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Cellular & Molecular Immunology 2009年第6期6卷 433-440页

作者： hou-jun xia Gao-Hong Zhang Rui-Rui Wang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanismsof the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Graduate School of the Chinese Academy of Sciences Beijing 100039China Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China

Non-human primates such as Chinese rhesus macaques are the favorable models for preclinical study of potential therapeutic drugs,vaccines and mechanisms of human *** is known about the normal levels of leukocyte subpopulations of Chinese rhesus *** obtain these data,100 blood samples from Chinese rhesus macaques were *** normal range of major leukocyte subpopulations,such as T lymphocytes,B lymphocytes,monocytes,myeloid dendritic cells(mDCs)and plasmacytoid dendritic cells(pDCs),were quantitatively analyzed by flow cytometry through BD trucount *** influence of age and sex on the cell counts of leukocyte subpopulations was *** counts of CD3^(+)T cells,CD3+CD4^(+)T cells,CD3+CD8^(+)T cells and B cells decreased with age,but those of monocytes,mDCs and pDCs had no significant correlation with *** differences existed in the cell counts of most leukocyte subpopulations between the male and female groups except *** the values of the females were higher than those of the *** study provided basic information about the leukocyte subpopulations of Chinese rhesus macaques,and it may be valuable for immunobiological study of Chinese rhesus macaques.

关键词： Chinese rhesus macaque leukocyte subpopulation absolute count age sex

Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

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Cellular & Molecular Immunology 2012年第5期9卷 410-416页

作者： Jian-Ping Ma hou-jun xia Gao-Hong Zhang Jian-Bao Han Li-Guo Zhang Yong-Tang Zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingChina Graduate University of the Chinese Academy of Sciences BeijingChina CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijingChina

It is currently widely accepted that immune activation in HIV-infected individuals leads to a severe loss of CD4＋ T cells and the progression to AIDS. However, the underlying mechanism of this immune activation remains unclear. Experimental data suggest that the activation of plasmacytoid dendritic cells （pDCs） by plasma viremia may play a critical role in HIV-induced immune activation. In this study, we found that the level of immune activation was higher in the late phase of SIVmac239 infection compared with chronic infection, which suggests that immune activation might be related to disease progression in SIVmac239-infected non-human primate models. Our work also showed that chloroquine could effectively inhibit the activation of pDCs in vitro and in vivo. However, chloroquine treatment of SIVmac239-infected macaques had no significant influence on the Cellular composition of peripheral blood in these animals.

关键词： Chinese rhesus macaque chloroquine immune activation pDC SIV

Establishment of AIDS Animal Model with SIVmac239 Infected Chinese Rhesus Monkey

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Virologica Sinica 2007年第6期22卷 509-516页

作者： Ming-hua LI Shao-you LI hou-jun xia Lu WANG Yuan-yuan WANG Gao-hong ZHANG Yong-tang ZHENG Laboratory of Molecular Immunopharmacology Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

In the present research,two Chinese rhesus monkeys were inoculated intravenously with 5000 TCID50 of SIVmac239. The changes in the numbers of CD4+ T lymphocyte in peripheral blood,plasma viral loads,proviral DNA and humoral antibodies against virus were periodically monitored during 121 days. At the early stage of infection,proviral DNA had been detected in PBMCs,and infectious SIVmac239 virus had been isolated from PBMCs. At the same period,the numbers of CD4+ T lymphocytes were significantly decreased,and maintained at low level during the 121-day period of infection. Plasma viral loads reached the peak at week 2 post-inoculation and kept at a steady state subsequently. Moreover,antibodies against viral proteins were detected from plasma. All the results showed that the two Chinese rhesus monkeys had been infected with SIVmac239 successfully. This animal model can be applied for further AIDS researches.

关键词： AIDS SIV SIVmac239 HIV Primate animal model Chinese rhesus monkey

Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin jun Xu Delong Jiang Jiayang hou Ying Liang Zhongyue Zou Xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

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我国通货膨胀影响因素动态效应分析

商业研究 2013年第5期 1-6页

作者：卢方元侯军霞郑州大学商学院郑州450001

基于2001年到2012年3月间的月度数据,本文选取通货膨胀率、国际粮食价格、外汇储备和固定资产投资作为指标,建立结构向量自回归(SVAR)模型,对影响通货膨胀率变化的各种因素进行结构分解,得到通货膨胀率变化对自身的影响程度,以及国际粮... 详细信息

基于2001年到2012年3月间的月度数据,本文选取通货膨胀率、国际粮食价格、外汇储备和固定资产投资作为指标,建立结构向量自回归(SVAR)模型,对影响通货膨胀率变化的各种因素进行结构分解,得到通货膨胀率变化对自身的影响程度,以及国际粮价、外汇储备和固定资产投资的变化对通货膨胀率的当期和长期影响结果。研究表明国际粮食价格只在短期内引起物价的波动,而外汇储备、固定资产投资在长期内对通货膨胀会产生稳定的影响。因此,加快建立外汇储备的运营管理机制,合理的控制粮食对外依存度,慎重地选取固定资产投资规模对于控制通货膨胀至关重要。

关键词：通货膨胀 SVAR模型外汇储备固定资产投资

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浅谈城市房屋拆迁估价

科技情报开发与经济 2006年第17期16卷 142-143页

作者：侯君霞运城市城市房屋拆迁管理办公室山西运城044000

在明确城市房屋拆迁估价内涵的基础上,说明了如何选择估价机构、拆迁估价实务、估价结果公示、拆迁估价纠纷调处等主要技术性问题。

关键词：拆迁估价估价实务纠纷调处

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei xia Yue Ma Mingtong Gao Shuai hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

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损伤肝组织匀浆与骨髓间充质干细胞的分化

中国组织工程研究 2012年第27期16卷 4963-4967页

作者：侯军霞梅浙川蒋明德重庆医科大学附属第二医院消化内科重庆市400010 解放军成都军区总医院消化内科四川省成都市610083

背景:目前认为,骨髓间充质干细胞能否分化为肝细胞与微环境关系密切。目的:探讨急性酒精性肝损伤组织匀浆对骨髓间充质干细胞的诱导分化作用。方法:分别用正常和损伤肝脏组织匀浆诱导骨髓间充质干细胞分化,在第0,3,7,10,14,21天用RT-PCR... 详细信息

背景:目前认为,骨髓间充质干细胞能否分化为肝细胞与微环境关系密切。目的:探讨急性酒精性肝损伤组织匀浆对骨髓间充质干细胞的诱导分化作用。方法:分别用正常和损伤肝脏组织匀浆诱导骨髓间充质干细胞分化,在第0,3,7,10,14,21天用RT-PCR和Westernblot法检测甲胎蛋白、白蛋白的表达。结果与结论:骨髓间充质干细胞在正常及损伤的肝脏组织匀浆诱导下均表现为类上皮样改变。两组均从第3天开始检测到甲胎蛋白的表达,并在第7天左右达到高峰,之后表达逐渐减少,第14天时量很少;在第7天检测到白蛋白的表达,且随时间延长表达量逐渐增加,mRNA水平与蛋白水平表达一致。表明肝细胞在诱导培养下逐渐从幼稚到成熟。但正常和损伤肝组织匀浆诱导的肝细胞甲胎蛋白和白蛋白的表达量差异无显著性意义(P>0.05)。结果说明急性酒精性肝损伤组织匀浆可以诱导骨髓间充质干细胞向肝细胞分化,其诱导效果与正常肝脏组织匀浆相近。

关键词：肝组织匀浆骨髓间充质干细胞细胞分化肝细胞酒精性肝损伤干细胞

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社科伦理审查制度的引进与文化适应性研究

湖南大学学报（社会科学版） 2013年第5期27卷 125-129页

作者：侯俊霞胡志雯朱亚宗国防科技大学人文与社会科学学院湖南长沙410073 湖南大学外国语学院湖南长沙410082

社会科学研究的伦理审查在欧美等国已有相对成熟的制度。为适应中国社会科学研究发展的需要,尤其是国际合作与跨文化研究的发展需要,需引进国外的成功经验,并研究伦理审查制度在中国的文化适应性问题。目前首先要从理论上确立价值正向... 详细信息

社会科学研究的伦理审查在欧美等国已有相对成熟的制度。为适应中国社会科学研究发展的需要,尤其是国际合作与跨文化研究的发展需要,需引进国外的成功经验,并研究伦理审查制度在中国的文化适应性问题。目前首先要从理论上确立价值正向、保护弱者、学术独立与尊重权利等四个原则,以便为进一步建立中国特色的社会科学伦理审查制度奠定理论基础。

关键词：伦理审查文化适应社科管理

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SHR大鼠脑出血急性期血压调控机制与NE、E、PRA、AngⅡ关系

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中华神经医学杂志 2009年第1期8卷 26-29页

作者：林高城吴钢林军侯俊霞施清晓福建医科大学附属第一医院神经内科福州350005 福建医科大学附属第一医院核医学科福州350005

目的研究白发性高血压大鼠脑出血急性期血压调控机制与去甲肾上腺素（NE）、肾上腺素（E）、血管紧张素Ⅱ（AngⅡ）、肾素（eRA）的关系，探讨脑出血急性期血压调控机制。方法采用胶原酶注入尾状核的方法建立大鼠脑出血模型，利用高效液... 详细信息

目的研究白发性高血压大鼠脑出血急性期血压调控机制与去甲肾上腺素（NE）、肾上腺素（E）、血管紧张素Ⅱ（AngⅡ）、肾素（eRA）的关系，探讨脑出血急性期血压调控机制。方法采用胶原酶注入尾状核的方法建立大鼠脑出血模型，利用高效液相-电化学法、放射免疫方法测定出血前及出血后1d、3d、7d和14d5个时间点（即5个组1血浆NE、E、AngⅡ、PRA及下丘脑NE、AngⅡ的含量。结果（1）血浆NE、E及下丘脑NE含量在脑出血1d时达高峰[分别为（4.31±0．97）μg/L、（8．55_＋2．41）μg/L、（919_＋128）ne／g]，与术前比较差异有统计学意义（p〈0．05），7～14d基本恢复至术前水平；（2）血浆PRA、AngⅡ及下丘脑AngⅡ含量在出血后3d达到高峰[分别为（8．81_＋3．1）ng／mL·h、（1204_＋269）pg／mL、（33．6_＋7．1）pg／mg]，与术前比较差异有统计意义（P〈0．05），7～14d基本恢复至术前水平；（3）大鼠脑出血第1天血压较术前明显升高，差异有统计学意义（P〈0．05），第3天较第1天明显下降，7～14d基本恢复至出血前水平。结论SHR大鼠脑出血急性期血压调控可能与交感-肾上腺髓质系统及肾素-血管紧张素系统在脑出血急性期的应激性激活密切相关。

关键词：自发性高血压大鼠去甲肾上腺素肾上腺素肾素血管紧张素Ⅱ 脑出血