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Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

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Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： hoyoun won Wang Soo Lee Sang-Wook Kim Byung Ryul Cho Young Jin Youn Young-Hyo Lim Min-Ho Lee Jae-Hwan Lee Seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal won-Ha Lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae won Hongwei Song Lin Xu Jong Seung Kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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Cascade Grating Structure for Increasing the Channel Number on Holographic Demultiplexer

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Chinese Physics Letters 2006年第6期23卷 1459-1461页

作者： Jun won AN Research Center LGS Co. Ltd. 248-1 Sancheok-ri Dongtan-myeon Hwasung-si Gyeonggi-do 445-812 Korea

The expansion capability of the channel number in the optical demultiplexer using two cascaded photopolymer volume gratings is reported. It could be accomplished by designing of two gratings with different spectral range. As a result of the experiment, a 0.4-nm-spaced 130-channel demultiplexer with the channel uniformity of 3.5 dB, the 3 riB-bandwidth of 0.12nm, and the channel crosstalk of-20 dB is experimentally demonstrated.

关键词： Cascade Grating Structure Holographic Demultiplexer

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Optical Security System Based on the Biometrics Using Holographic Storage Technique with a Simple Data Format

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Chinese Physics Letters 2006年第1期23卷 116-119页

作者： Jun won AN Research Centre LGS Co. Ltd. 248-1 Sancheok-ri Dongtan-myeon Hwasung-si Gyeonggi-do 445-812 Korea

We implement a first practical holographic security system using electrical biometrics that combines optical encryption and digital holographic memory technologies. Optical information for identification includes a picture of face, a name, and a fingerprint, which has been spatially multiplexed by random phase mask used for a decryption key. For decryption in our biometric security system, a bit-error-detection method that compares the digital bit of live fingerprint with of fingerprint information extracted from hologram is used.

关键词： Optical Security Biometrics Using

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Study on durability of Pt supported on graphitized carbon under simulated start-up/shut-down conditions for polymer electrolyte membrane fuel cells

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Journal of Energy Chemistry 2018年第1期27卷 326-334页

作者： won Suk Jung Department of Chemical Engineering University of South CarolinaColumbiaSC 29208USA

The primary issue for the commercialization of proton exchange membrane fuel cell（PEMFC） is the carbon corrosion of support under start-up/shut-down conditions. In this study, we employ the nanostructured graphitized carbon induced by heat-treatment. The degree of graphitization starts to increase between 900 and 1300 ℃ as evidenced by the change of specific surface area, interlayer spacing, and ID/IG value. Pt nanoparticles are deposited on fresh carbon black（Pt/CB） and carbon heat-treated at 1700 ℃（Pt/HCB17） with similar particle size and distribution. Electrochemical characterization demonstrates that the Pt/HCB17 shows higher activity than the Pt/CB due to the inefficient microporous structure of amorphous carbon for the oxygen reduction reaction. An accelerating potential cycle between 1.0 and 1.5 V for the carbon corrosion is applied to examine durability at a single cell under the practical start-up/shutdown conditions. The Pt/HCB17 catalyst shows remarkable durability after 3000 potential cycles. The Pt/HCB17 catalyst exhibits a peak power density gain of 3%, while the Pt/CB catalyst shows 65% loss of the initial peak power density. As well, electrochemical surface area and mass activity of Pt/HCB17 catalyst are even more stable than those of the Pt/CB catalyst. Consequently, the high degree of graphitization is essential for the durability of fuel cells in practical start-up/shut-down conditions due to enhancing the strong interaction of Pt and π-bonds in graphitized carbon.

关键词： Polymer electrolyte membrane fuel ceils Membrane electrolyte assembly Carbon corrosion Start-up/shut-down Durability

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Surface-enhanced Raman spectroscopy for emerging contaminant analysis in drinking water

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 51-65页

作者： Seo won Cho Haoran Wei Environmental Chemistry and Technology Program University of Wisconsin–MadisonMadisonWI 53706USA Department of Civil and Environmental Engineering University of Wisconsin–MadisonMadisonWI 53706USA

Emerging contaminants(ECs)in drinking water pose threats to public health due to their environmental prevalence and potential *** occurrence of ECs in our drinking water supplies depends on their physicochemical properties,discharging rate,and susceptibility to removal by water treatment *** health effects of long-term exposure to ECs justify their regular monitoring in drinking water *** this review article,we will summarize the current status and future opportunities of surface-enhanced Raman spectroscopy(SERS)for EC analysis in drinking *** principles of SERS are first introduced and a comparison of SERS and liquid chromatography-tandem mass spectrometry in terms of cost,time,sensitivity,and availability is ***,we discuss the strategies for designing effective SERS sensors for EC analysis based on five categories—per-and polyfluoroalkyl substances,novel pesticides,pharmaceuticals,endocrine-disrupting chemicals,and *** addition to maximizing the intrinsic enhancement factors of SERS substrates,strategies to improve hot spot accessibilities to the targeting ECs are equally *** is a review article focusing on SERS analysis of ECs in drinking *** discussions are not only guided by numerous endeavors to advance SERS technology but also by the drinking water regulatory policy.

关键词： Emerging contaminant Surface-enhanced Raman spectroscopy Drinking water monitoring Sensor Regulatory policy

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The Effect of Grain Size on the Viscosity and Yield Stress of Fine-Grained Sediments

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Journal of Mountain Science 2014年第1期11卷 31-40页

作者： Sueng won JEONG Korea Institute of Geoscience and Mineral Resources

In debris flow modelling,the viscosity and yield stress of fine-grained sediments should be determined in order to better characterize sediment *** particular,it is important to understand the effect of grain size on the rheology of fine-grained sediments associated with *** looking at the relationship between shear stress and shear rate before yielding,a high-viscosity zone(called pseudoNewtonian viscosity) towards the apparent yield stress *** yielding,plastic viscosity(called Bingham viscosity) governs the *** examine the effect of grain size on the rheological characteristics of fine-grained sediments,clay-rich materials(from the Adriatic Sea,Italy; Cambridge Fjord,Canada; and the Mediterranean Sea,Spain),silt-rich debris flow materials(from La Valette,France) and silt-rich materials(iron tailings from Canada) were *** characteristics were examined using a modified Bingham *** materials examined,including the Canadian inorganic and sensitive clays,exhibit typical shear thinning behavior and strong *** the relationships between the liquidity index and rheological values(viscosity and apparent yield stress),the effect of grain size on viscosity and yield stress is significant at a given liquidity *** viscosity and yield stress of debris flow materials are higher than those of low-activity clays at the same liquid *** the viscosity and yield stress of the tailings,which are mainly composed of silt-sized particles,are slightly lower than those of low-activity clays.

关键词： Debris Flow Viscosity Yield Stress Grain Size Fine-Grained Sediments

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