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Prescription practice of antihistamines for acute upper respiratory tract infections in pediatric patients in a local emergency department in Hong Kong

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World Journal of Emergency Medicine 2017年第1期8卷 47-54页

作者： chun tat Lui Department of Accident and Emergency Medicine Tuen Mun HospitalHong KongChina

BACKGROUND: Currently there is very limited data in the literature assessing the prevalence of antihistamine prescription, and there is no local prevalence data about the prescription of antihistamine agents among primary practitioner and emergency physicians. The objectives are 1) to report the prevalence of antihistamine prescription for children less than 6 years old with acute upper respiratory infection and 2) to explore the associated factors for the prescription ***: This is a cross-sectional study. All consecutive cases of paediatric patients aged 6 or below who presented to the emergency department during a study period of one week from April 1 to July 4, 2009 with diagnosis of acute upper respiratory infection were included. Totally 162 patients were ***: Among the 162 cases, 141(87%) patients were prescribed one antihistamine of any group. Sixty(37%) patients were prescribed two or more antihistamines. In multivariate logistic regression model, age was found to be signi? cantly(P<0.001) associated with multiple antihistamine prescription(OR=1.042, 95%CI=1.02 to 1.06). Years of graduation of attending physician for more than 5 years was also a strong predictor of multiple antihistamine prescription(OR=4.654, 95%CI=2.20 to 9.84, P<0.001).CONCLUSION: In the local emergency department, patients' age and the years of graduation from medical school of the attending physician were predictors of multiple antihistamine prescription for acute upper respiratory infections for children aged less than 6.

关键词： Upper respiratory infections Respiratory tract infections Common cold Drug prescription Drug utilization Prescription practice Antihistamine Histamine antagonist Children

Bevacizumab for neovascular age-related macular degeneration in Chinese patients in a clinical setting

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 424-430页

作者： Danny Siu-chun Ng Alvin Kwan-Ho Kwok Justin Man-Kit Tong Clement Wai-Nang chan Walton Wai-tat Li Department of Ophthalmology & Visual Sciences the Chinese University of Hong Kong Department of Ophthalmology Hong Kong Sanatorium and Hospital Department of Ophthalmology United Christian Hospital

AIM：To determine the outcome of non-investigational treatment with intravitreal bevacizumab（IVB） in neovascular age-related macular degeneration（AMD）patients.· METHODS：Retrospective chart review of 81 eyes with neovascular AMD followed-up for at least 12 mo and received 3-monthly loading IVB ***-treat was based upon the individual clinician＇s *** visual acuity（BCVA） and optical coherence tomography measurements of central foveal thickness outcomes were evaluated at 12,24 mo.· RESULTS：Eighty-one eyes（of 75 patients） completed12 mo of follow-up and 44 eyes（of 41 patients） completed24 mo of *** mean baseline logMAR BCVA significantly improved from 0.94±0.69 to 0.85±0.68 at12mo（P〈0.001） and from 0.91±0.65 to 0.85±0.60（P=0.004）at 24 *** proportion of eyes that lost 〈15 logMAR letters at 12 mo was 90.1%and at 24 mo was 81.8%.IVB was effective in improving visual acuity in both treatment naive and previous photodynamic therapy（PDT）-treated *** naive patients required significantly fewer injections than patients with prior *** regression analysis identified that poorer baseline visual acuity was associated with greater improvement in visual acuity（P=0.015）.· CONCLUSION：Fewer injections in clinical practice may result in suboptimal visual outcomes compared with clinical trials of IVB in neovascular AMD *** baseline visual acuity and prior PDT treatment may also improve vision after *** safety and durability of effect was maintained at 24 mo.

关键词： bcvacizumab age-related maculardegeneration Chinese

Cobalt Porphyrin Catalyzed Carbon-Carbon Bond Transfer Hydrogenation with DMF

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Cobalt Porphyrin Catalyzed Carbon-Carbon Bond Transfer Hydro...

Quality indicators in pediatric colonoscopy in a low-volume center:Implications for training

中国化学会第四届卟啉与酞菁学术研讨会

作者： chun Meng Tam Ching tat To Kin Shing chan Department of Chemistry The Chinese University of Hong Kong

The Co(ttp) catalyzed carbon-carbon bond transfer hydrogenation of [2.2]paracyclophane(PCP) with DMF was *** investigation suggested that the benzylic carbon-carbon bond of PCP reacts with Co II(ttp) to generate 1,subsequent homolysis of Co-C bond and hydrogen atom abstraction yield 2 and regenerate the Co(ttp) *** mechanism of cobalt porphyrin catalysis is distinctly different from the rhodium and iridium catalyses.1,2

关键词： C-C bond hydrogenation transfer hydrogenation cobalt porphyrin N,N-dimethylformamide

来源： cnki会议评论

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World Journal of Gastroenterology 2018年第9期24卷 1013-1021页

作者： Way-Seah Lee chun-Wei Tee Zhong-Lin Koay tat-Seng Wong Fatimah Zahraq Hee-Wei Foo Sik-Yong Ong Shin-Yee Wong Ruey-Terng Ng Department of Paediatrics University Malaya Medical CentreKuala Lumpur 59100Malaysia Paediatric and Child Health Research Group University MalayaKuala Lumpur 50603Malaysia

AIM To study implications of measuring quality indicators on training and trainees' performance in pediatric colonoscopy in a low-volume training *** We reviewed retrospectively the performance of pediatric colonoscopies in a training center in Malaysia over 5 years(January 2010-December 2015), benchmarked against five quality indicators: appropriateness of indications, bowel preparations, cecum and ileal examination rates, and complications. The European Society of Gastrointestinal Endoscopy guideline for pediatric endoscopy and North American Society for Pediatric Gastroenterology, Hepatology and Nutrition training guidelines were used as *** Median(± SD) age of 121 children [males = 74(61.2%)] who had 177 colonoscopies was 7.0(± 4.6) years. On average, 30 colonoscopies were performed each year(range: 19-58). Except for investigations of abdominal pain(21/177, 17%), indications for colonoscopies were appropriate in the remaining 83%. Bowel preparation was good in 87%. One patient(0.6%) with severe Crohn's disease had bowel perforation. Cecum examination and ileal intubation rate was 95% and 68.1%. Ileal intubation rate was significantly higher in diagnosing or assessing inflammatory bowel disease(IBD) than non-IBD(72.9% vs 50.0%; P = 0.016). Performance of four trainees was consistent throughout the study period. Average cecum and ileal examination rate among trainees were 97% and 77%.CONCLUSION Benchmarking against established guidelines helps units with a low-volume of colonoscopies to identify area for further improvement.

关键词： Pediatric colonoscopies Quality indicators Performance

A Survey of Mental Health of New Patients at Traditional Chinese Medical Clinic

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Chinese Medicine 2011年第1期2卷 32-35页

作者： Siu Man Ng Ted chun tat Fong Xiao Lu Wang 不详

In Chinese societies, traditional Chinese medical clinics are popular and play a significant role in primary healthcare. The current study aimed to examine the mental health of new patients at Chinese medical clinic. A cross-sectional questionnaire survey was conducted. Subjects were new patients of a Chinese medical clinic recruited through 100% consecutive sampling during a 5-week period. A response rate of 84.2% and a sample size of 367 were achieved. Sample included 111 (30.2%) men and 256 (69.8%) women. Mean age was 44.0 (SD = 17.1). Presenting problems were all somatic, with 68.3% lasted over 1 month and 37.1% lasted over 1 year. In the month prior to first consultation, 26.4%, 33.2% and 19.3% patients consulted other public, private and Chinese medical clinic on average 1.5, 1.9 and 3.0 times respectively. Besides, 7.4% and 6.5% patients self-administered Western and Chinese drugs on average 1.3 and 2.4 times respectively. Using a cut-off of ? 5 on GHQ-12, prevalence of common mental disorders was estimated at 21.0%. In conclusion, findings revealed that common mental disorders were prevalent among new Chinese medicine patients al-though presenting problems of subjects were all somatic. Many of these presenting medical conditions were chronic, with 68.3% lasting over 1 month and 37.1% lasting over 1 year. Over 70% patients had been seek-ing various forms of treatment in the month prior to first consultation. Mental health and illness behavior of Chinese medicine patients warrants further research and attention.

关键词： Alternative Medicine Mental Health Primary Healthcare

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Limits of Fidelity

外语研究 2019年第3期36卷 1-9,112页

作者：葛浩文林丽君不详

本主旨发言探讨文学翻译,尤其关注当代中国小说翻译。讨论聚焦翻译中的忠实,具体议题为忠实的限度。通过援引译事译例,就翻译中国小说是否应当保持忠实表达自己的观点。讲者首先分享自己阅读及翻译现当代中国小说的经验,并对“译文优于... 详细信息

本主旨发言探讨文学翻译,尤其关注当代中国小说翻译。讨论聚焦翻译中的忠实,具体议题为忠实的限度。通过援引译事译例,就翻译中国小说是否应当保持忠实表达自己的观点。讲者首先分享自己阅读及翻译现当代中国小说的经验,并对“译文优于或改进了原文”提出理性思考:这一说法到底是挖苦式赞美还是言之成理?接下来,讲者分析饱受争议的“创造性翻译”。当人们指出或指责译者在进行创造性翻译时,他究竟想表达什么?创造性翻译是违反原则的逾矩,还是为使译文更加顺畅的必要之举?此外,讲者还进一步阐释西方读者阅读一部非西方国家小说时,为何倾向于将其当作原语国家的代表。发言最后回到“忠实”与“可读性”的对立之上,呼吁译者在面对文化交流中一直存在的单向不平等时,抵制归化十分重要。

关键词：中国当代文学萧红莫言经典外译忠实异化归化

Utilization of the Accident & Emergency Departments by Chinese elderly in Hong Kong

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World Journal of Emergency Medicine 2015年第4期6卷 283-288页

作者： Wai Lam Yip Kit Ling Fan chun tat Lui Ling Pong Leung Fu Ng Kwok Leung Tsui Accident & Emergency Department Queen Mary Hospital Emergency Medicine Unit The University of Hong Kong Accident & Emergency Department Tuen Mun Hospital Accident & Emergency Department Caritas Medical Centre

BACKGROUND: The epidemiological data on elderly patients attending Accident and Emergency Departments(AEDs) in Hong Kong is lacking. The study aimed to examine the epidemiology of geriatric patient visits to AEDs in Hong Kong, including demographic data and predictors of life-saving interventions(LSI) and ***: A retrospective cross-sectional study of geriatric patients older than 64 years old attending three AEDs during the year 2012, with a sample of 1 200 patient visits recruited. The data were retrieved from the medical records of the respective hospitals. Descriptive characteristics of the visits were provided. Multivariate logistic regression was performed to evaluate the predictors of LSI and hospital ***: The mean age of the patients was 79.1 years. Totally 49.7% of the patients were male. "Diseases of the respiratory system" was the commonest diagnosis in AEDs as well as that required admission. The admission rate was 56.8%. Logistic regression demonstrated that dependent activity of daily living(ADL), arrival by ambulance, and the higher number of co-morbidities were predictors of LSI, while advanced age, dependent ADL, institutionalized patients, arrival by ambulance, and higher number of co-morbidities were predictors of hospital ***: Ageing population is creating an imminent burden on the emergency service in Hong Kong. Previously unavailable epidemiological information about geriatric attendance to AEDs was described. This forms the basis for development of future studies concerning the medical services on this specific group of patients.

关键词： Elderly Geriatric Emergency department Epidemiology

Protein dynamics elucidated by NMR technique

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Protein & Cell 2013年第10期4卷 726-730页

作者： Conggang Li chun Tang Maili Liu Key Laboratory of Magnetic Resonance in Biological Systems Wuhan Center for Magnetic ResonanceState Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China

In 1957,Christian Anfinsen postulated his famous dogma based on the study of ribonuclease(Sela et al.,1957),stating that the amino acid sequence of a protein determines its tertiary structure,a unique and kinetically accessible energy minimum,in a given *** a result,determination of a global energy minimum,or the most populated structure,has been the main focus of structural biology in the ensuing half a *** more and more structures have been determined,people have gain some insights of why protein functions,but the detailed mechanisms and the function process,or how protein functions,remains elusive.

关键词： elucidated structure dynamics

Effects of resistance training on cardiovascular health in non-obese active adolescents

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World Journal of Clinical Pediatrics 2016年第3期5卷 293-300页

作者： Clare chung-Wah Yu Alison Mary McManus Hung-Kwan So Ping Chook chun-Ting Au Albert Martin Li Jack tat-Chi Kam Raymond Chi-Hung So Christopher Wai-Kei Lam Iris Hiu-Shuen chan Rita Yn-Tz Sung Department of Health and Physical Education the Education University of Hong Kong Institute of Human Performance the University of Hong Kong Centre for Heart Lung and Vascular HealthSchool of Health and Exercise SciencesUniversity of British Columbia Department of Paediatrics the Chinese University of Hong Kong Hong Kong Sports Institute Faculty of Health Sciences and University Hospital Macao University of Science and Technology Department of Chemical Pathology Prince of Wales Hospitalthe Chinese University of Hong Kong

AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active ***:This is a pragmatic randomised controlled *** study was carried out in a Hong Kong Government secondary ***-eight lean and active boys and girls were randomised to either the resistance training group or the control *** in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 *** outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic ***:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(Pchange was more likely an outcome of normal growth and development as opposed to a training ***:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children.

关键词： Strength training Children Cardiometabolic risk factors Endothelial function School-based training program High sensitive C-reactive protein 24-h ambulatory blood pressure Aerobic fitness