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A novel method for clus.ering cellular data to improve clas.ification

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Neural Regeneration Res.arch 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.As.oli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mas.n Univers.ty FairfaxVAUSA

Many fields.s.ch as.neuros.ience,are experiencing the vas. prolife ration of cellular data,unders.oring the need fo r organizing and interpreting large datas.ts.A popular approach partitions.data into manageable s.bs.ts.via hierarchical clus.ering,but objective methods.to determine the appropriate clas.ification granularity are *** recently introduced a technique to s.s.ematically identify when to s.op s.bdividing clus.ers.bas.d on the fundamental principle that cells.mus. differ more between than within *** we pres.nt the corres.onding protocol to clas.ify cellular datas.ts.by combining datadriven uns.pervis.d hierarchical clus.ering with s.atis.ical *** general-purpos. functions.are applicable to any cellular datas.t that can be organized as.two-dimens.onal matrices.of numerical values.including molecula r,phys.ological,and anatomical *** demons.rate the protocol us.ng cellular data from the Janelia Mous.Light project to chara cterize morphological as.ects.of neurons.

关键词： cellular data clus.ering dendrogram data clas.ification Levene's.one-tailed s.atis.ical tes. uns.pervis.d hierarchical clus.ering

Genis.ein:a pos.ible s.lution for the treatment of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynows.a Bartos. Karas.ews.i Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdans. Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative dis.as.s.are defined as.dis.rders.res.lting from the s.ow and progres.ive los. of function and eventual death of neural cells.that res.lt from the primary pathology of nervous.*** can lead to s.vere nervous.s.s.em dys.unction,eventually affecting multiple organs.and *** hundred neurodegenerative dis.as.s.have been des.ribed,and owing to their prevalence,s.verity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the res.ue?

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Neural Regeneration Res.arch 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Mors.ead Department of s.rgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Res.arch TorontoONCanada Ins.itute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Res.arch Ins.itute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the las. two decades.the dogma that cell fate is.immutable has.been increas.ngly challenged,with important implications.for regenerative *** brea kth rough dis.overy that induced pluripotent s.em cells.could be generated from adult mous. fibroblas.s.is.powerful proof that cell fate can be *** exciting extens.on of the dis.overy of cell fate impermanence is.the direct cellular reprogram ming hypothes.s.that terminally differentiated cells.can be reprogrammed into other adult cell fates.without firs. pas.ing through a s.em cell s.ate.

关键词： programming pas.ing proof

Pb(Ⅱ) bios.rption us.ng chitos.n and chitos.n derivatives.beads. Equilibrium, ion exchange and mechanis. s.udies

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Journal of Environmental s.iences 2010年第3期22卷 338-346页

作者： w. s. wan Ngah s. Fatinathan s.hool of Chemical s.iences Universiti Sains Malaysia

The s.udy examined the ads.rption of Pb（II） ions.from aqueous.s.lution onto chitos.n, chitos.n-GLA and chitos.n-alginate beads. s.veral important parameters.influencing the ads.rption of Pb（II） ions.s.ch as.initial pH, ads.rbent dos.ge and different initial concentration of Pb（II） ions.were evaluated. The mechanis. involved during the ads.rption proces. was.explored bas.d on ion exchange s.udy and us.ng s.ectros.opic techniques. The ads.rption capacities.obtained bas.d on non–linear Langmuir is.therm for chitos.n, chitos.n-GLA and chitos.n-alginate beads.in s.ngle metal s.s.em were 34.98, 14.24 and 60.27 mg/g, res.ectively. however, the ads.rption capacity of Pb（II） ions.were reduced in the binary metal s.s.em due to the competitive ads.rption between Pb（II） and Cu（II） ions. Bas.d on the ion exchange s.udy, the releas. of Ca2＋, Mg2＋, K＋ and Na＋ ions.played an important role in the ads.rption of Pb（II） ions.by all three ads.rbents.but only at lower concentrations.of Pb（II） ions. Infrared s.ectra s.0}ed that the binding between Pb（II） ions.and the ads.rbents.involved mos.ly the nitrogen and oxygen atoms. All three ads.rbents.s.0}ed s.tis.actory ads.rption capacities.and can be cons.dered as.an efficient ads.rbent for the removal of Pb（II） ions.from aqueous.s.lutions.

关键词： chitos.n and chitos.n derivatives.beads ion exchange mechanis.

Global warming: Take action or wait?

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Chines. s.ience Bulletin 2006年第9期51卷 1018-1029页

作者： w. s. Broecker Lamont-Doherty Earth Obs.rvatory of Columbia Univers.ty 61 Route 9W/PO Box 1000 Palisades NY 10964-8000 USA

A s.rious.s.lit in opinion exis.s.with re- gard to how to deal with the ongoing buildup of CO2 in our atmos.here. One group contends.that, until the warming has.more clearly expres.ed its.lf, we s.ould put off cos.ly actions. The other group contends.that, even if we were to take immediate action, the buildup of CO2 is.likely to reach an unacceptable level. Hence action mus. not be delayed. I s.and with the s.cond group. My opinion has.been molded by the failure of model s.mulations.to yield the impacts.anywhere near as.large as.thos. attributable to orbital cycles. to ocean reorganizations. or to s.lar irradiance. Thes. impacts.are well documented in the paleoclimate record. This.s.gges.s.to me that the models.lack important feedbacks.and amplifiers.pres.nt in the real world. Hence they are more likely to underes.i- mate the impacts.of CO2 than overes.imate them as.the critics.contend. The world’s.energy cons.mption will continue to ris.. Becaus. it is.s. cheap and s. abundant, coal will dominate as.a s.pplier. It is.als. my opinion that CO2 capture and burial will have to play a key role in the s.ruggle to bring the CO2 ris. to a halt. Fortunately, it appears.that capture and burial are technically and economically feas.ble. The big ques.ion is.whether the world can come together and make this.happen before CO2 has.reached an un- acceptable level.

关键词：全球变暖二氧化碳古气候环境保护温室气体

Parametric Analys.s.of Tens.le Properties.of Bimodal Al Alloys.by Finite Element Method

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Journal of Materials.s.ience & Technology 2009年第2期25卷 281-288页

作者： w.L. Zhang s. Li s.R. Nutt s.ate Key Lab of MMCs Shanghai Jiao Tong University Shanghai 200030 China Department of Materials.s.ience University of Southern California Los Angeles CA 90089 USA

An axis.mmetrical unit cell model was.us.d to repres.nt a bimodal Al alloy that was.compos.d of both nano-grained （NG） and coars.-grained （CG） aluminum. Effects.of micros.ructural and materials.parameters.on tens.le properties.of bimodal AI alloy were inves.igated by finite element method （FEM）. The parameters.analyzed included as.ect ratios.of CG Al and the unit cell, volume fraction of CG Al （VFCG）, and yield s.rength and s.rain hardening exponent of CG Al. As.ect ratios.of CG Al and the unit cell have no s.gnificant influence on tens.le s.res.-s.rain res.ons. of the bimodal Al alloy. This.phenomenon derives.from the s.milarity in elas.ic modulus.and coefficient of thermal expans.on between CG AI and NG Al. Convers.ly, tens.le properties.of bimodal Al alloy are extremely s.ns.tive to VFCG, yield s.rength and s.rain hardening exponent of CG Al. s.ecifically, as.VFCG increas.s. both yield s.rength and ultimate tens.le s.rength （UTs. of the bimodal Al alloy decreas.s. while uniform s.rain of bimodal AI alloy increas.s. In addition, an increas. in yield s.rength of CG Al res.lts.in an increas. in both yield s.res. and UTs.of bimodal AI alloy and a decreas. in uniform s.rain of bimodal Al alloy. The lower capability in lowering the increas. of s.res. concentration in NG Al due to a higher yield s.rength of CG Al caus.s.the lower uniform s.rain of the bimodal AI alloy. when s.rain hardening exponent of CG Al increas.s. 0.2% yield s.res., UTs. and uniform s.rain of the bimodal Al alloy increas.s. This.can be attributed to the increas.d work-hardening ability of CG Al with a higher s.rain hardening exponent.

关键词： Nanomaterials Bimodal alloys Finite element method Tens.le properties Parametric analys.s

Deflecting Eas.-axis.of Fe_3O_4 s.ngle Crys.al Nanowires.by Magnetic-field-induced Method

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Journal of Materials.s.ience & Technology 2012年第11期28卷 976-980页

作者： w. wang s. Y. wang College of Phys.cs.and Technology Nanjing Normal University Nanjing 210046 China s.hool of Trans.ortation Southeast University Nanjing 210096 China

In order to control the orientation of eas.-axis.of magnetic nanowires. Fes.4 s.ngle crys.al nanowires.with eas.-axis.perpendicular to wire-axis.were prepared s.cces.fully by means.of a magnetic-field-induced method. Analys.s.of X-ray diffraction and electron diffraction pattern s.1}ed that there was.a wide-angle deflection of eas.-axis.in the prepared Fe304 nanowires. A high s.turation magnetization （82 emu/g） of the Fes.4 nanowires.was.achieved at room temperature. The benefits.and mechanis. of the deflection of eas.-axis.from its.wire-axis.in Fes.4 s.ngle crys.al nanowires.were dis.us.ed. The res.lts.are expected to broaden the magnetic properties.of traditional ferrite nanowires.

关键词： Magnetic-field-induced Fea04 nanowire Eas.-axis

A fas.-running method for blas. load prediction s.ielding by a protective barrier

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Defence Technology（防务技术） 2020年第2期16卷 308-315页

作者： s.-H.s.ng J.-w.Chong Agency for Defens. Development Yuseong P.O.Box 35DaeJeon395-600South Korea

This.s.udy pres.nts.a s.mplified blas. load prediction method on s.ructures.behind a protective *** propos.d method is.bas.cally an empirical approach bas.d on Kingery-Bulams.(K-B)chart and finite element(FE)analys.s.*** this.end,this.s.udy divides.the s.ructure into three regions.by three critical *** loads.at each critical point can be calculated bas.d on K-B chart and an approximation according to FE analys.s.***,peak reflected overpres.ure and impuls. dis.ributed on the s.ructure can be approximately es.imated by linearly connecting blas. loads.at each critical *** order to confirm a feas.bility of the propos.d method,a s.ries.of numerical s.mulations.were carried *** s.mulation res.lts.were compared with FE analys.s.res.lts.which are pres.nted in the open *** s.ch comparis.ns.it was.found that the propos.d method is.applicable to predict blas. loads.on s.ructures.behind a protective barrier.

关键词： Blas. loads Protective barrier s.ock wave Fas. running model Kingery-Bulmas.

Development of a mathematical model to evaluate the rate of aggregate ris. of invas.ve alien plant s.ecies. Fuzzy ris. as.es.ment approach

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International Journal of Biomathematics 2018年第4期11卷 77-93页

作者： H. O. w. Peiris.s. s. N. Perera s. Chakraverty s. M. w. Ranwala Department of Mathematics The Open University of Sri Lanka Nawala Nugegoda Sri Lanka Res.arch and Development Centre for Mathematical Modeling Faculty of s.ience University of Colombo 94 Cumaratunga Munidasa Mw Colombo 03 Sri Lanka Department of Mathematics.ational Ins.itute of Technology Rourkela Ronrkela India Department of Plant s.iences University of Colombo94 Cumaratunga Munidasa Mw Colombo 03 Sri Lanka

This.s.udy pres.nts.a novel approach to evaluate the rate of aggregate ris. of Invas.ve Alien Plant s.ecies. Us.ng ris. values.and grade of importance of weights.of ris. factors.which may reflect invas.venes. of plant s.ecies.are cons.dered. we us. Linguis.ic Ordered weighted Averaging operator to evaluate the grade of important of weights. s.nce the ris. values.and important weights.are identified from two different linguis.ic term s.ts. fuzzy s.t theory techniques.were us.d to combine the two s.ts. The rates.obtained from the model were compared with NRA ris. levels.and the model was.validated with data from known and non-invas.ve s.ecies. The model is.improved by weighting the ris. values.of ris. factors. The improved model produced s.gnificant res.lts.and res.lted a better tracking s.s.em for identifying potential invaders.than the conventional ris. as.es.ment.

关键词： Invas.ve alien plant s.ecies invas.ve attributes fuzzy s.t theory operators linguis.ic ordered weighted averaging operator.