检索结果-南通市图书馆

An SDN-Based Algorithm for Caching,Routing,and Load Balancing in ICN

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第5期21卷 64-76页

作者： MohammadBagher Tavasoli hossein Saidi Ali Ghiasian Department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahanIran Department of Technology and Engineering Shahrekord UniversityShahrekordIran

One of the challenges of Informationcentric Networking(ICN)is finding the optimal location for caching content and processing users’requests.In this paper,we address this challenge by leveraging Software-defined Networking(SDN)for efficient ICN management.To achieve this,we formulate the problem as a mixed-integer nonlinear programming(MINLP)model,incorporating caching,routing,and load balancing decisions.We explore two distinct scenarios to tackle the problem.Firstly,we solve the problem in an offline mode using the GAMS environment,assuming a stable network state to demonstrate the superior performance of the cacheenabled network compared to non-cache networks.Subsequently,we investigate the problem in an online mode where the network state dynamically changes over time.Given the computational complexity associated with MINLP,we propose the software-defined caching,routing,and load balancing(SDCRL)algorithm as an efficient and scalable solution.Our evaluation demonstrates that the SDCRL algorithm significantly reduces computational time while maintaining results that closely resemble those achieved by GAMS.

关键词： in-network caching information-centric network power efficiency routing software-defined networking

Near-zero stiffness accelerometer with buckling of tunable electrothermal microbeams

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第2期10卷 67-81页

作者： Hussein Hussein Chen Wang Rui Amendoeira Esteves Michael Kraft hossein Fariborzi Department of Mechanical Engineering MSFEAAmerican University of BeirutBeirut11072020Lebanon King Abdullah University of Science and Technology Thuwal23955-6900Saudi Arabia ESAT-MNS University of Leuven3001LeuvenBelgium

Pre-shaped microbeams,curved or inclined,are widely used in MEMS for their interesting stiffness properties.These mechanisms allow a wide range of positive and negative stiffness tuning in their direction of motion.A mechanism of pre-shaped beams with opposite curvature,connected in a parallel configuration,can be electrothermally tuned to reach a near-zero or negative stiffness behavior at the as-fabricated position.The simple structure helps incorporate the tunable spring mechanism in different designs for accelerometers,even with different transduction technologies.The sensitivity of the accelerometer can be considerably increased or tuned for different applications by electrothermally changing the stiffness of the spring mechanism.Opposite inclined beams are implemented in a capacitive micromachined accelerometer.The measurements on fabricated prototypes showed more than 55 times gain in sensitivity compared to their initial sensitivity.The experiments showed promising results in enhancing the resolution of acceleration sensing and the potential to reach unprecedent performance in micromachined accelerometers.

关键词： properties. mechanism. stiffness

CRISPR,CAR-T,and NK:Current applications and future perspectives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 246-257页

作者： Mohadeseh Khoshandam hossein Soltaninejad Amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom branch***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14965/161Iran Department of stem cells technology and Tissue Regeneration Faculty of Interdisciplinary Science and TechnologiesTarbiat Modares UniversityTehran 15614Iran Pediatric Cell Therapy and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran University of Medical SciencesTehran ***Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 15614Iran

Chimeric antigen receptor T(CAR-T)cell therapy represents a breakthrough in personalized cancer treatments.In this regard,synthetic receptors comprised of antigen recognition domains,signaling,and stimulatory domains are used to reprogram T-cells to target tum or cells and destroy them.Despite the success of this approach in refractory B-cell malignancies,the optimal potency of CAR T-cell therapy for many other cancers,particularly solid tumors,has not been validated.Natural killer cells are powerful cytotoxic lymphocytes specialized in recognizing and dispensing the tumor cells in coordination with other anti-tumor immunity cells.Based on these studies,many investigations are focused on the accurate designing of CAR T-cells with clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)system or other novel gene editing tools that can induce hereditary changes with or without the presence of a double-stranded break into the genome.These methodologies can be specifically focused on negative controllers of T-cells,induce modifications to a particular gene,and produce reproducible,safe,and powerful allogeneic CAR T-cells for on-demand cancer immunotherapy.The improvement of the CRISPR/Cas9 innovation offers an adaptable and proficient gene-editing capability in activating different pathways to help natural killer cells interact with novel CARs to particularly target tumor cells.Novel achievements and future challenges of combining next-generation CRISPR-Cas9 gene editing tools to optimize CAR T-cell and natural killer cell treatment for future clinical trials toward the foundation of modern cancer treatments have been assessed inthis review.

关键词： Cancer CAR T-cell CRISPR Gene editing Immunotherapy NK cell

Powering the future: A comprehensive review on calcium-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第3期90卷 77-97,I0004页

作者： Ameneh Taghavi-Kahagh hossein Roghani-Mamaqani Mehdi Salami-Kalajahi Faculty of Polymer Engineering Sahand University of TechnologyP.0.Box 51335-1996Tabriz Iran Institute of Polymeric Materials Sahand University of TechnologyP.0.Box 51335-1996Tabriz Iran

Due to concerns regarding the future availability,cost,and safety of lithium in Li-ion batteries(LIBs),researchers are exploring alternative chemistries such as Na-ion,Li-S,Li-air,and multivalent ion technologies.Multivalent ion technologies,which utilize divalent or trivalent ions,like Mg^(2+),Ca^(2+),and Al^(3+),show promise in achieving greater energy densities than LIBs due to their ability to deposit uniformly on anodes and intercalate into cathodes.While magnesium-ion batteries(MIBs) have been the primary area of research for multivalent ion batteries,the cost-effectiveness and abundance of calcium have sparked a growing interest in calcium-ion batteries(CIBs) in recent years.Compared to LIBs,CIBs have the potential to provide longer cycle life,enhanced safety,and increased energy densities.However,the development of CIBs comes with several challenges,such as finding suitable electrode and electrolyte materials that ensure the stability and safety of the battery.The primary hurdle in CIBs lies in the plating/stripping process.There is a significant hindrance preventing the occurrence of plating/stripping in CIBs,which lies in the formation of a passive layer resulting from the decomposition of the electrolyte.The objective of this article is to examine the advancements made in CIBs.Additionally,it aims to comprehensively assess the mechanisms and materials employed in various battery components,as well as the obstacles encountered in CIBs.This includes recent advancements in electrode materials,electrolytes,cell configurations,and the challenges and opportunities for enhancing the performance and commercial viability of CIBs.

关键词： Ca-ion batteries Cathode Anode Electrolyte

Characteristics of turbulent flow in 3-D pools in the presence of submerged rigid vegetation in channel bed

在线全文

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2024年第1期36卷 158-169页

作者： Kourosh Nosrati hossein Afzalimehr Jueyi Sui Hamid Reza Reisifar Natural Disasters Prevention Research Center Faculty of Civil EngineeringIran University of Science and TechnologyTehranIran School of Engineering University of Northern British ColumbiaPrince GeorgeCanada

In this study,the interaction between 3-D bedforms and submerged rigid vegetation has been investigated.Various laboratory experiments were conducted to study the distribution of flow velocity,Reynolds shear stress,turbulent kinetic energy,and skewness coefficients for a constant density of vegetation.Results showed that the velocity profile in the pool section deviates from those in the upstream section of the pool.It has been found that the dip parameter varied between 0.6H and 0.9H depending on various factors including bed roughness,vegetation distribution,and pool entrance/exit slopes.However,scattered vegetation in the pool and differences in slopes created non-uniform flow conditions.Also,in the wake region behind each vegetated element,flow velocity reduced significantly,and small-scale eddies are formed,causing increased perturbations.By decreasing the entrance slope and bed roughness,relatively uniform flow and weaker turbulence was resulted,but the random distribution of vegetated elements counteracted this balance and intensified turbulence.With the decrease in the pool entrance slope,the contribution of sweep event decreased and the contribution of ejection event increased.

关键词： Submerged rigid vegetation 3-D pool Reynolds shear stress skewness coefficients

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam hossein Soltaninejad Marziyeh Mousazadeh Amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous diseases.It depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing tool.Due to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked disorders.CRISPR/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing techniques.Here,the applications and clinical trials of CRisPR/Cas9 in various illnesses are described.Due to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific genes.The most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be discussed.The use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin David Hwang hossein Zamani Siboni Ehsanollah Fathi Reza Chaji Dayan Ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal InC. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-LEDs)with a metal–insulator-semiconductor(MIS)structure on the sidewall are proposed to improve efficiency.In this MIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the top.Electroluminescence(EL)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the EQE.The band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)recombination.Two suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of MIS micro-LEDs in future fabrication.

关键词： Micro-LED GaN EQE improvement Micro-fabrication

Seamless morphing trailing edge flaps for UAS-S45 using high-fidelity aerodynamic optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第2期37卷 12-29页

作者： Mir hossein NEGAHBAN Musavir BASHIR Victor TRAISNEL Ruxandra Mihaela BOTEZ LARCASE Laboratory of Applied Research in Active Controls Avionics and AeroservoelasticityEcole de Technologie SuperieureUniversite du QuebecMontreal H3C1K3Canada

The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,and gliding descent.A comparative study is also conducted between a wing equipped with morphing flap and a wing with conventional hinged flap.The optimization is performed by specifying a certain objective function and the flight performance goal for each flight condition.Increasing the climb rate,extending the flight range and endurance in cruise,and decreasing the descend rate,are the flight performance goals covered in this study.Various optimum configurations were found for the morphing wing by determining the optimum morphing flap deflection for each flight condition,based on its objective function,each of which performed better than that of the baseline wing.It was shown that by using optimum configuration for the morphing wing in climb condition,the required power could be reduced by up to 3.8%and climb rate increases by 6.13%.The comparative study also revealed that the morphing wing enhances aerodynamic efficiency by up to 17.8%and extends the laminar flow.Finally,the optimum configuration for the gliding descent brought about a 43%reduction in the descent rate.

关键词： Seamless morphing trailing edge flap Aerodynamic optimization Gradient-based optimiza-tion Climb flight condition Gliding descent Flight range Endurance

Effect of Aqueous-Alcoholic Extract of Ducrosia Anethifolia Boiss on the Fetal Liver of Diabetic Rats

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第1期10卷 104-113页

作者： hossein Kargar Jahromi Farangis Ghasemi Elmira Mikaeiliagah Research Center for Noncommunicable Diseases Jahrom University of Medical SciencesJahromIran Department of Biology Islamic Azad UniversityJahromIran Department of Biology Ardabil BranchIslamic Azad UniversityArdabilIran Stem Cell and Tissue Engineering Laboratory Department of OrthopaedicsWest Virginia UniversityMorgantownUSA

Objective:Moshgak(Ducrosia anethifolia)is a wild plant with medicinal value.The present study aimed to evaluate the effect of Moshgak on the liver tissue of the diabetic rat fetus.Materials and Methods:In this animal study,the aqueous-alcoholic extract of Moshgak was prepared in the standard method.Forty rats were divided randomly into five groups,including control,sham,and three diabetic groups.The rats were diabetic with intraperitoneal injection of a single dose of streptozotocin(80 mg)and 2 diabetic groups were treated with Moshgak extract(280 and 560 mg/kg/bw)for 19 days.The rats were anesthetized and their blood was taken to measure the blood glucose,insulin,and malondialdehyde.Then,their fetuses were removed.The fetal liver sections were obtained by using the stereological methods.The micrometry of the liver tissue was performed and data were analyzed.Results:The finding showed a statistically significant increase(P<0.01)in the total volume of liver,connective tissue,sinusoid,and hepatocytes in diabetic rats compared to control rats,while these parameters decreased significantly in treated groups with Moshgak.Hepatic cell count hepatic decreased in the treated groups.Furthermore,the changes in blood glucose,malondialdehyde,and insulin in diabetic rats were improved significantly by Moshgak treatment.The dilation of sinusoids,hepatocyte vacuolation,and mild lymphocytosis was observed in all diabetic groups except the treatment group with Moshgak 560 mg/kg/bw.Conclusions:According to obtained results,Moshgak extract was able to compensate partially the changes induced by diabetes in the fetal liver tissue.Therefore,due to the side effects of diabetes during pregnancy,further research on anti-diabetic properties of Moshgak is suggested.

关键词： Diabetes Ducrosia anethifolia hepatocyte insulin micrometry rat