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Assessment of cardiac output in liver transplantation recipients

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 362-366页

作者： Tomohide hori Chiduru Yamamoto Shintaro Yagi Taku Iida Kentaro Taniguchi Takashi Hasegawa Koichiro Yamakado Yukinobu hori Kan Takeda Kazuo Maruyama Shinji Uemoto Department of Hepato-Pancreato-Biliary Surgery and Transplantation Kyoto University Hospital54 Shogoinkawara- choSakyo-kuKyoto606-8507Japan Department of Hepatobiliary Pancreatic Surgery Mie University Hospital2-174 EdobashiTsu CityMie Prefecture514-8507 Japan Department of Anesthesiology and Critical Care Medicine Mie University Graduate School of Medicine2-174 EdobashiTsu CityMie Prefecture514-8507Japan Department of Radiology Mie University Graduate School of Medicine2-174 EdobashiTsu CityMie Prefecture514-8507Japan Nagoya Economic University Graduate School of Law 61-1 UchikuboInuyama City Aichi Prefecture 484-8504Japan

BACKGRoUND:Liver cirrhosis causes peculiar systemic hemodynamics,and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation(LDLT). We investigated the clinical advantages of a novel non- invasive method for measuring systemic hemodynamic parameters using indocyanine green(ICG). METHoDS:Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output(Co)using Swan-Ganz catheters and pulse dye densitometry(PDD) were performed every 12 hours after LDLT.A total of 155 sets of simultaneous Co measurements were obtained. RESULTS:The Co values obtained by PDD correlated well with those obtained by the invasive catheter *** addition,none of the recipients developed any side-effects, and we verified the safety of repeated ICG *** is safe,even for repeated use over time in the same recipient. Moreover,PDD can measure the blood volume(BV).CoNCLUSIoNS:Since the cirrhotic systemic hemody- namics characterized by high Co and large BV remains, even after LDLT,the ability to measure Co and BV in a non-invasive,simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients.

关键词： liver transplantation indocyanine green pulse dye densitometry blood volume cardiac output liver cirrhosis

Experimental and numerical study of water sprayed turbulent combustion: Proposal of a neural network modeling for five-dimensional flamelet approach

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Energy and AI 2021年第3期5卷 316-324页

作者： Takafumi Honzawa Reo Kai Kotaro hori Makoto Seino Takayuki Nishiie Ryoichi Kurose Department of Mechanical Engineering and Science Graduate School of EngineeringKyoto UniversityKyoto daigaku-KatsuraNishikyo-kuKyoto 615-8540Japan Tokyo Gas Co. Ltd.1-7-7 Suehiro-choTsurumi-kuYokohamaKanagawa 230-0045Japan Numerical Flow Designing Co. Ltd.1-10-10Higashi-GotandaShinagawa-kuTokyo 141-0022Japan

owing to the increasing worldwide demand for natural gas,the development of a large submerged combustion vaporizer is *** burner is equipped with a water spray nozzle to reduce nitrogen oxides,and a practi-cal simulation method is required for the optimal *** non-adiabatic flamelet approach can predict the combustion emissions and is useful for reducing simulation ***,as the number of control variables increases,the database requires larger memory and cannot be dealt with by general *** this study,an artificial neural network(ANN)model based on a five-dimensional flamelet database,which includes the effects of heat loss and vapor concentration by sprayed water evaporation,is ***,large eddy sim-ulations(LESs)for turbulent combustion fields with and without water spray are conducted employing flamelet generated manifold(FGM)approach with this ANN model,and the validity is *** comparison,a lab-scale burner equipped with a water spray nozzle is manufactured,and combustion experiments with and without water spray are *** results show that Co,No,temperature,and reaction rate of progress variable predicted by the present ANN model are in good agreement with those of a five-dimensional flamelet *** the condition without water spray,the flame behavior predicted by the LES employing the FGM/ANN ap-proach is in good agreement with that employing the conventional FGM approach,while indicating much lower memory,although there appeared some quantitative discrepancies in the temperature against the experiment probably partially because of the insufficiency of the FGM approach for the present complex flame *** the condition with water spray,the LES employing the FGM/ANN approach is able to capture the effect of the water spray on the flame behavior in the experiment,such that the water spray decreases the temperature,which causes the decrease in No but increase in Co.

关键词： Neural network modeling Five-dimensional flamelet approach Water spray Large eddy simulation

Impact of lymph node micrometastasis in hilar bile duct carcinoma patients

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World Journal of Gastroenterology 2006年第16期12卷 2549-2555页

作者： Kentaro Taniguchi Taku Iida Tomohide hori Shintaro Yagi Hiroshi Imai Taizo Shiraishi Shinji Uemoto First Department of Surgery Mie University School of Medicine2-174EdobashiTsu CityMie Prefecture514-8507Japan Second Department of Pathology Mie University School of Medicine2-174EdobashiTsu CityMie Prefecture514-8507Japan

AIM- To immunohistochemicaUy examine micrometastasis and VEGF-C expression in hilar bile duct carcinoma （HBDC） and to evaluate the clinical significance of the results. METHoDS： A total of 361 regional lymph nodes from 25 patients with node-negative HBDC were immunostained with an antibody against cytokeratins 8 and 18 （CAM 5.2）, and immunohistochemical staining of VEGF-C was performed in 34 primary resected tumors. RESULTS： Lymph node micrometastasis was detected in 6 （24%） of the 25 patients and 10 （2.8%） of the 361 lymph nodes. Patients with micrometastasis showed significantly poorer survival rates than those without （P= 0.025）. VEGF-C expression was positive in 17 （50%） of 34 HBDC, and significantly correlated with lymph node metastasis （P=0.042） and microscopic venous invasion （P=0.035）. CoNCLUSIoNS： It is suggested that immunohistochemically detected lymph node micrometastasis has an impact on the outcome of HBDC. VEGF-C expression is highly correlated with lymph node metastasis in HBDC and might therefore be a useful predictor.

关键词： Hilar bile duct carcinoma Lymph node metastasis Micrometastasis Vascular endothelial growth factor-C

Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis

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World Journal of Gastroenterology 2007年第44期13卷 5918-5925页

作者： Tomohide hori Shintaro Yagi Taku Iida Kentaro Taniguchi Kentaro Yamagiwa Chiduru Yamamoto Takashi Hasegawa Koichiro Yamakado Takuma Kato Kanako Saito Linan Wang Mie Torii Yukinobu hori Kan Takeda Kazuo Maruyama Shinji Uemoto Departments of Hepatobiliary Pancreatic Surgery Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Cellular and Molecular Immunology Mie University Graduate School of Medicine 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Hepatobiliary Pancreatic and Transplant Surgery Kyoto University Hospital 54 Kawahara-cho Shogoin Sakyo-ku Kyoto 606-8507 Japan Department of Anesthesiology and Critical Care Medicine Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Radiology Mie University Hospital 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Department of Medical oncology and Immunology Mie University Graduate School of Medicine 2-174 Edobashi Tsu City Mie Prefecture 514-8507 Japan Nagoya Economic University Graduate School of Law 61-1 Uchikubo Inuyama City Aichi Prefecture 484-8504 Japan

AIM： To investigate the correlation between systemic hemodynamics and splanchnic circulation in recipients with cirrhosis undergoing living-donor liver transplantation （LDLT）, and to clarify how systemic hemodynamics impact on local graft circulation after LDLT.METHoDS： Systemic hemodynamics, indocyanine green （ICG） elimination rate （K,cG） and splanchnic circulation were simultaneously and non-invasively investigated by pulse dye densitometry （PDD） and ultrasound. Accurate estimators of optimal systemic hyperdynamics after LDLT [i.e., balance of cardiac output （Co） to blood volume （BV） and mean transit time （MTT）, defined as the time required for half the administered ICG to pass through an attached PDD sensor in the first circulation] were also measured. Thirty recipients with cirrhosis were divided into two groups based on clinical outcomes corresponding to postoperative graft function.RESULTS： Cirrhotic systemic hyperdynamics characterized by high Co, expanded BV and low total peripheral resistance （TPR） were observed before LDLT. TPR reflecting cirrhotic vascular alterations was slowly restored after LDLT in both groups. Although no significant temporal differences in TPR were detected between the two groups, Co/BV and M＇IT differed significantly. Recipients with good outcomes showed persistent cirrhotic systemic hyperdynamics after LDLT, whereas recipients with poor outcomes presented with unstable cirrhotic systemic hyperdynamics and severely decreased KICG. Systemic hyperdynamic disorders after LDLT impacted on portal venous flow but not hepatic arterial flow.CoNCLUSIoN： We conclude that subtle systemic hyperdynamics disorders impact on splanchnic circulation, and that an imbalance between Co and BV decreases portal venous flow, which results in critical outcomes.

关键词： Cirrhosis Hyperdynamic Portal hypertension Splanchnic Indocyanine green

Type 2 Possibility Factor Rotation in No-Data Problem

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Applied Mathematics 2023年第10期14卷 673-683页

作者： Houju hori Nara Community Tsubakikishi Shrine Nara Japan

Uemura [1] discovered a mapping formula that transforms and maps the state of nature into fuzzy events with a membership function that expresses the degree of attribution. In decision theory in no-data problems, sequential Bayesian inference is an example of this mapping formula, and hori et al. [2] made the mapping formula multidimensional, introduced the concept of time, to Markov (decision) processes in fuzzy events under ergodic conditions, and derived stochastic differential equations in fuzzy events, although in reverse. In this paper, we focus on type 2 fuzzy. First, assuming that Type 2 Fuzzy Events are transformed and mapped onto the state of nature by a quadratic mapping formula that simultaneously considers longitudinal and transverse ambiguity, the joint stochastic differential equation representing these two ambiguities can be applied to possibility principal factor analysis if the weights of the equations are orthogonal. This indicates that the type 2 fuzzy is a two-dimensional possibility multivariate error model with longitudinal and transverse directions. Also, when the weights are oblique, it is a general possibility oblique factor analysis. Therefore, an example of type 2 fuzzy system theory is the possibility factor analysis. Furthermore, we show the initial and stopping condition on possibility factor rotation, on the base of possibility theory.

关键词： Type 2 Fuzzy Events Quadratic Mapping Formula Stochastic Differential Equation in Fuzzy Event Possibility Principal Factor Analysis Possibility oblique Factor Analysis Initial and Stopping Condition

Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis

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World Journal of Gastroenterology 2023年第17期29卷 2657-2665页

作者： Yoshiyuki Nishikawa Yoshio Ikeda Hidehiro Murakami Shin-Ichiro hori Megumi Yoshimatsu Naoki Nishikawa Department of Gastroenterology Nishikawa Gastrointestinal ClinicMatsuyama 790-0878EhimeJapan Endoscopy Center Ehime University HospitalToon 791-0295EhimeJapan Department of Internal Medicine Saiseikai Matsuyama HospitalMatsuyama 791-8026EhimeJapan Department of Gastroenterology Himeji Red Cross HospitalHimeji 670-8540HyogoJapan Department of Gastroenterology National Hospital Organization Shikoku Cancer CenterMatsuyama 791-0280EhimeJapan Department of Gastroenterology Matsuyama Shimin HospitalMatsuyama 790-0067EhimeJapan

BACKGRoUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and ***,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(***)*** To further substantiate and comprehensively investigate MP changes after *** eradication in a larger number of *** We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,*** them,325 patients were ***-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after *** eradication were evaluated for post-eradication MP *** patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical *** Among 76 patients with the spotty pattern before or after *** eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after *** eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after *** eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CoNCLUSIoN After *** eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate ***-related gastritis status.

关键词： Atrophic gastritis Helicobacter pylori Gastrointestinal endoscopy Image enhancement Classification

Role of phosphorylated Smad3 signal components in intraductal papillary mucinous neoplasm of pancreas

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 581-589页

作者： Yuichi hori Tsukasa Ikeura Takashi Yamaguchi Katsunori Yoshida Koichi Matsuzaki Mitsuaki Ishida Sohei Satoi Kazuichi okazaki Department of Gastroenterology and Hepatology Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan Department of Pathology Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan Department of Surgery Kansai Medical University2-5-1 ShinmachiHirakataOsaka 5731191Japan

Background:Malignant intraductal papillary mucinous neoplasm(IPMN)has poor *** carcinogenesis of IPMN is not *** aim of this study was to clarify transitions in phosphorylated Smad3 signaling during IPMN ***:By using immunohistochemistry,we examined the expression of pSmad3C and pSmad3L from 51 IPMN surgical specimens resected at our institution between 2010 and *** also examined the expression of Ki-67,c-Myc and ***:The median immunostaining index of pSmad3C was 79.2%in low-grade dysplasia,74.9%in highgrade dysplasia,and 42.0%in invasive carcinoma(Pof pSmad3L was 3.4%,4.3%,and 42.4%,respectively(Ponship between the expression of pSmad3C and c-Myc(Positive relationship between the expression of pSmad3L and c-Myc(Ponship between the expression of pSmad3C and Ki-67(Positive relationship between the expression of pSmad3L and Ki-67(Ponfirmed.p-JNK-positive cells were frequently observed among pSmad3L-positive cancer *** median of pSmad3L/pSmad3C ratio in the non-recurrence group and the recurrence group were 0.58(range,0.05–0.93),3.83(range,0.85–5.96),respectively(P=0.02).The median immunostaining index of c-Myc in the non-recurrence group and the recurrence group were 2.91(range,0–36.9)and 82.1(range,46.2–97.1),respectively(P=0.02).The median immunostaining index of Ki-67 in the non-recurrence group and the recurrence group were 12.9(range 5.7–30.8)and 90.9(range 52.9–98.5),respectively(P=0.02).Conclusions:pSmad3L was upregulated in malignant ***3L/pSmad3C ratio may be a useful prognostic factor in IPMN.

关键词： Intraductal papillary mucinous neoplasms of the pancreas Immunohistochemistry Phosphorylated Smad Carcinogenesis Prognosis

脑缺血后N-myc下游调控基因2保护血脑屏障完整性

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神经损伤与功能重建 2018年第4期13卷 217-217页

作者： Takarada-Iemata M Yoshikawa A Ta HM okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M hori o 聂昊 Department of Neuroanatomy Graduate School of Medical Sciences Kanazawa University Department of Neurosurgery Graduate School of Medical Sciences Kanazawa University Division of Functional Genomics Advanced Science Research Center Kanazawa University Laboratory of Neurogenesis and CNS Repair Institute for Advanced Medical Sciences Hyogo College of Medicine

脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶... 详细信息

脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAo)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAo后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAo后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。

关键词：星形胶质细胞血脑屏障炎症缺血基质金属蛋白酶

Fulminant liver failure models with subsequent encephalopathy in the mouse

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 611-619页

作者： Ann-Marie T Baine Tomohide hori Lindsay B Gardner Shinji Uemoto Justin H Nguyen Department of Neuroscience Mayo Clinic in Florida JacksonvilleFL 32224USA Divisions of Hepato-Pancreato-Biliary Transplant and Pediatric SurgeryDepartment of SurgeryKyoto University Graduate School of MedicineKyoto 606-8507Japan Division of Transplant Surgery Department of TransplantationMayo Clinic in FloridaJacksonvilleFL 32224USA

BACKGRoUND:A reliable model of fulminant liver failure (FLF) is urgently required in this research *** study aimed to develop a murine FLF ***:We used three groups of male C57BL/6 mice:control,with azoxymethane treatment (AoM group),and with galactosamine and tumor necrosis factor-alpha treatment (Gal+TNF-α group).The effects of body temperature (BT) control on survival in all three groups were investigated Using BT control,we compared the survival,histopathological findings and biochemical/coagulation profiles between the two experimental *** effects of hydration on international normalized ratios of prothrombin time (PT INRs) were also ***-dependent survival curves were constructed for both experimental *** behavior was assessed using a coma ***:No unexpected BT effects were seen in the control *** AoM group,but not the Gal+TNF-α group showed a significant difference in survival curves between those with and without BT *** assessment showed consistent FLF findings in both experimental groups with BT *** were significant differences between the experimental groups in aspartate aminotransferase levels and PT-INRs,and significant differences in PT-INRs between the sufficiently and insufficiently hydrated *** were significant differences between FLF models in the duration of each coma stage,with significant differences in stages 1 and 3 as percentages of the disease state (stages 1-4).The two FLF models with BT care showed different survival curves in the dose-dependent survival ***:AoM provides a good FLF model,but requires a specialized environment and careful BT *** FLF models may also be useful,depending on the research *** attention to caregiving and close observation are indispensable for successful FLF models.

关键词： animal model acute liver failure azoxymethane galactosamine tumor necrosis factor-alpha