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Common infection and allergy induced biomarkers status in respiratory diseases among Iranian Hajj pilgrims

Health 2014年第1期6卷 137-140页

作者： Seyed Mansour Razavi Ahmad Masoud hosein ziaee ardakani Soheila Dabiran Department of Community Medicine Tehran University of Medical Sciences Tehran Iran Department of Community Medicine Tehran University of Medical Sciences Tehran Iran Department of Immunology Tehran University of Medical Sciences Tehran Iran Department of Ophthalmology Shahid Beheshti University of Medical Sciences Tehran Iran

Background: The sources of respiratory disorders commonly occurred during the Hajj ceremony are now challenging and its infectious or allergic nature remained unknown. The present comprehensive study was conducted to assess sources of respiratory disorders in Hajj pilgrims. Method: In this prospective observational study, blood samples of 130 pilgrims were taken for assessment of serum levels of infectious and allergic sources. The measurement of IgA, IgG, IgM was used for assessment of infectious reactions against microbial antigens, NBT test was employed to assess phagocytic functions, and the measurement of gamma interferon was used for assessing immunity status against infections. Also, measurement of IgE and IL-4 was applied as two markers for assessing allergic reactions. The ELISA test was also used to assess serum levels of immunoglobulin A, G, M, E, IL-4 and gamma interferon before and three weeks after returning from Hajj ceremony. All of the volunteers were followed up along the trip and the involved pilgrim’s characteristics were recorded. Results: The present study showed no significant change in the level of allergic biomarkers including IgE and IL-4, however the mean levels of IgM, gamma Interferon and NBT test were increased after the trip compared with before that. Conclusion: Infections play a major role in occurrence of respiratory disorders among Hajj pilgrims and thus the role of allergic sources is doubtful.

关键词： Hajj Respiratory Disorder Nitro Blue Tetrazollium Reduction Test Gamma Interferon Immunoglobulin

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Emerging role of neuregulin-1beta1 in pathogenesis and progression of multiple sclerosis

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中国神经再生研究：英文版 2023年第1期18卷 133-134页

作者： Seyyed Mohyeddin ziaee Soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CenterRady Faculty of Health SciencesUniversity of ManitobaChildren Hospital Research Institute of ManitobaWinnipegMBCanada

Multiple sclerosis(MS)is a chronic immune-mediated disorder of the central nervous system(CNS)that causes focal demyelinating lesions,followed by axonal and neuronal *** genetic and environmental factors are found to be associated with MS *** MS etiology seems to be multifactorial and needs further elucidation,it is understood that the response of an immune system to specific myelin antigens triggers the onset of MS(Dendrou et al.,2015).However,how the autoimmune response initiates against myelin,and the cellular and molecular mechanisms underpinning the development and progression of MS are not fully ***,deconstructing MS pathogenesis is of paramount importance for identifying novel diagnostic and therapeutic targets for this complex disease.

关键词： pathogenesis sclerosis degeneration

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Effect of five diatomaceous earth formulations against Tribofium castaneum （Coleoptera： Tenebrionidae）, Oryzaephflus surinamensis （Coleoptera： Silvanidae） and Rhyzopertha dominica （Coleoptera： Bostrychidae）

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Insect Science 2007年第5期14卷 359-365页

作者： MASUMEH ziaee ADEL KHASHAVEH Department of Zoology Young Researcher Club of Urmia Islamic Azad University Urmia Department of Entomology Agricultural Faculty Urmia University Urmia Iran

Laboratory bioassays were conducted to determine the effect of food source on the survival of Tribolium castaneum Herbst, Oryzaephilus surinamensis L. and Rhyzopertha dominica F., after exposure to five diatomaceous earth （DE） formulations： Protect-It, Insecto, Perma-GuardTM, Dryacide and SilicoSec. Adults of these species were exposed to DEs at the rate of 0.5 mg/cm^2 for 1 day on filter paper inside plastic Petri dishes. After exposure, the initial mortality was counted and live individuals of the three species were held for a week in glass vials containing 50 mg wheat flour, rice and whole wheat, respectively. In the second experiment, after 1 day exposure to DEs, beetles were transferred to Petri dishes without food and held for a week to determine if the presence of food source would decrease the mortality of beetles. Experiments were carried out at 27℃ and 55% RH in the dark. The initial mortality in both of the experiments reached 100% for the three species exposed to Protect-It and in the case ofR. dominica and O. surinamensis exposed to Dryacide. In contrast, low level of mortality （〈 10%） was observed for T. castaneum exposed to Perma-GuardTM and Insecto. The mortality after the post-treatment period on food was decreased for the three species exposed to Perma-GuardTM and in the case of T. castaneum and R. dominica exposed to Insecto and SilicoSec. Adults of O. surinamensis were the most susceptible followed by R. dominica and 100% adult mortality was obtained, whereas T. castaneum were the least susceptible beetles to DEs. Protect-It and Dryacide were the most efficient DE formulations and can be used effectively in a stored grain integrated pest management program.

关键词： diatomaceous earth initial mortality food delayed mortality Oryzaephilus surinamensis Rhyzopertha dominica Tribolium castaneum

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Optimal Redundancy Allocation in Hierarchical Series-Parallel Systems Using Mixed Integer Programming

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Applied Mathematics 2013年第1期4卷 79-83页

作者： Mohsen ziaee Department of Industrial Engineering University of Bojnord Bojnord Iran

Reliability optimization plays an important role in design, operation and management of the industrial systems. System reliability can be easily enhanced by improving the reliability of unreliable components and/or by using redundant configuration with subsystems/components in parallel. Redundancy Allocation Problem (RAP) was studied in this research. A mixed integer programming model was proposed to solve the problem, which considers simultaneously two objectives under several resource constraints. The model is only for the hierarchical series-parallel systems in which the elements of any subset of subsystems or components are connected in series or parallel and constitute a larger subsystem or total system. At the end of the study, the performance of the proposed approach was evaluated by a numerical example.

关键词： Hierarchical Series-Parallel System Optimal Redundancy Allocation Mixed Integer Programming Formulation Reliability Optimization

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Retroperitoneal Cystic Lymphangioma: Case Report

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Surgical Science 2011年第4期2卷 209-211页

作者： S. A Fanaei S. A ziaee 不详

Introduction: Retroperitoneal cystic lymphangioma is a rare benign tumor of the retroperitoneal lymphatics that usually manifests in infancy. It is worth to Report of unexpected presentation especially in Adult. Case Presentation: An adult patient with Left Lower abdominal was referred to our hospital. Abdominal ultra-sonography revealed a large, multilocular, cystic mass with an obscure margin. CT of the abdomen showed a large homogeneous mass. Laparoscopy revealed a huge retroperitoneal cystic lymphangioma confirmed by histopathology. Conclusion: Adult cyst lymphangioma is the rare benign tumor with unclear intra abdominal manifestation. In our report the retroperitoneum was the rare location of this tumor.

关键词： Lymphangioma Cystic Retroperitoneal

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How to Approach Real Mathematical Modeling in Surge Capacity: Clinical Review

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Open Journal of Emergency Medicine 2017年第2期5卷 85-91页

作者： Ali ziaee Shervin Assari Helia Ghanean A. Jalali Saleem Abboud Youssef Emergency Department Saudi German Hospital Dubai UAE University of Michigan Michigan USA Research Associate UHN Toronto Canada Karolinska Institute Sweden Emergency Specialist Saudi German Hospital Dubai UAE

Objectives: Science of surge is one of most important topics in the realm of disaster preparedness. Since 2006, after Academic Emergency Medicine (AEM) Consensus Conference, few articles with quantitative data address decision making in surge capacity. The aim of this article is looking forward to the facts about mathematical modeling and proposes real modeling in decision making to have better outcome. Methods: Literature Research was performed on database for the last ten years (2007-2017). Articles with mathematical modeling were separated and classified based on the usage of them in the field. Results: All current mathematical studies compared based on pre-hospital and hospital setting and flexibility in change of global level of care in time. Integrated model of sigmoid curve and HASC (Hospital Acute Care Surge Capacity) with name B-H integrated modeling in two-hour interval proposed. Conclusion: This study shows dynamic process of disaster planning based on outcome and reality. The proposed model makes surge capacity more predictable and adjustable.

关键词： Surge Capacity Disaster Mathematical and Modeling

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Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal,akrlc2, and rablla expression

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World Journal of Gastroenterology 2004年第12期10卷 1716-1721页

作者： Sakineh Kazemi-Noureini Sergio Colonna-Romano Abed-Ali ziaee Mohammad-Ali Malboobi Mansour Yazdanbod Parviz Setayeshgar Bruno Maresca Institute of Biochemistry and Biophysics University of TehranTehranIran PO Box:13145-1384 International Institute of Genetics and Biophysics National Research CouncilVia Marconi 1280125 NaplesItaly National Research Center for Genetic Engineering and Biotechnology(NRCGEB) TehranIran Shanati Hospital Department of SurgeryMedical University of TehranTehranIran Pathology department Madaen HospitalTehranIran and University of Salerno School of PharmacyDept.Pharmaceutical SciencesFiscianoSalernoItaly

AIM: To identify the altered gene expression patterns in squamous cell carcinoma of esophagus (ESCC) in relation to adjacent normal esophageal epithelium. METHODS: Total RNA was extracted using SV total RNA isolation kit from snap frozen tissues of ESCC samples and normal esophageal epithelium far from the tumor. Radio-labeled cDNA were synthesized from equal quantities of total RNAs of tumor and normal tissues using combinations of 24 arbitrary 13-mer primers and three different anchoring oligo-dT primers and separated on sequencing gels. cDNA with considerable different amounts of signals in tumor and normal tissue were reamplified and cloned. Using southern blot, the clones of each band were controlled for false positive results caused by probable heterogeneity of cDNA population with the same size. Clones that confirmed differential expression by slot blot selected for sequencing and northern analysis. Corresponding full-length gene sequences was predicted using human genome project data, related transcripts were translated and used for various protein/motif searches to speculate their probable functions. RESULTS: The 97 genes showed different levels of cDNA in tumor and normal tissues of esophagus. The expression of mal gene was remarkably down. regulated in all 10 surveyed tumor tissues. Akrlc2, a member of the aldoketo reductase 1C family, which is involved in metabolism of sex hormones and xenobiotics, was up-regulated in 8 out of 10 inspected ESCC samples. Rablla, RPL7, and RPL28 showed moderate levels of differential expression. Many other cDNAs remained to further studies. CONCLUSION: The mal gene which is switched-off in all ESCC samples can be considered as a tumor suppressor gene that more studies in its regulation may lead to valuable explanations in ESCC development. Akrlc2 which is upregulated in ESCC probably plays an important role in tumor development of esophagus and may be proposed as a potential molecular target in ESCC treatments. Differentia

关键词：基因表达鳞状细胞癌上皮细胞家兔 ESCC 食管

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Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer

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World Journal of Gastroenterology 2006年第44期12卷 7104-7112页

作者： Ferdous Rastgar Jazii Zahra Najafi Reza Malekzadeh Thomas P Conrads Abed Ali ziaee Christian Abnet Mansour Yazdznbod Ali Asghar Karkhane Ghasem H Salekdeh National Institute of Genetic Engineering and Biotechnology POBOX: 14155 6343 Tehran Iran Digestive Disease Research Center Shariati Hospital Medical University Tehran Iran Laboratory of Proteomics and Analytical Technologies SAIC -Frederick B Frederick MD 21702 United States Institute of Biochemistry and Biophysics Tehran University Tehran Iran NCI Center for Cancer Research CancerPrevention Studies Branch Bethesda United States Department of surgery Shariati Hospital Medical University Tehran Iran Agricultural Biotechnology ResearchInstitute of Iran Karaj Iran

AIM: To assess the proteome of normal versus tumor tissue in squamous cell carcinoma of the esophagus (SCCE) in Iranian patients and compare our results with former reports by using proteomics. METHODS: Protein was extracted from normal and tumor tissues. Two dimensional electrophoresis was carried out and spots with differential expression were identified with mass spectrometry. RNA extraction and RT-PCR along with immunodetection were performed. RESULTS: Fourteen proteins were found whose expression levels differed in tumor compared to normal tissues. Mass spectrometric analysis resulted in the identification of β-tropomyosin (TMβ), myosin light chain 2 (and its isoform), myosin regulatory light chain 2, peroxyredoxin 2, annexinⅠand an unknown polypeptide as the down regulated polypeptides in tumor tissue. Heat shock protein 70 (HSP70), TPM4-ALK fusion oncoprotein 2, myosin light polypeptide 6, keratinⅠ, GH16431p and calreticulin were the up-regulated polypeptides found in tumor tissue. Several of these proteins, such as TMβ,HSP70, annexinⅠ, calreticulin, TPM4-ALK and isoforms of myosins, have been well recognized in tumorigenesis of esophageal or other types of cancers. CONCLUSION: Our study not only supports the involve- ment of some of the formerly reported proteins in SCCE but also introduces additional proteins found to be lost in SCCE, including TMβ.

关键词：食道鳞片细胞空间电泳多肽

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公共安全事件处置过程中的社交媒体及其利用——2011年伦敦骚乱中地方当局运用微博的策略

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中国社会公共安全研究报告 2015年第1期 191-204页

作者： Panagiotis Panagiotopoulos Alinaghi ziaee Bigdeli Steven Sams 陈喆伦敦大学玛丽皇后学院伦敦城市大学卡斯商学院伦敦布鲁内尔大学信息系统学院

本文在研究2011年夏季伦敦暴乱的基础上,探讨了微博沟通在紧急事件中的影响力。2011年8月,在5天时间里,伦敦等部分英格兰主要城市,经历了大规模的公众骚乱和暴力事件,甚至有人因此丧生。我们收集和分析了由28个伦敦当地政府部门持有的... 详细信息

本文在研究2011年夏季伦敦暴乱的基础上,探讨了微博沟通在紧急事件中的影响力。2011年8月,在5天时间里,伦敦等部分英格兰主要城市,经历了大规模的公众骚乱和暴力事件,甚至有人因此丧生。我们收集和分析了由28个伦敦当地政府部门持有的官方账号发布的微博。这些部门利用微博达到多种目的,如阻止谣言的传播,提供官方的信息,推进对罪犯的法律行动和组织骚乱后的社区参与。本研究显示了微博的即时性和交互性要素在突发事件的应对和后续处理阶段所发挥的显著作用。

关键词：推特社交媒体伦敦骚乱英国地方政府紧急沟通

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