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World Journal of Clinical Cases 2020年第20期8卷 4853-4857页

作者： Ken Goda Tsuneaki Kenzaka Kyosuke Kuriyama Masahiko Hoshijima hozuka akita Department of Internal Medicine Hyogo Prefectural Tamba Medical CenterTamba 669-3495Japan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineKobe 652-0032Japan Department of Medicine Tamba City mirune ClinicTamba 669-3464Japan Clinical Engineer Nursing DepartmentHyogo Prefectural Tamba Medical CenterTamba 669-3495Japan

BACKGROUND High-flow nasal cannula(HFNC)therapy and morphine continuous subcutaneous infusion(CSI)have been used to ameliorate dyspnea in non-cancer patients with end-stage respiratory diseases,including chronic obstructive pulmonary disease and interstitial pneumonia,primarily in hospital ***,it is rare to perform home-based medical treatment using *** observe a case to assess the feasibility of this treatment *** SUMMARY Here,we report a case of a 75-year-old man who was diagnosed with interstitial pneumonia 11 years ago and was successfully nursed at home during his terminal phase for over 10 mo without hospitalization,by introducing domiciliary uses of HFNC and morphine CSI with a patient-controlled analgesia *** Active utilization of HFNC and morphine CSI with patient-controlled analgesia device would substantiate successful end-of-life palliative home care of idiopathic interstitial pneumonia patients.

关键词： High flow nasal cannula Continuous subcutaneous infusion Morphine Patient controlled analgesia Home care Interstitial pneumonia Case report

No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho Satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa Takeshi Ishita Toshihiko Mouri akita Kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

Initial decrease in the lipoprotein(a)level is a novel prognostic biomarker in patients with acute coronary syndrome

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World Journal of Cardiology 2024年第6期16卷 329-338页

作者： Yasuhiko Saeki Jun Sawaguchi Satori akita Taka-aki Takamura Kosuke Fujibayashi Minoru Wakasa Hironobu Akao Michihiko Kitayama Yasuyuki Kawai Kouji Kajinami Department of Cardiology Kanazawa Medical UniversityUchinada 9200293Japan Trans-catheter Cardiovascular Therapeutics Kanazawa Medical UniversityUchinada 9200293Japan

BACKGROUND Lipoprotein(a)[Lp(a)]is a causal risk factor for atherosclerotic cardiovascular diseases;however,its role in acute coronary syndrome(ACS)remains *** To investigate the hypothesis that the Lp(a)levels are altered by various conditions during the acute phase of ACS,resulting in subsequent cardiovascular *** From September 2009 to May 2016,377 patients with ACS who underwent emergent coronary angiography,and 249 who completed≥1000 d of follow-up were ***(a)levels were measured using an isoform-independent assay at each time point from before percutaneous coronary intervention(PCI)to 48 h after *** primary endpoint was the occurrence of major adverse cardiac events(MACE;cardiac death,other vascular death,ACS,and non-cardiac vascular events).RESULTS The mean circulating Lp(a)level decreased significantly from pre-PCI(0 h)to 12 h after(19.0 mg/dL to 17.8 mg/dL,P<0.001),and then increased significantly up to 48 h after(19.3 mg/dL,P<0.001).The changes from 0 to 12 h[Lp(a)Δ0-12]significantly correlated with the basal levels of creatinine[Spearman’s rank correlation coefficient(SRCC):-0.181,P<0.01]and Lp(a)(SRCC:-0.306,P<0.05).Among the tertiles classified according to Lp(a)Δ0-12,MACE was significantly more frequent in the lowest Lp(a)Δ0-12 group than in the remaining two tertile groups(66.2%vs 53.6%,P=0.034).A multivariate analysis revealed that Lp(a)Δ0-12[hazard ratio(HR):0.96,95%confidence interval(95%CI):0.92-0.99]and basal creatinine(HR:1.13,95%CI:1.05-1.22)were independent determinants of subsequent *** Circulating Lp(a)levels in patients with ACS decreased significantly after emergent PCI,and a greater decrease was independently associated with a worse prognosis.

关键词： Lipoprotein(a) Acute coronary syndrome Percutaneous coronary intervention Major adverse cardiac events Prognosis

Surgical strategies for challenging common bile duct stones in the endoscopic era: A comprehensive review of current evidence

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 305-317页

作者： Tharathorn Suwatthanarak Vitoon Chinswangwatanakul Asada Methasate Chainarong Phalanusitthepha Minoru Tanabe Keiichi akita Thawatchai Akaraviputh Minimally Invasive Surgery Unit Department of SurgeryFaculty of Medicine Siriraj HospitalMahidol UniversityBangkok Noi 10700BangkokThailand Graduate School of Medical and Dental Sciences Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan Department of Hepatobiliary and Pancreatic Surgery Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan Department of Clinical Anatomy Tokyo Medical and Dental UniversityBunkyo 113-8519TokyoJapan

While endoscopic retrograde cholangiopancreatography(ERCP)remains the primary treatment modality for common bile duct stones(CBDS)or choledocho-lithiasis due to advancements in instruments,surgical intervention,known as common bile duct exploration(CBDE),is still necessary in cases of difficult CBDS,failed endoscopic treatment,or altered *** evidence also supports CBDE in patients requesting single-step cholecystectomy and bile duct stone removal with comparable *** review elucidates relevant clinical anatomy,selection indications,and outcomes to enhance surgical *** selection between trans-cystic(TC)vs trans-choledochal(TD)approaches is described,along with stone removal techniques and ductal *** surgical techniques and strategies for both the TC and TD approaches,including instrument selection,is also ***,this review comprehensively addresses operation-specific complications such as bile leakage,stricture,and entrapment,and focuses on preventive measures and treatment *** review aims to optimize the management of CBDS through laparoscopic CBDE,with the goal of improving patient outcomes and minimizing risks.

关键词： Choledocholithiasis Common bile duct stone Difficult common bile duct stone Common bile duct exploration Laparoscopic common bile duct exploration

Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

The Implications of Population Decline and Fiscal Austerity on Public Nature:Insights From the Evolution of Urban Park Management System in Japan

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景观设计学（中英文） 2024年第4期12卷 8-25页

作者： Xizi XU Fumihiko SETA Noriko akita Kai ZHOU School of Urban and Environmental Sciences Hunan University of TechnologyZhuzhou 412000China Department of Urban Engineering The University of TokyoTokyo 113-8654Japan Graduate School of Horticulture Chiba UniversityChiba 271-8510Japan Department of Urban and Rural Planning School of Architecture and PlanningHunan UniversityChangsha 410082China

Facing challenges of population decline and fiscal austerity,Japan has implemented a series of initiatives to promote public-private partnerships(PPP)to ensure the sustainability of urban parks and revitalize urban *** initiatives,while alleviating the government’s financial burdens on parks,have also raised concerns about the potential erosion of publicness and public interests resulted from the commercialization of public *** paper reviews the evolution of Japan’s urban park management system after World War II—including three phases of being purely public goods,initiating marketization,and diversifying management *** functions of parks have continuously enriched,and the construction,management,and operational modes have shifted from government-led towards multi-stakeholder participation,along with expanded funding *** examining the PPP types,driving forces,implementation mechanisms and challenges in urban park management,this paper points out that,in different eras and social contexts,the Japanese government has kept adjusting its role to maximize public *** has proactively updated the implications of publicness in infrastructure like urban parks,from a post-war opposite of publicness versus privateness on ownership,to the participation of private capital for a higher efficiency,and finally to a community for a stronger regional *** reforms of urban park management system in Japan offer significant lessons and insights for urban infrastructure management in other countries and regions.

关键词： Publicness Landscape Justice Public-Private Partnership “Private Finance Initiative”System for Parks Urban Parks Management System Urban Infrastructure

Surgical treatment algorithms for post-burn contractures

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Burns & Trauma 2017年第1期5卷 1-8页

作者： Kenji Hayashida Sadanori akita Division of Plastic and Reconstructive Surgery Department of DermatologyFaculty of MedicineShimane University Hospital89-1Enya-choIzumoShimane693-0021Japan Department of Plastic Surgery Wound Repair andRegenerationFukuoka UniversityFukuokaJapan.

Burn contractures produce restrictions in motion and unacceptable aesthetic results, frequently with persistent wounds. Proper planning and tissue selection are essential to minimize donor site morbidity optimizing outcomes. The principle of burn reconstructive surgery requires that the defects after release should be replaced with donor tissues which have matching texture and color as well as enough pliability. Autologous skin grafting or flap surgeries meet these criteria to replace scar tissues and resurface the subsequent to post-released scar defects. Despite the benefits, the use of flaps is often limited in burn patients for many reasons. If a surgeon intends to release completely and reconstruct in one-stage operation, a large defect may result in large donor site morbidity, necessitating flap surgery including free flap surgery. A lot of different methods and procedures are available for resurfacing the defects, and these are reviewed. In this article, algorithms for the release of burn contractures and reconstructive methods are presented. These treatment algorithms should aid in achieving significant improvement in both joint motions and aesthetic deformities.

关键词： BurnContracture Algorithm Donor site morbidity Perforator flap Surgical treatment

One-Step Synthesis of Magnetically Recyclable Au/Co/Fe Triple- Layered Core-Shell Nanoparticles as Highly Efficient Catalysts for the Hydrolytic Dehydrogenation of Ammonia Borane

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Nano Research 2011年第12期4卷 1233-1241页

作者： Kengo Aranishi Hai-Long Jiang Tomoki akita Masatake Haruta Qiang Xu National Institute of Advanced Industrial Science and Technology （AIST） Ikeda Osaka 563-8577 Japan Graduate School of Engineering Kobe University Nada Ku Kobe Hyogo 657-8501 Japan Graduate School of Urban Environmental Sciences Tokyo Metropolitan University Minami-Osawa Hachioji Tokyo 192-0397 Japan Core Research for Evolutional Science and Technology （CREST） Japan Science and Technology Agency （JST） Kawaguchi Saitama 332-0012 Japan

Magnetically recyclable Au/Co/Fe core-shell nanoparticles （NPs） have been successfully synthesized via a one-step in situ procedure. Transmission electron microscope （TEM）, energy dispersive X-ray spectroscopic （EDS）, and electron energy-loss spectroscopic （EELS） measurements revealed that the trimetallic Au/Co/Fe NPs have a triple-layered core-shell structure composed of a Au core, a Co-rich inter-layer, and a Fe-rich shell. The Au/Co/Fe core-shell NPs exhibit much higher catalytic activities for hydrolytic dehydrogenation of ammonia borane （NHBBH3, AB） than the monometallic （Au, Co, Fe） or bimetallic （AuCo, AuFe, CoFe） counterparts.

关键词： Triple-layered core-shell nanoparticles heterogeneous catalysis ammonia borane hydrogen generation

Total Synthesis of L-Oleandrose and L-Cymarose from an Achiral Precursor, Methyl Sorbata

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Chinese Chemical Letters 2006年第6期17卷 730-732页

作者： Xi Ying ZHAO Machiko ONO Hiroyuki akita Yu Ming CHI Beijing Umverslty of Traditional Chinese Medicine and Pharmacy Beijing 100029 School of Pharmaceutical Sciences Toho University Chiba-274-8510japan Seiwa Pharmaceutical. Ltd.Ibarki 3-19-1535 Japan

2,6-Dideoxy sugars L-oleandrose 1 and L-cymarose 2, the key carbohydrate of antibiotics and cardiac glycosides, were synthesized by an efficient synthetic method from an achiral precursor, methyl sorbate.

关键词： L-Oleandrose L-cymarose methyl sorbate.

Asymmetric Syntheses of Osmundalactones and 5-Hydroxy-2-hexen-4-olides from 4-Benzyloxy-5-hydroxy-2(E)-hexenoate

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Chinese Chemical Letters 2006年第6期17卷 727-729页

作者： Xi Ying ZHAO Machiko ONO Hiroyuki akita Yu Ming CHI Beijing University of Traditional Chinese Medicine and Pharmacy Beijing 100029 School of Pharmaceutical Sciences Toho University Chiba 274-8510 Japan Seiwa Pharmaceutical. Ltd. Ibaraki 319-1535 Japan

（＋）-（4S,5R）-and （-）-（4R,5S）-osmundalactones as well as （＋）-（4R,5S）- and （-）-（4S,5R）- 5-hydroxy-2-hexen-4-olides were synthesized by a concise and efficient synthesis method starting from 4-benzyloxy-... 详细信息

关键词： Osmundalactone 5-hydroxy-2-hexen-4-olide 4-benzyloxy-5-hydroxy-2(E)-hexenoate.