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nod鼠胸腺及外周淋巴细胞亚群变化与年龄关系

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中华微生物学和免疫学杂志 1994年第4期14卷 272-276页

作者：张志利 Geor.,hm 山西医学院第一附属医院

ＮＯＤ鼠可自发地患糖尿病，该鼠的发病与自身免疫性淋巴细胞对胰岛的浸润，从而引起胰岛β细胞的不断破坏有关。这种破坏可能是由Ｔ淋巴细胞所引起的。雌性ＮＯＤ鼠胸腺及外周淋巴细胞随年龄的增加胸腺细胞数量减少而脾细胞数量增加。... 详细信息

ＮＯＤ鼠可自发地患糖尿病，该鼠的发病与自身免疫性淋巴细胞对胰岛的浸润，从而引起胰岛β细胞的不断破坏有关。这种破坏可能是由Ｔ淋巴细胞所引起的。雌性ＮＯＤ鼠胸腺及外周淋巴细胞随年龄的增加胸腺细胞数量减少而脾细胞数量增加。用ＣＤ４／ＣＤ８双抗双标检测显示，雌性ＮＯＤ糖尿病鼠胸腺双阴性与单阳性细胞的比例增加而双阳性细胞的比例减少。外周ＣＤ４比ＣＤ８阳性细胞的比值在胰岛炎期增高，在糖尿病期下降。

关键词： nod小鼠自身免疫淋巴细胞亚群

Plant cover as an estimator of above-ground biomass in semi-arid woody vegetation in northeast Patagonia,Argentina

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Journal of Arid Land 2021年第9期13卷 918-933页

作者： Laura B RodRIGUEZ Silvia S TORRES ROBLES marcelo F ARTURI Juan m ZEBERIO Andrés C H GRAnD néstor I GASPARRI national University of Río negro Atlantic HeadquartersCenter for Environmental Studies from Norpatagonia(CEANPa)Viedma 8500Argentina national Council of Scientific and Technical Research(COnICET) Viedma 8500Argentina Ecological and Environmental Systems Research Laboratory(LISEA) National University of La PlataLa Plata 1900Argentina national Institute of Agricultural Technology(InTA) AER PatagonesCarmen de Patagones 8504Argentina Institute of Regional Ecology(IER) National University of Tucumán(UNT)-National Council of Scientific and Technical Research(CONICET)Tucumán 4000Argentina Faculty of natural Sciences and miguel Lillo Institute National University of Tucumán(UNT)Yerba Buena 4107Argentina

The quantification of carbon storage in vegetation biomass is a crucial factor in the estimation and mitigation of CO2 ***,arid and semi-arid regions are considered an important carbon ***,they have received limited attention and,therefore,it should be a priority to develop tools to quantify biomass at the local and regional *** plant variables,such as stem diameter and crown area,were reported to be good predictors of individual plant ***-level variables,such as plant cover and mean height,are also easy-to-measure estimators of above-ground biomass(AGB)in dry *** this study,we estimated the AGB in semi-arid woody vegetation in northeast Patagonia,*** evaluated whether the AGB at the stand level can be estimated based on plant cover and to what extent the estimation accuracy can be improved by the inclusion of other field-measured structure *** also evaluated whether remote sensing technologies can be used to reliably estimate and map the regional mean *** this purpose,we analyzed the relationships between field-measured woody vegetation structure variables and AGB as well as LAnDSAT Tm-derived *** obtained a model-based ratio estimate of regional mean AGB and its standard *** plant cover allowed us to obtain a reliable estimation of local AGB,and no better fit was attained by the inclusion of other structure *** stand-level plant cover ranged between 18.7%and 95.2%and AGB between about 2.0 and 70.8 mg/hm^(2).AGB based on total plant cover was well estimated from LAnDSAT Tm bands 2 and 3,which facilitated a model-based ratio estimate of the regional mean AGB(approximately 12.0 mg/hm^(2))and its sampling error(about 30.0%).The mean AGB of woody vegetation can greatly contribute to carbon storage in semi-arid ***,plant cover estimation by remote sensing images could be used to obtain regional estimates and map biomass,as well as to assess and monitor the i

关键词： above-ground biomass shrublands ratio estimation carbon storage remote sensing Patagonia

Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene

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Journal of Electromagnetic Analysis and Applications 2010年第6期2卷 382-394页

作者： Kikuji Yamashita Shine-od Dalkhsuren Tatsuo Ishikawa Kaori Sumida Jun Ishibashi Hiroyoshi Hosokawa Akemichi Ueno Fumio nasu Seiichiro Kitamura 不详

Far-infrared ray (FIR) is electromagnetic wave between 4 and 1000 μm. FIR causes heating, but how it affects cells is not well understood. In this study, we developed a culture incubator that can continuously irradiate cells with FIR and examined the effects of FIR on five human cancer cell lines, namely A431 (vulva), A549 (lung), HSC3 (tongue), mCF7 (breast) and Sa3 (gingiva). We found that FIR inhibits cell proliferation and induces cell hypertrophy without apoptosis in A549, HSC3 and Sa3 cells. Flow cytometry revealed that the inhibition of proliferation was due to G2/m arrest. Contrary, FIR did not inhibit cell proliferation and cause cell hypertrophy in A431 or mCF7 cells. microarray analysis revealed that FIR suppressed the expression of cell proliferation-related and stress-responsive genes in FIR-sensitive cell lines (A549, HSC3 and Sa3). ATF3 in particular was identified as a key mediator of the FIR effect. Over-expression of ATF3 inhibited cell proliferation and knockdown of ATF3 mRnA using an antisense oligonucleotide suppressed FIR-induced growth arrest. These results indicate that a body temperature range of FIR radiation suppresses the proliferation of A549, HSC3, Sa3 cells and it appears that ATF3 play important roles in this effect.

关键词： Far-Infrared Radiation Human Cancer Cell Lines G2/m Arrest Hypertrophy ATF3

牡丹籽油抑制结肠癌细胞HCT116的体外增殖和调控细胞周期作用

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现代食品科技 2020年第5期36卷 22-29,162页

作者：邹佳文罗依 Akan od 周潇恬徐魏白婕刘津良胡作民周亚萍罗非君中南林业科技大学食品科学与工程学院湖南长沙410004 中南大学湘雅医学院湖南长沙410008

以牡丹籽油为研究对象,结肠癌细胞HCT116为模型,评估了牡丹籽油对HCT116结肠癌细胞体外增殖和周期的影响,并对其分子机理进行了初步的研究。利用mTS实验、蛋白蛋印迹等检测了结肠癌细胞在增殖、迁移和分子水平上的变化。结果表明:牡丹... 详细信息

以牡丹籽油为研究对象,结肠癌细胞HCT116为模型,评估了牡丹籽油对HCT116结肠癌细胞体外增殖和周期的影响,并对其分子机理进行了初步的研究。利用mTS实验、蛋白蛋印迹等检测了结肠癌细胞在增殖、迁移和分子水平上的变化。结果表明:牡丹籽油能显著抑制HCT116细胞的增殖和迁移能力;当牡丹籽油的浓度达到100μg/m L时,细胞周期相关基因p15、p21、p53的m RnA相对表达量相比对照组(Con)分别上升了5.49、4.56和3.73倍,具有极显著性差异(pmAPK信号通路的激活,且能显著抑制其下游转录因子AP-1和nF-κB的活性。结果提示牡丹籽油可能通过抑制mAPK信号通路/AP-1和nF-κB活性下调,调控细胞周期相关基因的表达,从而抑制结直肠癌细胞的增殖,课题研究将为功能性抗癌类食用植物油的开发提供科学的理论基础。

关键词：牡丹籽油 HCT116细胞细胞周期 mAPK AP-1 nF-κB

Pollution of water resources due to industrialization in arid zone of Rajasthan, India

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Journal of Environmental Sciences 2001年第2期13卷 218-223页

作者： Khan m A Central Arid Zone Research Institute 印度 342003

In arid zone of Rajasthan, India, nearly 21,900 hm2 area along Bandi River has been affected by industrial effluent discharge into the river bed. Analysis of groundwater samples collected from these sites revealed that area at the vicinity of the river is most affected. The effluent water in the river is the main source of contamination of ground water. Concentration of sodium and chloride has been higher with proportional increase in TDS and EC value in the area within zone A (river water), zone B (0-100 m), zone C (101-250 m), zone D (251-500 m) and zone E (501-1000 m). There is decreasing trend in ion concentration from zone A to zone E and F, reflecting reduced effect of effluents. The pollution of water resources has resulted in the degradation of other natural resources such as land, soil and vegetation. nearly 4463 hm2 (20.38%) area has been very severely affected. EC value at places exceeds 20 dS/m. Soil and land have become hard, compact and saline. Cropping intensity has declined. In the area (3633 hm2) affected severely, the EC value of water varies from 10-20 dS/m. Irrigation with such water has created problem of salinity, sodicity in soils. Herbal biomass declined considerably. Double cropping has almost stopped. Almost 8494 hm2 area is affected moderately. EC of ground water varies from 5 to 10 dS/m. Fragile surface crust, declining trend of phosphorous and potassium in the soil, poor density of natural vegetation are significant manifestations. Apart from this, 5305 hm2 area is slightly affected.

关键词： India Pollution of water resources due to industrialization in arid zone of Rajasthan

Growth characteristics of multipurpose tree species, crop productivity and soil properties in agroforestry systems under subtropical humid climate in India

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Journal of Forestry Research 2007年第4期18卷 261-270页

作者： m. Datta n. P. Singh ICAR Research Complex for nEH Region Lembucherra Tripura 799 210 India

multipurpose tree species （mPTs） were studied in an agroforestry arboretum under subtropical humid climate in northeast India. Out of 12 mPTs planted under agroforestry systems, Acacia auriculiformis in spacing of 2 m × 2 m （2500 stems·hm^-2） could have the potentiality to meet the timber/fuelwood requirement due to its high wood production of 635 m^3·hm^-2 with mean annual increment （mAI） of 2.54×10^-2 m^***.a^-1 in a short rotation period of 10 years. Thus, A. auriculiformis is a short rotation forest tree species suitable to grow in subtropical humid climate. On the other hand, at 16 years of age, Eucalyptus hybrid and michelia champaca in spacing of 3 m × 3 m （1111 ***^2） produced appreciably high timber volume of 315 m^***^-2 and 165 m^***^-2 with mAI of 1.77×10^-2 m^***^-1·a^-1 and 0.92×10.2 m^***^-1.a^-1, respectively. At 16 years of age, Gmelina arborea produced a timber volume of 147 m^***^-2 with mAI of 1.47×10^-2 m^***^-1.a^-1 followed by Samania saman （140 m^***^-2）, Albizziaprocera （113 m^3·hm^-2） and Tectona grandis （79 ***^-2） with mAI of 1.40, 1.13 and 0.78 × 10^-2 m^3 .tree^-1a^-1, respectively in 4 m × 4 m spacing （625 ***^-2）. Gliricidia maculata and Leucaena leucocephala could be used as live fences around the farm boundary to supply their n-rich leaves for mulch as well as manure to crops. In agroforestry arboretum, direct seeded upland rice （Oryza sativa - variety, AR-11）, groundnut （Arachis hypogaea - variety, JL-24） and sesamum （Sesamum indicum - variety, B-67） were grown during the initial period upto 8 years of tree establishment. Under other mPTs, there was a reduction in crop productivity as compared to open space. After 8 years of tree establishment, horti-silvi and silvi-pastoral systems were developed and pineapple （Ananas comosus - variety Queen）, turmeric （Curcuma longa -variety RCT -1） and cowpea （Vigna sinensis - variety Pusa Barsati） as forage crop were raised. The productivity of pineapple, turmeric a

关键词： multipurpose trees Subtropical humid climate Growth characteristics Timber volume Crop productivity Soil organic car-bon Soil humus nutrient availability Soil erodibility indices Soil moisture.

Incidental congenital coronary artery vascular fistulas in adults:Evaluation with adenosine-13n-ammonia PET-CT

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World Journal of Cardiology 2018年第10期10卷 153-164页

作者： Salah Am Said Aly Agool Arno hm moons mounir WZ Basalus nils RL Wagenaar Rogier LG nijhuis Jutta m Schroeder-Tanka Riemer HJA Slart Department of Cardiology Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of nuclear medicine Hospital Group TwenteAlmelo-Hengelo 7555 DLOverijsselThe Netherlands Department of Cardiology Slotervaart HospitalAmsterdam 1066 ECNorth HollandThe Netherlands Department of Cardiology Hospital Onze Lieve Vrouwe GasthuisLocation WestAmsterdam 1061 AENorth HollandThe Netherlands Department of nuclear medicine and molecular Imaging University Medical Center GroningenGroningen 9713 GZThe Netherlands Faculty of Science and Technology Biomedical Photonic ImagingUniversity of TwenteEnschede 7522 NBThe Netherlands

AIm To assess the functionality of congenital coronary artery fistulas(CAFs) using adenosine stress ^(13)n-ammonia positron emission tomography computed tomography(PET-CT).mETHodS Congenital CAFs were incidentally detected during coronary angiography(CAG) procedures in 11 adult patients(six males and five females) with a mean age of 64.3 years(range 41-81). Patients were collected from three institutes in the netherlands. The characteristics of the fistulas(origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG. Five patients underwent adenosine pharmacologic stress ^(13)n-ammonia PET-CT to assess myocardial perfusion and the functional behavior of the fistula. RESULTS Eleven patients with 12 CAFs, 10 unilateral and one bilateral, originating from the left anterior descending coronary artery(n = 8), right coronary artery(n = 2) and circumflex(n = 2). All fistulas were of the vascular type, terminating into either the pulmonary artery(n = 11) or coronary sinus(n = 1). The CAG delineated the characteristics of the fistula(origin, pathway and termination). multiplicity of the origins and pathways of the fistulous vessels were common in most fistulas(8/12, 67% and 9/12, 75%, respectively). multiplicity was common among the different fistula components(23/36, 64%). Adenosine pharmacologic stress ^(13)n-ammonia PET-CT revealed normal myocardial perfusion and ejection fraction in all but one patient, who showed a reduced ejection *** PET-CT may be helpful for assessing the functional status of congenital CAFs in selected patients regarding clinical decision-making. Studies with a larger patient series are warranted.

关键词： Coronary angiography Coronary-pulmonary artery fistulas Adenosine ammonia positron emission tomography computed tomography Coronary vascular fistulas Congenital coronary artery fistulas

心血管学的分子生物学心功能不全和心肌肥大的表型改变

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德国医学 1994年第3期11卷 127-129页

作者： m.Bhm m.Wankerl E.Erdmann 王来 medizinisehe Klinik Ⅲ für Innere medizin der Universitt zu Kn Josef-Stelzmann-Str.9D-50924 KlnGermany medizinisehe Klinik Ⅲ für Innere medizin der Universitt zu Kln Josef-Stelzmann-Str.9D-50924 KlnGermany 同济医科大学附属同济医院

各种真核细胞的表型及功能取决于其蛋白质的功能状态(离子通道、酶)、转录和翻译过程,以及基本的基因密码有无变异。每个环节的变化均可影响细胞的功能状态和结构;心功能不全及心肌肥大的进程中,上述每一环节均有相应的质与量变化,影响... 详细信息

各种真核细胞的表型及功能取决于其蛋白质的功能状态(离子通道、酶)、转录和翻译过程,以及基本的基因密码有无变异。每个环节的变化均可影响细胞的功能状态和结构;心功能不全及心肌肥大的进程中,上述每一环节均有相应的质与量变化,影响着病程发展。

关键词：心血管学分子生物学心功能不全心肌肥大

西德联邦铁路120系列机车辅助传动变流器采用GTO元件关断的逆变器

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国外铁道机车与动车 1985年第1期 48-50页

作者： H.B hm m.Girschikofsky 罗远谋

1.引言安装于西德联邦铁路120系列五台原型机车上的、采用晶体管关断逆变器的辅助传动变流器,在严酷运行条件下经过长期试验,证实其工作可靠,并对该机车在这一期间被证实已经成熟、已可进行批量生产作出了贡献。然而,功率半导体元件领... 详细信息

1.引言安装于西德联邦铁路120系列五台原型机车上的、采用晶体管关断逆变器的辅助传动变流器,在严酷运行条件下经过长期试验,证实其工作可靠,并对该机车在这一期间被证实已经成熟、已可进行批量生产作出了贡献。然而,功率半导体元件领域的发展并未停顿于此,在这一试验过程中,两台机车(120002和120004)的辅助传动变流器已装有新近研制的逆变器,以考核今后推广使用的可能性。其中主可控硅的关断元件采用可关断的可控硅元件,即所谓 GTO 可控硅元件。下面叙述这种有发展前途的技术的作用方式和优点。

关键词：逆变器电子器件可控硅元件晶闸管变流器关断辅助传动联邦铁路西德德国