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Neutropenic enterocolitis in pediatric leukemia patients treated with intensive chemotherapy in Upper Egypt

Pediatric Investigation 2020年第1期4卷 5-10页

作者： Ereen Refaat Fouad Ahmed Mohammed Morsy hosam eldein mostafa kamel Amany Mohamed Ali Department of Pediatric Oncology South Egypt Cancer InstituteAssiut UniversityAssiutEgypt Department of Radiology South Egypt Cancer InstituteAssiut UniversityAssiutEgypt

Importance: In low resource countries, there has been scarcity of research on the risk factors associated with neutropenic enterocolitis, a serious complication that commonly develops during treatment of cancer ***: To identify the pattern of intestinal complications in pediatric leukemia patients treated with intensive chemotherapy, including those with neutropenic enterocolitis;to assess the outcome;and to evaluate the risk factors associated with the mortality in these ***: During the period from June 2015 to December 2016, a prospective study was carried out on pediatric patients diagnosed with acute leukemia who received induction/or re-induction phases of chemotherapy at South Egypt Cancer Institute. Patients with documented episodes of intestinal complications were included in the study. Recovery or death from an episode of intestinal complication was utilized as the primary outcome measure for the study. Using univariable and multivariable methods, potential risk factors associated with mortality were delineated by logistic regression analysis, both for the entire intestinal complications episodes as a whole and for those episodes of neutropenic enterocolitis ***: Out of 88 documented episodes of intestinal complications from 77 patients;58 episodes were identified as neutropenic enterocolitis from 47 patients. In those patients who were having episodes of neutropenic enterocolitis, the presence of abdominal tenderness (OR 4.529, 95%CI 1.062-19.317,P = 0.041);a longer duration of neutropenia (OR 1.215, 95%CI 1.030-1.434,P = 0.021);and hemodynamic instability (OR 17.023, 95%CI 4.095-70.772,P < 0.001), were found to be independently associated with worse ***: In Upper Egypt, the use of intensive systemic chemotherapy during the induction phase of acute leukemia was found to be associated with potentially lethal intestinal complications. A high index of clinical suspicion is warranted.

关键词： Neutropenic enterocolitis Acute leukemia Induction chemotherapy Intestinal complication Pediatric oncology

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Synthesis and surface modification of nanophosphorous-based flame retardant agent by continuous flow hydrothermal synthesis

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Particuology 2015年第5期13卷 82-88页

作者： Sherif Elbasuney hosam E.mostafa School of Chemical Engineering Military Technical College

Nanoparticles can provide flame retardance to hosting polymers and act as nano fire extinguishers. Hydroxyapatite （Ca5（OH）（PO4）3）（HA） is not hygroscopic, and is thermally stable up to 800℃, with 18.5 wt% phosphorous content. It is this high phosphorous content that can provide HA with flame retardant properties. In this paper, we report on the continuous synthesis of ultrafine HA using a hydrothermal synthesis technique. The HA surface properties were changed from hydrophilic to hydrophobic by post-synthesis surface modification. The ratio of the HA nanoparticles and an intumescent agent known as Exolit AP750 was investigated to yield a self-extinguishing multi-component epoxy nanocomposite for extended application under extreme fire conditions. The HA/AP750/epoxy nanocomposite was able to resist a flame at 1700 oc and self-extinguish after the flame had been removed. The nanocomposite showed an enhanced flammability performance in standard cone calorimetry testing and formed a compact and cohesive protective char layer with a 50% decrease in peak heat released compared with virgin epoxy. Our aim was to establish the use of HA as an effective nanofiller with phosphorous-based flame retardant properties. The surface of this nano fire extinguisher was modified effectively with different surfactants for enhanced compatibility with different polymeric matrices.

关键词： Flame retardancy Phosphorous-based agent Nanocomposites Hydrothermal synthesis Hydroxyapatite

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Chemical stability, thermal behavior, and shelf life assessment of extruded modified double-base propellants

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Defence Technology（防务技术） 2018年第1期14卷 70-76页

作者： Sherif Elbasuney Ahmed Fahd hosam E.mostafa Sherif F.mostafa Ramy Sadek School of Chemical Engineering Military Technical College

Double base propellant suffers from lack of chemical stability; this could result in self ignition during storing. Modified double base(MDB) propellant based on stoichiometric binary mixture of oxidizermetal fuel(Ammonium perchlorate/Aluminum), and energetic nitramines(HMX) offered enhanced thrust as well as combustion characteristics. This study is devoted to evaluate the impact of such energetic additives on thermal behavior, chemical stability, and shelf life. Extruded MDB formulations were manufactured by extrusion process. Artificial aging at 80℃ for 28 days was conducted. Shelf life assessment was performed using Van't Hoff's equation. Quantification of evolved NOxgases with aging time was performed using quantitative stability tests. MDB formulation based on HMX demonstrated extended service life of 16 years compared with(AP/Al)-MDB which demonstrated 9 years. This finding was ascribed to the reactivity of AP with nitroglycerin with the formation of perchloric acid. Thermal behavior of aged MDB, exhibited an increase in heat released with time; this was ascribed to the autocatalytic thermal degradation during artificial aging. The increase in released heat by 31% was found to be equivalent to evolved NOx gases of 6.2 cm^3/5 g and 2.5 cm^3/1 g for Bergmann-Junk test, and Vacuum stability test respectively. This manuscript shaded the light on a novel approach to quantify evolved NOx gases to heat released with aging time. MDB based on HMX offered balanced ballistic performance,chemical stability, and service life.

关键词： Double-base Chemical stability Thermal behavior Artificial aging Shelf life assessment

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Multi-layer protective armour for underwater shock wave mitigation

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Defence Technology（防务技术） 2015年第4期11卷 338-343页

作者： Ahmed HAWASS hosam mostafa Ahmed ELBEIH Military Technical College

The effect of underwater shock wave on different target plates has been *** underwater shock wave generator(shock tube) was used to study the interactions between water and different constructed targets which act as shock wave *** plates,composed of sandwich of two aluminum sheets with rubber and foam in between,were prepared and *** comparison,the target plates composed of triple aluminum sheets were *** study includes the testing of the selected plates in water under the effect of different peak pressures and the analysis of the *** strain gauge data and displacement sensors results showed that the multi-layer plates have higher level of underwater shock wave mitigation than the triple aluminum plates with strain and deflection of nearly 50%.

关键词：冲击波水下防护装甲位移传感器波发生器相互作用压力作用目标板

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Novel aspects for thermal stability studies and shelf life assessment of modified double-base propellants

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Defence Technology（防务技术） 2019年第3期15卷 300-305页

作者： Sherif Elbasuney Ashraf.M. A. Elghafour mostafa Radwan Ahmed Fahd hosam mostafa Ramy Sadek Amr Motaz School of Chemical Engineering Military Technical College Kobry El-Kobba Cairo Egypt British University in Egypt Elshrouk city Cairo Egypt

Modified DB propellants, based on energetic nitramine(RDX) were manufactured by solventless extrusion process. Thermal stability and shelf life assessment of modified DB propellant were investigated. Shelf life assessment was evaluated using Van’t Hoff’s formula and artificial aging at 70℃ up to120 days. Quantification of total heat released and heat flow with aging time was conducted using differential scanning calorimetry(DSC) and thermal activity monitoring(TAMIII) respectively. Modified DB formulation based on 20 wt % RDX demonstrated enhanced thermal stability in terms of controlled heat flow, and slow decomposition reactions at elevated temperature. This formulation demonstrated extended service life up to 56 years compared with reference formulation. These novel finding was ascribed to the high thermal stability of RDX and its compatibility with DB constituents. This manuscript shaded the light on novel and effective approach for thermal stability via monitoring thermal activity with aging.

关键词： Double-base propellant Thermal stability Artificial aging Shelf-life assessment

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Novel approach to quantify the chemical stability and shelf life of modified double-base propellants

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Defence Technology（防务技术） 2018年第6期14卷 720-724页

作者： Ashraf M.A.Elghafour mostafa Radwan Ahmed Fahd hosam E.mostafa Sherif Elbasuney School of Chemical Engineering Military Technical CollegeKobry El-KobbaCairoEgypt British University in Egypt Elshrouk CityCairoEgypt

Double-base(DB) propellant is vulnerable to auto-catalytic decomposition reactions during storing with the evolution of nitrogen oxides. Modified DB propellant based on energetic nitramines(RDX) can offer enhanced thrust and action time. This study is devoted to evaluate the impact of RDX on chemical stability and shelf life of DB propellant. Extruded modified DB propellant based on RDX was manufactured by solventless extrusion process. Shelf life assessment was performed using an artificial aging at70 ℃ up to 120 days and employing Van't Hoffs formula. Quantification of evolved NOx gases and stabilizer depletion with aging time was conducted using Bergmann-Junk test and HPLC *** DB formulation based on RDX 20 wt % demonstrated enhanced chemical stability and extended service life up to 46 years compared with reference formulation. This finding was ascribed to the high chemical and thermal stability of RDX as well as its compatibility with DB constituents; no side chemical reactions could take place during storing. This manuscript shaded the light on RDX as effective energetic constituent that offered DB propellants with enhanced performance, good chemical stability, and extended service life.

关键词： Double-base propellant Chemical stability Artificial aging Shelf life assessment

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Interstitial cells of Cajal, the Maestro in health and disease

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World Journal of Gastroenterology 2010年第26期16卷 3239-3248页

作者： Randa M mostafa Yasser M Moustafa hosam Hamdy Department of Basic Medical Sciences College of Medicine Sharjah University Sharjah 27272 United Arab Emirates Department of Pharmacology and Toxicology College of Pharmacy Suez Canal University Ismaelia 24421 Egypt Department of Surgery Vice Chancellor of Medical and Health sciences Colleges Sharjah University Sharjah 27272 United Arab Emirates

Interstitial cells of Cajal (ICC) are important players in the symphony of gut motility. They have a very signif icant physiological role orchestrating the normal peristaltic activity of the digestive system. They are the pacemaker cells in gastrointestinal (GI) muscles. Absence, reduction in number or altered integrity of the ICC network may have a dramatic effect on GI system motility. More understanding of ICC physiology will foster advances in physiology of gut motility which will help in a future breakthrough in the pharmacological interventions to restore normal motor function of GI tract. This mini review describes what is known about the physiologic function and role of ICCs in GI system motility and in a variety of GI system motility disorders.

关键词： Interstitial cells of Cajal Gastrointestinal motility Peristalsis

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Effect of dietary inclusion of sugar syrup on production performance,egg quality and blood biochemical parameters in laying hens

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Animal Nutrition 2018年第1期4卷 59-64页

作者： Ahmed S.Hussein mostafa A.Ayoub Ahmed Y.Elhwetiy Jamal A.Ghurair Mohsin Sulaiman hosam M.Habib College of Food and Agriculture United Arab Emirates University Al-Khaleej Sugar CO (L.L.C.)

The effects of dietary inclusion of sugar syrup on quality of egg,cholesterol level,production performance,serum total protein and blood biochemical parameters were evaluated in laying hens.A total of300 commercial Lohmann LSL hens(30 weeks of age) were randomly distributed into 3 dietary treatments which consisted of a normal corn diet containing cornesoy and 2 diets containing 5% and 10%sugar *** treatment was replicated 5 times(n=20).Egg production,feed intake,body weight and egg weight of laying hens fed different diets were *** experiment lasted for 20 *** Haugh unit scores of hens fed diets with sugar syrup were significantly increased(P < 0.05) compared with the control *** sugar syrup had no significant effect on liver enzymes,total protein,blood glucose and creatinine in all *** eggs laid by hens fed sugar syrup diets had lower cholesterol level(P < 0.05) compared with those laid by hens fed the control *** analysis showed that comparable electrophoretic patterns were noticed between serum proteins of treatment *** the results,it can be concluded that sugar syrup diets and corn diets have similar effects on feed intake,body weight,production of eggs and blood biochemical parameters in layer hens,which suggests sugar syrup can be used as an energy source for replacing part of corn in poultry layer diets.

关键词： Cholesterol Sugar syrup diet Egg Egg quality Protein

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Seminal plasma anti-Müllerian hormone level correlates with semen parameters but does not predict success of testicular sperm extraction （TESE）

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Asian Journal of Andrology 2007年第2期9卷 265-270页

作者： Taymour mostafa Medhat K. Amer Guirgis Abdel-Malak Taha Abdel Nsser Wael Zohdy Shedeed Ashour Dina El-Gayar hosam H. Awad Andrology ＆ Sexology Department Faculty of Medicine Cairo University Cairo 11553 Egypt Adam International Clinic Mohandesseen Giza 12411 Egypt Artificial Insemination and Embryo Transfer Department Reproductive Research Institute Alharam Giza 12111 Egypt Chemical Pathology Department Faculty of Medicine Cairo University Cairo 11553 Egypt

Aim： To assess seminal plasma anti-Müllerian hormone （AMH） level relationships in fertile and infertile males. Methods： Eighty-four male cases were studied and divided into four groups： fertile normozoospermia （n = 16）, oligoastheno- teratozoospermia （n = 15）, obstructive azoospermia （OA）（n = 13） and non-obstructive azoospermia （NOA）（n = 40）. Conventional semen analysis was done for all cases. Testicular biopsy was done with histopathology and fresh tissue examination for testicular sperm extraction （TESE） in NOA cases. NOA group was subdivided according to TESE results into unsuccessful TESE （n = 19） and successful TESE （n = 21）. Seminal plasma AMH was estimated by enzyme linked immunosorbent assay （ELISA） and serum follicular stimulating hormone （FSH） was estimated in NOA cases only by radioimmunoassay （RIA）. Results： Mean seminal AMH was significantly higher in fertile group than in oligoasthenoteratozoospermia with significance （41.5±10.9 pmol/L vs. 30.5±10.3 pmol/L, P 〈 0.05）. Seminal AMH was not detected in any OA patients. Seminal AMH wascorrelated positively with testicular volume （r = 0.329, P = 0.005）, sperm count （r = 0.483, P = 0.007）, sperm motility percent （r = 0.419, P = 0.021） and negatively with sperm abnormal forms percent （r = -0.413, p = 0.023）. Nonsignificant correlation was evident with age （r = -0.155, P = 0.414） and plasma FSH （ r = -0.014, P = 0.943）. In NOA cases, seminal AMH was detectable in 23/40 cases, 14 of them were successful TESE （57.5%） and was undetectable in 17/40 cases, 10 of them were unsuccessful TESE （58.2%）. Conclusion： Seminal plasma AMH is an absolute testicular marker being absent in all OA cases. However, seminal AMH has a poor predictability for successful testicular sperm retrieval in NOA cases.

关键词： seminal plasma anti-Müllerian hormone spermatogenesis azoospermia testicular sperm extraction

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