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移动电话资费管制的研究

电信科学 2006年第10期22卷 46-50页

作者：侯广吉马慧梁雄健北京邮电大学经济管理学院北京100876 北京邮电大学经济管理学院北京100876

伴随着中国电信行业,特别是移动电话用户数量的高速发展和有效市场竞争格局的初步建立,移动电话资费的调整、改革与管制等问题成为近几年社会各界关注的焦点。本文从电信管制理论出发,分析和介绍了电信资费管制理论的演进过程,进而对中... 详细信息

伴随着中国电信行业,特别是移动电话用户数量的高速发展和有效市场竞争格局的初步建立,移动电话资费的调整、改革与管制等问题成为近几年社会各界关注的焦点。本文从电信管制理论出发,分析和介绍了电信资费管制理论的演进过程,进而对中国电信市场特别是移动电话资费的管制实践进行了系统研究,深入地分析了中国建立的新的移动电话资费管制体系,并对未来移动电话资费管制的发展趋势作了展望。

关键词：电信市场移动电话资费管制

Research progress on the pharmacological effects and chemical constituents of Pien Tze Huang and its potential Q-markers

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Chinese Journal of Natural Medicines 2023年第9期21卷 658-669页

作者： DONG Zhaomin WANG Hong WANG guangji Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China

Pien Tze Huang(PTH)was documented as an imperial prescription composed of Notoginseng Radix,Calculus Bovis,Snake Gallbladder,and *** is famous in China and Asian countries due to its excellent effects in heat clearing,detoxifying,swelling reduction,and pain *** pharmacological studies demonstrate that PTH shows excellent effects against various inflammatory diseases,liver diseases,and *** review summaries the pharmacological effects,clinical applications,and mainchemical components of *** importantly,its potential quality markers(Q-markers)were then analyzed based on the“five principles”of Q-markers under the guidance of Traditional Chinese Medicine theory,including transfer and traceability,specificity,efficacy,compatibility,and *** a result,ginsenosides Rb1,ginsenoside Rg1,ginsenoside Rd,ginsenoside Re,notoginsenoside R1,dencichine,bilirubin,biliverdin,taurocholic acid,and muscone are considered as the Q-markers of *** findings will provide guidance and assistance for the construction of a quality control system for PTH.

关键词： Pien Tze Huang(PTH) Quality marker(Q-marker) Chemical components Pharmacological effects Clinical application Qualitycontrol

Research on Condenser Deterioration Evolution Trend Based on ANP-EWM Fusion Health Degree

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 679-698页

作者： Hong Qian Haixin Wang guangji Wang Qingyun Yan College of Automation Engineering Shanghai University of Electric PowerShanghai200090China Shanghai Key Laboratory of Power Station Automation Technology Shanghai200072China Empower Information Technology(Shanghai)Co. Ltd.Shanghai201508China China Nuclear Power Engineering Design Co. Ltd.Shenzhen518052China

This study presents a proposed method for assessing the condition and predicting the future status of condensers operating in seawater over an extended *** aim is to address the problems of scaling and corrosion,which lead to increased loss of cold *** method involves utilising a set of multivariate feature parameters associated with the condenser as input for evaluation and trend *** methodology offers a precise means of determining the optimal timing for condenser cleaning,with the ultimate goal of improving its overall *** proposed approach involves the integration of the analytic network process with subjective expert experience and the entropy weightmethod with objective big data analysis to develop a fusion health *** mathematical model is constructed quantitatively using the improved Mahalanobis ***,a comprehensive prediction model is developed by integrating the improved Informer model and Markov error *** model takes into account the health status of the equipment and several influencing factors,includingmultivariate feature *** model facilitates the objective examination and prediction of the progression of equipment deterioration *** present study involves the computation and verification of the field time series data,which serves to demonstrate the accuracy of the condenser health-related models proposed in this *** models effectively depict the real condition and temporal variations of the equipment,thus offering a valuable method for determining the precise cleaning time required for the condenser.

关键词： Condenser health degree improved Mahalanobis distance GC-Informer model Markov error correction

Reliability of dermatomal somatosensory-evoked potential in the evaluation of lumbosacral nerve root injury A concurrent case-control study

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Neural Regeneration Research 2008年第1期3卷 57-60页

作者： Ningjiang Shen Jian Chen guangji Wang Xiaoli Wu Yutian Wang Department of Orthopaedic Surgery Hainan Provincial People＇s Hospital Haikou 570311 Hainan Province China

BACKGROUND： It has been reported that dermatomal somatosensory evoked potential （DSEP） can be used for diagnosing nerve root injury in patients with lumbar disc herniation （LDH）, and that 83% 95% of patients suffer from the disease. Body height correction is not performed prior to determinations of latency and latency difference between the healthy and affected sides. However, latency noticeably correlates to body height. OBJECTIVE： This study aims to determine the lumbosacral nerve root injury in patients with LDH by DSEP, and to evaluate the sensitivity of the DSEP difference between the healthy and affected sides using a diagnostic index following body height correction. DESIGN： A case-control observation. SETTING： Department of Orthopedic Surgery, Hainan Provincial People＇s Hospital. PARTICIPANTS： Ninety-six patients, comprised of 67 males and 29 females, with an average age of 43 years and a mean body height of 1.65 m （range 1.48-1.81 m）, were recruited for this study. These patients suffered from unilateral lower limb radiation pain and received treatment at the Department of Orthopedic Surgery, Hainan Provincial People＇s Hospital between January 2004 and December 2006. All patients were confirmed to suffer from LDH at the L3-4, L-5, and/or Ls-SI by CT and/or MRI examinations. Central nervous system diseases were excluded. In order to obtain a normal reference value, DSEP was determined for a group of 50 subjects, who concurrently received health examinations in the same department. The subjects had no previous history of back leg pain or nervous system disease. The group of healthy controls included 26 males and 24 females, with an average age of 37 years and a mean body height of 1.63 m （range 1.50-1.80 m）. Written informed consent was obtained from all subjects for laboratory samples. The protocol was approved by the Hospital＇s Ethics Committees. DSEP was determined with myoelectricity-evoked potential equipment （Keypoint, Batch No. 9020A0042591, Dantec Com

关键词： dermatomal somatosensory evoked potential lumbar disc herniation nerve root injury

Quantitative determination of D_(4)-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability

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Journal of Pharmaceutical Analysis 2021年第5期11卷 580-587页

作者： Shuning Li Zhenyao Lu Li Jiao Ran Zhang Yu Hong Jiye Aa guangji Wang Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical UniversityNanjingJiangsu210009China

Cystine is the primary source material for the synthesis of ***,the pharmacokinetics and tissue distribution of cystine are largely unknown.A surrogate analyte D_(4)-cystine was employed to generate calibration curves for the determination of levels of D_(4)-cystine and endogenous cystine in mice by liquid chromatography-tandem mass spectrometry(LC-MS/MS).Validation assessments proved the sensitivity,specificity and reproducibility of the method with a lower limit of quantification(LLOQ)of 5 ng/mL over 5e5000 ng/mL in *** pharmacokinetics of D_(4)-cystine were evaluated after administering injections and oral solutions,both of which minimally impacted endogenous cystine *** absolute bioavailability of cystine was 18.6%,15.1%and 25.6%at doses of 25,50 and 100 mg/kg,*** injected D_(4)-cystine resulted in dramatically high plasma levels with reduced levels in the brain and *** administered D_(4)-cystine resulted in high levels in the plasma and stomach with relatively low levels in the lung,kidney,heart and brain.

关键词： Cystine LC-MS/MS Pharmacokinetics Distribution Absolute bioavailability

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

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Acta Pharmaceutica Sinica B 2020年第1期10卷 3-18页

作者： Tingting Yan Nana Yan Ping Wang Yangliu Xia Haiping Hao guangji Wang Frank JGonzalez Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism and PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Life Science and Medicine Dalian University of TechnologyPanjin 124221China

Few medications are available for meeting the increasing disease burden of nonalcoholic fatty liver disease(NAFLD)and its progressive stage,nonalcoholic steatohepatitis(NASH).Traditional herbal medicines(THM)have been used for centuries to treat indigenous people with various symptoms but without clarified modern-defined disease types and *** modern times,NAFLD was defined as a common chronic disease leading to more studies to understand NAFLD/NASH pathology and *** have garnered increased attention for providing therapeutic candidates for treating *** this review,a new model called"multiple organs-multiple hits"is proposed to explain mechanisms of NASH *** this proposed model,the effects and mechanisms of the frequentlystudied THM-yielded single anti-NAFLD drug candidates and multiple herb medicines are reviewed,among which silymarin and berberine are already under ***-sanctioned phase 4 clinical ***,experimental designs for anti-NAFLD drug discovery from THM in treating NAFLD are *** opportunities and challenges of reverse pharmacology and reverse pharmacokinetic concepts-guided strategies for THM modernization and its global recognition to treat NAFLD are *** mechanistic evidence is being generated to support the beneficial role of THM in treating NAFLD and anti-NAFLD drug discovery.

关键词： Natural products Fatty liver Metabolic syndrome TCM NAFLD

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

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Acta Pharmaceutica Sinica B 2023年第2期13卷 559-576页

作者： Shuang Cui Huijian Hu An Chen Ming Cui Xiaojie Pan Pengfei Zhang guangji Wang Hong Wang Haiping Hao State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism&PharmacokineticsChina Pharmaceutical UniversityNanjing 210009China

Farnesoid X receptor(FXR)is widely accepted as a promising target for various liver diseases;however,panels of ligands in drug development show limited clinical benefits,without a clear ***,we reveal that acetylation initiates and orchestrates FXR nucleocytoplasmic shuttling and then enhances degradation by the cytosolic E3 ligase CHIP under conditions of liver injury,which represents the major culprit that limits the clinical benefits of FXR agonists against liver *** inflammatory and apoptotic stimulation,enhanced FXR acetylation at K217,closed to the nuclear location signal,blocks its recognition by importin KPNA3,thereby preventing its nuclear ***,reduced phosphorylation at T442 within the nuclear export signals promotes its recognition by exportin CRM1,and thereby facilitating FXR export to the *** governs nucleocytoplasmic shuttling of FXR,resulting in enhanced cytosolic retention of FXR that is amenable to degradation by ***1 activators reduce FXR acetylation and prevent its cytosolic *** importantly,SIRT1 activators synergize with FXR agonists in combating acute and chronic liver *** conclusion,these findings innovate a promising strategy to develop therapeutics against liver diseases by combining SIRT1 activators and FXR agonists.

关键词： FXR Nuclear receptor Acetylation Phosphorylation Nucleocytoplasmic shuttling Degradation Nonalcoholic steatohepatitis Combinatorial drugs

STRUCTUREAND PROPERTY OF DIRECTIONALLY SOLIDIFIED EUTECTIC Bi/MnBi ALLOY

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Acta Metallurgica Sinica(English Letters) 1992年第12期5卷 512-515页

作者： FU Xuli LI Jun WANG Wu YANG Yongqing SHU guangji Southeast University,Nanjing,China Southeast Univ Nanjing China

Eutectic Bi/MnBi magnetic alloy was prepared by directional *** the growth rate,R>2 cm/h,the MnBi fibre spacing,λ,distributed homogeneously in Bi matrix,follows λ~2R=*** thermal gradient.G_L,does not influence λ.Th... 详细信息

关键词： eutectic Bi/MnBi alloy growth rate thermal gradient fiber spacing magnetic property

Sedimentary Expressions of the Early Jurassic Jenkyns Event in an Inland Lacustrine System in the Yin'gen-Ejinaqi Basin,North China

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Acta Geologica Sinica(English Edition) 2024年第5期98卷 1359-1375页

作者： YANG Bing XU Guozhen HUI guangji WEI Yi ZHANG Xinzhi YI Jinjun SUN Siyuan ZHANG Sujiang Cores and Samples Center of Natural Resources LangfangHebei 065201China Nanjing Institute of Geology and Palaeontology Chinese Academy of SciencesNanjing 210008China North China Institute of Science and Technology LangfangHebei 065201China

The Jenkyns Event,more widely known as the Toarcian Oceanic Anoxic Event(T-OAE),is marked by globally distributed negative carbon-isotope excursions,widespread oxygen depletion,and large-scale organic carbon burial,which indicate major climate/environmental perturbations in Earth's surface systems during the Early *** extensive research has been conducted in European continental settings,particularly in the western peri-Tethys regions,the impacts of this event beyond Europe remains largely ***,a multiapproach study including investigations into the sporepollen assemblages,pyrite framboids,clay minerals,total organic carbon(TOC)levels,and organic carbon isotope(δ13Corg)levels in a lacustrine borehole section(MED1)from the Yin'gen-Ejinaqi Basin,North China,provides evidence of the occurrence of the Jenkyns Event and its extensive sedimentary responses in the eastern Tethys terrestrial *** distinct spore-pollen assemblages have been identified in MED1(drilling depth:982.4 m to 1267.5 m),with the Cycadopites-Protopinus-Osmundacidites assemblage in the lower part(1267.5 m to 1132.9 m)indicating a middle Early Jurassic age and the Classopollis assemblage in the upper part(1132.9 m to 985.7 m)suggesting a Toarcian *** pyrite data suggest more anoxic conditions during the deposition of black mudstone and shale intercalations in the lower part of the Classopollis assemblage(1132.9 m to 1066.9 m),which combined with organic carbon enrichment and negativeδ13Corg excursions,are considered the paleoenvironmental response to the Jenkyns Event in the study ***,the evolution of vegetation groups changed from plant groups characterized by bisaccate and cycad pollen,as well as fern spores,to vegetation groups represented by Cheirolepidiaceae pollen across the Jenkyns Event,as evidenced by sporepollen data,together with the clay mineral assemblage change characterized by a notable increase in illite at the expense of kaolinite,

关键词： spore-pollen assemblages clay minerals pyrite framboids organic carbon isotope Jenkyns event