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PDL Reduction in Arrayed-Waveguide Gratings by Control of Stress in the Waveguide

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光学学报 2003年第S1期23卷 287-288页

作者： Se Yoon Kim Joo-hoon Lee Jaegeol cho Dong-Su Kim Sun Tae Jung Telecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 KoreaTelecom R&D Center Samsung Electronics Co. Ltd. 416 Suwon Gyeonggi-do 442-742 Korea

We have demonstrated polarization insensitive AWGs by controlling the doping concentration of Boron in overcladding and the etching depth of waveguide. The proposed method uses the conventional fabrication process and... 详细信息

关键词： PDL Reduction in Arrayed-Waveguide Gratings by Control of Stress in the Waveguide on of in by

Network-based identification of feedback modules that control RhoA activity and cell migration

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Journal of Molecular Cell Biology 2015年第3期7卷 242-252页

作者： Tae-Hwan Kim Naser Monsefi Je-hoon Song Alex von Kriegsheim Drieke Vandamme Olivier Pertz Boris NKholodenko Walter Kolch Kwang-Hyun cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 305-701Republic of Korea Systems Biology Ireland University College DublinBelfieldDublin 4Ireland Department of Biomedicine University of BaselBaselSwitzerland School of Medicine and Medical Science University College DublinBelfieldDublin 4Ireland Conway Institute of Biomolecular&Biomedical Research University College DublinBelfieldDublin 4Ireland

Cancer cell migration enables metastatic spread causing most cancer ***-family GTPases control cell migration,but being embedded in a highly interconnected feedback network,the control of their dynamical behavior during cell migration remains *** address this question,wereconstructed the Rho-family GTPases signaling network involved in cell migration,and developed a Boolean network model to analyze the different states and emergent rewiring of the Rho-family GTPases signaling network at protrusions and during extracellular matrix-dependent cell *** simulations and experimental validations revealed that the bursts of RhoA activity induced at protrusions by EGFare regulated by a negative-feedback module composed of Src,FAK,and ***,perturbing this module interfered with cyclic Rho activation and extracellular matrix-dependent migration,suggesting that CSK inhibition can be a novel and effective intervention strategy for blocking extracellular matrix-dependent cancer cell migration,while Src inhibition might fail,depending on the genetic background of ***,this study provides new insights into the mechanisms that regulate the intricate activation states of Rho-family GTPases during extracellular matrix-dependent migration,revealing potential new targets for interfering with extracellular matrix-dependent cancer cell migration.

关键词： cell migration Rho-family GTPases signaling network Boolean network model cyclical RhoA bursts

Phase separations in graded-indium content InGaN/GaN multiple quantum wells and its function to high quantum efficiency

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Journal of Semiconductors 2012年第5期33卷 13-16页

作者：郭洪英孙元平 Yong-hoon cho Eun-Kyung Suh Hai-Joon Lee Rak-Jun choi Yoon-Bong Hahn Institute of Science and Technology for Opto-Electronic Information Yantai University Department of Physics Korea Advanced Institute of Science and Technology School of Semiconductor and Chemical Engineering Semiconductor Physics Research CenterChonbuk National University School of Chemical Engineering Chonbuk National University

Phase separations have been studied for graded-indium content In_xGa_（1-x）N/GaN multiple quantum wells（MQWs） with different indium contents by means of photoluminescence（PL）,cathodeluminescence（CL） and time-resolved PL（TRPL） *** the main emission peaks,all samples show another 2 peaks at the high and low energy parts of the main peaks in PL when excited at 10 *** images show a clear contrast for 3 samples,which indicates an increasing phase separation with increasing indium *** spectra at 15 K of the main emissions show an increasing delay of rising time with indium content,which means a carrier transferring from low indium content structures to high indium content structures.

关键词： carrier transfer phase separation graded-indium content multiple quantum wells

Diphlorethohydroxycarmalol,a phlorotannin contained in brown edible seaweed Ishige okamurae,prevents AGE-related diabetic nephropathy by suppression of AGE-RAGE interaction

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Food Bioscience 2023年第3期53卷 1541-1550页

作者： Chi Heung cho Guijae Yoo Mingyeong Kim Chang Jun Lee In-Wook choi Bomi Ryu Byoung-Mok Kim Sang-hoon Lee Division of Functional Food Research Korea Food Research Institute245 nongsaengmyeong-roIseo-myeonWanju-gunJeollabuk-do55365Republic of Korea Department of Food Biotechnology University of Science and TechnologyDaejeon34113Republic of Korea Department of Food Science and Technology Chonbuk National UniversityJeollabuk-do54896Republic of Korea Major of Food Science and Nutrition Pukyong National UniversityBusan48513Republic of Korea Research Group of Food Processing Korea Food Research Institute245 nongsaengmyeong-roIseo-myeonWanju-gunJeollabuk-do55365Republic of Korea

Advanced glycation end-products(AGEs)are complex and heterogeneous compounds generated through various steps and are naturally produced during the glycation *** generated AGEs bind to long-lived proteins such as collagen and cause renal dysfunction,leading to AGE-related diabetic nephropathy(DN).In this study,we aimed to confirm the therapeutic potential of marine biological resources by evaluating the role of diphlorethohydroxycarmalol(DPHC),a major phlorotannin compound contained in edible brown algae Ishige okamurae,in the key mechanisms involved in the pathogenesis and progression of AGE-induced *** AGE formation inhibitory and AGE-collagen cross-link inhibiting/breaking ability assay were performed to evaluate the anti-glycation effect of *** AGE-RAGE interaction inhibitory effect was evaluated through molecular docking *** renoprotective effect of DPHC was confirmed in mouse glomerular mesangial *** treatment exhibited anti-glycation ability through suppression of AGE formation and AGE-collagen cross-linking generation,and disruption of cross-links formed between *** addition,DPHC pre-treatment significantly suppressed reactive oxygen species(ROS)production,intracellular methylglyoxal(MGO)/AGEs accumulation,and activation of apoptosis cascade by ***,DPHC suppressed AGE-receptor for AGE(RAGE)interaction by competing with MG-H1 for the binding site of ***,DPHC pre-treatment regulated apoptosis-related protein expression and increased Nrf2,Glo-1,HO-1,CAT,NQO1,and *** findings prove that the chemical structural characteristics of DPHC have the potential to prevent or manage AGE-induced DN by effectively mediating the key mechanisms responsible for its pathogenesis.

关键词： Diphlorethohydroxycarmalol Molecular docking RAGE Methylglyoxal Renoprotective effect

DISTRIBUTIONS ON ALMOST CONTACT MANIFOLDS

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Acta Mathematica Scientia 2017年第3期37卷 695-702页

作者： Hyunjoo cho National Center for Theoretical Sciences Mathematics Division Taipei 10617 China

It is known that any hypersurface in an almost complex space admits an almost contact manifold [11, 14]. In this article we show that a hyperplane in an almost contact manifold has an almost complex structure. Along with this result, we explain how to deter- mine when an almost contact structure induces a contact structure, followed by examples of a manifold with a closed G2-structure.

关键词： Almost contact structure contact structure G2-structure foliation integra-bility

Evaluation of non-ampullary duodenal polyps: Comparison of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2010年第43期16卷 5474-5480页

作者： Sung hoon Jung Woo Chul Chung Eun Jung Kim Seol Hye Kim Chang Nyol Paik Bo In Lee Young Seok cho Kang-Moon Lee Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To evaluate duodenal polyps, divided into nonneoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined. METHODS: We analyzed medical records of 50 114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps. RESULTS: Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On uni-variate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastroduodenal pathology, which was possibly associated with Helicobacter pylori . CONCLUSION: Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.

关键词： Duodenum Polyp Helicobacter pylori

Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis

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Molecular Plant 2021年第11期14卷 1951-1960页

作者： Arabidopsis Sera choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon cho Min-Sung Kim Sun Tae Kim Kee hoon Sohn Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea Department of Botany School of Chemical and Life SciencesJamia HamdardHamdard NagarNew Delhi 110062India Division of Biotechnology Korea UniversitySeoul 02841Republic of Korea The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate immunity. The bacterial acetyltransferase effectors HopZ5 and AvrBsT trigger immunity in Arabidopsis thaliana genotypes lacking SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1 (SOBER1). Using an Arabidopsis accession, Tscha-1, that naturally lacks functional SOBER1 but is unable to recognise HopZ5, we demonstrate that RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1) and RPM1-INTERACTING PROTEIN 4 (RIN4) are indispensable for HopZ5- or AvrBsT-triggered immunity. Remarkably, T166 of RIN4, the phosphorylation of which is induced by AvrB and AvrRpm1, was directly acetylated by HopZ5 and AvrBsT. Furthermore, we demonstrate that the acetylation of RIN4 T166 is required and sufficient for HopZ5- or AvrBsT-triggered RPM1-dependent defence activation. Finally, we show that SOBER1 interferes with HopZ5- or AvrBsT-triggered immunity by deacetylating RIN4 T166. We have thus elucidated detailed molecular mechanisms underlying the activation and suppression of plant innate immunity triggered by two bacterial acetyltransferases, HopZ5 and AvrBsT from different bacterial pathogens.

关键词： Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

Efficient Autonomous Defense System Using Machine Learning on Edge Device

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Computers, Materials & Continua 2022年第2期70卷 3565-3588页

作者： Jaehyuk cho School of Electronic Engineering Soongsil UniversitySeoul06978Korea

As a large amount of data needs to be processed and speed needs to be improved,edge computing with ultra-low latency and ultra-connectivity is emerging as a new *** changes can lead to new cyber risks,and should therefore be considered for a security threat *** this end,we constructed an edge system to study security in two directions,hardware and ***,on the hardware side,we want to autonomically defend against hardware attacks such as side channel attacks by configuring field programmable gate array(FPGA)which is suitable for edge computing and identifying communication status to control the communication method according to *** addition,on the software side,data collected on the server performs end-to-end encryption via symmetric encryption ***,we modeled autonomous defense systems on the server by using machine learning which targets to incoming and outgoing *** log utilizes existing intrusion detection datasets that should be used in real-world *** log was used to detect intrusion early by modeling an intrusion prevention system to identify behaviors that violate security policy,and to utilize the existing intrusion detection data set that should be used in a real *** this,we designed an efficient autonomous defense system that can provide a stable system by detecting abnormal signals from the device and converting them to an effective method to control edge computing,and to detect and control abnormal intrusions on the server side.

关键词： Autonomous defense side channel attack intrusion prevention system edge computing machine learning

Efficacy of hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第26期18卷 3426-3434页

作者： Yang Hyun Baek Kyoung Tae Kim Sung Wook Lee Jin Sook Jeong Byeong Ho Park Kyung Jin Nam Jin Han cho Young hoon Kim Young hoon Roh Hyung Sik Lee Young Min choi Sang Young Han Department of Internal Medicine Dong-A University College of MedicineBusan 602-103South Korea Department of Pathology Dong-A University College of MedicineBusan 602-103South Korea Department of Radiology Dong-A University College of MedicineBusan 602-103South Korea Department of Surgery Dong-A University College of MedicineBusan 602-103South Korea Department of Radiation Oncology Dong-A University College of MedicineBusan 602-103South Korea

AIM:To investigate the efficacy of hepatic arterial infusion chemotherapy(HAIC) using floxuridine(FUDR) in patients with advanced hepatocellular carcinoma(HCC) confined to the ***:Thirty-four patients who had advanced HCC with unresectability or unsuccessful previous therapy in the absence of extrahepatic metastasis were treated with intra-arterial FUDR chemotherapy at ourhospital between March 2005 and May *** the 34 patients,9 patients were classified as Child class C,and 18 patients had portal vein tumor thrombus(PVTT).One course of chemotherapy consisted of continuous infusion of FUDR(0.3 mg/kg during day 1-14) and dexamethasone(10 mg on day 1,4,7 and 11),and this treatment was repeated every 28 ***:Two patients(5.9%) displayed a complete response,and 12 patients(35.3%) had a partial *** tumor control rate was 61.8%.The median overall survival times were 15.3 mo,12.4 mo and 4.3 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0392).The progression-free survival was 12.9 mo,7.7 mo and 2.6 mo for the patients who were classified as Child class A,Child class B and Child class C,respectively(P = 0.0443).The cumulative survival differed significantly according to the Child-Pugh classification and the presence of *** addition to hepatic reserve capacity and PVTT,the extent of HCC was an independent factor in determining a poor *** most common adverse reactions to HAIC were mucositis,diarrhea and peptic ulcer disease,but most of these complications were improved by medical treatment and/or a delay of ***:The present study demonstrates that intra-arterial FUDR chemotherapy is a safe and effective treatment for advanced HCC that is recalcitrant to other therapeutic modalities,even in patients with advanced cirrhosis.

关键词： Hepatic arterial infusion chemotherapy Floxuridine Advanced hepatocellular carcinoma Child-Pugh classification Portal vein tumor thrombus