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Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 298-306页

作者： Mohammad Hadi Zarei Sami Akbulut Maryam Zafari Elham Saghaei Zahra Lorigooini hossein aminiKhoei Somaye Khosravi Elham Bijad Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Liver Transplant Institute and Biostatistics Inonu University Faculty of Medicine44280MalatyaTurkey Student Research Committee Shahrekord University of Medical SciencesShahrekordIran Physiology and Pharmacology Department School of MedicineShahrekord University of Medical SciencesShahrekordIran Department of Anatomical Sciences School of MedicineShahrekord University of Medical SciencesShahrekordIran

Objective:To explore the effect of black radish(Raphanus sativus *** niger)root extract on liver enzymes,oxidative stress,and histopathological alterations in mice with sodium valproate-induced ***:Thirty-two mice were divided into four groups:the control group received drinking water by gavage,the second group was administered with 100 mg/kg of sodium valproate,the third group received 300 mg/kg of black radish root extract,and the fourth group was given both sodium valproate(100 mg/kg)and black radish root extract(300 mg/kg).After 28 days,the mice were euthanized,and serum levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),and alkaline phosphatase(ALP),along with liver malondialdehyde(MDA),reactive oxygen species(ROS),mitochondrial parameters,tumor necrosis factor-alpha(TNF-α)gene expression,and histopathological changes were ***:Sodium valproate caused hepatic damage in mice,characterized by elevated serum levels of liver enzymes,increased MDA and ROS levels and TNF-αgene expression,as well as histopathological *** black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST,MDA,ROS,TNF-αgene expression,as well as mitochondrial impairment,but did not have a significant effect on sodium valproate-induced histopathological ***:The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury,possibly through mitigating oxidative stress,mitochondrial impairment,and inflammatory mediator expression.

关键词： Black radish Raphanus sativus Sodium valproate Hepatotoxicity Oxidative stress Anti-inflammation

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Numerical analysis and experimental validation of hydrodynamics of a thin bubbling fluidized bed for various particle-size distributions using a three-dimensional dense discrete phase model

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Particuology 2020年第2期18卷 191-204页

作者： Abolhasan Hashemisohi Lijun Wang Abolghasem Shahbazi hossein amini Department of Computational Science and Engineering North Carolina A&T State UniversityGreensboroNC 27411USA Department of Natural Resources and Environmental Design North Carolina A&T State UniversityGreensboroNC 27411USA Department of Chemical Biologicaland BioengineeringNorth Carolina A&T State UniversityGreensboroNC 27411USA Department of Natural Resources and Environmental Design North Carolina A&T State UniversityGreensboroNC 27411US

A dense discrete phase model combined with the kinetic theory of granular flows was used to study the bubbling characteristics and segregation of poly-dispersed particle mixtures in a thin fluidized *** simulations showed that in using the hybrid Eulerian-Lagrangian method,the common use of one computational cell in the thickness direction of the thin bed does not predict wall friction ***,a three-cell discretization of the thickness direction does predict the wall friction well but six cells were needed to prevent overprediction of the bed *** change in specularity factor(SF)of the model not only affected the predictions of the velocity of particles,but also had a considerable impact on their flow pattern.A decrease in SF,which decreases wall friction,showed an over-prediction in the size of bubbles,particle velocities,and void fraction of the bed,and led to a shift in the circulation center toward the bottom of the *** segregation of the Geldart B particles was studied in the narrow range from 400 to 600μm with a standard deviation less than 10%of the average *** showed that large particles accumulated close to the distributor at the bottom of the bed and the center of the bed,but small particles moved towards the wall and top *** decrease in the mean particle size and spread in shape of the distribution improves mixing by up to 30%at a superficial gas velocity of around 2.5 times the minimum fluidization ***-normal mixtures with a small proportion of large particles had the most uniform distribution with a thin layer of jetsam forming at the bottom of the ***,experimental verification of the segregation and mixing of polydisperse particles with narrow size distribution is suggested.

关键词： Computational fluid dynamics Fluidization Particle size distribution Hybrid Eulerian-Lagrangian model Dense discrete phase model Wall friction

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How much will be the cost for universal coverage of COVID-19 vaccination and how shall it be financed?

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 157-158页

作者： Mohammad Meskarpour-Amiri hossein amini Ali Mehrabi Tavana Health Management Research Center Baqiyatallah University of Medical SciencesTehranIran Department of Epidemiology School of HealthIran University of Medical SciencesTehranIran

Given the failure to find a definitive cure for COVID-19,the only hopes for controlling the pandemic right now are vaccine production and universal ***,vaccine is vital to the prevention and control of COVID-19 outbre... 详细信息

关键词： finance prevention cost

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Oxidative stress and antioxidants in diabetes mellitus

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Asian Pacific Journal of Tropical Medicine 2020年第10期13卷 431-438页

作者： Maryam Ghasemi-Dehnoo hossein amini-Khoei Zahra Lorigooini Mahmoud Rafieian-Kopaei Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Numerous studies have implicated oxidative stress in the development of complications of *** hyperglycemia,production of oxidant agents such as reactive oxygen species and reactive nitrogen species *** process,along with a decrease in the activity of antioxidant enzymes,induces oxidative stress in the *** redox imbalance causes damage to vital biomolecules such as proteins,lipids and DNA and results in the generation of harmful products for the *** associated with the creation of oxidative stress conditions and subsequently complications of diabetes are explained through several pathways such as flux through the polyol pathway,intracellular production of advanced glycation end products precursors,protein kinase-C activation,and increased activities of the hexosamine *** the other hand,the study of polymorphism in the antioxidant enzymes genes indicates that some of the gene polymorphisms reduce the antioxidant power of the *** article aims to review various studies to demonstrate the effect of oxidative stress on the pathogenesis of diabetes and the positive role of antioxidants on diabetic complications.

关键词： Diabetes Antioxidants Oxidative stress Pathogenesis

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Improvement of Surface Mechanical and Tribological Characteristics of L-PBF Processed Commercially Pure Titanium through Ultrasonic Impact Treatment

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1034-1046页

作者： Iman Ansarian Reza Taghiabadi Saeid amini Mohammad hossein Mosallanejad Luca Iuliano Abdollah Saboori Department of Materials Science and Metallurgy Imam Khomeini International University(IKIU)QazvinIran Department of Mechanical Engineering University of KashanKashanIran Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Multi-pass ultrasonic impact treatment(UIT)was applied to modify the microstructure and improve the mechanical and tribological characteristics at the near-surface region of commercially pure Ti(CP-Ti)specimens produced by the laser powder bed fusion(L-PBF)*** considerably refined the L-PBF process-related acicular martensites(α′-M)and produced a well-homogenized and dense surface microstructure,where the porosity content of 1-,3-,and 5-pass UITed samples was reduced by 43,60,and 67%,*** UITed samples showed an enhancement in their near-surface mechanical properties up to a depth of about 300μ*** nanoindentation results for the 3-pass UITed sample revealed an increase of about 53,45,and 220%in its nanohardness,H/E_(r),and H_(3)/E_(r)^(2)indices,*** stylus profilometry results showed that performing the UIT removed the L-PBF-related features/defects and offered a smooth *** roughness average(R_(a))and the skewness(R_(sk))of the 3-pass UITed sample were found to be lower than those of the L-PBFed sample by 95 and 223%,*** the UIT also enhanced the material ratio,where the maximum load-bearing capacity(~100%)in as-L-PBFed(as-built)and 3-pass UITed samples was obtained at 60-and 10-µm depths,*** tribological investigations showed that applying the UIT resulted in a significant reduction of wear rate and average coefficient of friction(COF)of *** instance,under the normal pressures of 0.05 and 0.2 MPa,the wear rate and COF of the 3-pass UITed sample were lower than those of the L-PBFed sample by 65 and 58%,and 20 and 17%,respectively.

关键词： Laser powder bed fusion Ultrasonic impact treatment Commercially pure Ti(CP-Ti) Surface mechanical properties Tribological properties

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An SDN-Based Algorithm for Caching,Routing,and Load Balancing in ICN

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China Communications 2024年第5期21卷 64-76页

作者： MohammadBagher Tavasoli hossein Saidi Ali Ghiasian Department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahanIran Department of Technology and Engineering Shahrekord UniversityShahrekordIran

One of the challenges of Informationcentric Networking(ICN)is finding the optimal location for caching content and processing users’*** this paper,we address this challenge by leveraging Software-defined Networking(SDN)for efficient ICN *** achieve this,we formulate the problem as a mixed-integer nonlinear programming(MINLP)model,incorporating caching,routing,and load balancing *** explore two distinct scenarios to tackle the ***,we solve the problem in an offline mode using the GAMS environment,assuming a stable network state to demonstrate the superior performance of the cacheenabled network compared to non-cache ***,we investigate the problem in an online mode where the network state dynamically changes over *** the computational complexity associated with MINLP,we propose the software-defined caching,routing,and load balancing(SDCRL)algorithm as an efficient and scalable *** evaluation demonstrates that the SDCRL algorithm significantly reduces computational time while maintaining results that closely resemble those achieved by GAMS.

关键词： in-network caching information-centric network power efficiency routing software-defined networking

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Special Issue:International Conference on Sustainable Energy Sources,Technologies and Systems 2023(ICSESTS-2023)

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Clean Energy 2024年第3期8卷 136-137页

作者： Ravinder Kumar Mohammad hossein Ahmadi School of Mechanical Engineering Lovely Professional UniversityPhagwra-144411PunjabIndia Faculty of Mechanical Engineering Shahrood University of TechnologyShahroodIran

The Division of Research and Development at Lovely Professional University,Punjab organized the International Conference on Sustainable Energy Sources,Technologies and Systems 2023(ICSESTS-2023),which took place on 3-... 详细信息

关键词： solar energy storage wind energy geothermal hydropower biofuels batteries

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Powering the future: A comprehensive review on calcium-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 77-97,I0004页

作者： Ameneh Taghavi-Kahagh hossein Roghani-Mamaqani Mehdi Salami-Kalajahi Faculty of Polymer Engineering Sahand University of TechnologyP.0.Box 51335-1996Tabriz Iran Institute of Polymeric Materials Sahand University of TechnologyP.0.Box 51335-1996Tabriz Iran

Due to concerns regarding the future availability,cost,and safety of lithium in Li-ion batteries(LIBs),researchers are exploring alternative chemistries such as Na-ion,Li-S,Li-air,and multivalent ion *** ion technologies,which utilize divalent or trivalent ions,like Mg^(2+),Ca^(2+),and Al^(3+),show promise in achieving greater energy densities than LIBs due to their ability to deposit uniformly on anodes and intercalate into *** magnesium-ion batteries(MIBs) have been the primary area of research for multivalent ion batteries,the cost-effectiveness and abundance of calcium have sparked a growing interest in calcium-ion batteries(CIBs) in recent *** to LIBs,CIBs have the potential to provide longer cycle life,enhanced safety,and increased energy ***,the development of CIBs comes with several challenges,such as finding suitable electrode and electrolyte materials that ensure the stability and safety of the *** primary hurdle in CIBs lies in the plating/stripping *** is a significant hindrance preventing the occurrence of plating/stripping in CIBs,which lies in the formation of a passive layer resulting from the decomposition of the *** objective of this article is to examine the advancements made in ***,it aims to comprehensively assess the mechanisms and materials employed in various battery components,as well as the obstacles encountered in *** includes recent advancements in electrode materials,electrolytes,cell configurations,and the challenges and opportunities for enhancing the performance and commercial viability of CIBs.

关键词： Ca-ion batteries Cathode Anode Electrolyte

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Characteristics of turbulent flow in 3-D pools in the presence of submerged rigid vegetation in channel bed

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Journal of Hydrodynamics 2024年第1期36卷 158-169页

作者： Kourosh Nosrati hossein Afzalimehr Jueyi Sui Hamid Reza Reisifar Natural Disasters Prevention Research Center Faculty of Civil EngineeringIran University of Science and TechnologyTehranIran School of Engineering University of Northern British ColumbiaPrince GeorgeCanada

In this study,the interaction between 3-D bedforms and submerged rigid vegetation has been *** laboratory experiments were conducted to study the distribution of flow velocity,Reynolds shear stress,turbulent kinetic energy,and skewness coefficients for a constant density of *** showed that the velocity profile in the pool section deviates from those in the upstream section of the *** has been found that the dip parameter varied between 0.6H and 0.9H depending on various factors including bed roughness,vegetation distribution,and pool entrance/exit ***,scattered vegetation in the pool and differences in slopes created non-uniform flow ***,in the wake region behind each vegetated element,flow velocity reduced significantly,and small-scale eddies are formed,causing increased *** decreasing the entrance slope and bed roughness,relatively uniform flow and weaker turbulence was resulted,but the random distribution of vegetated elements counteracted this balance and intensified *** the decrease in the pool entrance slope,the contribution of sweep event decreased and the contribution of ejection event increased.

关键词： Submerged rigid vegetation 3-D pool Reynolds shear stress skewness coefficients

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Seamless morphing trailing edge flaps for UAS-S45 using high-fidelity aerodynamic optimization

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Chinese Journal of Aeronautics 2024年第2期37卷 12-29页

作者： Mir hossein NEGAHBAN Musavir BASHIR Victor TRAISNEL Ruxandra Mihaela BOTEZ LARCASE Laboratory of Applied Research in Active Controls Avionics and AeroservoelasticityEcole de Technologie SuperieureUniversite du QuebecMontreal H3C1K3Canada

The seamless trailing edge morphing flap is investigated using a high-fidelity steady-state aerodynamic shape optimization to determine its optimum configuration for different flight conditions,including climb,cruise,and gliding descent.A comparative study is also conducted between a wing equipped with morphing flap and a wing with conventional hinged *** optimization is performed by specifying a certain objective function and the flight performance goal for each flight *** the climb rate,extending the flight range and endurance in cruise,and decreasing the descend rate,are the flight performance goals covered in this *** optimum configurations were found for the morphing wing by determining the optimum morphing flap deflection for each flight condition,based on its objective function,each of which performed better than that of the baseline *** was shown that by using optimum configuration for the morphing wing in climb condition,the required power could be reduced by up to 3.8%and climb rate increases by 6.13%.The comparative study also revealed that the morphing wing enhances aerodynamic efficiency by up to 17.8%and extends the laminar ***,the optimum configuration for the gliding descent brought about a 43%reduction in the descent rate.

关键词： Seamless morphing trailing edge flap Aerodynamic optimization Gradient-based optimiza-tion Climb flight condition Gliding descent Flight range Endurance

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