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Recurrent Transient Ischemic Attacks Revealing Cerebral Amyloid Angiopathy: A Comprehensive Case

World Journal of Neuroscience 2024年第1期14卷 33-36页

作者： Kenza Khelfaoui Tredano houyam tibar Kaoutar El Alaoui Taoussi Wafae Regragui Abdeljalil El Quessar Ali Benomar Neurology and Interventional Neuroradiology Department Cheikh Zaied International Hospital International University Abulcasis of Health Sciences Rabat Morocco Neurology and Neurogenetics Department Specialties Hospital Ibn Sina University Hospital Mohammed 5 University Rabat Morocco

This case report investigates the manifestation of cerebral amyloid angiopathy (CAA) through recurrent Transient Ischemic Attacks (TIAs) in an 82-year-old patient. Despite initial diagnostic complexities, cerebral angiography-MRI revealed features indicative of CAA. Symptomatic treatment resulted in improvement, but the patient later developed a fatal hematoma. The discussion navigates the intricate therapeutic landscape of repetitive TIAs in the elderly with cardiovascular risk factors, emphasizing the pivotal role of cerebral MRI and meticulous bleeding risk management. The conclusion stresses the importance of incorporating SWI sequences, specifically when suspecting a cardioembolic TIA, as a diagnostic measure to explore and exclude CAA in the differential diagnosis. This case report provides valuable insights into these challenges, highlighting the need to consider CAA in relevant cases.

关键词： Cerebral Amyloid Angiopathy Transient Ischemic Attacks Recurrent Hemiparesis Susceptibility-Weighted Imaging Cardioembolic Origin Bleeding Risk Management Differential Diagnosis

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Association Study of Two Polymorphisms in Vitamin D Pathway with Multiple Sclerosis in the Moroccan Population

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World Journal of Neuroscience 2017年第4期7卷 363-375页

作者： Asmae Skalli El Hachmia Ait Ben Haddou Rachid Tazi-Ahnini Ghislain Armel Mpandzou houyam tibar Naima Bouslam Ali Benomar Khadija Hajjout Mohamed Yahyaoui Elmostafa El Fahime Ahmed Bouhouche Research Team in Neurology and Neurogenetics Medical School and Pharmacy Mohammed V University Rabat Morocco Department of Neurology and Neurogenetics Specialties Hospital Rabat Morocco Laboratory of Biotechnology Medical School and Pharmacy Mohammed V University Rabat Morocco National Blood Transfusion Center Rabat Morocco Assistance Units for Scientific and Technical Research Rabat Morocco

Background: Hypovitaminosis D is reported through the literature to be involved in autoimmune diseases such as multiple sclerosis (MS). In the last decade, numerous studies have investigated the association of single nucleotide polymorphisms (SNPs) with MS, including rs2248359 (CYP24A1) and rs703842 (CYP27B1) that are involved in vitamin D metabolic pathway. However, results were conflicting, probably due to ethnic differences between the studied populations. In this context, the present study aimed to analyze the association between these two SNPs and MS within the Moroccan population. Methods: rs2248359 and rs703842 were genotyped in 113 patients and 146 healthy controls. To assess their association with the disease risk, we compared the genotypic and allelic frequencies between the study groups. We also explored their possible influence on certain clinical features (age at onset, type, disability status and severity score) and with vitamin D3 serum level (DSL) by comparing mean values of these variables between the different genotypes. Results: No statistically significant differences in the distribution of both SNPs were found between patients and controls. A trend has emerged concerning the minor G allele of rs703842 which appears to have a protective effect on developing MS, but this result remained slightly below significance. Also, the two polymorphisms had no impact on the clinical features tested and the DSL. Conclusion: There is no convincing evidence that rs2248359 and rs703842 are associated with MS risk, its clinical features or vitamin D level in Moroccans. Further larger investigations are needed to confirm these findings.

关键词： Multiple Sclerosis Risk rs2248359 rs703842 Clinical Features Serum 25(OH)D3 Level

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