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Prospect of Animal Models for Acute-on-chronic Liver Failure:A Mini-review

Journal of Clinical and Translational Hepatology 2022年第5期10卷 995-1003页

作者： hozeifa mohamed hassan Jun Li Precision Medicine Center Taizhou Central Hospital(Taizhou University Hospital)TaizhouZhejiangChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

Acute-on-chronic liver failure(ACLF)is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan *** a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment *** this context,this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.

关键词： Liver failure Acute-on-chronic liver failure Animal model Hepatotoxicants Inflammation

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Effects of methanolic extract of yohimbe bark (Pausinystalia yohimbe) on isolated rabbit aortic strip and rat uterus

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Health 2013年第6期5卷 1016-1020页

作者： hozeifa mohamed hassan Imad mohamed Taj Eldin Elhadi mohamed Ahmed Abd Elwahab hassan mohamed Nizar Sirag Department of Pharmacognosy Faculty of Pharmacy University of Gezira Wad Medani Sudan Department of Pharmacology and Toxicology Medicinal and Aromatic Plant Research Institute National Centre of Research Khartoum Sudan Department of Pharmacology Faculty of Pharmacy University of Gezira Wad Medani Sudan

Background: Medicinal plants contain physiologically active principles that over the years have been exploited in traditional medicine for the treatment of various ailments. Objectives and Methods: This study aimed to investigate the effects of the methanolic extract of Pausinystalia yohimbe bark (5 mg/ml) on isolated rabbit aortic strip and rat uterus. Results: methanolic extract of P. yohimbe bark (5 mg/ml) produced relaxation of the phenylephrine precontracted-rabbit aortic strip. This relaxation may be resulted through nitric oxide (NO), since the pretreatment of the isolated rabbit aortic strip with methylene blue inhibited the NO-mediated relaxation. Moreover, the extract exhibited relaxation of rat uterine muscles, which appeared to be not mediated by activation of β2-adrenoceptors and/or H2 receptors, since the relaxant effect continued even after the pretreatment of the tissue with propranolol and ranitidine respectively. Conclusion: The obtained results revealed that methanolic extract of P. yohimbe bark caused relaxation of both isolated rat uterus and rabbit aortic strip through facilitating the role of endogenous compounds such as NO.

关键词： P. yohimbe Bark Isolated Tissues Aortic Strip Rat Uterus Relaxation Nitric Oxide

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Effects of methanolic extract of Pausinystalia yohimbebark on blood glucose level in normal fasting rats

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Health 2012年第12期4卷 1225-1228页

作者： hozeifa mohamed hassan Taj Eldin Imad mohamed Elhadi mohamed mohamed Ahmed Abd Elwahab hassan mohamed Nizar Sirag Department of Pharmacognosy Faculty of Pharmacy University of Gezira Wad Medani Sudan Department of Pharmacology and Toxicology Medicinal and Aromatic Plant Research Institute National Centre of Research Khartoum Sudan Department of Pharmacology Faculty of Pharmacy University of Gezira Wad Medani Sudan

Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels;such effect is unclear and remains requiring further studies.

关键词： Pausinystalia yohimbe Bark Yohimbine Fasting Blood Glucose Level Hypoglycemia

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The relaxant effect of methanolic extract of yohimbe bark (Pausinystalia yohimbe) on rabbit corpus cavernosum smooth muscles

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Health 2012年第9期4卷 656-659页

作者： mohamed hassan hozeifa Imad Eldin mohamed Taj Eldin mohamed mohamed Ahmed Elhadi hassan mohamed Abd Elwahab Sirag Elteyb Nizar Department of Pharmacognosy Faculty of Pharmacy University of Gezira Wad Madani Sudan Department of Pharmacology and Toxicology Medicinal and Aromatic Plant Research Institute National Center for Research Khartoum Sudan Department of Pharmacology Faculty of Pharmacy University of Gezira Wad Madani Sudan

Background: Development and maintenance of penile erection requires the relaxation of corpus cavernosum smooth muscle (CCSM) cells and it is essentially mediated by nitric oxide (NO). Pausinystalia yohimbe bark is traditionally used for the treatment of erectile dysfunction (ED). Objectives and Methods: This study aimed to evaluate the effects of the methanolic extract of P. yohimbe bark (10 mg/ml) on isolated rabbit corpus cavernosum smooth muscle (CCSM). Results: Methanolic extract of P. yohimbe bark blocked contractions in CCSM induced by adrenergic agonists, through facilitating NO release from the endothelial cells. Conclusion: The obtained results revealed that, methanolic extract of P. yohimbe bark caused relaxation of CCSM that validates its traditional aphrodisiac property, thus it could be used to initiate and maintain erection in cases of erectile dysfunction.

关键词： P. yohimbe Bark Corpus Cavernosum Relaxation Nitric Oxide Aphrodisiac Erectile Dysfunction

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