonic Transducer Technology and Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Department of Biomedical Engineering Inje UniversityGimhaeGyeongnam 50834Republic of Korea

Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer *** the progress made in cancer prognosis,we still rely on the visual analysis of tissues or cells from histopathologists,where the subjectivity of traditional manual interpretation *** paper presents the development of a dual diagnosis and treatment tool using an in vitro acoustic tweezers platform with a 50MHz ultrasonic transducer for label-free trapping and bursting of human breast cancer *** cancer cell detection and classification,the mechanical properties of a single cancer cell were quantified by single-beam acoustic tweezers(SBAT),a noncontact assessment tool using a focused acoustic ***-mimicking phantoms and agarose hydrogel spheres(AHSs)served to standardize the biomechanical characteristics of the *** on the analytical comparison of deformability levels between the cells and the AHSs,the mechanical properties of the cells could be indirectly measured by interpolating the Young’s moduli of the *** a result,the calculated Young’s moduli,i.e.,1.527kPa for MDA-MB-231(highly invasive breast cancer cells),2.650kPa for MCF-7(weakly invasive breast cancer cells),and 2.772 kPa for SKBR-3(weakly invasive breast cancer cells),indicate that highly invasive cancer cells exhibited a lower Young’s moduli than weakly invasive cells,which indicates a higher deformability of highly invasive cancer cells,leading to a higher metastasis ***-cell treatment may also be carried out by bursting a highly invasive cell with high-intensity,focused ultrasound.

关键词： diagnosis treatment weakly

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Polar solvent induced in-situ self-assembly and oxygen vacancies on Bi_(2)MoO_(6)for enhanced photocatalytic degradation of tetracycline

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Nano Research 2024年第6期17卷 4951-4960页

作者： Fangyan liu Dongyue Su Weizhen liu Baiquan liu chuan liu Hong Wang Mengye Wang State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and TechnologySchool of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275China School of Materials Sun Yat-Sen UniversityShenzhen 518107China School of Environment and Energy Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and RecyclingSouth China University of TechnologyGuangzhou 510006China

It has been proved to be an effective route to efficiently ameliorate photocatalytic performance of catalysts via designing three-dimensional(3D)hierarchical nanostructures and constructing oxygen vacancies(VOs).However,controlling the self-assembly of organization into 3D hierarchical nanostructures while introducing VOs in photocatalysts remains a ***,we reported an ethylene glycol(EG)mediated approach to craft 3D hydrangea-structure Bi_(2)MoO_(6)with VOs for efficient photocatalytic degradation of *** manipulating the EG concentration during the fabrication process,the influence of EG concentration on the Bi_(2)MoO_(6)structure was systematically *** could promote the self-assembly of Bi_(2)MoO_(6)nanosheets to form a 3D hierarchical *** with 2D nanoplates,3D hierarchical architecture enhanced the surface area and the amount of active sites of Bi_(2)MoO_(6).In addition,the reduction effect of EG on metallic oxide enabled the generation of VOs in Bi_(2)MoO_(6).The VOs adjusted the electronic structure of Bi_(2)MoO_(6),which not only enhanced the light harvesting,but also facilitated the simultaneous utilization of photo-induced electrons and holes to form reactive oxygen species(·O2−and·OH)for the efficient tetracycline decomposition.3D Bi_(2)MoO_(6)hydrangea with VOs achieved a 79.4%removal efficiency of tetracycline after 75 *** work provides a simple yet robust EG-mediated strategy,which not only promotes the self-assembly of nano-catalysts into 3D hierarchical architectures,but also crafts tunable VOs for highly efficient photocatalysis.

关键词： three-dimensional(3D)hierarchical nanostructures tunable oxygen vacancies ethylene glycol(EG)-mediated strategy bismuth molybdate photocatalytic degradation tetracycline

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Graph foundation model

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Frontiers of Computer Science 2024年第6期18卷 186355-186355页

作者： SHI chuan CHEN Junze liu Jiawei liu YANG Cheng School of Computer Science Beijing University of Posts and Telecommunications

Graph Foundation Models represent an evolving direction in graph machine learning. Drawing inspiration from the success of Large Language Models in NLP, GFMs are designed to be trained on extensive graph data and adapted for a diverse array of downstream tasks. In this article, we have explained and introduced the concept of GFMs, comparing them with Language Foundation Models to highlight their similarities and differences. We identified the key technologies in building GFMs as the pre-train and adaptation techniques from the fields of GNNs and LLMs. Additionally, we discussed the potential for GFMs to have significant applications in various domains, ranging from social network analysis to bioinformatics and beyond.

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A Dual Closed-Loop Digital Twin Construction Method for Optimizing the Copper Disc Casting Process

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 581-594页

作者： Zhaohui Jiang chuan Xu Jinshi liu Weichao Luo Zhiwen Chen Weihua Gui IEEE the School of Automation Central South UniversityChangsha 410083China the Peng Cheng Laboratory Shenzhen 518000China

The copper disc casting machine is core equipment for producing copper anode plates in the copper metallurgy *** copper disc casting machine casting package motion curve(CPMC) is significant for precise casting and efficient ***,the lack of exact casting modeling and real-time simulation information severely restricts dynamic CPMC *** this end,a liquid copper droplet model describes the casting package copper flow pattern in the casting ***,a CPMC optimization model is proposed for the first *** top of this,a digital twin dual closed-loop self-optimization application framework(DT-DCS) is constructed for optimizing the copper disc casting process to achieve self-optimization of the CPMC and closed-loop feedback of manufacturing information during the casting ***,a case study is carried out based on the proposed methods in the industrial field.

关键词： Copper disc casting machine digital twin(DT) mechanism modeling self-optimization

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Mismatch loss analysis of solar array output power on stratospheric airship during flight

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Chinese Journal of Aeronautics 2024年第2期37卷 371-384页

作者： Siyu liu Kangwen SUN Haoquan LIANG Xinzhe JI Tong ZOU chuan SHAN School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Yunnan Innovation Institute Beihang UniversityKunming 650233China Institute of Unmanned System Beihang UniversityBeijing 100191China

Stratospheric airships are long-endurance aerostats and have broad *** of the energy required for their operation is obtained from solar radiation,which makes accurate calculation of the energy output from the solar array crucial to the design and flight planning of the ***,the status of each photovoltaic module in the solar array may differ due to the airship curvature,resulting in mismatch losses and lowered output power,which has not been widely *** this paper,an irradiation model and a thermal model are established based on the actual arrangement of the *** output power model is established considering the non-uniform radiation in the *** mismatch losses of the array are analyzed under different flight *** output power of the solar array is decreased by up to 31.6%compared to the ideal ***,the proportion of mismatch losses increases with latitude,but the maximum mismatch loss power occurs at ***,an array reconfiguration method is proposed based on the irradiance dispersion index and position dispersion *** reconfigured array increases output power by 11.5%and can maintain energy balance in continuous *** results can be used to correct the overestimation of the output power during the airship design or to guide the configuration of the solar array.

关键词： Stratospheric airship Solar panels Solar energy Non-uniform irradiation Mismatch loss assessment Reconfiguration

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Resonant Beam Communications:A New Design Paradigm and Challenges

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Journal of Communications and Information Networks 2024年第1期9卷 80-87页

作者： Yuanming Tian Dongxu Li chuan Huang Qingwen liu Shengli Zhou Future Network of Intelligence Institute and School of Science and Engineering the Chinese University of Hong KongShenzhen 518172China School of Science and Engineering and the Future Network of Intelligence Institute the Chinese University of Hong KongShenzhen 518172China College of Electronics and Information Engineering Tongji UniversityShanghai 201804China Department of Electrical and Computer Engineering University of ConnecticutStorrsCT 06250USA

Resonant beam communications (RBCom), which adopts oscillating photons between two separate retroreflectors for information transmission, exhibits potential advantages over other types of wireless optical communications (WOC). However, echo interference generated by the modulated beam reflected from the receiver affects the transmission of the desired information. To tackle this challenge, a synchronization-based point-to-point RBCom system is proposed to eliminate the echo interference, and the design for the transmitter and receiver is discussed. Subsequently,the performance of the proposed RBCom is evaluated and compared with that of visible light communications(VLC)and free space optical communications (FOC). Finally, future research directions are outlined and several implementation challenges of RBCom systems are highlighted.

关键词： resonant beam communications(RBCom) wireless optical communications(WOC) echo interference elimination mobility multiple access

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Sliced Average Variance Estimation for Tensor Data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 630-655页

作者： chuan-quan LI Pei-wen XIAO Chao YING Xiao-hui liu School of Statistics Jiangxi University of Finance and EconomicsNanchang 330013China Key Laboratory of Data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang 330013China Biostatistics and Medical Informatics University of Wisconsin MadisonMadison 53726USA

Tensor data have been widely used in many fields,e.g.,modern biomedical imaging,chemometrics,and economics,but often suffer from some common issues as in high dimensional *** to find their low-dimensional latent structure has been of great interest for *** this end,we develop two efficient tensor sufficient dimension reduction methods based on the sliced average variance estimation(SAVE)to estimate the corresponding dimension reduction *** first one,entitled tensor sliced average variance estimation(TSAVE),works well when the response is discrete or takes finite values,but is not■consistent for continuous response;the second one,named bias-correction tensor sliced average variance estimation(CTSAVE),is a de-biased version of the TSAVE *** asymptotic properties of both methods are derived under mild *** and real data examples are also provided to show the superiority of the efficiency of the developed methods.

关键词： tensor data sliced average variance estimation sufficient dimension reduction central subspace

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Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

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Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao Lu Long Yang Zhuoyang Li Yin liu Shun'en Xu chuan Ye Department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue Engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China Department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China Department of Dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic *** scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were *** subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction *** fabricated P34HB ultrafine fiber slow-release *** ization *** distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active *** vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular *** Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on ***,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 *** findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

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Experimental investigation on pyrolysis products and pore structure characteristics of organic-rich shale heated by supercritical carbon dioxide

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Petroleum Science 2024年第4期21卷 2393-2406页

作者： Bai-Shuo liu chuan-Jin Yao Jia-Long Qi Ya-Qian liu Liang Xu Jing-Xuan Hou State Key Laboratory of Deep Oil and Gas China University of Petroleum (East China) Key Laboratory of Unconventional Oil & Gas Development (China University of Petroleum (East China)) Ministry of Education School of Petroleum Engineering China University of Petroleum (East China)

The efficient pyrolysis and conversion of organic matter in organic-rich shale,as well as the effective recovery of pyrolysis shale oil and gas,play a vital role in alleviating energy *** state of carbon dioxide（CO2） in the pyrolysis environment of shale reservoirs is the supercritical *** unique supercritical fluid properties not only effectively heat organic matter,displace pyrolysis products and change shale pore structure,but also achieve carbon storage to a certain *** samples were made into powder and three sizes of cores,and nitrogen（N2） and supercritical carbon dioxide（ScCO2）pyrolysis experiments were performed at different final pyrolysis *** properties and mineral characteristics of the pyrolysis products were studied based on gas chromatography analysis,Xray diffraction tests,and mass spectrometry ***,the pore structure characteristics at different regions of cores before and after pyrolysis were analyzed using N2adsorption tests to clarify the impact of fracturing degree on the pyrolysis *** results indicate that the optimal pyrolysis temperature of Longkou shale is about 430℃.Compared with N2,the oil yield of ScCO2pyrolysis is *** pyrolysis oil obtained by ScCO2extraction has more intermediate fractions and higher relative molecular *** ScCO2can effectively improve the pore diameter of shale and its effect is better than that of *** micropores are produced in shale after pyrolysis,and the macropores only are generated in ScCO2pyrolysis environments with temperatures greater than 430℃.The pore structure has different development characteristics at different pyrolysis temperatures,which are mainly affected by the pressure holding of volatile matter and products *** to the surface of the core,the pore development effect inside the core is *** the decrease in core size,the pore diameter,specific surface area,and pore volume of cores all increase after pyrolysis.

关键词： Organic-rich shale Supercritical carbon dioxide In-situ pyrolysis Pore structure Core size and region

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Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure

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World Journal of Gastroenterology 2024年第33期30卷 3791-3798页

作者： Zhong-Yuan Xing chuan-Jie Zhang Li-Juan liu Department of Medical Microbiology School of Basic Medical SciencesWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Children Health Care Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430061Hubei ProvinceChina

In this editorial,we comment on the article published in the recent issue of the World Journal of *** liver failure(ALF)is a fatal disease that causes uncontrolled massive hepatocyte death and rapid loss of liver *** and pyroptosis,cell death forms that can be initiated or blocked concurrently,can play significant roles in developing inflammation and various ***,their roles in ALF remain *** article discovered the positive feedback between ferroptosis and pyroptosis in the progression of ALF,and revealed that the silent information regulator sirtuin 1(SIRT1)inhibits both pathways through p53,dramatically reducing inflammation and protecting *** suggests the potential use of SIRT1 and its downstream molecules as therapeutics for ***,we will discuss the role of ferroptosis and pyroptosis in ALF and the crosstalk between these cell death ***,we address potential treatments that could alleviate ALF by simultaneously inhibiting both cell death pathways,as well as examples of SIRT1 activators being used as disease treatment strategies,providing new insights into the therapy of ALF.

关键词： Acute liver failure Ferroptosis Pyroptosis Crosstalk Silent information regulator sirtuin 1 P53 Glutathione peroxidase 4 Gasdermin D Treatment

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