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Effect of acacetin on inhibition of apoptosis in Helicobacter pyloriinfected gastric epithelial cell line

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3624-3634页

作者： Qi-Xi Yao Zi-Yu Li hou-le kang Xin He Min kang Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Orthopaedics The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Emergency Luzhou People’s HospitalLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)infection can cause extensive apoptosis of gastric epithelial cells,serving as a critical catalyst in the progression from chronic gastritis,gastrointestinal metaplasia,and atypical gastric hyperplasia to gastric *** eradication of *** is paramount for ameliorating the pathophysiological conditions associated with chronic inflammation of the gastric mucosa and the primary prevention of gastric ***,which has multifaceted pharmacological activities such as anti-cancer,anti-inflammatory,and antioxidative properties,has been extensively investigated across various ***,the impact and underlying mechanisms of action of acacetin on ***-infected gastric mucosal epithelial cells remain *** To explore the defensive effects of acacetin on apoptosis in ***-infected GES-1 cells and to investigate the underlying *** GES-1 cells were treated with *** and acacetin in *** viability was assessed using the CCK-8 assay,cell mortality rate via lactate dehydrogenase assay,alterations in cell migration and healing capacities through the wound healing assay,rates of apoptosis via flow cytometry and TUNEL staining,and expression levels of apoptosis-associated proteins through western blot *** *** infection led to decreased GES-1 cell viability,increased cell mortality,suppressed cell migration,increased rate of apoptosis,increased expressions of Bax and cle-caspase3,and decreased Bcl-2 ***,acacetin treatment enhanced cell viability,mitigated apoptosis induced by *** infection,and modulated the expression of apoptosis-regulatory proteins by upregulating Bcl-2 and downregulating Bax and cleaved *** Acacetin significantly improved GES-1 cell viability and inhibited apoptosis in ***-infected GES-1 cells,thereby exerting a protective effect on gastric mucosal epithelial cells.

关键词： Gastric epithelial GES-1 cells Helicobacter pylori Infection Acacetin Antibiotic resistance Apoptosis

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Boundless love:a German Professor Uli Schwarz in China

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Protein & Cell 2024年第8期15卷 553-558页

作者： le kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China

More than 20 years ago,an old German man embarked on a quest to explore the suburbs of Shanghai and the villages of jiangsu Province in search of antique Chinese *** was not a mere antique collector or aficionado of ancient furmiture,but a German scientist motivated by his profound love of Chinese *** name was Uli Schwarz(Fig.1),a distinguished German scientist who had dedicated the majority of his life to promoting cross-cultural scientific exchanges,an effort that left an indelible mark on the landscape of research collaborations between China and Germany.

关键词： Schwarz German landscape

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Regulation of insect behavior by non-coding RNAs

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Science China(Life Sciences) 2024年第6期67卷 1106-1118页

作者： Jing He le kang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institutes of Life Sciences Chinese Academy of SciencesBeijing 100101China College of Life Science Hebei UniversityBaoding 071002China

The adaptation of insects to environments relies on a sophisticated set of behaviors controlled by molecular and physiological *** the past several decades,accumulating studies have unveiled the roles of non-coding RNAs(nc RNAs)in regulating insect *** RNAs assume particularly pivotal roles in the behavioral plasticity of insects by rapidly responding to environmental *** RNAs also contribute to the maintenance of homeostasis of insects by fine-tuning the expression of target ***,a comprehensive review of nc RNAs'roles in regulating insect behaviors has yet to be ***,we present the recent progress in our understanding of how nc RNAs regulate various insect behaviors,including flight and movement,social behavior,reproduction,learning and memory,and *** refine the intricate mechanisms by which nc RNAs modulate the function of neural,motor,reproductive,and other physiological systems,as well as gene expression in insects like fruit flies,social insects,locusts,and ***,we discuss potential avenues for future studies in nc RNA-mediated insect behaviors.

关键词： ncRNAs insect behavior plasticity fine-tuning environmental adaptation

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In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie Hu Hong-Xin Lao Xiu-Wu Xu Wei-kang Wang le-le Wang Qin-Qin Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into Hf-BPDC MOF by forming coordinating bonds with Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

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A Novel Supercapacitor Degradation Prediction Using a 1D Convolutional Neural Network and Improved Informer Model

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Protection and Control of Modern Power Systems 2024年第4期9卷 51-68页

作者： Hao Zhang Zhenxiao Yi le kang Yi Zhang Kai Wang the College of Materials Science and Engineering Xi’an University of Science and Technol-ogyXi’an 710054China the School of Electrical Engineering Qingdao UniversityQingdao 266071China the School of Energy Sciences and Engineering Nanjing Tech UniversityNanjing 211816China

Safety and reliability are crucial for the next-generation supercapacitors used in energy storage systems,while accurate prediction of the degradation trajectory and remaining useful life(RUL)is essential for analyzing degradation and evaluating performance in energy storage *** study proposes a novel data processing and improved one-dimensional convolutional neural network(1D CNN)-informer framework for robust RUL *** data preprocessing,all data from two structures are adjusted to a unified format,and cross-entropy loss is used to couple the 1D CNN and ***,the minimum-maximum feature scaling method is used for normalization to accelerate the training process in reaching the minimum cost function.A relative position encoding algorithm is introduced to improve the Informer model,enabling it to better learn the sequence relationships between data and effectively reduce prediction *** data in dif-ferent working conditions are used to validate the proposed *** with other existing methods,the maximum root mean square error is reduced by 32.71%,the mean absolute error is reduced by 28.50%,and R^(2) is increased by 4.79%.The strategy considers the complementarity between two single models,which can extract features and enrich local details,as well as enhance the model’s global perception *** experimental results demonstrate that the proposed model achieves high-precision and robust RUL prediction,thereby pro-moting the industrial application of supercapacitors.

关键词： Supercapacitors remaining useful life convolution neural network transformer informer

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Diarrhea induced by insufficient fat absorption in weaned piglets:Causes and nutrition regulation

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Animal Nutrition 2024年第01期16卷 299-305页

作者： Yuying Li Pengjun Shi kang Yao Qian Lin Mansheng Wang Zhenping hou Wenjie Tang Hui Diao Institute of Bast Fiber Crops Chinese Academy of Agricultural Sciences Institute of Subtropical Agriculture Chinese Academy of Sciences Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process Animal Breeding and Genetics Key Laboratory of Sichuan Province Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animal Science Academy Sichuan Animtech Feed Co. Ltd

Fat is one of the three macronutrients and a significant energy source for piglets. It plays a positive role in maintaining intestinal health and improving production performance. During the weaning period,physiological, stress and diet-related factors influence the absorption of fat in piglets, leading to damage to the intestinal barrier, diarrhea and even death. Signaling pathways, such as fatty acid translocase(CD36), pregnane X receptor(PXR), and AMP-dependent protein kinase(AMPK), are responsible for regulating intestinal fat uptake and maintaining intestinal barrier function. Therefore, this review mainly elaborates on the reasons for diarrhea induced by insufficient fat absorption and related signaling pathways in weaned-piglets, with an emphasis on the intestinal fat absorption disorder. Moreover, we focus on introducing nutritional strategies that can promote intestinal fat absorption in piglets with insufficient fat absorption-related diarrhea, such as lipase, amino acids, and probiotics.

关键词： Weaned piglet Diarrhea Fat absorption Nutrient regulation

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Divergent total synthesis of marine meroterpenoids(+)-dysidavarones A–C

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Chinese Chemical letters 2024年第3期35卷 234-238页

作者： Qunlong Zhang Yang Kuang le Chang Jingyi kang Bingjian Wang Chuanke Chong Zhaoyong Lu State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300350China

Here,we report a concise and divergent enantioselective total synthesis of marine sesquiterpene quinone meroterpenoids(+)-dysidavarones A–C(1–3)using predysidavarone 6 as a key common *** highly strained and bridged eight-membered carbocycle of predysidavarone 6 was constructed by a one-pot intermolecular alkylation and intramolecular arylation of Wieland–Miescher ketone derivative 11 and benzyl bromide *** total synthesis of(+)-dysidavarones A–C(1–3)was achieved from predysidavarone 6 in a divergent manner by a late-stage introduction of the ethoxy group,which reveals the possible source of the ethoxy group within(+)-dysidavarones A–C(1–3)and provides a late-stage modifiable route for the synthesis of dysidavarone analogs for further anti-cancer activity evaluation.

关键词： Total synthesis Natural product Dysidavarones A–C Sesquiterpene quinone Meroterpenoid

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Renewable conversion of coal gangue to 13-X molecular sieve for Cd^(2+)-containing wastewater adsorption performance

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Rare Metals 2024年第2期43卷 702-710页

作者： le kang Si-Fan Liu Da-Wei Yi Kai Wang Hui-Ling Du Hao-Qi Huang Peng Chen College of Materials Science and Engineering Xi’an University of Science and TechnologyXi’an710054China School of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao266000China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials and Chemical Engineering Tongren UniversityTongren554300China

Using coal gangue(CG)as raw material,a new type of all solid-waste-based 13-X molecular sieve material was controllably prepared by alkali fusion-hydrothermal *** synthetic molecular sieve was used as a solid adsorbent to treat Cd^(2+)-containing wastewater,and its adsorption behavior on Cd^(2+)in aqueous solution was studied and *** microstructure and morphology of the molecular sieve were investigated by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM)and specific surface area *** results show that the synthesized 13-X molecular sieve has higher Brunauer–Emmett–Teller(BET)specific surface area with higher crystallinity and higher adsorption capacity for the heavy metal Cd^(2+).The adsorption process of Cd^(2+)by molecular sieve conforms to the Langmuir isotherm adsorption equation and Lagergren pseudo-second-order rate *** with thermodynamic calculation,it can be concluded that the adsorption process is physically monolayer,spontaneous and *** this study,a low-cost and naturally available synthesis method of 13-X molecular sieve is *** with its adsorption mechanism for Cd^(2+),it provides a feasible and general method for removing heavy metal ions from coal gangue and also provides a new way for the utilization of coal gangue with high added value.

关键词： Coal gangue Hydrothermal synthesis 13-X molecular sieve Adsorption Wastewater containing Cd^(2+)

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PVDF/6H-SiC composite fiber films with enhanced piezoelectric performance by interfacial engineering for diversified applications

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Journal of Materials Science & Technology 2024年第3期170卷 238-245页

作者： Linlin Zhou Tao Yang Chunyu Guo kang Wang Enhui Wang Laipan Zhu Hailong Wang Sheng Cao Kuo-Chih Chou Xinmei hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China School of Materials Science Engineering Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

Piezoelectric silicon carbide(SiC)has been quite attractive due to its superior chemical and physical properties as well as wide potential ***,the inherent brittleness and unsatisfactory piezoelectric response of piezoelectric semiconductors remain the major obstacles to their diversified ***,flexible multifunctional PVDF/6H-SiC composite fiber films are fabricated and utilized to assemble both piezoelectric nanogenerators(PENGs)and stress/temperature/light *** open cir-cuit voltage(V_(oc))and the density of short circuit current(I_(sc))of the PENG based on the PVDF/5 wt%6H-SiC composite fiber films reach 28.94 V and 0.24μA cm^(-2),showing a significant improvement of 240%and 300%compared with that based on the pure PVDF *** effect of 6H-SiC nanoparticles(NPs)on inducing interfacial polarization and stress concentration in composite fiber films is proved by first-principles calculation and finite element *** stress/temperature/light sensors based on the composite fiber film also show high sensitivity to the corresponding *** study shows that the PVDF/6H-SiC composite fiber film is a promising candidate for assembling high-performance energy harvesters and diverse sensors.

关键词： 6H-SiC PVDF Multifunctional composite fiber film Energy harvester Stress/temperature/light sensor

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Hybrid electromechanical properties of hetero-doped and homogeneously bonded dual-mode pressure sensor for indoor body area network node

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Science China(Information Sciences) 2024年第1期67卷 240-253页

作者： Junbin YU Shuai XIAN Jinbiao MU Min WANG Yin WANG Xiaojuan hou le ZHANG Jian HE Jiliang MU Xiujian Chou Science and Technology on Electronic Test and Measurement Laboratory North University of China Sichuan Aerospace Fenghuo Servo Control Technology Corporation

Pressure sensors are considerably important for continuous monitoring of human movement and the surrounding environment to construct a caregiving system for the elderly living *** challenge for pressure sensors that still remains is combining self-driven,comfort,and ***,an all-in-one conformal pressure sensor(ACPS) based on a homogeneous integrated triboelectric-piezoelectric hybrid sensor is *** ACPS has dual-mode sensing properties due to coupling triboelectrification and piezoelectric effect ensuring a stable response to various external ***-coated glass microspheres and polyacrylonitrile were uniformly filleted into the silicone rubber substrate using a hetero-doping method to create a stretchable electrode layer with flexible conformal characteristics and a piezoelectric layer with excellent piezoelectric properties,***,the triboelectric layer was fabricated using the same silicone rubber,allowing ACPS to be homogeneously bonded into an all-in-one structure with reliable *** allowed various functional layers to have outstanding interface characteristics and thus improve the electrical transmission *** developed ACPS had outstanding sensitivity(1.04 V/104Pa),high linearity(about 0.984),a wide measurement range(10–700 k Pa),and can accurately and continuously distinguish multiple ***,using a homemade signal processing circuit,ACPSs can be deployed in the human body and the room as indoor body area network *** successfully applied to the remote tracking of daily dynamic home life and the remote operation of small electrical equipment,these ACPSs can achieve real-time caregiving for the elderly living *** an application area desperately needed by society,this study envisions a caregiving system for the elderly living alone without violating personal privacy.

关键词： dual-mode pressure sensor homogeneous bonding all-in-onestructure indoor body area network node elderly caregiving microsystem

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