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Effect of vitamin A and E on carbohydrate and lipid metabolism in diet-induced obese wistar rats

Advances in Bioscience and Biotechnology 2014年第1期5卷 4-11页

作者： Mohamed Mohamed Soliman Mohamed Mohamed Ahmed Samir Ahmed El-Shazly Tamer Ahmed Ismail hossam fouad attia Ahmed Farag Elkirdasy Department of Biochemistry College of Veterinary Medicine University of Sadat City Sadat City Egypt Department of Biomedical Sciences Shaqraa University College of Pharmacy Shaqraa Saudi Arabia Department of Biotechnology College of Science Taif University Taif Saudi Arabia Department of Biochemistry College of Veterinary Medicine Kaferel-sheikh University Kafer El-Sheikh Egypt Department of Biotechnology College of Science Taif University Taif Saudi Arabia Department of Biochemistry College of Veterinary Medicine University of Sadat City Sadat City Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Biochemistry College of Veterinary Medicine Benha University Banha Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Histology College of Veterinary Medicine Benha Uni-versity Banha Egypt Medical Laboratory Department College of Applied Medical Sciences Taif University Turabah Saudi Arabia Department of Physiology College of Veterinary Medicine Zagazig University Zagazig Egypt

In the present study, we investigated the biochemical alterations and gene expression of carbohydrate and lipid metabolism after oral administration of vitamin A and E for 2 months in diet-induced obese Wistar rats. Vitamin A and E administration reduced significantly the increase in body weight and food intake and normalized the alterations in lipid profiles in obese rats compared to normal rats. Moreover, both vitamins decreased the fat accumulation in liver tissues of obese rats. Finally, they up-regulated mRNA expression of Pyruvate Kinase (PK) and Glucose Transporter-2 (GLUT-2), and increased lipolysis and cholesterol metabolism through up-regulation of lipoprotein lipase (LPL), Sterol Responsible Element Binding Protein-1a (STREBP-1a) and STREBP-1c mRNA expression. In conclusion, vitamin A and E regulate gene expression of carbohydrate and lipid metabolism, and also ameliorate changes associated with obesity induced by high fat diet in Wistar rats.

关键词： Vitamin A and E Lipid Metabolism Carbohydrate Metabolism Gene Regulation Wistar Rats

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Spontaneous ejaculation after spinal cord trauma

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Asian Journal of Andrology 2010年第4期12卷 609-610页

作者： hossam A. Yasien Abdalla M. attia Department of Dermatology Andrology ＆ STDs Faculty of Medicine Menoufiya University Menoufiya 32511 Egypt

I am Dr hossam A. Yasien, from the Department of Dermatology, Andrology ＆ STDs, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt. Spinal cord lesions in humans are associated with impaired ejaculation [1], suggesting that the effects of descending pathways on the spinal ejaculatory mechanism are predominantly excitatory. In rodents, however, there may be an additional and important descending inhibitory pathway [2]. We report a case of a patient in whom a spinal trauma was unusually associated with spontaneous ejaculation.

关键词： ejaculation spinal trauma

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MAFLD Not NAFLD is Associated with Impairment of Health-related Quality of Life

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 4-5页

作者： Dina attia Nadia Abdel Aty Ahmed Shawket Ebada Said Yasser fouad Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBeni-Suef UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAin Shams UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineAssiut UniversityEgypt Depart-ment of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineBenha UniversityEgypt Department of Gastroenterology Hepatology and Endemic MedicineFaculty of MedicineMinia UniversityEgypt

Citation of this article:attia D,Aty NA,Shawket A,Said E,fouad *** Not NAFLD is Associated with Impairment of Health-related Quality of Life.J Clin Transl Hepatol 2022;10(1):***:10.14218/*** the Editor,We read with great interest the article by Yu et al.1 who reported that the metabolic dysfunction-associated fatty liver disease(MAFLD)criteria are more practical and im-prove the identification of high-risk patients with fatty liver disease compared with the previous nonalcoholic fatty liver disease(NAFLD)criteria.

关键词： NAFLD Quality MAF

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Association of serum levels of transforming growth factor β1 with disease severity in patients with hepatocellular carcinoma

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Hepatoma Research 2017年第12期3卷 294-301页

作者： Mohamed Ahmed Samy Kohla Ahmed attia Nehad Darwesh Manar Obada hossam Taha Marwa FYoussef Departments of Hepatology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Oncology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Clinical Biochemistry National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Epidemiology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt.

Aim: Transforming growth factor (TGF) is overexpressed by tumor cells like other proteins and growth factors. TGF-β1 is then activated in the extracellular compartment but is unable to control cell proliferation because of the absence or low level of TGF-β1 receptors on the plasma membrane of malignant hepatocytes. This potential mechanism might interrupt the autocrine regulation loop of TGF-β1 and its blocking effect on cell proliferation. TGF-β1 is a multifunctional cytokine involved in the regulation of growth and differentiation of both normal and transformed cells. This study aimed to evaluate the association of serum levels of TGF-β1 with disease severity. Methods: A total of 180 subjects were classified into 6 groups according to Barcelona clinic liver cancer (BCLC) classification, 30 patients each:early (BCLC 0 and A), intermediate (BCLC B), advanced stage (BCLC C), and terminal stage (BCLC D) of hepatocellular carcinoma as well as 1 group of patients with cirrhosis only and 1 control group. Serum levels of TGFβ1 were measured. Results: Serum levels of TGF-β1 were significantly higher in patients with HCC (1,687.47 ± 1,462.81 pg/mL) than cirrhotics (487.98 ± 344.23 pg/mL, P < 0.001) and controls (250.16 ± 284.61 pg/mL, P <0.001). Conclusion: TGF-β1 may have a role in tumor growth and progression.

关键词： Transforming growth factor β1 hepatocellular carcinoma disease severity Egyptian patients

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Assessment of Physicians’ Knowledge, Attitude and Practices of Radiation Safety at Suez Canal University Hospital, Egypt

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Open Journal of Radiology 2015年第4期5卷 250-258页

作者： Rasha F. Abdellah Shaimaa A. attia Ahmed M. fouad Amani W. Abdel-Halim Community Medicine Department Faculty of Medicine Suez Canal University Ismailia Egypt

Doctors who request imaging must be well trained in deciding whether diagnostic imaging is indicated and have an accurate knowledge of the associated risks. Although radiological doses are low and the chance of late effect is minimal, it should be kept as low as reasonably achievable. This cannot be achieved without a proper knowledge and adherence to safe practices. This cross-sectional study investigates the level of physicians’ knowledge about radiation safety and their attitude towards radiation protection. A self-administered questionnaire, for radiation safety was sent to a purposive sample of 120 physicians at Suez Canal University Hospital. Eighty questionnaires were filled by participants (response rate;66.7%). The sample included 22 radiologists, 15 oncologists, 25 surgeons and 18 orthopedists. Most participants did not receive any radiation safety-related training (88.8%). Radiologists and oncologists were exposed to ionizing radiation more frequently;however, their knowledge was as low as that of other physicians. The overall knowledge score ranged from 40% - 60% (mean;56.5 ± 15.2), with a low score among surgeons and orthopedics. The most deficient knowledge was in the dose of background radiation and the radiation dose received by patients in each type of radiation procedure. Adherence to safe radiation practices was violated by most of participants, especially surgeons and orthopedics, but they attributed it to the poor applicability of the protective measures during performing the procedures. This study concluded that physicians at the Suez Canal University Hospital had deficient knowledge, unsafe practices and negative attitude towards radiation safety policies & precautions.

关键词： Physicians’ Knowledge Attitude Practice Radiation Safety

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Predictors of Complete Early Virological Response to Pegylated Interferon and Ribavirin in Egyptian Patients with Chronic Hepatitis C Genotype 4

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Advances in Infectious Diseases 2013年第2期3卷 78-83页

作者： Gamal El Din Esmat Gamil Maissa El Said El Raziky Rabab Maamoun Salama Wafaa Ahmed El Akel Waleed fouad Fathalah Dina Ismail attia Endemic Medicine and Hepatology Department Faculty of Medicine Cairo University Cairo Egypt

We aim to determine the baseline factors associated with partial and cEVR by analyzing the data of 1861 Egyptian patients treated for 12 weeks with a course of Peg-IFN plus RBV. Base line data of 1861 Egyptian patients with chronic hepatitis C coming at Cairo-Fatemic Hospital for HCV treatment were studied including full clinical, Ultrasonographic examination, laboratory evaluation and liver biopsy. The most significant variables in relation to complete early virological response were low Hb level (13 gm/dl) with p 0.01, the stage of fibrosis p value < 0.05 and the grades of inflammation p value were associated with less achievement of c EVR. We conclude that identifying the most significant predictors of response such as Hb, stage of fibrosis F, at baseline before initiating treatment is mandatory to predict which patient will be more expected to achieve a cEVR and thus reducing the side-effects and healthcare costs associated with interferon therapies.

关键词： Predictors of Response cEVR HCV Treatment Peg IFN/Ribavirin

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Redefinition of Fatty Liver Disease from NAFLD to MAFLD through the Lens of Drug Development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers Robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin Blake David A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh Dina attia Steven Bollipo Alastair D.Smith Bradley Freilich Robert G.Gish Detlef Schuppan Department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA Division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum Diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology Department Beni-Suef UniversityBeni SuefEgypt Department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA Division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLD)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLD)to MAFLD,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLD care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLD term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLD initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLD *** hope it will bring promising new opportunities for a brighter future for MAFLD care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLD MAFLD NASH Fatty liver disease Liver Fibrosis

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The Effectiveness of Intraoperative Frozen Section Analysis of Safety Margins in Breast Conserving Surgery and the Role of Surgeon in Decreasing the Rate of Positive Margins

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Surgical Science 2017年第12期8卷 499-509页

作者： Omar Farouk Ahmed Senbel Mosab Shetiwy Essam attia Ahmed Abdallah Osama El-Damshety Ashraf Khater Sameh Roshdy Amr Abouzid Amr hossam Islam H. Metwally Omar Hamdy Amir M. Zaid Mahmoud Abdelaziz Mohamed Elmetwally Adel Fathi Emad-Eldeen Hamed Khaled Abdel Wahab Wagdi El-Kashef Mohamed Hafez Khaled Zalata Mohamed Hegazy Adel Denewer Surgical Oncology Department Oncology Center Faculty of Medicine Mansoura University Mansoura Egypt Pathology Department Faculty of Medicine Mansoura University Mansoura Egypt

Introduction: Nowadays the more accepted surgical option for treating early breast cancer is breast conserving surgery. The main challenge in this type of surgery is to get free safety margins without need of second surgical operation, so many breast surgeons have started to depend on intraoperative frozen sections to ensure free safety margins. Aim of work: To assess our policy that we prefer to depend on intraoperative frozen section analysis to get free safety margin in breast conserving surgery from the 1st surgery, and its oncologic outcome. Patients and Methods: This is a retrospective study conducted in Oncology Center—Mansoura University (OCMU), where the data of 219 patients with breast cancer, who were managed by breast conserving surgery with intraoperative frozen section analysis of the safety margins, was analyzed. Results: The intraoperative frozen section analysis of safety margin was negative from the start in 183 (83.6%) patients, while it was positive in 36 patients (16.4%). Intraoperative decision of margin re-excision was applied for 29 patients (13.2%) in order to reach negative margin, modified radical mastectomy was offered for 4 patients (1.8%), while nipple sparing mastectomy with immediate breast reconstruction using latissimus dorsi flap was offered for 3 patients (1.4%). The postoperative paraffin results were typical with intraoperative frozen section analysis results in 216 patients (98.6%) and different results were obtained in only 3 patients (1.4%) who were managed by modified radical mastectomy in a second operation. Only 4 patients had local recurrence (1.8%) during the period of follow-up duration which was ranged from 1 to 86 months with mean ± SD (22.3 ± 14.1). Conclusion: The intraoperative frozen section analysis of safety margins in breast conserving surgery has very high-rate typical results with the paraffin section analysis and it is very helpful in decreasing the rate of second surgical operation in cases of infiltrated m

关键词： Breast Conserving Surgery Intraoperative Frozen Section Analysis Safety Margins Breast

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