检索结果-南通市图书馆

中国蒙医药（蒙） 2023年第3期18卷 98-103页

作者：浩斯锡林其其格斯琴不详

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医德认知专项教育过程性评价体系的构建研究

中国卫生产业 2024年第1期21卷 146-149页

作者：孙源博朱敏李思瓯于伟光刘鹤宋先东赵雪寒牡丹江医学院第一临床医学院黑龙江牡丹江157000 牡丹江医学院影像学院黑龙江牡丹江157000 牡丹江医学院附属红旗医院教务科黑龙江牡丹江157000

目的探讨过程性评价对医德认知专项教育教学效果的影响。方法选取2022年4—11月于牡丹江医院附属红旗医院实习的62名学生为研究对象。将2022年4—7月实习的学生纳入对照组,将2022年8—11月实习的学生纳入观察组,对照组(n=30)行结果性评... 详细信息

目的探讨过程性评价对医德认知专项教育教学效果的影响。方法选取2022年4—11月于牡丹江医院附属红旗医院实习的62名学生为研究对象。将2022年4—7月实习的学生纳入对照组,将2022年8—11月实习的学生纳入观察组,对照组(n=30)行结果性评价,观察组(n=32)行过程性评价。教学后,比较两组的考核评价体系与医德认知教育关联度评分,两种评价方式分别对医德认知教学效果影响。结果观察组考核与医德认知教学目标关联度、考核与医德认知教学内容贴合度评分均高于对照组,差异有统计学意义(P均<0.05);观察组对医德认知相关临床操作掌握能力影响评分低于对照组,对医德认知教育课后投入时间的影响高于对照组,差异有统计学意义(P均<0.05)。结论过程性评价有效提高了医德认知专项教育的教学效果,但增加了学生课后投入的时间,建议可以适当缩短日常教学时间,以完成过程性评价。

关键词：医德认知专项教育结果性评价过程性评价教学改革

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国国际贸易模式:金融制度效应的分析视角

山西财经大学学报 2009年第8期31卷 1-8页

作者：和红厦门大学经济学院福建厦门361005

通过引入金融制度因素对hechscher-Ohlin-Samuelson(hos)基准模型进行扩展,分析了不合理的金融体制下中国制造业国际分工地位总体低下的现状。结合中国的情况,讨论了由于中央政府、地方政府不合理的经济管制导致的金融市场分割,使得社... 详细信息

通过引入金融制度因素对hechscher-Ohlin-Samuelson(hos)基准模型进行扩展,分析了不合理的金融体制下中国制造业国际分工地位总体低下的现状。结合中国的情况,讨论了由于中央政府、地方政府不合理的经济管制导致的金融市场分割,使得社会要素禀赋结构出现错误的配置。因此,完善金融资源的市场化配置,对于中国产业技术结构和经济结构的升级与变迁极为重要。在推进金融市场化、自由化的过程中,对风险问题必须加以审慎的考虑。

关键词：金融制度外部融资要素禀赋

Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 220-226页

作者： Deng-Fu Yao, Xin-Hua Wu, Yong Zhu, Gong-Sheng Shi, Zhi-Zhen Dong, Deng-Bing Yao, Wei Wu, Li-Wei Qiu and Xian-Yong Meng Nantong, China Research Center of Clinical Molecular Biology , Department of Pathology and Department of Gastroenterology , Affiliated hos- pital of Nantong University Department of Diagnostics , and Institute of Neurosciences , Nantong University Nantong 226001, China Research Center of Clinical Molecular Biology Affiliated Hospital of Nantong University Nantong 226001 China. dfyrcmb@***

BACKGROUND: Angiogenesis is known to be essential to the survival, growth, invasion, and metastasis of tumor cells. Vascular endothelial growth factor (VEGF) are an important angiogenic factor regulating tumor angiogenesis, but its significance and tumor pathologic features are un- clear in hepatocellular carcinoma (HCC). In the present study, we analyzed expression of tissue VEGF, alteration of microvascular density (MVD) in microvessel angiogenesis, development and metastasis of HCC, and level of serum VEGF in differential diagnosis of benign and malignant liv- er diseases. METHODS: Tumor specimens were prospectively collected from HCC patients undergoing resection. Total RNAs were extracted and the expression levels were detected from different parts of HCC tissues. The cellular distributions of VEGF and MVD of liver tumors and their paracancerous and distal cancerous tissues were investigated by streptavi- din peroxidase (S-P) immunohistochemistry, respectively. The VEGF levels of circulating blood and hepatoma tissues were measured by enzyme-linked immunosorbent assay. RESULTS: The incidence of VEGF expression was 63.9% in HCCs (23/36 cases), 78.3% in non-encapsulated HCCs (18/23), and 90.9% in HCCs with extrahepatic metastasis (10/11), respectively. The VEGF expression was tightly correlated with MVD (P he MVD in HCC with metastasis, low differentiation or non-encapsulation was significantly higher than that in HCC with intact capsule, high differentiation, or no metastasis. No significant diffe- rence was found between VEGF, MVD, tumor size, and hepatitis virus infection. The level of total RNA in HCC tis- sues was significantly lower but the VEGF level significantly higher than those in paracancerous or distal cancerous ones (Phe abnormal expression levels of VEGF in sera of HCC patients were directly correlated with the me- tastasis and recurrence of tumors. CONCLUSION: The high expression of VEGF and abnor- mality of tissue MVD are useful

关键词： vascular endothelial growth factor hepatocellular carcinoma ELISA microvascular density, immunohistochemistry

ACE2 activation prevents and partially reverses severe pulmonary arterial hypertension by enhancing ACE2-aniotensin-(1-7)-mas axis actions

在线全文

学校读者我要写书评

暂无评论

ACE2 activation prevents and partially reverses severe pulmo...

计算机辅助研究正畸治疗与颞下颌关节紊乱病关系

第14届中国南方国际心血管病学术会议(南方会)

作者： Gang Li,Yulin Xu,Yinglong Liu (Pediatric Center of Cardiac Surgery,Cardiovascular Institute and Fuwai hos’pital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100047,China)

Objectives Severe pulmonary arterial hypertension (PAH)is an incurable disease characterized by high pulmonary pressure,vascular remodeling and right ventricular *** data indicated that angiotensin-converting enzyme 2(ACE2)involved in the development of PAH;the study using a severe PAH model will be more effective in evaluating the influence of *** We investigated the efficacy of resorcinoInaphthalein(an ACE2 activator)on preventing and reversing pulmonary hypertension and underlying mechanisms in a well-mimicked severe PAH model. Results Monocrotaline injection 1 week following left pneumonectomy caused severe PAH[mean pulmonary arterial pressure(mPAP),48 mm Hg]in 2 weeks and death within 5 *** treatment(120 ug/d)from day 0 to 14 after monocrotaline injection resulted in 100% survival and inhibition of occurrence of severe PAH(mPAP, 22 mmHg)without change of systemic arterial pressure. Right ventricular hypertrophy,medial hypertrophy,neointimal formation and plexiform lesions were *** effects were blocked by an Angiotensin-(1-7)receptor antagonist, ***,the PAH-linked pathophysiologies were attenuated when injected resorcinolnaphthalein from day 15 to day *** blot analysis or immunohistochemistry revealed that resorcinolnaphthalein not only upregulated the protein expression of ACE2 and Mas,but also reduced proliferation and increased apoptosis of pulmonary smooth muscle cells in affected pulmonary *** These results indicated that activation of ACE2 by resorcinolnaphthalein prevented and partially reversed the pathological lesions of lung from PAH rats via promoting the actions of ACE2-Angiotensin-(1-7)-Mas axis and restoring the balance between proliferation and apoptosis of vascular cells in pulmonary arteries.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

实用口腔医学杂志 2003年第6期19卷 637-639页

作者：王生王光耀谷志远浙江温州118医院口腔科 325000 浙江大学附属口腔医院

目的 :探讨正畸治疗和颞下颌关节紊乱病的关系。方法 :设计调查表和相应的数据库 ,对 173例已正畸治疗者和 95例未治疗的错牙合患者进行颞下颌关节紊乱病的症状、体征及相关情况的问卷调查和专科检查 ,所得结果用数据库进行分析和统计... 详细信息

目的 :探讨正畸治疗和颞下颌关节紊乱病的关系。方法 :设计调查表和相应的数据库 ,对 173例已正畸治疗者和 95例未治疗的错牙合患者进行颞下颌关节紊乱病的症状、体征及相关情况的问卷调查和专科检查 ,所得结果用数据库进行分析和统计。结果 :成功地建立了调查表和数据库 ;正畸组和错牙合组在主诉症状指数、临床症状指数和咬合指数的分布上都有显著性差异 (P <0 .0 0 1)。结论 :数据库在颞下颌关节紊乱病的临床研究中有较大的实用价值 ;

关键词：计算机正畸治疗颞下颌关节紊乱病数据收集数据库

Influence of enterococci on human sperm membrane in vitro

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2007年第1期9卷 77-81页

作者： Hua Qiang Ming-Sen Jiang Jian-Yin Lin Wei-Min he Department of Pathogenic Biology Etiology School of Medicine Wuhan University Wuhan 430071 China Department of Etiology 3Department of Anatomy Histology and Embryology Fujian Medical University Fuzhou 350004 China 不详　

Aim： To study the influence of enterococci on human sperm membrane in vitro. Methods： Ejaculated human sperm were artificially infected with β-hemolytic or non-β-hemolytic enterococci at the bacteria： sperm ratio of 50：1 at 37℃. Sperm membrane integrity was examined after incubation for 1, 3 and 5 h by hypoosmotic swelling （hos） test and electron microscopy. Results： Sperm infected with β-hemolytic enterococci had lower hos scores compared with non-β-hemolytic strains or uninfected control （P 〈 0.01）. The hos test scores of sperm infected with β-hemolytic enterococci increased in the presence of phosphatidylcholine, an inhibitor of hemolysin. Non-β-hemolytic strains showed no significant difference in swelling rate, compared with the control group （P 〉 0.05）. It was shown by electron microscopy that β-hemolytic enterococci caused significant rupture of human sperm membrane. Conclusion： β-hemolytic enterococci caused human sperm membrane injury, and might be mediated by the hemolysin of enterococci.

关键词： enterococci sperm sperm membrane hypoosmotic swelling test ultrastructure

Hsa_circ_0002137 stabled by LIN28B promotes osteosarcoma cell growth through the hsa-miR-1246/BCL2 axis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第3期46卷 699-709页

作者： FEI ZHANG JIANZHONG LAI RONGHAN he YI SHI KUN XU SHIHAI JIANG TANGZHAO LIANG WANYU ZHAO WEIDA REN LEI ZHU SONG JIN KUN WANG Department of Joint and Trauma Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China Department of Othopaedic Surgery The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen518033China Department of Othopaedic Surgery Dongguan Dongcheng HospitalDongguan523007China Department of Orthopedic The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Key Laboratory for Regenerative Medicine Ministry of EducationCollege of Life Science and TechnologyJinan UniversityGuangzhou510632China Department of Plastic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China

Circular RNAs(circRNAs)are a novel class of non-coding RNA that have recently shown to have huge capabilities in the regulation of gene expression at the posttranscriptional *** evidence has indicated that circRNAs could serve as competing endogenous RNAs(ceRNAs)to sponge microRNAs(miRNAs)and suppress functions of targeted ***(OS)is the most common malignant primary bone ***_circ_0002137 is upregulated in ***,the role of hsa_circ_0002137 in OS remains *** miRNA pull-down assay,we showed that cir_0002137 sponged hsa-miR-1246,and BCL2 apoptosis regulator(BCL2)mRNA was a potential target of hsa-miR-1246 in human osteosarcoma(hos)***,we found that hsa_cir_0002137 could enhance the expression of BCL2 hsa-miR-1246 and promote hos cell growth through sponging ***,RNA binding protein immunoprecip itation(RIP)assay revealed that lin-28 homolog B(LIN28B)protein associated with hsa_circ_0002137,and LIN28B could increase hsa_circ_0002137 stability and thus accelerate OS cell *** work was the first to study the functions of hsa_circ_0002137,has-miR-1246 and LIN28B in OS,and these results may provide novel therapeutic targets for OS treatment.

关键词： Osteosarcoma hsa_circ_0002137 hsa-miR-1246 Proliferation Apoptosis

血管内超声检测对冠状动脉粥样硬化斑块病变性质的应用价值──附100例报告

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新医学 2002年第7期33卷 400-402页

作者：肖长华杨希立李健民广东佛山市第一人民医院 528000

目的:探讨血管内超声显像(IVUS)检测对冠状动脉粥样硬化斑块病变性质的诊断价值及其在指导介入性治疗中的作用。方法:采用IVUS检测100例冠状动脉粥样硬化性心脏病(冠心病)患者124处冠状动脉血管段总截面积及其平均径、血管腔面积及其平... 详细信息

目的:探讨血管内超声显像(IVUS)检测对冠状动脉粥样硬化斑块病变性质的诊断价值及其在指导介入性治疗中的作用。方法:采用IVUS检测100例冠状动脉粥样硬化性心脏病(冠心病)患者124处冠状动脉血管段总截面积及其平均径、血管腔面积及其平均径,计算直径狭窄率及面积狭窄率,了解粥样硬化斑块的组成、分布及特性,并与同时进行的冠状动脉造影结果相比较。结果:IVUS检测发现偏心性斑块92处,向心性斑块32处,其中96处为严重冠状动脉病变节段,需要进行冠状动脉的介入性治疗或冠状动脉旁路移植术。冠状动脉造影(CAG)对于狭窄血管的直径及直径狭窄率的测值较低,IVUS测值与其比较有显著的统计学意义。结论:IVUS对于冠状动脉粥样硬化斑块病变性质的检测明显优于冠状动脉造影,对冠状动脉介入手术的选择方案有着指导意义。

关键词：诊断冠状动脉粥样硬化斑块冠状动脉造影经皮腔内冠状动脉成形术血管内超声显像 IVUS

富血小板血浆联合股骨近端防旋髓内钉治疗股骨粗隆间骨折的疗效及对患者骨折愈合的影响

在线全文

学校读者我要写书评

暂无评论

当代医学 2024年第12期30卷 57-60页

作者：郭佳勇翁荔芳何振森阮原芳王新标陈宇林峰林建鑫莆田市第一医院骨科福建莆田351100

目的探究富血小板血浆(PRP)联合股骨近端防旋髓内钉(PFNA)治疗股骨粗隆间骨折(FIF)的临床疗效及对患者骨折愈合的影响。方法选取2018年1月至2021年12月莆田市第一医院收治的62例FIF患者作为研究对象,按照随机数字表法分为PRP+PFNA组与PF... 详细信息

目的探究富血小板血浆(PRP)联合股骨近端防旋髓内钉(PFNA)治疗股骨粗隆间骨折(FIF)的临床疗效及对患者骨折愈合的影响。方法选取2018年1月至2021年12月莆田市第一医院收治的62例FIF患者作为研究对象,按照随机数字表法分为PRP+PFNA组与PF-NA组,每组31例。PFNA组行单纯PFNA治疗,PRP+PFNA组行PFNA联合PRP治疗。比较两组骨折愈合时间、术后至完全负重时间及术后不同时间点骨折愈合情况、视觉模拟评分法(VAS)评分、Harris评分与并发症发生情况。结果PRP+PFNA组骨折愈合时间、术后至完全负重时间均短于PFNA组,差异有统计学意义(P<0.05)。术后1、3、6个月,PRP+PFNA组Fernandez-Esteve骨痂评分均高于PFNA组,差异有统计学意义(P<0.05)。术后1、3、6个月,PRP+PFNA组VAS评分均低于PFNA组,差异有统计学意义(P<0.05)。术后1、3个月,PRP+PFNA组Harris评分均高于PFNA组,差异有统计学意义(P<0.05);术后6个月,两组Harris评分比较差异无统计学意义。PRP+PFNA组术后并发症发生率为6.45%,低于PFNA组的32.26%,差异有统计学意义(P<0.05)。结论PRP联合PFNA治疗FIF疗效显著,可有效促进患者骨折愈合,显著缓解疼痛感,利于髋关节功能恢复且具有一定安全性,值得临床推广应用。

关键词：富血小板血浆股骨近端防旋髓内钉股骨粗隆间骨折内固定