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聚集体(英文) 2023年第1期4卷 41-89页

作者： Jinhyo Hwang Peethani Nagaraju Min Ju cho Dong hoon choi Department of Chemistry Research Institute for Natural SciencesKorea UniversitySeongbuk-guSeoulRepublic of Korea

Organic light-emitting diodes(OLEDs)have garnered increasing attention as a promising candidate for application in next-generation displays and solid-state lighting *** doping technique commonly used to fabricate light-emitting layers(EMLs)of OLEDs disperses the emitting material in a host matrix to mitigate aggregation-induced quenching(ACQ).Alternatively,owing to their high efficiency and ease of manufacture,nondoped OLEDs have been developed as a substitute for doped *** fabricating nondoped OLEDs,it is essential to suppress the ACQ effect in the EML and efficiently utilize the generated excitons for radiative *** the discovery of aggregation-induced emission(AIE)by Tang et al.,significant work has been done to improve the stability and efficiency of nondoped OLEDs based on fluorescent AIE luminogens(AIEgens).Fluorescent AIEgens,synthesized using various molecular frameworks,such as silole,tetra/triphenylethylene,tetraphenylpyrazine,and tetraphenylbenzene,exhibit high photoluminescence quantum yields in the solid ***,many studies have reported that fluorescent AIEgen-based OLEDs have excellent external quantum efficiency and exhibit emission at various wavelengths,including deep-blue/blue/green *** the development of fluorescent AIEgens,delayed fluorescent AIEgens with efficient triplet utilization through reverse intersystem crossing and AIE properties have been adopted as ideal emitters and used in nondoped *** review systematically discusses and summarizes recent reports on the development of AIEgens for nondoped OLEDs by grouping them into fluorescent and delayed fluorescent *** purpose of this review is to provide deep insights into the design of novel AIEgens for high-performance nondoped OLEDs.

关键词： aggregation-induced emission nondoped emitting layer organic light-emitting diode

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Chronic Hepatitis B in Indian Americans: Lack of Screening and Poor Linkage to Care

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International Journal of Clinical Medicine 2024年第4期15卷 197-209页

作者： Chul Hyun Soonsik Kim Emily Li Minhee Lee Mitchell K. Spinnell Joseph McMenamin Dohyun cho The Center for Viral Hepatitis Englewood Cliffs NJ USA Korean Community Services of Metropolitan New York New York City NY USA Englewood Hospital Medical Center Englewood NJ USA Christian & Barton LLP Richmond VA USA

Background: Chronic hepatitis B (CHB) is a major cause of liver-related morbidity and mortality in the United States (US) and globally. CHB disproportionately affects Asian Americans and many other immigrant minority populations, primarily owing to the high prevalence of CHB in their countries of origin. India is a country with a medium-to-high prevalence of hepatitis B (HB) (>2%) and has over 40 million people infected with hepatitis B virus (HBV), with more than 115,000 deaths annually from HBV-related complications. Indian Americans are one of the largest immigrant populations in the US but remain underdiagnosed and poorly linked to clinical care. We, therefore, assessed the HBV prevalence and evaluated the linkage-to-care (LTC) among Indian Americans to develop strategic plans to reduce the impact of HBV in the US. Methods: Between April 2022 and January 2024, serologic screening and surveys were provided to 328 Indian American adults (age 20 - 80) in New York City. All participants were tested for a triple panel consisting of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and hepatitis B core IgG antibody (anti-HBc). A survey was conducted on the subjects chronically infected with HBV regarding their histories of infection. Self-administered questionnaires were employed to evaluate demographic and epidemiologic characteristics. Results: Of 328 screened and evaluated (246 males and 82 females), 10 (3.0%) were HBV-infected, 222 (67.7%) were susceptible to HBV, and 96 (29.3%) were immune. The prevalence of chronic HBV varied between the age groups: 4.6% (age 20 - 40), 3.4% (age 41 - 60), and 1.7% (age 61 - 80). Of 10 chronically infected, only two subjects had been previously diagnosed but were not engaged in care. Conclusion: HBV disproportionately affects Asian Americans, primarily owing to immigration from parts of the world where the disease is endemic. Indian Americans belong to an intermediate-risk group, with an HBV prevalence

关键词： Hepatitis B Virus Chronic Hepatitis B Indian Americans Health Disparity Community-Based Screening Linkage-to-Care

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min choi WonWoo Lee Ji-Won Park Bohyun Yun Su-Hyeon cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Surgical perspectives of symptomatic omphalomesenteric duct remnants: Differences between infancy and beyond

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World Journal of Clinical Cases 2021年第36期9卷 11228-11236页

作者： Ayoung Kang Soo-Hong Kim Yong-hoon cho Hae-Young Kim Department of Surgery Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Pusan National University School of MedicineYangsan 50612South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND The clinical manifestations of omphalomesenteric duct remnant(OMDR)can vary with the age at diagnosis,from asymptomatic incidental findings to symptoms related to gastrointestinal *** lifelong complication rates are reported as 4%-34%,and complications are more common in patients younger than 2 years of *** authors attempted to identify different clinical features and management for the various pediatric age *** To find surgical perspectives for the pediatric age-related variants of OMDR and make recommendations for optimal *** The medical records of pediatric patients diagnosed with OMDR were reviewed *** patients diagnosed based on incidental findings during other surgeries were *** patients were divided into two groups based on age:12 mo(beyond infancy).We analyzed the demographic characteristics,clinical manifestations,diagnostic tools,surgical procedures,and clinical outcomes of the patients and compared them for the age ***-squared and Fisher's exact tests were used for nominal scales and a Mann-Whitney test was used for ratio *** A total of 35 patients(7 infants,28 children beyond infancy)were finally *** both groups,Meckel's diverticulum(MD)was the most common type of OMDR,while umbilical lesions were more common in the infant group(P=0.006).Hematochezia and abdominal pain were common in the beyond infancy group,while umbilical lesions were the most frequent symptoms in the infant *** diagnostic tools were used,but Meckel's scan was most useful in diagnosing OMDR in patients with painless rectal *** invasive surgery was more commonly performed for children than for infants(P=0.016).Single-incision laparoscopic surgery(SILS)was performed for fifteen patients who underwent laparoscopic *** were only three cases of postoperative complications,and all patients survived in good *** The cli

关键词： Omphalomesenteric duct remnant Age Surgical Meckel's diverticulum Single-incision laparoscopic surgery Children

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Pancreatic arteriovenous malformation treated with transcatheter arterial embolization:Two case reports and review of literature

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世界临床病例杂志 2023年第28期11卷 6920-6930页

作者： Sang hoon Shin chol Kyoon cho Sung Yeol Yu Department of Surgery Chonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Surgery Chonnam National University Medical SchoolChonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Surgery Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Various treatment methods are available for the treatment of pancreatic arteriovenous malformation(P-AVM);however,there are no established treatment options for asymptomatic *** SUMMARY A 47-year-old and a 50-year-old male patients sought treatment for P-AVM in the pancreas,which was incidentally detected during routine abdominal computed tomography and magnetic resonance imaging conducted as part of a health *** underwent transcatheter arterial embolization(TAE),and over the course of a 9-year follow-up period,the AVM did not worsen and was *** TAE can be considered as an alternative treatment option for P-AVM in selective cases where patients are asymptomatic or have a high surgical risk.

关键词： Pancreatic arteriovenous malformation Transcatheter arterial embolization Surgical treatment Asymptomatic Angiography Case report

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Role of Jun amino-terminal kinase （JNK） in apoptosis of cavernosal tissue during acute phase after cavernosal nerve injury

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Asian Journal of Andrology 2018年第1期20卷 50-55页

作者： Won hoon Song Hwancheol Son Soo Woong Kim Jae-Seung Paick Min Chul cho Department of Urology Seoul National University College of Medicine Seou103080 Korea Department of Urology Seoul National University Boramae Medical Center Seeu107061 Korea

The present study aimed to identify which mitogen-activated protein kinase （p38 or Jun amino-terminal kinase [JNK]） was involved in cavernosal apoptosis during the acute phase after cavernosal nerve crush injury （CNCI） in rats to ameliorate apoptosis of cavernosal tissue, such as smooth muscle （SM）. A total of twenty 10-week-old male Sprague-Dawley rats were divided equally into two groups： sham surgery （S） and CNCI （I）. The I group approximated the clinical situation of men undergoing radical prostatectomy using two 60-second compressions of both CNs with a microsurgical vascular clamp. At 2-week postinjury, erectile response was assessed using electrostimulation. Penile tissues were harvested for immunohistochemistry analysis of alpha-SM actin （（x-SMA）, western blot analysis, and double immunofluorescence analysis of （x-SMA and phosphorylated p38 or JNK, as well as double immunofluorescent of TUNEL and phosphorylated p38 or JNK. At 2-week postinjury, the I group had a significantly lower intracavernous pressure （ICP）/mean arterial pressure （MAP） and a lower area under the curve （AUC）/MAP than the S group. The I group also exhibited decreased immunohistochemical staining of α-SMA, an increase in the number of SM cells positive for phosphorylated JNK, an increased number of apoptotic cells positive for phosphorylated JNK, and increased JNK phosphorylation compared with the S group. However, there was no significant difference in p38 phosphorylation expression or the number of SM cells positive for phosphorylated p38 between the two groups. In conclusion, our data suggest that JNK, not p38, is involved in cavernosal apoptosis during the acute phase after partial CN damage.

关键词： apoptosis erectile dysfunction Jun amino-terminal kinase mitogen-activated protein kinases p38 penis prostatectomy

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Verification and Correction of Cloud Base and Top Height Retrievals from Ka–band Cloud Radar in Boseong,Korea

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Advances in Atmospheric Sciences 2016年第1期33卷 73-84页

作者： Su-Bin OH Yeon-Hee KIM Ki-hoon KIM Chun-Ho cho Eunha LIM Numerical Data Application Division National Institute of Meteorological Sciences KMA Republic of Korea Applied Meteorology Research Division National Institute of Meteorological Sciences KMA Republic of Korea Observation Research Division National Institute of Meteorological Sciences KMA Republic of Korea National Institute of Meteorological Sciences KMA Republic of Korea

In this study,cloud base height（CBH） and cloud top height（CTH） observed by the Ka-band（33.44 GHz） cloud radar at the Boseong National Center for Intensive Observation of Severe Weather during fall 2013（September-November） were verified and *** comparative verification,CBH and CTH were obtained using a ceilometer（CL51） and the Communication,Ocean and Meteorological Satellite（COMS）.During rainfall,the CBH and CTH observed by the cloud radar were lower than observed by the ceilometer and COMS because of signal attenuation due to raindrops,and this difference increased with rainfall *** dry periods,however,the CBH and CTH observed by the cloud radar,ceilometer,and COMS were *** and low-density clouds were observed more effectively by the cloud radar compared with the ceilometer and *** cases of rainfall or missing cloud radar data,the ceilometer and COMS data were proven effective in correcting or compensating the cloud radar *** corrected cloud data were used to classify cloud types,which revealed that low clouds occurred most frequently.

关键词： cloud radar ceilometer satellite retrieval cloud base height cloud top height cloud type

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Transparent neural implantable devices:a comprehensive review of challenges and progress

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npj Flexible Electronics 2022年第1期6卷 439-456页

作者： Young Uk cho Se Lin Lim Jung-hoon Hong Ki Jun Yu Department of Electrical and Electronic Engineering Yonsei UniversitySeoulKorea Department of Electrical and Electronic Engineering YU-Korea Institute of Science and Technology InstituteYonsei UniversitySeoulKorea

The key to designing an implantable device lies in condensing the synergistic effects of diagnostic and therapeutic methods in a single *** conjunction with the integration of electrophysiology and optical modalities,a transparent neural interface alleviates challenges of conventional metal-based *** this review,the multimodal sensing and stimulation functionalities of recent research are ***,issues that arise when combining functionalities of conventional metal-based,opaque electrode arrays together with optical modalities—(1)photoelectric artifacts,(2)optical image blocking,and(3)light transmission efficiency—are ***,an introduction of advancing material candidates for transparent neural interfaces follows with the latest research.

关键词： neural transparent modal

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Clinical characteristics of asymptomatic Terson syndrome in the patients with aneurysmal subarachnoid hemorrhage

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 292-300页

作者： Hae Min Kang Jin Mo cho So Yeon Kim Jeong hoon choi Department of Ophthalmology Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Neurosurgery Catholic Kwandong UniversityInternational St.Mary’s HospitalIncheon 22711Republic of Korea Department of Ophthalmology Choikang Eye ClinicSeoul 01110Republic of Korea

●AIM:To investigate clinical characteristics of asymptomatic Terson syndrome and its clinical impact in patients with aneurysmal subarachnoid hemorrhage(SAH).●METHODS:This retrospective,interventional study included 31 patients with aneurysmal SAH,and the medical records were *** addition to baseline characteristics of the study population such as age,sex,and underlying medical history,multi-modal imaging analysis,including fluorescein angiography(FA),spectral domain optical coherence tomography(SD-OCT),were also *** Coma Scale(GCS),Hunt-Hess(HH)grade,and Fisher scale at the time of admission,and functional outcome by using modified Rankin Scale(mRS)at 6 mo were compared.●RESULTS:Of the 31 patients,10 patients(32.3%)were diagnosed with Terson *** the patients with Terson syndrome did not report visual symptoms at the time of ophthalmologic *** showed microvascular changes of retinal capillaries and varying degrees of disc ***-OCT allowed intuitive anatomical localization of multi-layered retinal hemorrhages and assessment of ellipsoid zone *** patients with Terson syndrome showed significantly worse GCS(P=0.047)and HH grade(P=0.025)than those without,except Ficher scale(P=0.385).There was no significant difference in the mRS(P=0.250)at 6 *** baseline factors,the HH grade was the only significant factor associated with Terson syndrome(B=1.079,P=0.016).●CONCLUSION:In our study,32.3%of the patients have Terson syndrome without visual *** baseline HH grade is significantly correlated with Terson syndrome,and there is no significant difference in the functional outcome between the patients with and without Terson *** syndrome may develop without any visual symptoms as shown in our study,and ophthalmologic screening may be recommended to prevent further visual deterioration especially in the patients with poor HH grade at the time of aneurysmal SAH.

关键词： cerebral aneurysm subarachnoid hemorrhage Terson syndrome

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Patient-reported ejaculatory function and satisfaction in men with lower urinary tract symptoms/benign prostatic hyperplasia

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Asian Journal of Andrology 2018年第1期20卷 69-74页

作者： Min Chul cho Jung Kwon Kim Sang hoon Song Sung Yong cho Sang Wook Lee Soo Woong Kim Jae-Seung Paick Department of Urology Seoul National University Boramae Medical Center Seou107061 Korea Department of Urology Seoul National University College of Medicine Seoul 03080 Korea Department of Urology Asan Medical Center Seou105505 Korea Department of Urology Kangwon National University College of Medicine Chuncheon 24289 Korea

This study aimed to investigate perceived ejaculatory function/satisfaction before treatment for lower urinary tract symptoms （LUTS）/benign prostatic hyperplasia （BPH） and to identify associations between specific categories of ejaculatory dysfunctions （EjDs） and LUTS. A total of 1574 treatment-naive men with LUTS/BPH were included in this study. All patients underwent routine evaluation for LUTS/BPH including the International Index of Erectile Function and a 5-item questionnaire developed to assess ejaculatory volume/force/pain/satisfaction/latency time. Patients who had sexual intercourse over the past 4 weeks were classified as sexually active group. A total of 783 patients were categorized as sexually active group. Decreased ejaculatory volume and force were reported by 53.4% and 55.7% of 783 sexually active men, respectively, There was a strong correlation between ejaculatory volume and force. Ejaculatory pain/discomfort, premature ejaculation （PE）, and delayed ejaculation （DE） were reported in 41,0%, 16.3%, and 41.4% of the patients, respectively. Over 40.0% of men without decreased ejaculation volume/force were satisfied with ejaculatory function, whereas approximately 6.0% of men with decreased volume/force were satisfied with ejaculatory function. About 30.0% of men with decreased volume/force had orgasmic dysfunction, while approximately 10.0% of men without decreased volume/force did. Decreased ejaculatory volume or force was associated with LUTS severity after adjusting for other influential factors including testosterone level, erectile function, and prostate size on ultrasonography, but PE or DE or ejaculatory pain/discomfort was not. In conclusion, a considerable portion of men with LUTS/BPH appear to have a variety of EjDs. Ejaculatory volume/force and satisfaction/orgasm do not always appear to be concordant. Ejaculatory volume or force is independently associated with LUTS severity, whereas PE or DE or ejaculatory pain/discomfort is not.

关键词： dysfunction ejaculation lower urinary tract symptoms (LUTS) satisfaction

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