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Role of T cells in cancer immunotherapy:Opportunities and challenges

Cancer Pathogenesis and Therapy 2023年第2期1卷 116-126页

作者： hossain ahmed Aar Rafi Mahmud Mohd.Faijanur-Rob-Siddiquee Asif Shahriar Partha Biswas Ebrahim Khalil Shimul Shahlaa Zernaz ahmed Tanzila Ismail Ema Nova Rahman Arif Khan Furkanur Rahaman Mizan Talha Bin Emran Department of Biotechnology and Genetic Engineering University of Development Alternative(UODA)4/4BBlock ALalmatiaDhaka1209Bangladesh Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology UniversityTangail1902Bangladesh Department of Biochemistry and Molecular Biology Faculty of Biological ScienceUniversity of DhakaDhaka1000Bangladesh Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA Department of Genetic Engineering and Biotechnology Faculty of Biological Science and TechnologyJashore University of Science and Technology(JUST)Jashore7408Bangladesh Department of Biochemistry and Microbiology North South UniversityDhaka1229Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar UniversitySavarDhaka1342Bangladesh Department of Food Science and Technology Chung-Ang UniversityAnseong17546Republic of Korea Department of Pharmacy BGC Trust University BangladeshChittagong4381Bangladesh Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhaka1207Bangladesh

Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types,yet clinical responses differ among patients and ***,there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor ***-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune *** molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy,including checkpoint blockade,adoptive and chimeric antigen receptor(CAR)T cell therapy,and cancer *** review addresses all the strategies targeting tumor pathogenesis,including metabolic pathways,to evaluate the clinical significance of current and future immunotherapies for patients with cancer,which are further engaged in T cell activation,differentiation,and response against tumors.

关键词： Immunotherapy T cell Cancer Immune system Metabolic pathways

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： ahmed Shakir AL-HITI Hiba HASSAN Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of MAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Application of metal oxides-based nanofluids in PV/T systems: a review

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Frontiers in Energy 2022年第3期16卷 397-428页

作者： Shahriar ahmed KH.Nazmul Ahshan MdNur Alam Mondal Shorab hossain Department of Mechanical Engineering Hajee Mohammad Danesh Science and Technology UniversityDinajpur5200Bangladesh Department of Engineering BGMEA University of Fashion and TechnologyDhaka1230Bangladesh

Having the wide application of metal oxides in energy technologies, in recent years, many researchers tried to increase the performance of the PV/T system by using metal oxide-based nanofluids (NFs) as coolants or optical filters or both at the same time. This paper summarizes recent research activities on various metal oxides (Al2O3, TiO2, SiO2, Fe3O4, CuO, ZnO, MgO)-based NFs performance in the PV/T system regarding different significant parameters, e.g., thermal conductivity, volume fraction, mass flowrate, electrical, thermal and overall efficiency, etc. By conducting a comparative study among the metal oxide-based NFs, Al2O3/SiO2-water NFs are mostly used to achieve maximum performance. The Al2O3-water NF has a prominent heat transfer feature with a maximum electrical efficiency of 17%, and a maximum temperature reduction of PV module of up to 36.9°C can be achieved by using the Al2O3-water NF as a coolant. Additionally, studies suggest that the PV cell’s efficiency of up to 30% can be enhanced by using a solar tracking system. Besides, TiO2-water NFs have been proved to have the highest thermal efficiency of 86% in the PV/T system, but TiO2 nanoparticles could be hazardous for human health. As a spectral filter, SiO2-water NF at a size of 5 nm and a volume fraction of 2% seems to be very favorable for PV/T systems. Studies show that the combined use of NFs as coolants and spectral filters in the PV/T system could provide a higher overall efficiency at a cheaper rate. Finally, the opportunities and challenges of using NFs in PV/T systems are also discussed.

关键词： metal oxide nanofluids(NFs) nanoparticles(NPs) optical filter PV/T systems solar energy

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Numerical Investigation of a modified Kalina cycle system for high-temperature application and genetic algorithm based optimization of the multi-phase expander’s inlet condition

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Energy and AI 2021年第4期6卷 71-87页

作者： Mohammad Masrur hossain MdSakib hossain Niyaz Afnan ahmed M Monjurul Ehsan Department of Mechanical and Production Engineering Islamic University of TechnologyBoard BazarGazipur 1704Bangladesh

As an alternative to the conventional steam Rankine Cycle,Kalina Cycle has witnessed a growing interest over the past years for high-temperature applications(A working fluid temperature of 500◦C at the turbine inlet).However,the possibility of implementing an additional multi-phase expander on the weak ammonia-water solution loop of the Kalina cycle was hardly analyzed in the available *** this research,two novel Kalina cycles(Kalina cycle-12A and Kalina cycle-12B)have been presented by integrating a multi-phase expander in addition to the turbine installed downstream of the Kalina *** Kalina cycle-12A,this additional multi-phase expander is positioned downstream of the Kalina separator and on the weak ammonia-water solution loop for Kalina Cycle-12B.A detailed mathematical model based on the thermodynamic laws has been developed to solve and optimize the Kalina *** influence of critical decision parameters,specifically the ammonia concentration on working fluid and evaporation pressure,were *** optimization was performed based on the objective to maximize the net power output from the multi-phase expander under steady-state operating *** the performance of the proposed Kalina cycles was compared with the conventional Kalina Cycle-12,both of them demonstrated superior performance,i.e.,net power output and peak thermal efficiency increased by a maximum value of 3.23%for the proposed Kalina Cycle-12A cycle and 3.94%for the proposed Kalina Cycle-12B *** terms of second law efficiency,Kalina Cycle-12A is 3.68 percent more efficient than Kalina Cycle-12,while Kalina Cycle-12B is 4.04 percent more ***,2nd law analysis also reveals,maximum destruction of exergy occurs at the condensers of the cycles.

关键词： Kalina cycle Genetic algorithm-based optimization Exergy analysis High temperature

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Recent Progress and Future Trends on the State of Charge Estimation Methods to Improve Battery-storage Efficiency: A Review

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CSEE Journal of Power and Energy Systems 2022年第1期8卷 105-114页

作者： Md Ohirul Qays Yonis Buswig Md Liton hossain ahmed Abu-Siada Department of Electrical and Electrical Engineering Faculty of EngineeringUniversiti Malaysia SarawakKota SamarahanSarawakMalaysia Department of Electrical and Computer Engineering Curtin UniversityKent StreetBentleyPerth 6102WAAustralia

Battery storage systems are subject to frequent charging/discharging cycles,which reduce the operational life of the battery and reduce system reliability in the long *** such,several Battery Management Systems(BMS)have been developed to maintain system reliability and extend the battery’s operative *** estimation of the battery’s State of Charge(SOC)is a key challenge in the BMS due to its non-linear *** paper presents a comprehensive review on the most recent classifications and mathematical models for SOC *** trends for SOC estimation methods are also presented.

关键词： Battery Management System(BMS) battery modeling battery storage efficiency state of charge(SOC)

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Assaying the allelopathic effects of Eucalyptus camaldulensis in a nursery bed incorporated with leaf litter

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Journal of Forestry Research 2018年第3期29卷 592-598页

作者： Romel ahmed Mohammad Shafioul Alam Farid Uddin ahmed M.K.hossain Department of Forestry and Environmental Science Shahjalal University of Science and TechnologySylhet 3114Bangladesh Ministry of Public Administration TeknafCoxsbazarDhaka 4761Bangladesh Arannayk Foundation House 21 Western RoadDOHSBananiDhaka 1206Bangladesh Institute of Forestry and Environmental Science University of ChittagongChittagong 4331Bangladesh

Allelopathic effects of Eucalyptus camaldulensis Dehnh. were confirmed in Petri dish and pot experiments in our previous studies. However, the degree to which such effects under controlled experiments exist in more complex ecological settings remains to be tested. Thus, the present study was carried out by incorporating different proportions of ground litter of E. camaldulensis in soil. The growth of three agricultural crops: falen(Vigna unguiculata(L.) Walp.), chickpea(Cicer arietinum L.), and arhor(Cajanus cajan(L.) Millsp.), and two tree species, kala koroi(Albizia procera(Roxb.) Benth.) and ipil ipil(Leucaena leucocephala(Lam.) de Wit) were tested. There were inhibitory effects of leaf litter on germination, shoot and root growth, leaf number, and collar diameter as well as a reduction of nodulation by legume crops(25–80%reduction). The extent of the effects was dependent on the proportion of leaf litter, the species and the type of traits. In contrast to shoot growth, the effect on root growth was more severe. No effect on germination was found with the agriculture crops while the two tree species showed reduced germination. The effect was greater in the presence of higher proportions of leaf litter mixed in soil while in some cases lower proportions stimulated growth. Not all species were suppressed; A. procera, C. cajan, V. unguiculata showed compatible growth while C. arietinum and *** were found incompatible. This study provides evidence that E. camaldulensis has allelopathic potential under field conditions and a careful selection of associated crops in agroforestry systems is highly recommended.

关键词： Allelopathy Eucalyptus camaldulensis Inhibitory effects Germination Growth Nodulation

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Active Cell Balancing Control Strategy for Parallelly Connected LiFePO_(4) Batteries

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CSEE Journal of Power and Energy Systems 2021年第1期7卷 86-92页

作者： Md Ohirul Qays Yonis Buswig Md Liton hossain Md Momtazur Rahman ahmed Abu-Siada Department of Electrical and Electrical Engineering Faculty of EngineeringUniversity Malaysia SarawakKota SamarahanSarawakMalaysia Department of Electrical and Computer Engineering Curtin UniversityKent StreetBentleyPerth 6102WAAustralia Electron Science Research Institute Edith Cowan University270 Joondalup DriveJoondalupWA6027Australia

While several recent studies have focused on elimi-nating the imbalance of energy stored in series-connected battery cells,very little attention has been given to balancing the energy stored in parallel-connected battery *** such,this paper aims at presenting a new balancing approach for parallel LiFePO_(4) battery *** this regard,a Backpropagation Neural Network(BPNN)based technique is employed to develop a Battery Management System(BMS)that can assess the charging status of all cells and control its operations through a DC/DC Buck-Boost *** results demonstrate the effectiveness of the proposed approach in balancing the energy stored in parallel-connected battery cells in which the state of charge(SoC)estimation error is found to be only 1.15%.

关键词： Active cell balancing battery management system DC/DC buck-boost converter state of charge estimation

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Industrial IoT Based Condition Monitoring for Wind Energy Conversion System

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 654-664页

作者： Md Liton hossain ahmed Abu-Siada S.M.Muyeen Md Mubashwar Hasan Momtazur Rahman Department of Electrical and Computer Engineering Curtin UniversityPerthAustralia School of Science Engineering and ITFederation UniversityAustralia Edith Cowan University Australia

Wind energy has been identified as the second dominating source in the world renewable energy generation after *** and distribution of wind energy has brought technology revolution by developing the advanced wind energy conversion system(WECS)including multilevel inverters(MLIs).The conventional rectifier produces ripples in their output waveforms while the MLI suffers from voltage balancing issues across the DC-link *** paper proposes a simplified proportional integral(PI)-based space vector pulse width modulation(SVPWM)to minimize the output waveform ripples,resolve the voltage balancing issue and produce better-quality output *** experiences various types of faults particularly in the DC-link capacitor and switching devices of the power *** faults,if not detected and rectified at an early stage,may lead to catastrophic failures to the WECS and continuity of the power *** paper proposes a new algorithm embedded in the proposed PI-based SVPWM controller to identify the fault location in the power converter in real *** most wind power plants are located in remote areas or offshore,WECS condition monitoring needs to be developed over the internet of things(IoT)to ensure system *** this paper,an industrial IoT algorithm with an associated hardware prototype is proposed to monitor the condition of WECS in the real-time environment.

关键词： Asset management condition monitoring fault diagnosis industrial internet of things(IoT) wind energy conversion system

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Investigation of heat transfer of a building wall in the presence of phase change material(PCM)

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Energy and Built Environment 2020年第2期1卷 199-206页

作者： Rafid Jahangir Khan Md.Zubayer hossain Bhuiyan Dewan Hasan ahmed Department of Mechanical and Production Engineering Ahsanullah University of Science and Technology141-142 Love RoadTejgaon Industrial AreaDhakaBangladesh

The energy consumption in buildings for heating,ventilation,and air-conditioning is increasing with the in-creasing demand for thermal *** energy storage with phase change material(PCM)has attracted growing attention for its role in achieving energy conservation in buildings with thermal *** paper investigates the effect of PCM on the heat transfer rate in a building wall and the role of PCM on the indoor thermal comfort of the *** models of building wall fragments were developed for the experimental *** one model,tests were conducted for different positions of the PCM layer in the building wall to identify the optimal position of the PCM layer inside the *** another model,tests were carried out integrating PCM,air gap,and other conventional building materials(brickbat and sand),one at a time,to investigate the role of PCM on the heat transfer rate in the building wall *** results show that placing the PCM layer closer to the heat source gives a low-temperature gain of the cold water bath(indoor state)as compared with the PCM layer near the heat *** PCM,the temperature rise of the cold water bath(indoor state)of the building wall fragment was the lowest,and the slope of the temperature rise of the cold water bath becomes steadier with time i.e.,fewer temperature *** was a significant time delay for the cold water bath to reach a given *** heat required for a unit degree increase in the temperature of the cold water bath was higher and the peak heat flux of the wall was lower relative to the other building materials.

关键词： Phase change material(PCM) Thermal energy storage Building wall fragment Thermal comfort

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