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Is fat-free mass-based gentamicin dosing regimen preferable than whole-body weight in neonates?

Pediatric Investigation 2023年第2期7卷 86-94页

作者： Kannan Sridharan Muna Al Jufairi Eman Al Ansari Lulwa Alsadah howra wasel Department of Pharmacology and Therapeutics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain Neonatal Intensive Care Unit Salmaniya Medical ComplexMinistry of HealthManamaKingdom of Bahrain Department of Pediatrics College of Medicine and Medical SciencesArabian Gulf UniversityManamaKingdom of Bahrain College of Medicine and Medical Sciences Arabian Gulf UniversityManamaKingdom of Bahrain

Importance:Body fluid dynamics and renal maturation status vary during the neonatal *** hypothesized that differences in peak and trough gentamicin concentrations could be ***:To predict the peak and trough gentamicin concentrations in critically ill neonates and to predict the changes in the predicted peak plasma concentrations of gentamicin following fat-free mass ***:Critically ill neonates that received gentamicin and have gentamicin concentration measured were *** mass was estimated using skinfold *** in the peak plasma concentrations(Cmax)using whole-body weight(estimated using the current dosing regimen)and predicted concentrations following the fat-free mass-based dosing were the outcome ***:Eighty-nine critically ill neonates were ***-therapeutic Cmax was estimated using the current dosing regimen in 32.6%,and 22.5%neonates following the first and second doses of *** neonates had significantly higher fat mass compared to term *** except one had Cmax above 12μg/ml after the first dose and all had after the second gentamicin dose following the predicted fat-free massbased gentamicin *** recommended doses are as follows:extreme preterm:7.95 mg/kg every 48 h;very preterm:7.30 mg/kg every 36-48 h;late preterm:5.90 mg/kg every 36-48 h;and term neonates at 5.10 mg/kg every 24 ***:Fat-free mass dosing may be considered for obtaining optimal therapeutic effects in the neonatal population.

关键词： Aminoglycosides Body weight Fat Fat-free mass Gentamicin

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