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Boric Acid-Assisted Pyrolysis for High-Loading Single-Atom Catalysts to Boost Oxygen Reduction Reaction in Zn-Air Batteries

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Energy & Environmental Materials 2024年第2期7卷 102-110页

作者： Chenxi xu Jiexing Wu Liang Chen Yi Gong Boyang Mao Jincan Zhang Jinhai Deng mingxuan Mao Yan Shi Zhaohui hou Mengxue Cao Huanxin Li Haihui Zhou Zhongyuan Huang Yafei Kuang State Key Laboratory for Chemo/Biosensing and Chemometrics and College of Chemistry and Chemical Engineering Hunan UniversityChangsha 410082China School of Chemistry and Chemical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional MaterialsHunan Institute of Science and TechnologyYueyang 414006China Advanced Technology Institute University of SurreyGuildford Surrey GU27XHUK Department of Engineering University of Cambridge9 JJ Thomson AvenueCambridge CB30FAUK King's College London London SE11ULUK Department of Electrical and Electronic Engineering Imperial College LondonLondon SW72AZUK College of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Department of Chemistry Physical&Theoretical Chemistry LaboratoryUniversity of OxfordSouth Parks RoadOxford OX13QZUK

The emerging of single-atom catalysts(SACs)offers a great opportunity for the development of advanced energy storage and conversion devices due to their excellent activity and durability,but the actual mass production of high-loading SACs is still ***,a facile and green boron acid(H_(3)BO_(3))-assisted pyrolysis strategy is put forward to synthesize SACs by only using chitosan,cobalt salt and H_(3)BO_(3)as precursor,and the effect of H_(3)BO_(3)is deeply *** results show that molten boron oxide derived from H_(3)BO_(3)as ideal high-temperature carbonization media and blocking media play important role in the synthesis *** a result,the acquired Co/N/B tri-doped porous carbon framework(Co-N-B-C)not only presents hierarchical porous structure,large specific surface area and abundant carbon edges but also possesses high-loading single Co atom(4.2 wt.%),thus giving rise to outstanding oxygen catalytic *** employed as a catalyst for air cathode in Zn-air batteries,the resultant Co-N-B-C catalyst shows remarkable power density and long-term ***,our work gains deep insight into the role of H_(3)BO_(3)and provides a new avenue to synthesis of high-performance SACs.

关键词： boric acid oxygen reduction reaction single-atom catalysts Zn-air batteries

MXene Sediment-Based Poly(vinyl alcohol)/Sodium Alginate Aerogel Evaporator with Vertically Aligned Channels for Highly Efficient Solar Steam Generation

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Nano-Micro Letters 2024年第10期16卷 638-654页

作者： Tian Wang Meng Li Hongxing xu Xiao Wang mingshu Jia Xianguang hou Shuai Gao Qingman Liu Qihang Yang mingwei Tian Lijun Qu Zhenhua Song Xiaohu Wu Lili Wang Xiansheng Zhang Shandong Key Laboratory of Medical and Health Textile Materials College of Textiles and ClothingState Key Laboratory of Bio-Fibers and Eco-TextilesResearch Center for Intelligent and Wearable TechnologyQingdao UniversityQingdao 266071People's Republic of China Department of Pharmacology Qingdao University School of PharmacyQingdao UniversityQingdao 266071People's Republic of China Shandong Institute of Advanced Technology Jinan 250100People's Republic of China College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061People's Republic of China

Solar-driven interfacial evaporation from seawater is considered an effective way to alleviate the emerging freshwater crisis because of its green and environmentally friendly ***,developing an evaporator with high efficiency,stability,and salt resistance remains a key ***,with an internal photothermal conversion efficiency of 100%,has received tremendous research interest as a photothermal ***,the process to prepare the MXene with monolayer is inefficient and generates a large amount of“waste”MXene sediments(MS).Here,MXene sediments is selected as the photothermal material,and a three-dimensional MXene sediments/poly(vinyl alcohol)/sodium alginate aerogel evaporator with vertically aligned pores by directional freezing method is innovatively *** vertical porous structure enables the evaporator to improve water transport,light capture,and high evaporation *** swabs and polypropylene are used as the water channel and support,respectively,thus fabricating a self-floating *** evaporator exhibits an evaporation rate of 3.6 kg m^(-2)h^(-1)under one-sun illumination,and 18.37 kg m^(-2)of freshwater is collected in the condensation collection device after 7 h of outdoor sun *** evaporator also displays excellent oil and salt *** research fully utilizes“waste”MS,enabling a self-floating evaporation device for freshwater collection.

关键词： MXene sediments Porous structure Desalination Self-floating

Infrared imaging of magnetic octupole domains in non-collinear antiferromagnets

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National Science Review 2024年第6期11卷 197-205页

作者： Peng Wang Wei Xia Jinhui Shen Yulong Chen Wenzhi Peng Jiachen Zhang Haolin Pan xuhao Yu Zheng Liu Yang Gao Qian Niu Zhian xu Hongtao Yang Yanfeng Guo Dazhi hou International Center for Quantum Design of Functional Materials(ICQD) School of Emerging TechnologyUniversity of Science and Technology of China College of Mathematics and Physics Qingdao University of Science and Technology School of Physical Science and Technology Shanghai Tech University Shanghai Tech Laboratory for Topological Physics Shanghai Tech University Department of Physics University of Science and Technology of China CAS Key Laboratory of Strongly-Coupled Quantum Matter Physics University of Science and Technology of China Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences

Magnetic structure plays a pivotal role in the functionality of antiferromagnets（AFMs）, which not only can be employed to encode digital data but also yields novel phenomena. Despite its growing significance,visualizing the antiferromagnetic domain structure remains a challenge, particularly for non-collinear AFMs. Currently, the observation of magnetic domains in non-collinear antiferromagnetic materials is feasible only in Mn3Sn, underscoring the limitations of existing techniques that necessitate distinct methods for in-plane and out-of-plane magnetic domain imaging. In this study, we present a versatile method for imaging the antiferromagnetic domain structure in a series of non-collinear antiferromagnetic materials by utilizing the anomalous Ettingshausen effect（AEE）, which resolves both the magnetic octupole moments parallel and perpendicular to the sample surface. Temperature modulation due to AEE originating from different magnetic domains is measured by lock-in thermography, revealing distinct behaviors of octupole domains in different antiferromagnets. This work delivers an efficient technique for the visualization of magnetic domains in non-collinear AFMs, which enables comprehensive study of the magnetization process at the microscopic level and paves the way for potential advancements in applications.

关键词： non-collinear antiferromagnet domain structure infrared imaging anomalous Ettingshausen effect

A machine learning-based crystal graph network and its application in development of functional materials

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Materials Genome Engineering Advances 2024年第3期2卷 107-116页

作者： Gang xu You xue Xiaoxiao Geng Xinmei hou Jinwu xu Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijingChina Institute for Carbon Neutrality University of Science and Technology BeijingBeijingChina

An active area of MGI(Materials Genome Initiative)/MGE(Materials Genome Engineering)is to accelerate the development of new materials by means of active learning and“digital trial-error”using a prediction model of material *** learning methods have widely been employed for predicting crystalline materials properties with crystal graph neural networks(CGNN).The prediction accuracy of the state-of-the-art(SOTA)CGNN models based on big models and big data is generally ***,for the development of some classes of materials,the datasets obtained by experiments are usually lacking due to costly experiments and measurement *** lack of datasets will impact the accuracy of CGNN models and may result in overfitting during training *** paper proposes a simplified crystal graph convolutional neural network(S-CGCNN)which possesses higher prediction accuracy while reducing the vast amount of train datasets and computation *** S-CGCNN model has successfully predicted properties of crystalline materials,such as piezoelectric materials and dielectric materials,and increased the prediction accuracy up to 12%-20%than existing SOTA CGNN ***,the distribution map between properties and compositions of materials has been built to screen the latent space of candidate materials efficiently by principal component analysis.

关键词： crystal graph neural network crystalline materials functional material machine learning

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei Zeng Meizhu Zhang Congcong xu Benyan Lu Chengpeng Tao Weiming Chen Wen hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao Huang Yiru hou Hong Fang Ling xu Yue Yu Huifang Zhang Jing Zhang Yu Tang Gongtao Lan Wenbao Zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China Department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China Department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China Department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

The incidence rate and histological characteristics of intimal hyperplasia in elastase-induced experimental abdominal aortic aneurysms in mice

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Animal Models and Experimental Medicine 2024年第3期7卷 388-395页

作者： Meng Li Panpan Wei Kexin Li Haole Liu Naqash Alam Haiwen hou Jie Deng Baohui xu Enqi Liu Sihai Zhao Yankui Li Laboratory Animal Center Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery The Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'anChina Department of Vascular Surgery Stanford University School of MedicineStanfordCaliforniaUSA

Intimal hyperplasia(IH)is a negative vascular remodeling after arterial *** occasionally occurs in elastase-induced abdominal aortic aneurysm(AAA)mouse *** study aims to clarify the incidence and histological characteristics of IH in aneurysmal mice.A retrospective study was conducted by including 42 male elastaseinduced mouse AAA *** IH incidence,aortic diameters with or without IH,and hyperplasia lesional features of mice were *** 42 elastase-induced AAA mouse models,10 mice developed mild IH(24%)and severe IH was found in only 2 mice(5%).The outer diameters of the AAA segments in mice with and without IH did not show significant *** mild and severe IH lesions show strong smooth muscle cell positive staining,but endothelial cells were occasionally observed in severe IH *** was obvious macrophage infiltration in the IH lesions of the AAA mouse models,especially in mice with severe ***,only a lower numbers of T cells and B cells were found in the IH *** cell-secreted matrix metalloproteinases(MMP)2 was highly expressed in all IH lesions,but MMP9 was only overexpressed in severe *** conclusion,this study is the first to demonstrate the occurrence of aneurysmal IH and its histological characteristics in an elastaseinduced mouse AAA *** will help researchers better understand this model,and optimize it for use in AAA-related research.

关键词： abdominal aortic aneurysms animal model histology intimal hyperplasia

Mechanism of Rosae Rugosae Flos flavonoids in the treatment of hyperlipidemia and optimization of extraction process based on network pharmacology

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Journal of Polyphenols 2024年第2期6卷 65-77页

作者： Yunxiao Xia Aijinxiu Ma Zihan hou xu Zhao Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

This study aims to identify a natural plant chemical with hypolipidemic effects that can be used to treat high cholesterol without adverse *** network pharmacology screening,it was found that Rosae Rugosae Flos(RF)flavonoids had potential therapeutic effects on hyperlipidemia and its mechanism of action was *** and GeneCards databases were used to obtain active ingredients and disease *** diagrams were drawn to illustrate the *** interaction network diagram was created using Cytoscape 3.8.0 *** PPI protein network was constructed using *** and KEGG enrichment analysis was performed using *** results revealed 2 active flavonoid ingredients and 60 potential targets in *** key targets,including CCL2,PPARG,and PPARA,were found to play a role in multiple pathways such as the AGE-RAGE signaling pathway,lipid and atherosclerosis,and cancer pathway in diabetic *** solvent extraction method was optimized for efficient flavonoid extraction based on network pharmacology prediction *** was achieved through a single factor and orthogonal test,resulting in an optimum process with a reflux time of 1.5 h,a solid-liquid ratio of 1:13 g/mL,and an ethanol concentration of 50%.

关键词： Rosae Rugosae Flos flavonoids extraction process optimization network pharmacology hyperlipidemia

Agriculture green development in China: insights and advances

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 5-19,I0005页

作者： Jianbo SHEN Qichao ZHU Yong hou Wen-Feng CONG Wen xu Jiuliang xu Zhichao AN Xiaoqiang JIAO Kai ZHANG Tianxiang YU Lin MA Oene OENEMA William J.DAVIES Fusuo ZHANG State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesNational Academy of Agriculture Green DevelopmentChina Agricultural UniversityBeijing 100193China Key Laboratory of Agricultural Water Resources Center for Agricultural Resources ResearchInstitute of Genetic and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China Wageningen Environmental Research Wageningen University&ResearchWageningen6700 AAthe Netherlands Lancaster Environment Centre University of LancasterLancasterLA14YQUK

Reconciling the tasks of producing adequate amounts of nutritious food for the increasing global population while preserving the environment and natural ecosystems simultaneously is an enormous challenge. The concept of agriculture green development(AGD) and the necessary governmental policies were developed to address the aforementioned challenge in China and to help achieve the related global sustainable development goals. Agriculture green development emphasizes the synergy between green and development;current agriculture has to transform from the intensive farming with high inputs, high environmental impacts and low resource-use efficiency to a more sustainable agriculture, in order to ensure an adequate supply of nutritious food while delivering environmental integrity, improved economic profitability,and social equity. A research program on AGD was established by China Agricultural University with four research themes, namely: green crop production, green integrated crop-animal production, green food and industry,and green ecological environment and ecosystem services, to provide a scientific basis for future developments and to facilitate the implementation of AGD in practice. AGD requires a multistakeholder approach, fueled by innovative and interdisciplinary research. Joint actions have to be taken by governments, farmers, supply industries, consumers, educators, extension services and researchers to support AGD. This requires strong coordination and public awareness campaigns. This review presents the progress that has been made over the past 5 years and makes recommendations for more research and development, in order to better deliver agricultural green and sustainable development on national and international scales.

关键词： Agriculture ecosystem services environmental protection food security green development multi-sectoral cooperation sustainable development