检索结果-南通市图书馆

The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype,promoting a favorable response to anti-PD-1 therapy via NLRP3 activation

引用

Cellular & Molecular Immunology 2024年第1期21卷 60-79页

作者： Fan luo Han Li Wenjuan Ma Jiaxin Cao Qun Chen Feiteng Lu Miaozhen Qiu Penghui Zhou Zengfei Xia Kangmei Zeng Jianhua Zhan Ting Zhou Qiuyun luo Wentao Pan Lin Zhang Chaozhuo Lin Yan Huang Li Zhang Dajun Yang hongyun Zhao State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Ascentage Pharma(Suzhou)Co Ltd 218 Xinghu StreetSuzhouJiangsu ProvinceChina

The main challenges in the use of immune checkpoint inhibitors(ICIs)are ascribed to the immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated CD8+T cells.Transforming the tumor microenvironment(TME)from“cold”to“hot”and thus more likely to potentiate the effects of ICIs is a promising strategy for cancer treatment.We found that the selective BCL-2 inhibitor APG-2575 can enhance the antitumor efficacy of anti-PD-1 therapy in syngeneic and humanized CD34+mouse models.Using single-cell RNA sequencing,we found that APG-2575 polarized M2-like immunosuppressive macrophages toward the M1-like immunostimulatory phenotype with increased CCL5 and CXCL10 secretion,restoring T-cell function and promoting a favorable immunotherapy response.Mechanistically,we demonstrated that APG-2575 directly binds to NF-κB p65 to activate NLRP3 signaling,thereby mediating macrophage repolarization and the activation of proinflammatory caspases and subsequently increasing CCL5 and CXCL10 chemokine production.As a result,APG-2575-induced macrophage repolarization could remodel the tumor immune microenvironment,thus improving tumor immunosuppression and further enhancing antitumor T-cell immunity.Multiplex immunohistochemistry confirmed that patients with better immunotherapeutic efficacy had higher CD86,p-NF-κB p65 and NLRP3 levels,accompanied by lower CD206 expression on macrophages.Collectively,these data provide evidence that further study on APG-2575 in combination with immunotherapy for tumor treatment is required.

关键词： BCL-2 APG-2575 ICIs Macrophages NLRP3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of magnetic field on dislocation morphology and precipitation behaviour in ultrafine-grained 7075 aluminium alloy

引用

Journal of Materials Science & Technology 2021年第34期93卷 128-146页

作者： Jun luo hongyun luo Tianshu Zhao Runze Wang Key Laboratory of Aerospace Materials and Performance(Ministry of Education) School of Materials Science and EngineeringBeihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China

The influence of magnetic field(1 T)on dislocation morphology and precipitation behaviour of ultrafinegrained(UFG)Al 7075 alloy was investigated after ageing from 90 to 200℃ via wide angle X-ray scattering(WAXS),small angle X-ray scattering(SAXS),and transmission electron microscopy(TEM).Experimental results reveal that the improved precipitation kinetics of alloys in the thickness plane(denoted as sample II)as compared to those in the rolling plane(denoted as sample I),which arises due to a higher dislocation density(morphology of dislocation cells)of the thickness plane than that of the rolling plane(morphology of dislocations and dislocation tangles).Specifically,because of different dislocation morphologies,the magnetic field positively and negatively affects the dislocation activity in samples I and II,leading to enhanced and suppressed precipitation behaviors,respectively.Interestingly,nucleation of theηphase is facilitated in the UFG alloy at the critical temperature(140℃)because it affords a faster rate of atom diffusion and a higher dislocation density as compared to those exhibited by its coarse-grained alloy.This systematic and comprehensive study provides new insights into dislocation morphology and precipitation behaviour of the UFG 7075 Al alloy,while enabling the optimization of precipitation kinetics.

关键词： Ultrafine-grained Al alloy Precipitation behaviors Magnetic field Dislocation morphology Critical temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

密集追踪研究中测验信度的估计:多层结构和动态特性的视角

引用

心理科学进展 2024年第4期32卷 700-714页

作者：罗晓慧刘红云北京师范大学心理学部应用实验心理北京市重点实验室心理学国家级实验教学示范中心(北京师范大学)北京100875

随着密集追踪研究在心理学等社会科学领域的广泛运用,密集追踪情境中测验信度的估计也受到越来越多研究者的关注。早期沿用横断研究中信度估计思想或基于概化理论的信度估计方法存在诸多局限,并不适用于密集追踪的情境。针对密集追踪数... 详细信息

随着密集追踪研究在心理学等社会科学领域的广泛运用,密集追踪情境中测验信度的估计也受到越来越多研究者的关注。早期沿用横断研究中信度估计思想或基于概化理论的信度估计方法存在诸多局限,并不适用于密集追踪的情境。针对密集追踪数据的多层结构和动态特性这两大特点,可基于多层验证性因子分析、动态因子分析和动态结构方程模型估计密集追踪研究中测验的信度。通过实证数据的演示与比较,讨论三种估计方法的特点和适用情境。未来研究可基于其它密集追踪模型探讨测验信度的估计,也应重视测验信度的检验与报告。

关键词：密集追踪研究信度多层结构动态特性动态结构方程模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国绿色创新效率空间关联网络特征及其驱动因素研究

引用

生态经济 2024年第7期40卷 57-65页

作者：王东罗红云新疆财经大学财政税务学院新疆乌鲁木齐830012

运用基于序列DEA的SE-U-SBM模型测度我国30个省份2007—2019年绿色创新效率,利用修正的引力模型和社会网络分析方法解构了我国省际绿色创新效率的空间关联特征,并借助QAP方法探讨了绿色创新效率空间关联网络的驱动因素。研究结果显示:(1... 详细信息

运用基于序列DEA的SE-U-SBM模型测度我国30个省份2007—2019年绿色创新效率,利用修正的引力模型和社会网络分析方法解构了我国省际绿色创新效率的空间关联特征,并借助QAP方法探讨了绿色创新效率空间关联网络的驱动因素。研究结果显示:(1)我国省际绿色创新效率上升趋势明显,呈现东部>中部>西部的空间分布格局。(2)中国绿色创新效率的空间关联呈现出复杂的多线程空间网络关联关系,省际绿色创新效率的关联性不断加强,空间关联网络稳定性进一步增强,东部省份大多属于净溢出板块,中西部省份为相对受益板块。(3)地理距离、城镇化水平差异、人力资本差异、财政分权差异、相近的R&D投入强度和资源禀赋差异是影响我国绿色创新效率空间关联网络形成与发展的重要驱动因素,对绿色创新效率空间关联网络具有显著的促进作用。应着力推动要素市场化改革,破除区域市场分割和行政壁垒,加强区域政策协调性,实现绿色创新效率协同提升。

关键词：绿色创新效率社会网络分析 QAP方法驱动因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Precipitation behavior and grain refinement of burnishing Al-Zn-Mg alloy

引用

Progress in Natural Science:Materials International 2018年第1期28卷 54-59页

作者： Ce Pang hongyun luo Zheng Zhang Yue Ma Key Laboratory of Aerospace Materials and Performance School of Materials Science and Engineering Beihang University

Burnishing is a unique strengthening approach to improve the strength of surface layer and remains the ductility of the interior of metallic materials. In this work, burnishing treatment was employed to improve the surface microstructure of naturally aged Al-Zn-Mg alloys after solid solution. Transmission electron microscopy, highresolution transmission electron microscopy, X-ray diffraction and nano-indentation were used to characterize the effects of the burnishing on the microstructures of surface layer and Guinier-Preston(GP) zones. It was indicated that GP zones uniformly distributed and dispersed in the matrix before burnishing, and the amount of GP zones decreased dramatically after burnishing processing. Additionally, the grains in the surficial layer were refined into nano-crystals with an average grain size of 78 nm. Burnishing treatment not only led to formation of large number of dislocation substructures in the sub-surface and near-matrix surface, but also promoted the precipitation of metastable η’ phase at grain boundaries. The synergistic effects of the grain refinement, dislocation multiplication and the precipitation of η’ phase strengthen the burnished layer of Al-Zn-Mg alloy.

关键词： Al-Zn-Mg alloy Burnishing Nano-crystal Precipitation Grain refinement

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants

引用

Journal of Environmental Sciences 2023年第2期124卷 397-413页

作者： Yicheng Wang hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian luo Yongchun Zhao Hong Yao State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution Control School of Energy and Mechanical EngineeringNanjing Normal UniversityNanjing 210023China

Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed.

关键词： Coal combustion Particulate lead Formation and migration Removal strengthen Environmental risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of Passive Films Formed on As-received and Sensitized AISI 304 Stainless Steel

引用

Chinese Journal of Mechanical Engineering 2019年第2期32卷 61-72页

作者： Yubo Zhang hongyun luo Qunpeng Zhong Honghui Yu Jinlong Lv Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics The Collaborative Innovation Center for Advanced Aero-Engine (CICAAE) Beijing University of Aeronautics and Astronautics Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beijing University of Aeronautics and Astronautics China Waterborne Transport Research Institute Beijing Key Laboratory of Fine Ceramics Institute of Nuclear and New Energy Technology Tsinghua University

The current research of corrosion resistance of stainless steels mainly focuses on characterization of the passive films by point defect mode and mixed-conduction model. The corrosion resistance of the passive films formed on asreceived and sensitized AISI304 stainless steel in borate bu er solution were evaluated in this paper. The degree of sensitization and corrosion resistance of AISI304 stainless steels was evaluated by double loop electrochemical potentiodynamic reactivation and electrochemical impedance spectroscopy. The passive films formed on the stainless steels were studied by XPS technique. It was found that as-received specimen had higher pitting corrosion potential and corrosion resistance than sensitized one. The Mott-Schottky results showed that sensitized stainless steel had more defects in the passive film than as-received one. The compositions of the passive films were mainly Cr and Fe oxides according to XPS results.

关键词： 304 stainless steel Sensitization Passive films XPS Impedance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Self-energy dynamics and the mode-specific phonon threshold effect in Kekulé-ordered graphene

引用

National Science Review 2022年第5期9卷 81-88页

作者： hongyun Zhang Changhua Bao Michael Schüler Shaohua Zhou Qian Li Laipeng luo Wei Yao Zhong Wang Thomas P.Devereaux Shuyun Zhou State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Stanford Institute for Materials and Energy Sciences (SIMES) SLAC National Accelerator Laboratory Department of Materials Science and Engineering Stanford University Institute for Advanced Study Tsinghua University Frontier Science Center for Quantum Information

Electron-phonon interaction and related self-energy are fundamental to both the equilibrium properties and non-equilibrium relaxation dynamics of solids.Although ele ctron-phonon interaction has been suggested by various time-resolved measurements to be important for the relaxation dynamics of graphene,the lack of energy-and momentum-resolved self-energy dynamics prohibits direct identification of the role of specific phonon modes in the relaxation dynamics.Here,by performing time-and angle-resolved photoemission spectroscopy measurements on Kekulé-ordered graphene with folded Dirac cones at the Γ point, we have succeeded in resolving the self-energy effect induced by the coupling of electrons to two phonons at Ω=177 meV and Ω=54 meV,and revealing its dynamical change in the time domain.Moreover,these strongly coupled phonons define energy thresholds,which separate the hierarchical relaxation dynamics from ultrafast,fast to slow,thereby providing direct experimental evidence for the dominant role of mode-specific phonons in the relaxation dynamics.

关键词： TrARPES self-energy electron-phonon coupling Kekulé-ordered graphene

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

区块链技术在碳管理中的应用与创新

引用

能源研究与信息 2024年第2期40卷 116-123页

作者：林向义连樱洹罗洪云张建华东北石油大学经济管理学院黑龙江大庆163318 衢州学院商学院浙江衢州324000 东北石油大学能源经济研究院黑龙江大庆163318

区块链是具有去中心化、共识机制、非对称性加密等独特优势的新兴技术,能够针对性地解决碳管理过程中存在的脱碳对象识别不精准、数据信息统计不对称、部门权责整合不规范、相关数据安全管控弱、碳中和绩效难以考核等问题。提出基于区... 详细信息

区块链是具有去中心化、共识机制、非对称性加密等独特优势的新兴技术,能够针对性地解决碳管理过程中存在的脱碳对象识别不精准、数据信息统计不对称、部门权责整合不规范、相关数据安全管控弱、碳中和绩效难以考核等问题。提出基于区块链技术的碳管理实现体系,重点阐释其创新形式、架构和功能,并从加强宣传力度、转变传统理念、培育优秀人才、强化技术创新、先试点后推广、完善制度制定、优化监管体系、建立健全法律、明确奖惩制度等方面来全面解读其实现路径,对加速我国“30·60”碳中和战略目标的实现进程,促进我国经济高质量发展,具有非常重要的现实意义。

关键词：区块链碳管理体系设计政策

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Degradative solvent extraction of low-rank coal:Role of water on pyrolysis mechanism of low-rank coal in a highly-dispersed medium

引用

Carbon Resources Conversion 2022年第2期5卷 111-118页

作者： Zhenzhong Hu Xu Zhang Xian Li Weixiang Qian Guangqian luo Huan Liu hongyun Hu Nakorn Worasuwannarak Hong Yao State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyHubei 430074People’s Republic of China Key Laboratory of Coal Clean Conversion and Chemical Process Autonomous Region College of Chemistry and Chemical EngineeringXinjiang UniversityXinjiang 830000People’s Republic of China The Joint Graduate School of Energy and Environment Center of Excellence on Energy Technology and EnvironmentKing Mongkut’s University of Technology ThonburiBangmodTungkruBangkok 10140Thailand

A degradative solvent extraction(DSE)method was proposed to upgrade low-rank coals(LRC)for their cascaded utilizations in a highly-dispersed medium.The derived products exhibited well improved properties in comparison to the raw LRCs.Previously,the LRCs were pre-dried to eliminate the potential impact of the varied water content of raw LRCs,but in light of the abundant water in fresh coals,the hydrolyzing effect of water on coals under heating,and the energy cost to pre-dry the LRCs,it is consequently essential to clarify the effect of water so as to verify the necessity of pre-drying process.In this study,the roles of inherent water and extra-added water were respectively investigated,using dried,raw and wet coals from two typical LRCs.The results show that increasing the moisture content of raw LRCs contributed to the extraction ability of DSE method without noticeably changing the elemental composition,chemical structure and thermal decomposition behavior of extractable products,thus pre-drying of LRCs before DSE treatment was proven unnecessary.Additionally,the roles of the inherent water were concluded as:1)leading to the formation of stable covalent bond during drying process;and 2)acting as H donor to promote extraction ability,while the added water can only function as H donor.Since excessive water will increase the pressure during DSE treatment and lead to the waste water treatment,the LRCs with a water content between 10%and 30%were consequently recommended for the practical application of DSE treatment.

关键词： Low-rank coal Degradative solvent extraction Upgrading mechanism Water

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：