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四等级三尖瓣反流分级较指南三等级分级的临床适用性研究

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中华超声影像学杂志 2024年第6期33卷 475-481页

作者：张曦张宇新谭碧君侯颖文立伟袁丽君邢长洋空军军医大学唐都医院超声医学科西安710038

目的探讨近年来学界提倡的四等级分级(G4)相较于指南三等级分级(G3)在功能性三尖瓣反流(FTR)中的临床适用性。方法前瞻性连续纳入2023年5-12月在空军军医大学唐都医院门诊及住院就诊的FTR患者137例。所有患者均接受超声心动图检查,并参... 详细信息

目的探讨近年来学界提倡的四等级分级(G4)相较于指南三等级分级(G3)在功能性三尖瓣反流(FTR)中的临床适用性。方法前瞻性连续纳入2023年5-12月在空军军医大学唐都医院门诊及住院就诊的FTR患者137例。所有患者均接受超声心动图检查,并参照2017年美国超声心动图学会瓣膜评估指南为参考标准进行反流等级划分。将纳入的反流患者按指南G3和学界近年提倡的G4分别进行分组,通过Kappa检验对二者在FTR反流程度分级中的多指标与单指标进行一致性分析,并采用ROC曲线分析缩流颈宽度(VCW)、彩色反流束面积(A_(Jet))、PISA半径(R_(PISA))相关定量反流参数对G4的诊断效能。结果一致性分析结果显示,相较于G3,G4多指标综合评估与单指标评估中反流容积(RVol)一致性显著提高(Kappa值0.84比0.30);有效反流口面积(EROA)与VCW一致性等级不变(Kappa值分别为0.76比0.89,0.51比0.66)。ROC曲线分析显示,对于G4,A_(Jet)、R_(PISA)、VCW对轻度与中度反流区分能力的曲线下面积(AUC)分别为0.854、0.993、0.894,对中度与中重度反流区分能力的AUC分别为0.899、0.979、0.917。结论对于FTR,目前学界提倡的G4相较于G3在单指标与综合指标分级一致性方面表现更佳,临床适用性好;A_(Jet)、R_(PISA)、VCW可补充至G4,有助于完善其定量评估体系。

关键词：超声心动描记术,二维功能性三尖瓣反流反流严重程度分级

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几种传统酸浆的制作工艺、应用及研究进展

食品与发酵工业 2024年第19期50卷 388-396页

作者：李毅昊赵仕达李海阳李阳徐建强侯颖河南科技大学食品与生物工程学院河南洛阳471023 河南省食品微生物工程技术研究中心河南洛阳471023 微生物资源开发与利用河南科技大学重点实验室河南洛阳471023 河南科技大学园艺与植物保护学院河南洛阳471023

酸浆是豆类或薯类等农作物加工过程中,自然发酵形成的一种乳白色、酸性浆状产物。在我国使用酸浆加工农产品已经拥有数百年的历史,主要用于红薯淀粉、绿豆淀粉的加工和酸浆豆腐的制作等;也有一些地区用酸浆制作具有地方特色的美食如北... 详细信息

酸浆是豆类或薯类等农作物加工过程中,自然发酵形成的一种乳白色、酸性浆状产物。在我国使用酸浆加工农产品已经拥有数百年的历史,主要用于红薯淀粉、绿豆淀粉的加工和酸浆豆腐的制作等;也有一些地区用酸浆制作具有地方特色的美食如北京豆汁、洛阳浆面条和西北地区浆水面等。目前对于酸浆的研究主要聚焦于酸浆的微生物多样性组成、酸浆中微生物的分离鉴定及其在农产品加工中的应用等。本文主要从常用酸浆的制作工艺、应用和酸浆的研究进展等展开论述,并对酸浆未来的研究方向进行展望。

关键词：酸浆乳酸菌制作工艺应用研究进展

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40%氟啶胺·乙螨唑悬浮剂分析方法研究

农药科学与管理 2024年第7期45卷 38-42页

作者：宋怀挺侯影余德勉上海悦联生物科技有限公司

文章中，建立了液相色谱法同柱分析乙螨唑、氟啶胺的含量的分析方法，以甲醇和0.1%磷酸水溶液为流动相，使用CAPCELL PAK C18/5μm为填充料的不锈钢柱，检测波长为225 nm。结果表明，在该方法中乙螨唑、氟啶胺的标准曲线线性回归系数分... 详细信息

文章中，建立了液相色谱法同柱分析乙螨唑、氟啶胺的含量的分析方法，以甲醇和0.1%磷酸水溶液为流动相，使用CAPCELL PAK C18/5μm为填充料的不锈钢柱，检测波长为225 nm。结果表明，在该方法中乙螨唑、氟啶胺的标准曲线线性回归系数分别为0.999 9和0.999 9，标准偏差分别为0.027 1和0.034 6，变异系数分别为0.26%和0.11%，平均回收率分别为99.54%和99.91%。

关键词：乙螨唑氟啶胺分析

Characteristics of Mechanical Properties and Microstructure for 316L Austenitic Stainless Steel

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Journal of Iron and Steel Research International 2011年第11期18卷 53-59页

作者： SONG Ren-bo XIANG Jian-ying hou Dong-po School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

A comparative study on mechanical properties and microstructure of 316L austenitic stainless steel between solution treated specimen and hot rolled specimen was conducted. After a specimen was subjected to solution treatment at 1 050 ℃ for 6 min, its mechanical properties were determined through tensile and hardness tests. Based on the true stress vs true strain and engineering stress vs engineering strain flow curves, the work hardening rate has been explored. The results show that the solution treated specimen has an excellent combination of strength and elongation, and that this steel is easy to work-hardening during deformation. Optical microscope, scanning electron micro- scope, transmission electron microscope and X-ray diffraction examinations were conducted, these reveal that twins in 316L austenitic stainless steel can be divided into suspended twin and transgranular twin which have different for mation mechanisms in growth, and that the deformation induced martensite nucleated and grown in the shear band intersections can be observed, and that the fracture surfaces are mainly composed of dimples and exhibit a tough fracture character.

关键词： 316L mechanical property twin martensite fracture morphology

Defect band formation in high pressure die casting AE44 magnesium alloy

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China Foundry 2022年第3期19卷 201-210页

作者： ying-ying hou Meng-wu Wu Feng Huang Xiao-bo Li Shou-mei Xiong Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

The characteristics of defect bands in the microstructure of high pressure die casting(HPDC)AE44 magnesium alloy were *** attention was paid to the effects of process parameters during the HPDC process and casting structure on the distribution of defect *** show that the defect bands are solute segregation bands with the enrichment of Al,Ce and La elements,which are basically in the form of Al_(11)RE_(3) *** is no obvious aggregation of porosities in the defect *** width of the inner defect band is 4-8 times larger than that of the outer *** variation trends of the distribution of the inner and outer defect bands are not consistent under different process parameters and at different locations of *** is due to the discrepancy between the formation mechanisms of double defect *** filling and solidification behavior of the melt near the chilling layer is very complicated,which finally leads to a fluctuation of the width and location of the outer defect *** affecting the content and aggregation degree of externally solidified crystals(ESCs)in the cross section of die castings,the process parameters and casting structure have a great influence on the distribution of the inner defect band.

关键词： high pressure die casting magnesium alloy AE44 defect band microstructure

Application of patient-derived tumor models in anticancer drug development and individualized medicine

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Life Research 2024年第1期7卷 3-9页

作者： Kai-Ling Chen Yu-Fei Deng Xiao-ying hou Yu-Chen Liu Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan 430056China Cancer Institute School of MedicineJianghan UniversityWuhan 430056China

Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.

关键词： patient-derived xenograft(PDX) patient-derived organoid(PDO) patient-derived cell(PDC) individualized medicine

一种基于前向成像模型的光声层析图像重建方法

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中国光学（中英文） 2024年第2期17卷 444-455页

作者：程丽君孙正孙美晨侯英飒华北电力大学电子与通信工程系河北保定071003 华北电力大学河北省电力物联网技术重点实验室河北保定071003

在光声层析成像(photoacoustic tomography,PAT)时,不均匀光通量分布、组织复杂的光学和声学特性以及超声探测器的非理想特性等因素会导致重建图像质量下降。本文考虑不均匀光通量、非定常声速、超声探测器的空间脉冲响应和电脉冲响应... 详细信息

在光声层析成像(photoacoustic tomography,PAT)时,不均匀光通量分布、组织复杂的光学和声学特性以及超声探测器的非理想特性等因素会导致重建图像质量下降。本文考虑不均匀光通量、非定常声速、超声探测器的空间脉冲响应和电脉冲响应、有限角度扫描和稀疏采样等因素的影响,建立了前向成像模型。通过交替优化求解成像模型的逆问题,实现光吸收能量分布图和声速分布图的同时重建。仿真、仿体和在体实验结果表明,与反投影法、时间反演法和短滞后空间相干法相比,该方法重建图像的结构相似度和峰值信噪比可分别提高约83%、56%、22%和80%、68%、58%。由上述结果可知,对非理想成像场景采用该方法重建的图像质量有显著提高。

关键词：光声层析成像图像重建前向成像模型探测器脉冲响应有限角度扫描稀疏采样

Breakdown of Energy Equipartition in Vibro-Fluidized Granular Media in Micro-Gravity

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Chinese Physics Letters 2012年第7期29卷 160-163页

作者： CHEN Yan-Pei Pierre Evesque hou Mei-ying Key Laboratory of Soft Matter Physics Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190 Lab MSSMat Ecole Centrale de ParisUMR 8579 CNRS92295 Châtenay-Malabry CedexFrance

We present a micro-gravity experimental study of intermediate number density vibro-fluidized inelastic spheres in a rectangular *** velocity distributions are investigated,and are found to deviate measurably from a symmetric distribution for the velocity component of the vibrating direction when dividing particles along the vibration direction into several *** feature does not exist in the molecular *** further study the hydrodynamic profiles of pressures p and temperatures T in positive and negative components,such as p+y and p-y and T+y and T-y,in accordance with the sign of velocity components of the vibrating *** vibration direction,granular media are found to be not only inhomogeneous and anisotropic,but also different greatly in positive and negative *** equipartition breaks down in this case.

关键词： partition vibrating dividing

Preparation and Characterization of Nano-Se/Silk Fibroin Colloids

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Chemical Research in Chinese Universities 2011年第1期27卷 158-160页

作者： hou Ju-ying AI Shi-yun SHI Wei-jie College of Chemistry and Material Science Shandong Agricultural University Tai ＇an 271018 P. R. China

A solution-phase approach to the synthesis of nano-Se/silk fibroin colloids（NSeSFC） by reducing selenious acid solution with silk fibroin（SF） was proposed, and the composites were in situ prepared by macrowave method. The nanocomposites were characterized with ultraviolet-visible（UV-Vis） absorption spectrometry, resonance Rayleigh scattering（RRS） spectrometry and transmission electron microscopy（TEM）. The nano-Se（0） solution exhibited the strongest resonance Rayleigh scattering at 579 rim. Through the RRS discussion, we found the best preparation and conservation condition of NSeSFC. The TEM image shows the sizes of the Se（0） particles were about 50 nm and dispersed equably. The resulted NSeSFC exhibited good stability, and it can be kept for a long period.

关键词： Silk fibroin Red selenium nanoparticle Resonance Rayleigh scattering Transmission electron microscopy