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Mitogenome-based phylogeny of mosquitoes(Diptera:Culicidae)

Insect Science 2024年第2期31卷 599-612页

作者： De-Hong Chen Shu-Lin He wen-Bo Fu Zhen-tian Yan Yun-Jian Hu Huan Yuan Ming-Bin Wang Bin Chen Chongqing Key Laboratory of Vector Insects Institute of Entomology and Molecular BiologyChongqing Normal UniversityChongqingChina

Mosquitoes are of great medical significance as vectors of many deadly *** have been widely used in phylogenetic studies,but mitogenome knowledge within the family Culicidae is limited,and Culicidae phylogeny is far from *** this study,we surveyed the mitogenomes of 149 Culicidae species,including 7 newly sequenced *** analysis of 149 mosquito mitogenomes shows gene composition and order to be identical to that of an ancestral insect,and the AT bias,length variation,and codon usage are all consistent with that of other reported Dipteran *** analyses based on the DNA sequences of the 13 protein-coding genes from the 149 species robustly support the monophyly of the subfamily Anophelinae and the tribes Aedini,Culicini,Mansonini,Sabethini,and *** resolve ambiguous relationships between clades within the subfamily Culicinae,we performed topological tests and show that Aedini is a sister to Culicini and that Uranotaenini is a sister to(Mansonini)+(Toxorhynchitini+Sabethini).In addition,we estimated divergence times using a Bayesian relaxation clock based on the sequence data and 3 fossil calibration *** results show mosquitoes diverged during the Early Jurassic with massive Culicinae radiations during the Cretaceous,coincident with the emergence of angiosperms and the burst of mammals and ***,this study,which uses the largest number of Culicidae mitogenomes sequenced to date,comprehensively reveals the mitogenome characteristics and mitogenome-based phylogeny and divergence times of Culicidae,providing information for further studies on the mitogenome,phylogeny,evolution,and taxonomic revision of Culicidae.

关键词： characterization Culicidae evolution mitogenomes mosquitoes phylogeny

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Botulinum toxin type A-targeted SPP1 contributes to neuropathic pain by the activation of microglia pyroptosis

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World Journal of Psychiatry 2024年第8期14卷 1254-1266页

作者： Li-Ping Chen Xiao-Die Gui wen-Di tian hou-Ming Kan Jin-Zhao Huang Fu-Hai Ji Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Pain Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Neuropathic pain(NP)is the primary symptom of various neurological *** with NP often experience mood disorders,particularly depression and anxiety,that can severely affect their normal *** cells are as-sociated with *** inflammatory responses,especially the secretion of large amounts of pro-inflammatory cytokines,ultimately lead to *** pyroptosis is a newly discovered form of inflammatory cell death associated with immune responses and inflammation-related diseases of the central nervous *** Two models,an in vitro lipopolysaccharide(LPS)-stimulated microglial cell model and a selective nerve injury model using BTX-A and SPP1 knockdown treatments,were *** proteins in the pyroptosis signaling pathway,NLRP3-GSDMD,were assessed using western blotting,real-time quantitative polymerase chain reaction,and *** factors[interleukin(IL)-6,IL-1β,and tumor necrosis factor(TNF)-α]were assessed using enzyme-linked immuno-sorbent *** also evaluated microglial cell proliferation and ***,we measured pain sensation by assessing the delayed hind paw withdrawal latency using thermal *** The expression levels of ACS and GSDMD-N and the mRNA expression of TNF-α,IL-6,and IL-1βwere enhanced in LPS-treated ***,SPP1 expression was also induced in LPS-treated ***,BTX-A inhibited SPP1 mRNA and protein expression in the LPS-treated ***,depletion of SPP1 or BTX-A inhibited cell viability and induced apoptosis in LPS-treated microglia,whereas co-treatment with BTX-A enhanced the effect of SPP1 short hairpin(sh)RNA in LPS-treated ***,SPP1 depletion or BTX-A treatment reduced the levels of GSDMD-N,NLPRP3,and ASC and suppressed the production of inflammatory *** Notably,BTX-A therapy and SPP1 shRNA enhance microglial proliferation and apoptosis and inhibit microglia

关键词： Botulinum toxin A SPP1 Microglia Pyroptosis Neuropathic pain

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An Analysis of the Fragmentation of Observing Time At the Muztagh-Ata Site

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Research in Astronomy and Astrophysics 2024年第3期24卷 29-33页

作者： wen-Bo Gu Jing Xu Guo-Jie Feng Xuan Zhang Le-tian Wang Xin-Liang Wang Ali Esamdin Li-Xian Shen Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 83001lChina School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

Cloud cover plays a pivotal role in assessing observational conditions for astronomical *** for the fraction of observing time,its fragmentation also wields a significant influence on the quality of nighttime sky *** this article,we introduce the functionΓ∈[0,1],designed to comprehensively capture both the fraction of available observing time and its *** in situ measurement data gathered at the Muztagh-Ata site between 2017 and 2021,we showcase the effectiveness of our *** statistical result illustrates that the Muztagh-Ata site affords approximately 122 nights that were absolutely clear and 205 very good nights annually,corresponding toΓ≥0.9 andΓ≥0.36 respectively.

关键词： site testing-atmospheric effects-methods statistical

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Use of Evidence-Based Research Approach in RCTs of Acupuncture-Related Therapies for Primary Dysmenorrhea: A Meta-Research

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Chinese Journal of Integrative Medicine 2024年第6期30卷 551-558页

作者： HU Xiao-yi tian Zi-yu CHEN Huan HU Xiang-yu MING tian-yu PENG Hao-xuan JIAO Rui-min SHI Lan-jun XIU wen-cui YANG Ji-wei GANG Wei-juan JING Xiang-hong Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina Department of Traditional Chinese Medicine Beijing Puren HospitalBeijing100062China

Objective To assess the use of evidence-based research(EBR)approach in randomized controlled trials(RCTs)of acupuncture-related therapies for primary dysmenorrhea(PD).Methods PubMed,EMBASE,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Biomedical Database,and China Science and Technology Journal Database were searched from January 2013 to December 2022 for RCTs of acupuncture on *** full text and references of each RCT were read to assess whether systematic reviews(SRs)or other types of studies with similar research questions and end-users’perspectives were cited to justify and design the *** addition,the discussion section were analyzed to evaluate whether trials placed the new result in the existing SRs to draw a *** logistic regression was used to find variables that associated with 3 aspects of EBR approach:(1)citing clinical studies for justification,(2)citing relevant studies that obtain the perspectives of end users,and(3)citing clinical studies for results *** Of 473 RCTs included,45.67%(216)of the trials cited relevant similar studies,21.56%(102)referenced to the studies that collected end-users’perspectives,and 10.99%(52)placed result in the context of the previous *** RCTs appropriately applied EBR *** all the included studies,3.17%(15)of the trials used SRs to inform study questions but none of them used updated SRs with acceptable quality;1.05%(5)of the trials cited SRs of end-user’s perspectives in the justification and design of the study,and only 1 trial added results in existing SR to draw a *** of publication,language,funding,registration,ethical approval and number of sites were significantly associated with 1 of the 3 aspects of EBR *** Few RCTs in acupuncture-related therapies for PD used the EBR approach to minimize research ***,research institutes,funding agencies,ethics committees,journals and peer

关键词： evidence-based research acupuncture therapy primary dysmenorrhea randomized controlled trial systematic review end-usersperspective meta-research

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How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： Shan-Shan Liu Xiang Fang Xin wen Ji-Shan Liu Miribangvl Alip tian Sun Yuan-Yuan Wang Hong-Wei Chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and *** transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into *** studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in ***,the mechanism underlying the adipogenic differentiation of MSCs is not fully ***,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC ***,the relationship between maladipogenic differentiation and diseases is briefly *** hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation Signaling pathway Noncoding RNA Epigenetic regulation

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Joint Effects of Multipollutant Mixtures on Mortality in Chengdu,China

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Biomedical and Environmental Sciences 2024年第1期37卷 112-116页

作者： ZHANG Ying tian Qi Qi HU wen Dong ZHANG Shao Bo WANG Shi Gong ZHENG Can Jun Plateau Atmosphere and Environment Key Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225SichuanChina Yunnan R&D Institute of Natural Disaster on Chengdu University of Information Technology Kunming 650034YunnanChina Chengdu Plain Urban Meteorology and Environment Sichuan Provincial Field Scientific Observation and Research Station Chengdu 610225SichuanChina Chinese Center for Disease Control and Prevention National Institute for Communicable Disease Control and PreventionBeijing 102206China

Significant epidemiological research has revealed that exposure to air pollution is substantially associated with numerous detrimental health consequences^([1-3]).The negative health effects of individual air pollutants(e.g.,fine particulate matter:PM_(2.5);nitrogen dioxide:NO_(2);carbon monoxide,CO;or ozone:O_(3))have been widely explored^([4]).However,humans are constantly exposed to multipollutant mixtures in real life,and biological responses to inhaled pollutants are likely to depend on the interplay of pollutant ***,it is critical and imperative to explore the joint effects of multipollutant mixtures on human beings.

关键词： mixtures monoxide consequences

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Potential evaluation of saline aquifers for the geological storage of carbon dioxide: A case study of saline aquifers in the Qian-5 member in northeastern Ordos Basin

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China Geology 2024年第1期7卷 12-25页

作者： Yan Li Peng Li Hong-jun Qu Gui-wen Wang Xiao-han Sun Chang Ma tian-xing Yao Guoneng Jinjie Energy Co. Ltd.Shenmu 719319China Department of Geology Northwest UniversityXi’an 710069China Carbon Neutrality College(Yulin) Northwest UniversityXi’an 710069China National&Local Joint Engineering Research Center of Carbon Capture and Storage Technology Xi’an 710069China

The well-developed coal electricity generation and coal chemical industries have led to huge carbon dioxide(CO_(2))emissions in the northeastern Ordos *** geological storage of CO_(2) in saline aquifers is an effective backup way to achieve carbon *** this case,the potential of saline aquifers for CO_(2) storage serves as a critical basis for subsequent geological storage *** study calculated the technical control capacities of CO_(2) of the saline aquifers in the fifth member of the Shiqianfeng Formation(the Qian-5 member)based on the statistical analysis of the logging and the drilling and core data from more than 200 wells in the northeastern Ordos Basin,as well as the sedimentary facies,formation lithology,and saline aquifer development patterns of the Qian-5 *** results show that(1)the reservoirs of saline aquifers in the Qian-5 member,which comprise distributary channel sand bodies of deltaic plains,feature low porosities and permeabilities;(2)The study area hosts three NNE-directed saline aquifer zones,where saline aquifers generally have a single-layer thickness of 3‒8 m and a cumulative thickness of 8‒24 m;(3)The saline aquifers of the Qian-5 member have a total technical control capacity of CO_(2) of 119.25×10^(6) *** the largest scale and the highest technical control capacity(accounting for 61%of the total technical control capacity),the Jinjie-Yulin saline aquifer zone is an important prospect area for the geological storage of CO_(2) in the saline aquifers of the Qian-5 member in the study area.

关键词： Carbon burial Carbon neutral CO_(2) storage in saline aquifer Distributary channel sand body Potential evaluation Technical control capacity CO_(2)geological storage engineering Ordos Basin

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Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 CAR-T in the treatment of B-cell hematologic malignancies in vivo

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Oncology Research 2024年第6期32卷 1109-1118页

作者： ZHIGANG XIA MENGYAO tian YUCAI CHENG wenFANG YI ZEFAN DU tianwen LI YUCHEN wen LINDI LI YONG LIU CHUN CHEN Pediatric Hematology Laboratory Division of Hematology/OncologyDepartment of PediatricsThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Background:Chimeric antigen receptor T(CAR-T)cell therapy has achieved marked therapeutic success in ameliorating hematological ***,there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T(CAR-T)cell therapy,as well as the optimal timing for CAR-T cell infusion *** and Methods:We employed cell-derived tumor xenograft(CDX)murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell ***,transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment ***:Our preclinical in vivo evaluation determined that a combination of cyclophosphamide and fludarabine,followed by the infusion of CD19 CAR-T cells five days subsequent to the chemotherapy,exerts the most efficacious therapeutic effect in B-cell hematological ***,RNA-seq data indicated that the therapeutic efficacy predominantly perturbs tumor cell metabolism,primarily through the inhibition of key mitochondrial targets,such as C-Jun Kinase enzyme(C-JUN).Conclusion:In summary,the present study offers critical clinical guidance and serves as an authoritative reference for the deployment of CD19 CAR-T cell therapy in the treatment of B-cell hematological malignancies.

关键词： CD19 CAR-T B-cell hematologic malignancies Metabolism In vivo

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Numerical investigation on characteristics of interfacial wave of liquid film in gas-liquid two-phase flow using OpenFOAM

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Chinese Journal of Aeronautics 2024年第2期37卷 233-248页

作者： Xiaoqi MA Yueshe WANG Jiaming tian State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

Liquid film cooling as an advanced cooling technology is widely used in space *** operation of liquid film along the rocket combustion inner wall is crucial for thermal protection of rocket *** stability of liquid film is mainly determined by the characteristics of interfacial wave,which is rarely investigated right *** to improve the stability of thin film has become a hot *** view of this,an advanced model based on the conventional Volume of Fluid(VOF)model is adopted to investigate the characteristics of interfacial wave in gas-liquid flow by using OpenFOAM,and the mechanism of formation and development of wave is revealed intuitively through numerical *** effects from gas velocity,surface tension and dynamic viscosity of liquid(three factors)on the wave are studied *** can be found that the gas velocity is critical to the formation and development of wave,and four modes of droplets generation are illustrated in this ***,a gas vortex near the gas-liquid interface can induce formation of wave easily,so changing the gas vortex state can regulate formation and development of ***’s more,the change rules of three factors influencing on the interfacial wave are obtained,and the surface tension has a negative effect on the formation and development of wave only when the surface tension coefficient is above the critical value,whereas the dynamic viscosity has a positive effect in this ***,the maximum height and maximum slope angle of wave will level off as the gas velocity ***,the maximum slope angle of wave is usually no more than 38°,no matter what happens to the three factors.

关键词： Interfacial wave Gas-liquid Two-phase flow VOF model OpenFOAM

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Interface property of dissimilar Ti-6Al-4V/AA1050 composite laminate made by non-equal channel lateral co-extrusion and heat treatment

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Defence Technology（防务技术） 2024年第3期33卷 197-208页

作者： Juan Liao Mengmeng tian Xin Xue School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350116China

The purpose of this paper is to examine the effect of processing parameters and subsequent heat treatments on the microstructures and bonding strengths of Ti-6Al-4V/AA1050 laminations formed via a non-equal channel lateral co-extrusion *** microstructural evolution and growth mechanism in the diffusion layer were discussed further to optimize the bonding quality by appropriately adjusting process *** electron microscopes(SEM),energy dispersive spectrometer(EDS),and X-ray diffraction(XRD)were used to characterize interfacial diffusion *** shear test was used to determine the mechanical properties of the interfacial diffusion *** experimental results indicate that it is possible to co-extrusion Ti-6Al-4V/AA1050 compound profiles using non-equal channel lateral *** heat treatment processes affect the thickness of the diffusion *** the temperature and time of heat treatment increase,the thickness of the reaction layers increases ***,the shear strength of the Ti-6Al-4V/AA1050 composite interface is proportional to the diffusion layer *** is observed that a medium interface thickness results in superior mechanical performance when compared to neither a greater nor a lesser interface *** characterization of all heat treatments reveals that the only intermetallic compound observed in the diffusion layers is TiAl_(3).Due to the inter-diffusion of Ti and Al atoms,the TiAl_(3) layer grows primarily at AA1050/TiAl_(3) interfaces.

关键词： Shear strength Co-extrusion Heat treatment Microstructure Intermetallic compounds

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