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Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema

Chinese Medical Journal 2014年第3期127卷 469-474页

作者： Ye Qiao Huang Kewu Ding Yi Lou Baohui hou ziliang Dai Huaping Wang Chen Department of Respiratory and Critical Care Medicine Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Department of Radiology Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Institute of Respiratory Medicine Beijing Hospital Ministry of Heath Beijing 100730 China

Background Combined emphysema and pulmonary fibrosis,including idiopathic pulmonary fibrosis （IPF）,is a distinct disorder described with upper-lobe emphysema and lower-lobe fibrosis on chest computed tomography.Smoking appears to be the predominant risk factor for this disorder.We aimed to compare clinical features,smoking history,physiological and radiological findings between IPF with and without emphysema.Methods A sample of 125 IPF patients over a period of 48 months were evaluated.High resolution CT scans were reviewed blinded to clinical data.The IPF patients with or without emphysema were classified accordingly.Results The prevalence of emphysema in this IPF sample was 70/125.IPF with emphysema was significantly associated with smoking status （OR 63; 95％ CI 4.4 to 915; P=0.002） and smoking pack year （OR 1.1; 95％ CI 1.05 to 1.13; P=-0.000）.The patients with IPF and emphysema had a higher decrease in carbon monoxide diffusing capacity adjusted for alveolar volume （（58±19）％ pred vs.（66：±：21）％ pred; P=-0.021） and a higher prevalence of pulmonary hypertension （24/70 vs.7/55; P=0.006）.The two groups of patients had similar forced and residual volumes.No significant differences were found in cell differentials of bronchoalveolar lavage or the scores of fibrosis on chest CT.Survival of the patients with emphysema was significantly less than that of patients with IPF alone.Conclusions Cigarette smoking induces IPF combined with emphysema.Emphysema further impairs physiological function and increases the prevalence of pulmonary hypertension that leads to poor prognosis.The inclusion of the patients with combined pulmonary fibrosis and emphysema in IPF clinical trials may lead to under evaluation of the effect of treatment in patients.

关键词： idiopathic pulmonary fibrosis emphysema smoking

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HEC-HMS水文模型不同降雨损失方法对比研究

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水文 2024年第2期44卷 83-88页

作者：赵直冯民权侯梓良西安理工大学西北旱区生态水利国家重点实验室陕西西安710048

为对比分析HEC-HMS模型三种降雨损失方法在沁河流域的适用性。借助Morris筛选法识别降雨损失方法的关键参数,选用流域内5场雨洪资料进行参数率定和模拟精度分析。结果表明:(1)SCS CN值曲线法、Green-Ampt法、Initial and Uniform法主要... 详细信息

为对比分析HEC-HMS模型三种降雨损失方法在沁河流域的适用性。借助Morris筛选法识别降雨损失方法的关键参数,选用流域内5场雨洪资料进行参数率定和模拟精度分析。结果表明:(1)SCS CN值曲线法、Green-Ampt法、Initial and Uniform法主要敏感性参数分别为CN值、土壤饱和导水率、恒定损失率。(2)选取洪峰流量、洪水总量、峰现时刻误差以及Nash系数对模型模拟精度进行评价,SCS CN值曲线法和Initial and Uniform法模拟结果达到乙等精度,Green-Ampt法模拟结果达到丙等精度。研究成果可为半湿润地区中小流域降雨损失方法的选择提供参考。

关键词： HEC-HMS 洪水模拟降雨损失方法参数敏感性分析沁河流域

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Functional gastrointestinal disorders, mental health, genetic susceptibility, and incident chronic kidney disease

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中华医学杂志(英文版) 2024年第9期137卷 1088-1094页

作者： Liu Mengyi He Panpan Ye ziliang Yang Sisi Zhang Yanjun Wu Qimeng Zhou Chun Zhang Yuanyuan hou Fan Fan Qin Xianhui Division of Nephrology Nanfang Hospital Southern Medical University National Clinical Research Center for Kidney Disease State Key Laboratory of Organ Failure Research Guangdong Provincial Institute of Nephrology Guangdong Provincial Key Laboratory of Renal Failure Research Guangzhou Guangdong China

Background: Whether functional gastrointestinal disorders (FGIDs) are associated with the long-term risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the association.Methods: About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were included. Participants with FGIDs (including irritable bowel syndrome [IBS], dyspepsia, and other functional intestinal disorders [FIDs; mainly composed of constipation]) were the exposure group, and non-FGID participants were the non-exposure group. The primary outcome was incident CKD, ascertained from hospital admission and death registry records. A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD, and the mediation analysis was performed to investigate the mediation proportions of mental health.Results: At baseline, 33,156 (8.0%) participants were diagnosed with FGIDs, including 21,060 (5.1%), 8262 (2.0%), and 6437 (1.6%) cases of IBS, dyspepsia, and other FIDs, respectively. During a mean follow-up period of 12.1 years, 11,001 (2.6%) participants developed CKD. FGIDs were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.28–1.44). Similar results were observed for IBS (HR, 1.27; 95% CI, 1.17–1.38), dyspepsia (HR, 1.30; 95% CI, 1.17–1.44), and other FIDs (HR, 1.60; 95% CI, 1.43–1.79). Mediation analyses suggested that the mental health score significantly mediated 9.05% of the association of FGIDs with incident CKD and 5.63–13.97% of the associations of FGID subtypes with CKD. Specifically, the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of CKD.Conclusion: Participants with FGIDs had a higher risk of incident CKD, which was partly explained by mental health scores and was more pronounced

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

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中国火电厂自动化发展趋势及对策

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中国电力 1999年第10期32卷 41-45页

作者：侯子良国家电力公司电力规划设计总院北京100011

在研究国外自动化技术发展及其在火电厂工程中应用经验的基础上，从工程观点出发，对未来２１世纪最初１０年火电厂自动化化技术应用的发展趋势、管理体制的改革。

关键词：火电厂自动化信息网络化现场总线控制系统

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和川水库沉积物-水界面氮赋存特征及交换通量分析

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人民黄河 2023年第10期45卷 90-95,100页

作者：侯梓良冯民权赵直西安理工大学省部共建西北旱区生态水利国家重点实验室陕西西安710048

为明确氮营养盐在沉积物-水界面的交换过程,以和川水库沉积物为研究对象,分析水库整体氮营养盐污染现状及内源释放特征。采集水库不同点位表层沉积物和上覆水,以此分析氮营养盐空间分布特征及差异性;以原位沉积物柱样沉积物静态释放试... 详细信息

为明确氮营养盐在沉积物-水界面的交换过程,以和川水库沉积物为研究对象,分析水库整体氮营养盐污染现状及内源释放特征。采集水库不同点位表层沉积物和上覆水,以此分析氮营养盐空间分布特征及差异性;以原位沉积物柱样沉积物静态释放试验获取沉积物-水界面氮营养盐交换通量,并分析和川水库内源释放对水体营养盐的潜在贡献率。结果表明:和川水库上覆水中总氮含量劣于V类水标准,且空间差异明显;上覆水中氮营养盐以硝酸盐氮为主,间隙水中氮营养盐以氨氮为主,沉积物中氮以有机氮为主;沉积物表现为总氮、氨氮的“源”和硝酸盐氮、亚硝酸盐氮的“汇”;和川水库库区界面交换对上覆水氮营养盐的贡献率较小,TN、NH^(+)_(4)-N、NO^(-)_(3)-N、NO^(-)_(2)-N的潜在贡献率小于10%。

关键词：沉积物-水界面氮营养盐交换通量和川水库

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双重三要素型转子吸振器抑振性能的稳定性分析

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内燃机 2024年第1期40卷 28-32页

作者：侯建安刘子良李梦瑶沈阳理工大学机械工程学院辽宁沈阳110159

利用转子动力学方法对双重三要素型吸振器-转子系统进行动力学建模,并基于局部灵敏度分析法建立了灵敏度评价模型,分析了最优抑振性能对吸振器参数、不平衡力、安装位置的灵敏度,探讨了吸振器抑振性能的稳定性。结果显示:当参数偏离系数... 详细信息

利用转子动力学方法对双重三要素型吸振器-转子系统进行动力学建模,并基于局部灵敏度分析法建立了灵敏度评价模型,分析了最优抑振性能对吸振器参数、不平衡力、安装位置的灵敏度,探讨了吸振器抑振性能的稳定性。结果显示:当参数偏离系数为-0.35时,最优抑振性能对两个单体吸振器质量的灵敏度分别为0.54和0.36,而对串联刚度的灵敏度仅为0.03和0.12。整体上看,固有频率较大的单体吸振器的参数灵敏度系数相对较小。不平衡力增大时,系数均为正值。存在安装位置误差的情况下,吸振器使用时的安装位置若靠近优化时的安装位置,其灵敏度系数降低至0.05;而远离时,灵敏度系数提高至1.58。因此,在吸振器的参数中,质量对最优抑振性能的稳定性影响最大,而串联刚度的影响最小。固有频率较小的单体吸振器的参数对稳定性影响较大。使用安装位置距离优化时的安装位置越接近,其稳定性越高。

关键词：转子吸振器局部灵敏度分析不平衡力安装位置稳定性

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电厂厂级实时监控信息系统建设探讨

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电力设备 2001年第2期2卷 20-23页

作者：芶建兵侯子良电力规划设计总院北京100011

针对电厂厂级实时监控系统(SIS)建设中实时/历史数据库选型、数据采集技术和应用软件开发以及网络架构等主要问题进行了一些初步讨论和分析,认为 SIS 网络建设是实现电厂管理控制一体化,提高运行可靠性和经济效益的重要途径。

关键词： SIS 实时/历史数据库网络架构数据采集

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Influencing factors and optimization on mechanical performance of solid waste-derived rapid repair mortar

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Waste Disposal and Sustainable Energy 2023年第2期5卷 223-234页

作者： Jingwei Li Xiangshan hou Aiguang Jia Xin Xiao Xujiang Wang Yonggang Yao ziliang Zhang Wenlong Wang The National Engineering Laboratory of Coal-Fired Pollutants Emission Reduction Shandong University17923 Jingshi RoadJinanShandongChina

There is a great demand for high performance rapid repair mortar(RRM)because of the wide use of cement concrete.Solid-waste-based sulfoaluminate cement(WSAC)is very suitable as a green cementitious material for repair materials because of its characteristics of high early-age strength and short setting time.However,the influence and optimization of various factors of WSAC-based RRM,such as water-to-RRM ratio,binder-to-sand ratio and additives,as well as the further solid waste replacement of aggregate,remain to be studied.This paper comprehensively studied the influence of the above factors on the performance of WSAC-based RRM and obtained a green high-performance RRM by optimizing these factors.The experimental results showed that the early and late strength of the obtained RRM is excellent,and the setting time and fluidity are appropriate,which reflected good mechanical properties and construction performance.Ordinary Portland cement(OPC)doping could not improve RRM strength.It was feasible to prepare RRM with gold tailing sand replacing part of the quartz sand.This paper provides data and a theoretical basis for the preparation of high-performance RRM based on solid waste,expanding the high value utilization of solid waste,which is conducive to the development of a low carbon society.

关键词： Rapid repair mortar Solid-waste-based sulfoaluminate cement Ordinary Portland cement Pilot production Gold tailing sand Environmental friendliness

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胶体金免疫层析试纸条在生物毒素检测领域的研究进展

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饲料工业 2024年第5期45卷 134-140页

作者：闫海兴袁子钦袁嘉康李梦迪张超伟侯洁覃婷王自良河南科技学院动物科技学院河南新乡453003

胶体金免疫层析试纸条是一种常用的检测方法,广泛应用于疾病诊断、生物毒素检测等领域。该技术基于胶体金标记的特异性抗原(抗体)与待检样品中的目标分子相互作用,在试纸条上形成可见的测试线或信号变化。其流程包括样品预处理、标记抗... 详细信息

胶体金免疫层析试纸条是一种常用的检测方法,广泛应用于疾病诊断、生物毒素检测等领域。该技术基于胶体金标记的特异性抗原(抗体)与待检样品中的目标分子相互作用,在试纸条上形成可见的测试线或信号变化。其流程包括样品预处理、标记抗体制备、试纸条组装步骤。胶体金免疫层析试纸条可以用于快速检测食品中的毒素残留、环境中的有害物质以及临床诊断中的相关指标。该技术具有无创、快速、灵敏和准确的特点,在临床应急检测和大规模筛查中能快速获得结果。文章总结了胶体金免疫层析试纸条技术及其在生物毒素检测中的研究进展,并分析了当前胶体金免疫层析试纸条技术的优缺点,展望了该技术在生物毒素检测领域的未来发展方向。

关键词：胶体金免疫层析试纸条生物毒素快速检测灵敏准确

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J-shaped association between dietary zinc intake and new-onset hypertension:a nationwide cohort study in China

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Frontiers of Medicine 2023年第1期17卷 156-164页

作者： Panpan He Huan Li Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Chun Zhou ziliang Ye Qimeng Wu Min Liang Jianping Jiang Guobao Wang Jing Nie Fan Fan hou Chengzhang Liu Xianhui Qin Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangdong Provincial Clinical Research Center for Kidney DiseaseGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510515China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China Institute of Biomedicine Anhui Medical UniversityHefei 230032China

We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults.A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included.Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory.Participants with systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension.During a median follow-up duration of 6.1 years,4269 participants developed new-onset hypertension.Overall,the association between dietary zinc intake and new-onset hypertension followed a J-shape(P for non-linearity<0.001).The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake(per mg/day:hazard ratio(HR)0.93;95%confidence interval(CI)0.88–0.98)in participants with zinc intake<10.9 mg/day,and increased with the increment of zinc intake(per mg/day:HR 1.14;95%CI 1.11–1.16)in participants with zinc intake≥10.9 mg/day.In conclusion,there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults,with an inflection point at about 10.9 mg/day.

关键词： dietary zinc intake new-onset hypertension general population CHNS

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