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中药药理与临床 2017年第1期33卷 33-37页

作者：张燕陈恬黄厚意杨洁曾南成都医学院基础医学院成都610500 成都中医药大学药学院成都610057

目的:探讨盐酸小檗碱体外抗单纯疱疹病毒1型(HSV-1)的作用及作用机制。方法:MTT法检测盐酸小檗碱对Vero细胞的毒性作用,观察HSV-1感染Vero细胞后所致的细胞病变效应(Cytopathologic effects,CPE),实时荧光定量PCR法检测盐酸小檗碱对病... 详细信息

目的:探讨盐酸小檗碱体外抗单纯疱疹病毒1型(HSV-1)的作用及作用机制。方法:MTT法检测盐酸小檗碱对Vero细胞的毒性作用,观察HSV-1感染Vero细胞后所致的细胞病变效应(Cytopathologic effects,CPE),实时荧光定量PCR法检测盐酸小檗碱对病毒蛋白gD的mRNA表达水平,免疫印迹(Western blot)法检测盐酸小檗碱对病毒蛋白ICP27和ICP8表达的影响。结果:盐酸小檗碱半数中毒浓度(TC50)为392.5μmol/L,病毒半数抑制浓度(IC50)为66.49μmol/L,选择性指数(SI)为5.9。实时荧光定量PCR结果显示盐酸小檗碱可降低HSV-1 gD的mRNA表达水平。Western blot显示盐酸小檗碱可明显抑制病毒蛋白ICP27和ICP8的表达。结论:盐酸小檗碱具有抗HSV-1的作用,可能与抑制病毒蛋白ICP27的表达进而影响ICP8和gD的表达有关。

关键词：盐酸小檗碱抗病毒作用单纯疱疹病毒1型

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生长调节剂对欧洲鹅耳枥水培生根的影响

中南林业科技大学学报 2021年第1期41卷 52-59页

作者：火艳陈周祥周琦黄厚毅祝遵凌南京林业大学风景园林学院江苏南京210037 南京林业大学南方现代林业协同创新中心江苏南京210037 南京林业大学艺术设计学院江苏南京210037

【目的】筛选适合欧洲鹅耳枥水培生根的植物生长调节剂处理方法,并讨论欧洲鹅耳枥水培苗与土培苗的差异,为欧洲鹅耳枥生根机制研究及进一步生理生化研究提供理论基础。【方法】以欧洲鹅耳枥硬枝枝条为试材,研究不同植物生长调节剂种类... 详细信息

【目的】筛选适合欧洲鹅耳枥水培生根的植物生长调节剂处理方法,并讨论欧洲鹅耳枥水培苗与土培苗的差异,为欧洲鹅耳枥生根机制研究及进一步生理生化研究提供理论基础。【方法】以欧洲鹅耳枥硬枝枝条为试材,研究不同植物生长调节剂种类、质量浓度和处理时间对生根率、愈伤组织率、存活率、平均根数、平均根长、皮部生根枝条率、皮部平均根数、切口平均根数的影响及生根过程中的指标动态,并研究水培苗与土培苗形态、生理、根显微结构的区别。【结果】欧洲鹅耳枥水培既存在切口生根,也存在皮部生根,可通过不同的生长调节剂来诱导不同的生根方式。欧洲鹅耳枥水培生根最佳的生长调节剂处理方式为800 mg/L ABT1处理1 h,在此条件下,欧洲鹅耳枥枝条生根率60.14%,愈伤组织率75.25%,存活率96.67%,其生根方式主要为切口生根,生根数量较少但粗壮,大小一致,便于标准化生产;采用1 200 mg/L NAA浸泡1 h的处理方式,获得的水培苗全部为皮部生根,生根数量多但较细弱,发根位置不定,有大量根很长,不适合移植土壤但适合水培观赏根系。水培苗根含水量是土培苗根含水量的1.90倍,水培苗的根系活力显著低于土培。水培根系呈白色至浅褐色,基本没有木质化,不定根长且直,二级根少且短,缺少三级根,缺少角质层,且皮层的薄壁细胞体积大、形状不规则、排列疏松,维管柱占根横截面积比例较小。【结论】欧洲鹅耳枥水培既存在切口生根,也存在皮部生根,可通过不同的生长调节剂来诱导不同的生根方式。欧洲鹅耳枥水培苗与土培苗相比,根系形态及显微结构都发生明显变化。

关键词：欧洲鹅耳枥水培生根生长调节剂

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

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观赏石榴表型遗传多样性分析

浙江农林大学学报 2020年第5期37卷 939-949页

作者：火艳招雪晴黄厚毅黄贤斌许云方祝遵凌苑兆和南京林业大学风景园林学院南方现代林业协同创新中心江苏南京210037 南京林业大学林学院江苏南京210037 南京林业大学艺术设计学院江苏南京210037

【目的】探究观赏石榴Punica granatum表型遗传多样性,为中国观赏石榴种质资源的鉴定与评价提供理论依据。【方法】对24个观赏石榴品种的株型、枝型、花色、花的尺寸、花瓣数、瓣化雄蕊数等13个观赏性状进行表型调研与多样性分析,在此... 详细信息

【目的】探究观赏石榴Punica granatum表型遗传多样性,为中国观赏石榴种质资源的鉴定与评价提供理论依据。【方法】对24个观赏石榴品种的株型、枝型、花色、花的尺寸、花瓣数、瓣化雄蕊数等13个观赏性状进行表型调研与多样性分析,在此基础上进行主成分分析与聚类分析,并利用流式细胞仪对24个品种进行倍性及C值测定。【结果】多样性指数检测发现:观赏石榴数量性状(1.715)大于质量性状(1.148),质量性状中花瓣色、花萼色、花型、1年生小枝颜色的多样性指数较大。数量性状中瓣化雄蕊数和花瓣数的变异系数分别为117.59%和78.86%,表现出丰富的表型多样性,说明花瓣数增多、雄蕊瓣化是观赏石榴的选育方向。瓣化雄蕊数和花瓣数的多样性指数变化趋势与变异系数变化趋势不一致,说明其变异范围很大,且变异分布不均匀。主成分分析结果表明:前4个主成分特征值均大于1,累计贡献率达80.10%,枝的形态与颜色、花大小、花瓣数及花瓣形成、株型、花色是造成观赏石榴表型差异的主要影响因子。聚类分析表明:供试的24个观赏石榴品种可分为3个组群,其遗传聚类与花型、颜色、株型关系密切。橙色花品种与粉色花品种、白色花品种的亲缘关系较近,与复色花品种的亲缘关系较远。单瓣品种与所有的复瓣品种、大部分重瓣品种的亲缘关系较近,小部分重瓣品种与台阁品种的亲缘关系较近,与主流的花型演化观点一致。流式细胞仪分析表明:24个观赏石榴均为二倍体,说明石榴品种遗传稳定。【结论】观赏石榴表型多样性丰富,测试品种均为二倍体。

关键词：园艺学石榴观赏品种表型多样性主成分分析聚类分析

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居家养老环境下适老化家具设计

家具 2021年第4期42卷 36-39,49页

作者：毛海蓉黄厚毅南京林业大学艺术设计学院南京210037

通过对当下国内外家具市场中适老化家具的调研,查阅相关文献资料并结合人体工程学相关概念分析当下老年人在居家养老环境下对于适老化家具的使用及情感需求。以安全、舒适、可操作为设计目标,为适老化家具的设计提供具有参考价值的意见... 详细信息

通过对当下国内外家具市场中适老化家具的调研,查阅相关文献资料并结合人体工程学相关概念分析当下老年人在居家养老环境下对于适老化家具的使用及情感需求。以安全、舒适、可操作为设计目标,为适老化家具的设计提供具有参考价值的意见和建议,并针对居家养老环境下的适老化家具设计提出了5项设计原则:安全性原则、舒适性原则、可操作性原则、无障碍原则、人文关怀原则,从多个维度出发提高适老化家具给使用者带来的体验感,让适老化家具设计的发展能够紧跟时下"居家养老"这一养老新趋势的步伐,为老年人提供舒适安逸的晚年生活。

关键词：家具设计人体工程学适老化家具居家养老

Economic effect of China's carbon neutrality target under shared socioeconomic pathways

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Science China Earth Sciences 2025年第1期68卷 142-157页

作者： Zemiao LIU Xianjin huang Xinxian QI School of Geography and Ocean Science Nanjing University Key Laboratory of Carbon Neutrality and Territory Optimization Ministry of Natural Resources Frontiers Science Center for Critical Earth Material Cycling Nanjing University

Economic feasibility is crucial for achieving the carbon neutrality target. However, current integrated assessments often underestimate the economic impacts of mitigation policies due to the lack of consideration of their economic benefits. This study integrates a warming-labour productivity model with a typical integrated assessment model using shared socioeconomic pathways. It simulates China's economic development and carbon emission levels under both baseline and carbon-neutral policy scenarios, evaluating the economic costs and benefits of emission reduction policies aimed at achieving carbon neutrality. These findings reveal the following:(1) The economic costs of emission reduction policies are projected to peak between 2050 and 2060, ranging from 0.41% to 9.37% of total GDP in the baseline scenario, primarily due to increased energy prices and R&D investments. These costs are expected to decline rapidly after 2070.(2) China's carbon-neutral policies will mitigate global warming, with the economic benefits of mitigation projected to reach 5.65% to 17.24% of China's total GDP by 2100.(3) Lowcarbon scenarios SSP1 and SSP4 could significantly reduce initial economic costs and advance the onset of net economic gains to 2060. This integrated assessment confirms that China's carbon neutrality target offers substantial net economic benefits in the long term. To minimize initial economic costs, efforts should focus on enhancing consumption-side transitions, upgrading lowcarbon technologies, and adopting new energy sources.

关键词： Climate change China Carbon neutrality Economic effects Policy

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Tectonic modes of mantle convection and their implications for Earth's tectonic evolution based on three-dimensional numerical simulations

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Science China Earth Sciences 2025年第1期68卷 270-296页

作者： Song XIANG Jinshui huang Bingcheng WU School of Earth and Space Sciences University of Science and Technology of China CAS Center of Excellence in Comparative Planetary Studies

Five tectonic modes of mantle convection are obtained and analyzed with three-dimensional numerical models in a spherical shell domain. The five tectonic convective modes are non-plate mobile-lid, plate-like mobile-lid, episodic plate-like mobile-lid, episodic stagnant-lid, and stagnant-lid convective modes, respectively. The typical characteristics of these five tectonic modes and their numerical classification criteria based on plateness, mobility, and their standard deviations are presented and discussed. The results show that the yield stress of the lithosphere has profound effects on the tectonic convective *** the gradual increase of yield stress, the tectonic mode of mantle convection changes from one to another sequentially through the aforementioned five modes. Additionally, as the Rayleigh number increases, the range of yield stress for the platelike mobile-lid convective mode decreases, and the dimensionless transition stress between different tectonic modes ***, the dimensional transition stress between the non-plate mobile-lid convective mode and plate-like mobile-lid convective mode increases with the increase of Rayleigh number, but decreases between other tectonic modes. Furthermore, we find that the transition stress between different tectonic modes is inversely proportional to the internal heating rate, with the transition stress decreasing as the internal heating rate increases. The fitting analysis of the transition stress between tectonic modes shows that Earth's current plate tectonics correspond to a lithospheric yield stress of 150–250 MPa, which aligns with the strength of serpentinized mantle rock determined by experimental petrography. If the Archean mantle was 300°C warmer than it is today, then the Earth was in an episodic stagnant-lid convective mode. The tectonic evolution of the Earth's surface is closely related to the lithospheric strength and the process of thermal evolution. If the lithospheric strength w

关键词： Tectonic mode of mantle convection Plate-like mobile-lid convection Episodic plate-like mobile-lid convection Episodic stagnant-lid convection Plate tectonics and tectonic evolution of the Earth

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对“乙烯炉的优化设计”一文的探讨

化工设备设计 1999年第3期36卷 12-14页

作者：代厚益黄维光四川省精细化工研究设计院

本文就乙烯炉设计中如何分析、解决影响设备寿命的主要问题提出了不同的看法。并介绍了本单位该设备的设计和运行情况。

关键词：壁温温差应力乙烯炉设计

Local-contrastive-learning machine with both generalization and adversarial robustness: A statistical physics analysis

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 109-123页

作者： Mingshan Xie Yuchen Wang Haiping huang PMI Lab School of Physics Sun Yat-sen University Guangdong Provincial Key Laboratory of Magnetoelectric Physics and Devices Sun Yat-sen University

Distinct from human cognitive processing, deep neural networks trained by backpropagation can be easily fooled by adversarial examples. To design a semantically meaningful representation learning, we discard backpropagation, and instead, propose a local contrastive learning, where the representations for the inputs bearing the same label shrink(akin to boson) in hidden layers,while those of different labels repel(akin to fermion). This layer-wise learning is local in nature, being biologically plausible.A statistical mechanics analysis shows that the target fermion-pair-distance is a key parameter. Moreover, the application of this local contrastive learning to MNIST benchmark dataset demonstrates that the adversarial vulnerability of standard perceptron can be greatly mitigated by tuning the target distance, i.e., controlling the geometric separation of prototype manifolds.

关键词： machine learning statistical mechanics adversarial robustness neural networks